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    • 24. 发明授权
    • Method for manufacturing non-oriented electrical steel sheet showing
superior adherence of insulating coated layer
    • 制造无取向电工钢板的方法,其表现出优异的绝缘涂层粘附性
    • US5803988A
    • 1998-09-08
    • US894394
    • 1997-08-18
    • Byung Keun BaeSam Kyu ChangJong Soo WooWun Gul Lee
    • Byung Keun BaeSam Kyu ChangJong Soo WooWun Gul Lee
    • C21D3/04C21D8/12C22C38/02H01F1/147H01F1/18
    • C21D8/1288C21D8/1272C21D8/1277H01F1/147H01F1/18C21D3/04
    • The annealing conditions of a cold rolled steel sheet are properly controlled so as to form a dense surface oxide layer, thereby improving the adherence strength of the insulating layer on non-oriented electrical steel sheet. The method includes the following steps. A steel slab is prepared which is composed of in weight %: 0.05% or less of C, 3.5% or less of Si, 1.5% or less of Mn, 0.15% or less of P, 0.015% or less of S, 1.0% or less of Al, one or more elements selected from a group consisting of 0.03-0.30% of Sn, 0.03-0.3% of Sb, 0.03-1.0% of Ni and 0.03-0.50% of Cu, the balance of Fe and unavoidable impurities. The steel slab is reheated, hot rolled, pickled after annealing or without annealing and cold-rolled. A low temperature annealing is carried out on the cold rolled steel sheet at a temperature of 750.degree.-850.degree. C. for 30 seconds to 5 minutes under a humid atmosphere having a dew point of 25.degree.-65.degree. C. A high temperature annealing is carried out on the low-temperature-annealed cold rolled steel sheet at a temperature of 800.degree.-1070.degree. C. for 10 seconds to 3 minutes under a dry atmosphere having a dew point of 0.degree. C. or below. Insulating layers are coated on the surfaces of the high-temperature-annealed steel sheet, and a hardening heat treatment is carried out on the steel sheet.
    • PCT No.PCT / KR96 / 00078 Sec。 371日期:1997年8月18日 102(e)1997年8月18日PCT PCT 1996年6月1日PCT公布。 公开号WO97 / 22723 日期1996年6月26日冷轧钢板的退火条件被适当地控制,以形成致密的表面氧化物层,从而提高无取向电工钢板上的绝缘层的粘附强度。 该方法包括以下步骤。 制备钢板,其重量%:C:0.05%以下,Si:3.5%以下,Mn:1.5%以下,P:0.15%以下,S:0.015%以下,1.0% 或更少的Al,一种或多种选自Sn,0.03-0.30%的Sn,0.03-0.3%的Sb,0.03-1.0%的Ni和0.03-0.50%的Cu,其余的Fe和不可避免的杂质 。 再次加热,热轧,退火或不退火冷轧后酸洗。 在露点为25〜-65℃的潮湿气氛下,在750〜-850℃的温度下对冷轧钢板进行低温退火30秒〜5分钟。高温退火 在露点为0℃以下的干燥气氛下,在800〜-1070℃的温度下在低温退火冷轧钢板上进行10秒钟〜3分钟。 在高温退火钢板的表面上涂布绝缘层,对钢板进行硬化热处理。
    • 29. 发明授权
    • Cyclosporin soft capsule composition
    • 环孢菌素软胶囊组合物
    • US5639474A
    • 1997-06-17
    • US427465
    • 1995-04-24
    • Jong Soo Woo
    • Jong Soo Woo
    • A61K38/13A61K9/10A61K9/48
    • B82Y5/00A61K38/13Y10S514/885Y10S514/937Y10S514/962Y10S514/97Y10S514/975
    • The present invention relates to a microemulsion concentrate containing cyclosporin as an active ingredient, dimethylisosorbide as a cosurfactant, oil and a surfactant which is suitable for the formulation of a soft capsule for oral administration, said cyclosporin, dimethyl isosorbide, oil and surfactant being present in the ratio of 1:1-5:1-5:2-10, and preferably in the ratio of 1:2-4:2-5:2-4:7, by weight. Since dimethylisosorbide has substantially no membrane permeation property, the soft capsule preparation according to the present invention is outstandingly stable in comparison with the soft capsules containing ethanol, propylene glycol, transcutol, glycofurol, etc., as a cosurfactant in the prior art, and further provides an advantage in that the pharmaceutical effect, appearance and composition content of the soft capsule according to the present invention are not changed.
    • 本发明涉及含有环孢菌素作为活性成分的微乳液浓缩物,二甲基异山梨醇作为辅助表面活性剂,油和表面活性剂,其适用于配制口服软胶囊,所述环孢菌素,二甲基异山梨醇,油和表面活性剂存在于 1:1-5:1-5:2-10的比例,优选的比例为1:2-4:2-5:2-4:7。 由于二甲基异山梨醇基本上没有膜渗透性,因此与现有技术中作为辅助表面活性剂的乙醇,丙二醇,吡咯醇,糖醇等软胶囊相比,本发明的软胶囊制剂显着稳定 提供了根据本发明的软胶囊的药物作用,外观和组合物含量不改变的优点。