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21. 发明申请

US20070248251A1 SYSTEM AND METHOD FOR LEARNING-BASED 2D/3D RIGID REGISTRATION FOR IMAGE-GUIDED SURGERY 有权
标题翻译：用于图像导向手术的基于学习的2D / 3D刚体注册的系统和方法
公开(公告)号：US20070248251A1
公开(公告)日：2007-10-25
申请号：US11686533
申请日：2007-03-15
申请人： Rui Liao , Christoph Guetter , Chenyang Xu , Yiyong Sun , Ali Khamene , Frank Sauer
发明人： Rui Liao , Christoph Guetter , Chenyang Xu , Yiyong Sun , Ali Khamene , Frank Sauer
IPC分类号： G06K9/00 , G06T11/00
CPC分类号： G06K9/00208 , G06K9/6212 , G06T7/33 , G06T7/35 , G06T2207/30101
摘要： A method of registering 3-dimensional digitized images to 2-dimensional digitized images during a medical procedure includes providing a pair of correctly-registered training images L={lr, lf} and their joint intensity distribution pl(ir, if), wherein ir and if are reference and floating images, respectively, providing a pair of observed images O={or, of} and their joint intensity distribution po(ir, if), mapping a marginal intensity distribution of the observed pair O={or, of} to a marginal intensity distribution of the training pair L={lr, lf}, and estimating a set of parameters T that registers image of to image or by maximizing a weighted sum of a Jensen-Shannon divergence (JSD) of a joint intensity distribution of the observed pair and a joint intensity distribution of the training pair and a similarity measure between the observed images.
摘要翻译：在医疗过程中将三维数字化图像记录到二维数字化图像的方法包括提供一对正确注册的训练图像L =（1/2） >}和它们的联合强度分布p（i），其中i i和i i f分别是提供一对观察图像的参考和浮动图像，它们的联合强度分布映射所观察到的对的边缘强度分布O = {o 以及训练对的边缘强度分布L = {1> 1，...，...），并且估计一组通过最大化所观察到的对的联合强度分布的Jensen-Shannon发散（JSD）的加权和来加权对照图像的参数T，以使图像o 训练对的联合强度分布以及观察到的图像之间的相似性度量。

22. 发明申请

US20050094898A1 Method and system for hybrid rigid registration of 2D/3D medical images 有权
标题翻译： 2D / 3D医学图像混合刚性配准的方法和系统
公开(公告)号：US20050094898A1
公开(公告)日：2005-05-05
申请号：US10946204
申请日：2004-09-21
申请人： Chenyang Xu , Xiaolei Huang , Frank Sauer , Christophe Chefd'hotel , Jens Guhring , Sebastian Vogt , Yiyong Sun
发明人： Chenyang Xu , Xiaolei Huang , Frank Sauer , Christophe Chefd'hotel , Jens Guhring , Sebastian Vogt , Yiyong Sun
IPC分类号： G06K9/00 , G06K9/64 , G06T7/40
CPC分类号： G06K9/00208 , G06T7/33 , G06T7/35
摘要： A method of aligning a pair of images with (101) a first image and a second image, wherein said images comprise a plurality of intensities corresponding to a domain of points in a D-dimensional space includes identifying (102) feature points on both images using the same criteria, computing (103) a feature vector for each feature point, measuring a feature dissimilarity (104) for each pair of feature vectors, wherein a first feature vector of each pair is associated with a first feature point on the first image, and a second feature vector of each pair is associated with a second feature point on the second image. A correspondence mapping (105) for each pair of feature points is determined using the feature dissimilarity associated with each feature point pair, and an image transformation (106) is defined to align (108) the second image with the first image using one or more pairs of feature points that are least dissimilar.
摘要翻译：一种将一对图像与（101）第一图像和第二图像对准的方法，其中所述图像包括对应于D维空间中的点的区域的多个强度，包括在两个图像上识别（102）特征点使用相同的标准，计算（103）每个特征点的特征向量，测量每对特征向量的特征不相似性（104），其中每对特征向量的第一特征向量与第一图像上的第一特征点相关联并且每对的第二特征向量与第二图像上的第二特征点相关联。使用与每个特征点对相关联的特征不相似度来确定每对特征点的对应映射（105），并且定义图像变换（106）以使用一个或多个对象（108）将第二图像与第一图像对准成对的特征点是最不相似的。

23. 发明授权

US08428316B2 Coronary reconstruction from rotational X-ray projection sequence 失效
标题翻译：旋转X射线投影序列冠状动脉重建
公开(公告)号：US08428316B2
公开(公告)日：2013-04-23
申请号：US12275714
申请日：2008-11-21
申请人： Yiyong Sun , Rui Liao , Luc Duong , Frank Sauer , Chenyang Xu
发明人： Yiyong Sun , Rui Liao , Luc Duong , Frank Sauer , Chenyang Xu
IPC分类号： A61B6/03
CPC分类号： G06T7/55 , G06T7/136 , G06T2207/10116 , G06T2207/20044 , G06T2207/30101 , G06T2207/30172
摘要： A method for three-dimensional reconstruction of a branched object from a rotational sequence of images of the branched object includes segmenting the branched object from each image of the sequence, extracting centerlines of the branched object, performing symbolic reconstruction via a stereo correspondence matching between the centerlines from different views of the sequence of images using a graph cut-based optimization, and creating a three-dimensional tomographic reconstruction of the branched object compensated for motion of the branched object between the images of the sequence.
摘要翻译：从分支对象的图像的旋转顺序对分支对象进行三维重建的方法包括从分支对象的每个图像分割分支对象，提取分支对象的中心线，通过在对象之间的立体对应匹配进行符号重建使用基于图切割优化的图像序列的不同视图的中心线，以及创建分支对象的三维断层重建，以补偿分支对象在序列图像之间的运动。

24. 发明授权

US07715604B2 System and method for automatically registering three dimensional cardiac images with electro-anatomical cardiac mapping data 有权
标题翻译：用于自动记录三维心脏图像与电解剖心脏图像数据的系统和方法
公开(公告)号：US07715604B2
公开(公告)日：2010-05-11
申请号：US11330633
申请日：2006-01-12
申请人： Yiyong Sun , Fred S. Azar , Chenyang Xu , Frank Sauer , Norbert Rahn
发明人： Yiyong Sun , Fred S. Azar , Chenyang Xu , Frank Sauer , Norbert Rahn
IPC分类号： G06K9/00 , G06K9/32 , A61B5/05
CPC分类号： A61B5/0035 , A61B5/042 , A61B5/055 , A61B6/03 , G06T7/33 , G06T2207/30048
摘要： A system and method for automatically registering a three dimensional (3D) pre-operative image of an anatomical structure with intra-operative electrophysiological (EP) points of a 3D electro-anatomical (EA) image map of the anatomical structure is disclosed. The pre-operative image is displayed in a first supporting view. The intra-operative EA image map is displayed in a second supporting view. An alignment of the pre-operative image with the intra-operative map is performed by identifying at least one corresponding point on each image. The view of the pre-operative image is integrated with the EA map based on the alignment.
摘要翻译：公开了一种用于自动登记解剖结构的三维（3D）术前图像的解剖结构的3D电解剖（EA）图像的手术电生理（EP）点的系统和方法。术前图像显示在第一支持视图中。术中EA图像映射显示在第二支持视图中。通过识别每个图像上的至少一个对应点来执行术前图像与手术前图像的对准。基于对齐，将术前图像的视图与EA图集成。

25. 发明申请

US20080275467A1 Intraoperative guidance for endovascular interventions via three-dimensional path planning, x-ray fluoroscopy, and image overlay 审中-公开
标题翻译：通过三维路径规划，X射线透视和图像叠加进行血管内干预的术中指导
公开(公告)号：US20080275467A1
公开(公告)日：2008-11-06
申请号：US12110415
申请日：2008-04-28
申请人： Rui Liao , Ashraf Mohamed , Yiyong Sun , Chenyang Xu
发明人： Rui Liao , Ashraf Mohamed , Yiyong Sun , Chenyang Xu
IPC分类号： A61B17/00
CPC分类号： A61B6/5235 , A61B5/055 , A61B6/032 , A61B6/12 , A61B6/466 , A61B6/481 , A61B6/504 , A61B17/12022 , A61B34/10 , A61B90/36 , A61B2017/1205 , A61B2090/364 , A61F2/95
摘要： A method for planning a path for an endovascular intervention includes acquiring and displaying 3D angiographic images; selecting a target on the displayed images; extracting a skeleton of a vascular tree from the displayed images; extracting a symbolic vessel path to the target based on the skeleton of the vascular tree; and overlaying and displaying the symbolic vessel path on 2D fluoroscopic images for guiding the endovascular intervention.
摘要翻译：用于规划血管内干预的路径的方法包括获取和显示3D血管造影图像; 在显示的图像上选择目标; 从所显示的图像中提取血管树的骨架; 基于血管树的骨架提取到目标的符号血管路径; 并在2D荧光镜图像上叠加和显示符号血管路径，用于引导血管内介入。

26. 发明申请

US20080095421A1 REGISTERING 2D AND 3D DATA USING 3D ULTRASOUND DATA 有权
标题翻译：使用3D超声数据注册2D和3D数据
公开(公告)号：US20080095421A1
公开(公告)日：2008-04-24
申请号：US11874266
申请日：2007-10-18
申请人： Yiyong Sun , Rui Liao , Chenyang Xu , Frank Sauer
发明人： Yiyong Sun , Rui Liao , Chenyang Xu , Frank Sauer
IPC分类号： A61B5/00
CPC分类号： A61B6/487 , A61B5/06 , A61B5/062 , A61B6/12 , A61B6/481 , A61B6/504 , A61B6/5247 , A61B8/0833 , A61B8/12 , A61B8/4254 , A61B8/4416
摘要： A fluoroscopy image is registered with data representing a volume, identifying a catheter position relative to a volume represented by preoperative volume data. The catheter position relative to a patient volume represented by data acquired without scanning the catheter is displayed. For example, a 2D fluoroscopy image is registered with respect to coordinates of a 3D preoperative CT or MRI volume by registering the fluoroscopy image and the preoperative volume to 3D ultrasound coordinates.
摘要翻译：用表示体积的数据记录荧光透视图像，识别相对于由术前体积数据表示的体积的导管位置。显示相对于由不扫描导管获取的数据表示的患者体积的导管位置。例如，通过将荧光透视图像和术前体积登记到3D超声坐标，相对于3D术前CT或MRI体积的坐标登记2D透视图像。

27. 发明申请

US20070247476A1 Fast smooth up-sampling of binary volumes derived from medical imaging 审中-公开
标题翻译：从医学成像衍生的二进制体积的快速平滑上采样
公开(公告)号：US20070247476A1
公开(公告)日：2007-10-25
申请号：US11699188
申请日：2007-01-29
申请人： Liron Yatziv , Yiyong Sun , Chenyang Xu
发明人： Liron Yatziv , Yiyong Sun , Chenyang Xu
IPC分类号： G09G5/00
CPC分类号： G06T3/4023
摘要： This invention describes a computer method of up-sampling (enlarging) a binary volume where the shapes and regions in the final up-sampled volume have smooth shapes and regions without the jagged edges exhibited in the up-sampled volumes processed by conventional methods. This up-sampling method is suitable for any multi-dimensional binary volumes including 3 dimensional medical imaging data.
摘要翻译：本发明描述了一种二进制体积的上采样（放大）的计算机方法，其中最终上采样体积中的形状和区域具有平滑形状和区域，而在通过常规方法处理的上采样体积中没有锯齿状边缘。该采样方法适用于包括三维医学成像数据的任何多维二进制体积。

28. 发明申请

US20060159323A1 System and method for automatically registering three dimensional cardiac images with electro-anatomical cardiac mapping data 有权
标题翻译：用于自动记录三维心脏图像与电解剖心脏图像数据的系统和方法
公开(公告)号：US20060159323A1
公开(公告)日：2006-07-20
申请号：US11330633
申请日：2006-01-12
申请人： Yiyong Sun , Fred Azar , Chenyang Xu , Frank Sauer , Norbert Rahn
发明人： Yiyong Sun , Fred Azar , Chenyang Xu , Frank Sauer , Norbert Rahn
IPC分类号： G06K9/00 , G06K9/32
CPC分类号： A61B5/0035 , A61B5/042 , A61B5/055 , A61B6/03 , G06T7/33 , G06T2207/30048
摘要： A system and method for automatically registering a three dimensional (3D) pre-operative image of an anatomical structure with intra-operative electrophysiological (EP) points of a 3D electro-anatomical (EA) image map of the anatomical structure is disclosed. The pre-operative image is displayed in a first supporting view. The intra-operative EA image map is displayed in a second supporting view. An alignment of the pre-operative image with the intra-operative map is performed by identifying at least one corresponding point on each image. The view of the pre-operative image is integrated with the EA map based on the alignment.
摘要翻译：公开了一种用于自动登记解剖结构的三维（3D）术前图像的解剖结构的3D电解剖（EA）图像的手术电生理（EP）点的系统和方法。术前图像显示在第一支持视图中。术中EA图像映射显示在第二支持视图中。通过识别每个图像上的至少一个对应点来执行术前图像与手术前图像的对准。基于对齐，将术前图像的视图与EA图集成。

29. 发明申请

US20050249434A1 Fast parametric non-rigid image registration based on feature correspondences 失效
标题翻译：基于特征对应的快速参数非刚性图像配准
公开(公告)号：US20050249434A1
公开(公告)日：2005-11-10
申请号：US11099143
申请日：2005-04-05
申请人： Chenyang Xu , Xiaolei Huang , Yiyong Sun
发明人： Chenyang Xu , Xiaolei Huang , Yiyong Sun
IPC分类号： G06K9/00 , G06K9/32 , G06K9/64
CPC分类号： G06K9/6211
摘要： A method and system for non-rigidly registering a fixed to a moving image utilizing a B-Spline based free form deformation (FFD) model is disclosed. The methodology utilizes sparse feature correspondences to estimate an elastic deformation field in a closed form. In a multi-resolution manner, the method is able to recover small to large non-rigid deformations. The resulting deformation field is globally smooth and guarantees one-to-one mapping between the images being registered. The method generally comprises the steps of: detecting feature points on the fixed image and feature points on the moving image; assigning a feature vector to each feature point; calculating the dissimilarity of each pair of feature vectors for feature pairs on the fixed image and the moving image; calculating the correspondence between feature pairs based on the dissimilarity measure; solving for a dense deformation field P using a closed form FFD model; and transforming the moving image and the feature points on the moving image using a current FFD deformation field estimate.
摘要翻译：公开了一种使用B-Spline的自由形状变形（FFD）模型非固定地将固定到运动图像上的方法和系统。该方法利用稀疏特征对应来估计封闭形式的弹性变形场。以多分辨率方式，该方法能够恢复小到大的非刚性变形。所产生的变形场全局平滑，并保证要注册的图像之间的一对一映射。该方法通常包括以下步骤：检测固定图像上的特征点和运动图像上的特征点; 向每个特征点分配特征向量; 计算固定图像和运动图像上特征对的每对特征向量的不相似性; 基于不相似度计算特征对之间的对应关系; 使用封闭形式的FFD模型求解致密变形场P; 以及使用当前FFD变形场估计来变换运动图像上的运动图像和特征点。

30. 发明授权

US08131075B2 Fast 4D segmentation of large datasets using graph cuts 有权
标题翻译：使用图形切割快速4D分割大型数据集
公开(公告)号：US08131075B2
公开(公告)日：2012-03-06
申请号：US11927777
申请日：2007-10-30
申请人： Yiyong Sun , Herve Jun Alfred Lombaert , Farida Cheriet
发明人： Yiyong Sun , Herve Jun Alfred Lombaert , Farida Cheriet
IPC分类号： G06K9/34
CPC分类号： G06K9/342
摘要： A method for segmenting at least a pair of regions of an image. High resolution data is obtained of the image. Each one of the pair of the regions in the image is marked. Graph cuts are used on the downsampled data to obtain first voxels along an outer boundary of a selected one of the pair of marked regions and second voxels along an inner boundary the selected region. The graphs cuts are projected to the previously obtained high-resolution image data. First and second sets of seeds are placed on the first voxels and a second set of seeds respectively. The first seeds grow into first areas extending inwardly of the selected region while simultaneously the second seeds grow into second areas extending towards the first extending areas until the first areas and the second areas meet to thereby establish the outer boundary of the selected region.
摘要翻译：一种用于分割图像的至少一对区域的方法。获得图像的高分辨率数据。图像中的一对区域中的每一个被标记。在下采样数据上使用图形切割以沿着所选择的一对标记区域中的所选择的一个的外边界和沿所选区域的内边界的第二体素获得第一体素。图形切割投影到先前获得的高分辨率图像数据。第一组和第二组种子分别放置在第一个体素上，第二组种子分别放置在第一个体素上。第一种子生长到从所选择的区域向内延伸的第一区域中，同时第二种子生长到朝向第一延伸区域延伸的第二区域，直到第一区域和第二区域相交，从而建立所选区域的外边界。

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