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21. 发明授权

US08440630B2 Akt activity specifically inhibiting polypeptide 有权
标题翻译： Akt活性特异性抑制多肽
公开(公告)号：US08440630B2
公开(公告)日：2013-05-14
申请号：US10583058
申请日：2004-12-14
申请人： Masayuki Noguchi , Futoshi Okada , Makoto Hiromura
发明人： Masayuki Noguchi , Futoshi Okada , Makoto Hiromura
IPC分类号： A61K38/10 , A61K38/16 , A61P35/00 , A61P35/02 , G01N33/574
CPC分类号： C07K14/4703 , A61K38/00 , C07K7/08 , C07K14/47 , C07K16/40
摘要： The present invention is to provide a polypeptide specifically inhibiting the activity of Akt (Protein Kinase B), the DNA thereof, the antibody thereof, an inhibitor of Akt activity or an antitumor agent, and the like. The polypeptide comprises polypeptides (SEQ ID NO: 1, 3, 5, 7, and 9 of the sequence listing) that contain an amino acid sequence corresponding to any of the position of amino acid residue 10-24 of human TCL1, amino acid residue 8-22 of human TCL1B, amino acid residue 5-19 of human MTCP1, and amino acid residue 9-24 of mouse or rat TCL1; and the derivatives. Further, the present invention includes DNA encording the polypeptide (SEQ ID NO: 2, 4, 6, 8 or 10 of the sequence listing), and the antibodies specifically binding to the polypeptides. The polypeptide of the present invention can be used for an inhibitor of Akt activity, an antitumor agent, or the like.
摘要翻译：本发明提供特异性抑制Akt（蛋白激酶B）活性的多肽，其DNA，其抗体，Akt活性抑制剂或抗肿瘤剂等的活性。多肽包含多肽（序列表的SEQ ID NO：1,3,5,7和9），其含有对应于人TCL1的氨基酸残基10-24的任何位置的氨基酸序列，氨基酸残基人类TCL1B 8-22，人类MTCP1的5-19氨基酸残基，小鼠或大鼠TCL1的氨基酸残基9-24; 和衍生品。此外，本发明包括根据多肽的DNA（序列表的SEQ ID NO：2,4,6,8或10）和与多肽特异性结合的抗体。本发明的多肽可用于Akt活性抑制剂，抗肿瘤剂等。

22. 发明授权

US08146924B2 Low-compression force metal gaskets 有权
标题翻译：低压力金属垫片
公开(公告)号：US08146924B2
公开(公告)日：2012-04-03
申请号：US12137361
申请日：2008-06-11
申请人： Tadahiro Ohmi , Yasuyuki Shirai , Yasushi Aburatani , Akira Muramatsu , Masayuki Noguchi , Kouji Sato , Satoshi Kumaki
发明人： Tadahiro Ohmi , Yasuyuki Shirai , Yasushi Aburatani , Akira Muramatsu , Masayuki Noguchi , Kouji Sato , Satoshi Kumaki
IPC分类号： F16J15/12
CPC分类号： F16J15/0887
摘要： A low-compression force metal gasket includes a coating layer containing a polymer material on at least a sealing surface of the gasket, and the coating layer satisfies the following conditions (1) to (3): (1) the layer comprises a resin, a rubber or a mixture thereof having an oxygen gas permeability coefficient at 25° C. of 10×10−12 to 0.1×10−12 (m2/s); (2) when the layer is compression deformed, the storage elastic modulus (E′) at 200° C. is in the range of 1.0×107 to 1.0×102 Pa; and (3) the coating layer has a thickness of 1 to 40 μm. The gasket provides a high seal at a low clamping force.
摘要翻译：低压力金属垫片包括在垫片的至少密封面上含有聚合物材料的涂层，涂层满足以下条件（1）〜（3）：（1）该层包含树脂，在25℃下的氧气渗透系数为10×10-12〜0.1×10-12（m2 / s）的橡胶或其混合物; （2）当层压缩变形时，200℃下的储能弹性模量（E'）在1.0×10 7〜1.0×10 2 Pa的范围内; 和（3）涂层的厚度为1〜40μm。垫圈在低夹紧力下提供高密封。

23. 发明授权

US08143260B2 Tricyclic amine compound 失效
标题翻译：三环胺化合物
公开(公告)号：US08143260B2
公开(公告)日：2012-03-27
申请号：US12673221
申请日：2008-08-14
申请人： Yohei Amano , Masayuki Noguchi , Koichi Shudo
发明人： Yohei Amano , Masayuki Noguchi , Koichi Shudo
IPC分类号： A01N43/54 , C07D239/42 , C07D401/04
CPC分类号： C07C229/60 , C07C2601/02 , C07C2603/28 , C07C2603/34 , C07D239/42
摘要： A compound represented by the following general formula (I): [wherein R1 represents hydrogen atom or a C1-6 alkyl group, A and B represent —(CH2)2—, —(CH2)3— or —(CH2)4—, X represents —N(R2)— (R2 represents hydrogen atom or a C1-6 alkyl group), —CO—, —C(═N—R3)— (R3 represents hydrogen atom or a C1-6 alkyl group), or —C(═C(R4)(R5))— (R4 and R5 independently represent hydrogen atom or a C1-6 alkyl group), and Ar represents an aryldiyl group or a heteroaryldiyl group], which has an action of controlling physiological activities of retinoids and useful as an active ingredient of a medicament.
摘要翻译：由下列通式（I）表示的化合物：[其中R1表示氢原子或C1-6烷基，A和B表示 - （CH2）2-， - （CH2）3-或 - （CH2）4- ，X表示-N（R 2） - （R 2表示氢原子或C 1-6烷基），-CO-，-C（= N-R 3） - （R 3表示氢原子或C 1-6烷基）或-C（= C（R4）（R5）） - （R4和R5独立地表示氢原子或C1-6烷基），Ar表示芳基二基或杂芳基二基]，其具有控制生理类维生素A的活性并且可用作药物的活性成分。

24. 发明申请

US20120025420A1 SHEET PRESS MOLDING METHOD AND METHOD OF MANUFACTURING FUEL CELL SEPARATOR 有权
标题翻译：板坯压制成型方法及制造燃料电池分离器的方法
公开(公告)号：US20120025420A1
公开(公告)日：2012-02-02
申请号：US13260662
申请日：2010-03-29
申请人： Tomoya Utashiro , Yoshinori Ito , Masayuki Noguchi
发明人： Tomoya Utashiro , Yoshinori Ito , Masayuki Noguchi
IPC分类号： B29C59/02
CPC分类号： B29C43/021 , B29C2043/025 , B29K2105/16 , B29K2105/256 , B29L2031/3468 , H01M8/0213 , H01M8/0221 , H01M8/0226 , H01M8/026 , H01M2008/1095 , Y02P70/56
摘要： Provided is a sheet press molding method by which a molded product having a small plate thickness deviation is obtained. Such a sheet press molding method is provided with a process in which a molded product (30) having a recess and protrusion pattern portion (32), to which a recess and protrusion pattern (3) is transferred, is formed by pressurizing a sheet-shaped material (20) including 60 vol. % to 95 vol. % of a filler and a resin composition using a pair of molds (40) having the predetermined recess and protrusion pattern (3) composed of recessed portions (3a, 3b, and 3c) and protrusion portions (23a, 23b, 23c, and 23d) in at least one of a pair of the molds, in which the mold provided with a dummy pattern (24) composed of dummy protrusion portions (24a) that offset the difference between the total volume of the protrusion portions (23a, 23b, 23c, and 23d) formed on the inside (14) and the total volume of the recessed portions (3a, 3b, and 3c) disposed between the protruding portions (23a, 23b, 23c, and 23d) and the side surfaces (14b) of the inside (14) and the recessed portions (3a, 3b, and 3c) disposed between the protruding portions (23a, 23b, 23c, and 23d) on the inside (14) is used as a pair of the molds (40).
摘要翻译：提供一种片压制成型方法，通过该方法得到板厚偏差小的成型品。这种片材压制成型方法具有这样的工序，即通过对片状物进行加压而形成具有凹部和突起图形部分（32）的模制产品（30），凹部和突起图案（3）（20），包括60vol。％至95体积使用具有由凹部（3a，3b，3c）和突出部（23a，23b，23c，23d）构成的规定的凹凸突起图案（3）的一对模具（40）的填料和树脂组合物的％）在模具中的至少一个中，其中模具设置有由虚设突出部分（24a）组成的虚拟图案（24），该虚拟突起部分（24a）抵消突出部分（23a，23b，23c）的总体积之间的差异和23d）和设置在突出部分（23a，23b，23c和23d）之间的凹部（3a，3b和3c）的总体积和侧表面（14b）的总体积设置在内侧（14）上的突出部（23a，23b，23c，23d）之间的内侧（14）和凹部（3a，3b，3c）用作一对模具（40）。

25. 发明授权

US07398692B2 Sealing ring and its managing system 有权
标题翻译：密封圈及其管理系统
公开(公告)号：US07398692B2
公开(公告)日：2008-07-15
申请号：US10570109
申请日：2004-09-24
申请人： Tsutomu Hiroki , Masayuki Noguchi , Shinya Sakurai
发明人： Tsutomu Hiroki , Masayuki Noguchi , Shinya Sakurai
IPC分类号： G01L7/00
CPC分类号： F16J15/3296 , F16J15/064 , F16J15/104
摘要： An object of the present invention is to make it possible to accurately and simply manage the performance deterioration and life duration of sealing rings and other various information about each sealing ring. As a means of achieving this object, a sealing ring according to the present invention is a sealing ring 30 to be fitted to a face-to-face part of members 12, 14 to thus seal a space between both members, comprising: a main body part 32 that is ring-shaped and is capable of becoming elastically deformed; and a circuit chip 40 that is attached unitedly to the main body part 32 and has an information-transmitting means 42 for transmitting the information with the outside of the sealing ring 30.
摘要翻译：本发明的目的是使得可以准确且简单地管理密封环的性能下降和寿命以及关于每个密封环的其它各种信息。作为实现该目的的手段，根据本发明的密封环是密封环30，其被装配到构件12,14的面对部分，从而密封两个构件之间的空间，包括：主体能够弹性变形的环状体32; 以及与主体部32一体地连接的电路芯片40，具有用于将信息与密封环30的外部传送的信息传递装置42。

26. 发明授权

US07338730B2 Conductive curable resin composition and separator for fuel cell 有权
标题翻译：导电固化树脂组合物和燃料电池隔板
公开(公告)号：US07338730B2
公开(公告)日：2008-03-04
申请号：US11058283
申请日：2005-02-16
申请人： Masayuki Noguchi , Tomoaki Kobayashi , Tadashi Iino
发明人： Masayuki Noguchi , Tomoaki Kobayashi , Tadashi Iino
IPC分类号： H01M2/02
CPC分类号： H01M8/0221 , B82Y30/00 , H01M8/0213 , H01M8/0226 , Y02P70/56
摘要： There is provided a conductive curable resin composition comprising (A) a curable resin composition comprising an elastomer with a Mooney viscosity (ML1+4 (100° C.)) of 25 or greater at 2-80 wt % and (B) a carbon material, with a weight ratio of component (A) to component (B) of 70-5:30-95. The curable resin composition of component (A) preferably comprises (A1) an elastomer at 80-2 wt %, (A2) a radical reactive resin at 20-98 wt % and (A3) an organic peroxide at 0.2-10 parts by weight to 100 parts by weight of (A1+A2). Also provided are a process for production of a conductive cured resin by shaping and curing of the conductive curable resin composition, and a fuel cell separator, an assembly for a cell, an electrode or a heat releasing plate, obtained thereby.
摘要翻译：提供一种导电性固化性树脂组合物，其包含（A）包含门尼粘度（ML 1 + 4（100℃））的弹性体的固化性树脂组合物的摩尔比为25以上，2-80 （B）的重量比为70-5:30-95的（B）碳材料。组分（A）的可固化树脂组合物优选包含（A 1）80-2重量％的弹性体，（A 2）20-98重量％的自由基反应性树脂和（A 3）0.2-10的有机过氧化物（A 1 + A 2）100重量份。还提供了通过导电性固化性树脂组合物的成形和固化以及由此获得的燃料电池隔板，电池组，电极或散热板来制造导电性固化树脂的方法。

27. 发明授权

US06294599B1 Highly-rigid, flame-resistant polyamide composite material 失效
标题翻译：高刚性，耐火聚酰胺复合材料
公开(公告)号：US06294599B1
公开(公告)日：2001-09-25
申请号：US09529009
申请日：2000-04-06
申请人： Hirofumi Inoue , Kenji Tamura , Tsuguo Ebata , Masayuki Noguchi
发明人： Hirofumi Inoue , Kenji Tamura , Tsuguo Ebata , Masayuki Noguchi
IPC分类号： C08K334
CPC分类号： C08K5/34922 , C08K3/34 , C08K7/02 , C08L77/00
摘要： The present invention relates to a highly-rigid, flame-resistant polyamide composite material that is applicable to various uses such as in materials for electric and electronic parts, automobile parts, materials for house appliances, mechanical parts, and the like. The polyamide composite material according to the present invention is characterized in comprising (a) polyamide resin; (b) silicate complex comprising a layered silicate and triazine compound; (c) fibrous reinforcement; and (d) flame retarder. The polyamide composite material according to the present invention exhibits a high flame resistance, a superior performance with respect to its mechanical property, thermal property, dimensional stability, and reduced warp.
摘要翻译：本发明涉及一种适用于各种用途的高刚性耐火聚酰胺复合材料，例如用于电气和电子部件的材料，汽车部件，家用电器材料，机械部件等。本发明的聚酰胺复合材料的特征在于：（a）聚酰胺树脂; （b）包含层状硅酸盐和三嗪化合物的硅酸盐络合物; （c）纤维增强; 和（d）阻燃剂。根据本发明的聚酰胺复合材料显示出高阻燃性，相对于其机械性能，热性能，尺寸稳定性和减少翘曲性能优异。

28. 发明授权

US5664064A Object form division method and system 失效
标题翻译：对象形式划分方法和系统
公开(公告)号：US5664064A
公开(公告)日：1997-09-02
申请号：US379959
申请日：1995-01-27
申请人： Takashi Nakao , Akira Maeda , Masayuki Noguchi , Taiichi Kadouno , Atsushi Suzuki , Eiji Suzuki
发明人： Takashi Nakao , Akira Maeda , Masayuki Noguchi , Taiichi Kadouno , Atsushi Suzuki , Eiji Suzuki
IPC分类号： G06N3/12 , G06T17/20 , G06F15/18
CPC分类号： G06N3/126 , G06T17/20
摘要： A system for automatically dividing the form of an object to be analyzed using a finite element method, etc., into meshes, includes initial group generation means for generating a plurality of area division forms based on the form of the analysis object input through input means, and area division form evaluation means the generated area division forms. If the evaluation result does not satisfy a predetermined determination criterion, end determination means starts selection and crossover means for generating a new group and further starts mutation means for deforming the area division forms of the new group, then again starts the area division form evaluation means. If the evaluation result satisfies the predetermined determination criterion, an optimum area division form in the group is adopted as the optimum area division form. Division-into-meshes means subdivides the optimum area division form into meshes. The result of subdividing into the meshes is output to mesh output means. A method for automatically dividing the form of an object to be analyzed using a finite element method is also disclosed.
摘要翻译：一种用于使用有限元方法等将要分析的对象的形式自动划分为网格的系统包括：初始组生成装置，用于基于通过输入装置输入的分析对象的形式生成多个区域划分形式，区域划分形式评估是指生成区域划分形式。如果评价结果不满足规定的判定基准，则结束判定单元开始生成新组的选择和交叉单元，进一步开始使新组的区域分割形式变形的变形单元，再次开始区域划分形式评价单元。如果评价结果满足规定的判定基准，则采用该组中的最佳区域划分形式作为最佳区域划分形式。分割网格意味着将最佳区域划分形式细分为网格。细分为网格的结果输出到网格输出装置。还公开了一种使用有限元法自动分割待分析对象的形式的方法。

29. 发明授权

US08722730B2 5-membered heterocyclic compound 失效
标题翻译： 5元杂环化合物
公开(公告)号：US08722730B2
公开(公告)日：2014-05-13
申请号：US12673177
申请日：2008-08-14
申请人： Hideaki Muratake , Masayuki Noguchi , Koichi Shudo
发明人： Hideaki Muratake , Masayuki Noguchi , Koichi Shudo
IPC分类号： A61K31/341 , C07D307/40
CPC分类号： A61K31/341 , A61K31/381 , A61K31/401 , A61K31/443 , A61K31/4436 , C07D207/416 , C07D307/54 , C07D307/68 , C07D333/24 , C07D333/38 , C07D333/40 , C07D405/12 , C07D409/12
摘要： A compound represented by the following general formula (I): [wherein R1 and R2 represent an alkyl group, X represents —S—, —O— or —NH—, Y represents C or N, R3 represents hydrogen atom or a C1-10 alkyl group, Z represents —CO—N(R5)— (R5 represents hydrogen atom or a C1-6 alkyl group) or —C(R6)═C(R7)—CO—NH— (R6 and R7 represent hydrogen atom or a C1-6 alkyl group), Ar represents an aryldiyl group or a heteroaryldiyl group, and R4 represents —COOH, —OCH2—COOH, —CH2—COOH, or —CH2—CH2—COOH], which has a retinoid action and is useful as an active ingredient of a medicament.
摘要翻译：由下列通式（I）表示的化合物：[其中R1和R2表示烷基，X表示-S-，-O-或-NH-，Y表示C或N，R3表示氢原子或C1- 10表示烷基，Z表示-CO-N（R5） - （R5表示氢原子或C1-6烷基）或-C（R6）= C（R7）-CO-NH-（R6和R7表示氢原子或C 1-6烷基），Ar表示芳基二基或杂芳基二基，R 4表示-COOH，-OCH 2 -COOH，-CH 2 -COOH或-CH 2 -CH 2 -COOH]，其具有类视黄醇作用和可用作药物的活性成分。

30. 发明授权

US08232300B2 Tricyclic amide compound 失效
标题翻译：三环酰胺化合物
公开(公告)号：US08232300B2
公开(公告)日：2012-07-31
申请号：US12673207
申请日：2008-08-14
申请人： Yohei Amano , Masayuki Noguchi , Koichi Shudo
发明人： Yohei Amano , Masayuki Noguchi , Koichi Shudo
IPC分类号： C07D333/36 , C07D211/68 , C07D211/80 , C07C63/00 , C07C65/00 , A61K31/38 , A61K31/045
CPC分类号： C07C233/81 , C07C233/65 , C07C311/21 , C07C2603/28 , C07C2603/34 , C07D213/79 , C07D213/81 , C07D213/82 , C07D333/38 , C07D333/40
摘要： A compound represented by the following general formula (I): [wherein R1 represents hydrogen atom or a C1-6 alkyl group, A and B represent —(CH2)2—, —(CH2)3—or —(CH2)4—, X represents —N(R2)—CO—(R2 represents hydrogen atom or a C1-6 alkyl group), —CO—N(R3)—(R3 represents hydrogen atom or a C1-6 alkyl group), —C(R4)═C(R5)—(R4 and R5 represent hydrogen atom or a C1-6 alkyl group), or —N(R6)—SO2—(R6 represents hydrogen atom or a C1-6 alkyl group), and Ar represents an aryldiyl group or a heteroaryldiyl group], which has a retinoid action and is useful as an active ingredient of a medicament.
摘要翻译：由以下通式（I）表示的化合物：其中R 1表示氢原子或C 1-6烷基，A和B表示 - （CH 2）2 - ， - （CH 2）3 - 或 - （CH 2）4 - ，X表示-N（R 2）-CO-（R 2表示氢原子或C 1-6烷基），-CO-N（R 3） - （R 3表示氢原子或C 1-6烷基）， - C R4）= C（R5） - （R4和R5代表氢原子或C1-6烷基）或-N（R6）-SO2-（R6代表氢原子或C1-6烷基），Ar代表芳基二基或杂芳基二基]，其具有类视黄醇作用并且可用作药物的活性成分。

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