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21. 发明授权

US09540702B2 Stabilization of enzymes with stable coenzymes 有权
标题翻译：用稳定的辅酶稳定酶
公开(公告)号：US09540702B2
公开(公告)日：2017-01-10
申请号：US13400209
申请日：2012-02-20
申请人： Wolfgang Roedel , Carina Horn , Nelli Steinke , Nadine Bucci , Thomas Meier , Rainer Schmuck , Rolf Nagel , Dieter Heindl
发明人： Wolfgang Roedel , Carina Horn , Nelli Steinke , Nadine Bucci , Thomas Meier , Rainer Schmuck , Rolf Nagel , Dieter Heindl
IPC分类号： C12N9/04
CPC分类号： C12N9/96 , C12N9/0006 , C12N9/0036 , C12Q1/26 , C12Q1/32 , C12Y101/01001 , C12Y101/01002 , C12Y101/01047 , C12Y101/01049 , C12Y106/05002 , C12Y106/99
摘要： Methods for stabilizing an enzyme by storing the enzyme in the presence of a stabilized coenzyme are disclosed. In addition, an enzyme stabilized with a stabilized coenzyme as well as the use thereof in test elements for detecting analytes are also disclosed. Other aspects include unique compositions, methods, techniques, systems and devices involving enzyme stabilization.
摘要翻译：公开了通过在稳定的辅酶的存在下储存酶来稳定酶的方法。此外，还公开了用稳定的辅酶稳定的酶以及其用于检测分析物的测试元件中的用途。其他方面包括独特的组合物，方法，技术，涉及酶稳定化的系统和装置。

22. 发明授权

US09528977B2 Simplified storage of at least one test element including a dry reagent layer having an enzyme and a stabilized coenzyme 有权
标题翻译：至少一个测试元件的简化存储，包括具有酶和稳定的辅酶的干试剂层
公开(公告)号：US09528977B2
公开(公告)日：2016-12-27
申请号：US13400267
申请日：2012-02-20
申请人： Carina Horn , Christian Freitag , Hans-Peter Haar , Heino Eikmeier
发明人： Carina Horn , Christian Freitag , Hans-Peter Haar , Heino Eikmeier
IPC分类号： G01N33/487 , G01N33/32 , G01N27/327
CPC分类号： G01N27/3272 , G01N33/48757 , G01N33/48764 , G01N33/48778
摘要： Storage containers for storing at least one diagnostic test element including an enzyme and a stabilized coenzyme are disclosed. In addition, diagnostic products which include diagnostic test elements including an enzyme and a stabilized coenzyme, as well as analytical measuring devices which include such storage containers or diagnostic products, are also disclosed. Other aspects include, but are not limited to, unique methods, techniques, products, systems and devices involving test elements which include an enzyme and a stabilized coenzyme.
摘要翻译：公开了用于存储至少一种包括酶和稳定化辅酶的诊断测试元件的储存容器。此外，还公开了包括酶和稳定化辅酶的诊断测试元件以及包括这种储存容器或诊断产品的分析测量装置的诊断产品。其他方面包括但不限于独特的方法，技术，产品，系统和涉及包括酶和稳定化辅酶的测试元件的装置。

23. 发明授权

US08636894B2 Electrochemical determination of factor XA inhibitors 有权
标题翻译：因子XA抑制剂的电化学测定
公开(公告)号：US08636894B2
公开(公告)日：2014-01-28
申请号：US12432490
申请日：2009-04-29
申请人： Liesel Doerge , Margarete Galm , Carina Horn
发明人： Liesel Doerge , Margarete Galm , Carina Horn
IPC分类号： G01N27/26
CPC分类号： G01N27/26 , C12Q1/005 , C12Q1/56 , G01N33/86
摘要： Methods and devices for determining factor Xa inhibitors, in particular heparins and fractionated or low-molecular-weight heparins, as well as direct factor Xa inhibitors in blood samples. The methods include contacting a blood sample with a detection reagent that contains at least one thrombin substrate having a peptide residue that can be cleaved by thrombin and is amidically bound via the carboxyl end to an electrogenic substance, and with a known amount of factor X reagent and an activator reagent which induces the conversion of factor X into factor Xa. Subsequently, in a second step, the amount or activity of the electrogenic substance that is cleaved from the thrombin substrate by the factor Xa-mediated thrombin activation and/or the time course thereof is determined as the measurement signal using electrochemical methods. In a third step, the amount of the factor Xa inhibitor in the sample of the blood to be analyzed or a measured quantity that correlates therewith, in particular a clotting time that correlates therewith, is determined on the basis of this measurement signal.
摘要翻译：用于确定因子Xa抑制剂，特别是肝素和分级或低分子量肝素的方法和装置，以及血液样品中的直接因子Xa抑制剂。所述方法包括使血液样品与含有至少一个凝血酶底物的检测试剂接触，所述凝血酶底物具有可被凝血酶切割的肽残基，并且经由羧基末端与电生物质酰胺结合，并且使用已知量的因子X试剂和诱导因子X转化成因子Xa的活化剂。随后，在第二步骤中，通过因子Xa介导的凝血酶活化和/或其时间过程将从凝血酶底物切割的电生物质的量或活性确定为使用电化学方法的测量信号。在第三步骤中，基于该测量信号确定要分析的血液样品中的因子Xa抑制剂的量或与其相关的测量量，特别是与其相关的凝血时间。

24. 发明申请

US20120241335A1 SIMPLIFIED STORAGE OF INTEGRATED SYSTEMS 有权
标题翻译：简化的集成系统存储
公开(公告)号：US20120241335A1
公开(公告)日：2012-09-27
申请号：US13400267
申请日：2012-02-20
申请人： Carina Horn , Christian Freitag , Hans-Peter Haar , Heino Eikmeier
发明人： Carina Horn , Christian Freitag , Hans-Peter Haar , Heino Eikmeier
IPC分类号： B65D79/00
CPC分类号： G01N27/3272 , G01N33/48757 , G01N33/48764 , G01N33/48778
摘要： Storage containers for storing at least one diagnostic test element including an enzyme and a stabilized coenzyme are disclosed. In addition, diagnostic products which include diagnostic test elements including an enzyme and a stabilized coenzyme, as well as analytical measuring devices which include such storage containers or diagnostic products, are also disclosed. Other aspects include, but are not limited to, unique methods, techniques, products, systems and devices involving test elements which include an enzyme and a stabilized coenzyme.
摘要翻译：公开了用于存储至少一种包括酶和稳定化辅酶的诊断测试元件的储存容器。此外，还公开了包括酶和稳定化辅酶的诊断测试元件以及包括这种储存容器或诊断产品的分析测量装置的诊断产品。其他方面包括但不限于独特的方法，技术，产品，系统和涉及包括酶和稳定化辅酶的测试元件的设备。

25. 发明申请

US20120045843A1 TEST ELEMENT FOR DETERMINING A BODY FLUID AND MEASUREMENT METHOD 失效
标题翻译：用于确定体液和测量方法的测试单元
公开(公告)号：US20120045843A1
公开(公告)日：2012-02-23
申请号：US13224751
申请日：2011-09-02
申请人： Hans-Peter Haar , Carina Horn
发明人： Hans-Peter Haar , Carina Horn
IPC分类号： G01N21/64 , G01N21/75 , G01N33/66
CPC分类号： G01N33/66 , G01N21/6408 , G01N21/77 , G01N21/78 , G01N21/8483 , G01N33/525 , G01N2021/7786 , Y10T436/144444
摘要： A test element for determining a body fluid, in particular for determining the blood glucose level, comprises a detection region which is charged with a reagent sensitive to the body fluid. A function element is arranged in and/or adjacent to the detection region for detecting at least one status parameter for the detection region, wherein said functional element can be evaluated by means of a status measurement. A method for measuring the test element is also disclosed.
摘要翻译：用于确定体液的测试元件，特别是用于确定血液葡萄糖水平的测试元件包括带有对体液敏感的试剂的检测区域。功能元件布置在检测区域和/或邻近检测区域中，用于检测用于检测区域的至少一个状态参数，其中可以通过状态测量来评估功能元件。还公开了一种用于测量测试元件的方法。

26. 发明申请

US20100144042A1 AUTOMATIC DIFFERENTIATION OF A SAMPLE SOLUTION AND A CONTROL SOLUTION 审中-公开
标题翻译：一个样品溶液的自动分辨和一个控制解决方案
公开(公告)号：US20100144042A1
公开(公告)日：2010-06-10
申请号：US12705792
申请日：2010-02-15
申请人： Guenter Frey , Carina Horn , Otto Gaa , Hans Kintzig , Hans-Ruediger Murawski
发明人： Guenter Frey , Carina Horn , Otto Gaa , Hans Kintzig , Hans-Ruediger Murawski
IPC分类号： G01N33/48
CPC分类号： G01N33/96 , Y10T436/10 , Y10T436/104165 , Y10T436/104998 , Y10T436/106664 , Y10T436/25
摘要： The invention concerns a method for automatically differentiating between a sample liquid and a control liquid especially within the context of analytical measuring systems, wherein the presence of a special property of the control liquid and/or at least two criteria are used for the differentiation. In addition the invention concerns appropriate control liquids that are suitable for the new method.
摘要翻译：本发明涉及一种用于自动区分样品液体和对照液体的方法，特别是在分析测量系统的上下文中，其中存在控制液体的特殊性质和/或至少两个标准用于鉴别。此外，本发明涉及适用于新方法的合适的对照液体。

27. 发明授权

US07517664B2 Inactivated enzyme variants and associated process and reagent system 失效
标题翻译：灭活的酶变体和相关的过程和试剂系统
公开(公告)号：US07517664B2
公开(公告)日：2009-04-14
申请号：US11559607
申请日：2006-11-14
申请人： Zhixin Shao , Joachim Hoenes , Carina Horn , Wolfgang-Reinhold Knappe , Rainer Schmuck
发明人： Zhixin Shao , Joachim Hoenes , Carina Horn , Wolfgang-Reinhold Knappe , Rainer Schmuck
IPC分类号： C12Q1/32 , C12Q1/54 , C12N9/04 , C12N1/20
CPC分类号： C12N9/0004 , C12N9/0006
摘要： The present invention relates to oxidoreductase apoenzyme variants which are enzymatically inactive but have coenzyme-binding properties. Further, the present invention relates to DNA sequences encoding these oxidoreductase apoenzyme variants, expression vectors containing such DNA sequences and the use of these oxidoreductase apoenzyme variants in diagnostic applications.
摘要翻译：本发明涉及酶促无活性但具有辅酶结合特性的氧化还原酶脱辅基酶变体。此外，本发明涉及编码这些氧化还原酶脱辅基酶变体的DNA序列，含有这些DNA序列的表达载体以及这些氧化还原酶脱辅基酶变体在诊断应用中的用途。

28. 发明申请

US20080262386A1 ANALYTICAL SYSTEM FOR DETECTING AN ANALYTE IN A BODY FLUID AND DISPOSABLE INTEGRATED PUNCTURING AND ANALYZING ELEMENT 有权
公开(公告)号：US20080262386A1
公开(公告)日：2008-10-23
申请号：US12105596
申请日：2008-04-18
申请人： Hans-Peter Haar , Joachim Hoenes , Carina Horn , Andreas Poredda
发明人： Hans-Peter Haar , Joachim Hoenes , Carina Horn , Andreas Poredda
IPC分类号： A61B5/157
CPC分类号： A61B5/157 , A61B5/14546 , A61B5/150022 , A61B5/150358 , A61B5/150442 , A61B5/150503 , A61B5/150572 , A61B5/150717 , A61B5/151 , A61B5/15105 , A61B5/15142 , A61B5/15188 , A61B2562/0295
摘要： An analytical system for detecting an analyte in a body fluid comprises a disposable integrated puncturing and analyzing element and a reusable analytical system. The integrated puncturing and analyzing element includes a puncturing element having a tip for generating a puncture wound in a body part and an elongated flat test strip having a top side and a bottom side. The analyzing instrument having a housing has a holder for holding an integrated puncturing and analyzing element, and a coupling unit which is provided such as to couple the puncturing element to a drive by means of which a puncturing movement of the puncturing element is driven, during which it is moved on a path of movement in the puncturing direction during an advancement phase and, after reaching a reversal point of the puncturing movement, is moved opposite to the puncturing direction in a return phase. The puncturing element is arranged to be parallel to the test strip and such as to be mobile with respect to the test strip along the movement path. The integrated puncturing and analyzing element is held in the holder such that, in a sample application position of the test strip, the top side of the test strip is facing upward and, in a puncturing position of the test strip, the tip of the puncturing element is moved beyond an end of the test strip which is its front end in the puncturing direction, in order to generate a puncture wound in a body part. A sample application area for manual application of a drop exiting from the puncture wound of the body part is provided on the top side of the test strip such that, in the sample application position, the drop is applied to the sample application area from directly above. The housing is shaped to allow access to the sample application area of a test strip positioned in the sample application position, and to allow access to the front end of a test strip which is positioned in the puncturing position.

29. 发明授权

US07378255B2 Fluorimetric determination of analytes by an intramolecular quencher-fluorophore conjugate 有权
标题翻译：通过分子内猝灭剂 - 荧光团缀合物进行荧光测定分析物
公开(公告)号：US07378255B2
公开(公告)日：2008-05-27
申请号：US10766457
申请日：2004-01-28
申请人： Carina Horn , Hans-Peter Josel , Jürgen Spinke , Rupert Herrmann , Dieter Heindl
发明人： Carina Horn , Hans-Peter Josel , Jürgen Spinke , Rupert Herrmann , Dieter Heindl
IPC分类号： C12Q1/26
CPC分类号： G01N21/6428 , G01N2021/6432 , Y10S436/80 , Y10S436/904
摘要： A method and reagent for detecting an analyte by a redox reaction and a fluorimetric determination, is disclosed. The method comprises contacting a sample containing the analyte with a detection reagent which contains a compound of the general formula Q-F as a fluorimetric redox indicator, wherein Q is a quencher group and F is a fluorophore group.
摘要翻译：公开了一种用于通过氧化还原反应和荧光测定来检测分析物的方法和试剂。该方法包括将含有分析物的样品与含有通式Q-F化合物的检测试剂接触，作为荧光氧化还原指示剂，其中Q为猝灭剂基团，F为荧光团。

30. 发明授权

US07172890B2 Inactivated enzyme variants and associated process and reagent system 失效
标题翻译：灭活的酶变体和相关的过程和试剂系统
公开(公告)号：US07172890B2
公开(公告)日：2007-02-06
申请号：US10975697
申请日：2004-10-28
申请人： Zhixin Shao , Joachim Hoenes , Carina Horn , Wolfgang-Reinhold Knappe , Rainer Schmuck
发明人： Zhixin Shao , Joachim Hoenes , Carina Horn , Wolfgang-Reinhold Knappe , Rainer Schmuck
IPC分类号： C12N9/04 , C12N9/54 , C12N1/20 , C12P7/22 , C12P21/06 , C07H21/02
CPC分类号： C12N9/0004 , C12N9/0006
摘要： The present invention relates to oxidoreductase apoenzyme variants which are enzymatically inactive but have coenzyme-binding properties. Further, the present invention relates to DNA sequences encoding these oxidoreductase apoenzyme variants, expression vectors containing such DNA sequences and the use of these oxidoreductase apoenzyme variants in diagnostic applications.
摘要翻译：本发明涉及酶促无活性但具有辅酶结合特性的氧化还原酶脱辅基酶变体。此外，本发明涉及编码这些氧化还原酶脱辅基酶变体的DNA序列，含有这些DNA序列的表达载体以及这些氧化还原酶脱辅基酶变体在诊断应用中的用途。

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