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21. 发明授权

US07006710B2 Method and apparatus for correcting crosstalk and spatial resolution for multichannel imaging 有权
公开(公告)号：US07006710B2
公开(公告)日：2006-02-28
申请号：US10783530
申请日：2004-02-20
申请人： James K. Riley , Keith L. Frost
发明人： James K. Riley , Keith L. Frost
IPC分类号： G06K9/32
CPC分类号： G06K9/00503 , G01J3/28 , G01J3/2803 , G01J3/32 , G01J3/36 , G01N15/147 , G01N15/1475 , G06K9/00127 , G06T5/50 , G06T7/32 , G06T7/33 , G06T2207/10036
摘要： A multichannel imaging system generates an ensemble of images for each field of view of an object. Each image in the ensemble is intended to contain information from only one source among a plurality of sources for the object. However, due to crosstalk, at least a portion of the signal from a first source appears in a channel intended for a second source. Because the accuracy of the correction will be degraded if the images in an ensemble are spatially misaligned with respect to one another, the spatial offset between images is determined and a correction is applied to substantially eliminate the offset. Then, a correction to the signals is determined to substantially reduce the contributions to the signal in a channel from the signals in other channels. The signal processing can be employed to process the output signals for each of a plurality of different disclosed imaging systems.

22. 发明授权

US5627908A Method for cytological system dynamic normalization 失效
标题翻译：细胞学系统动态归一化方法
公开(公告)号：US5627908A
公开(公告)日：1997-05-06
申请号：US309063
申请日：1994-09-20
申请人： Shih-Jong J. Lee , Alan C. Nelson , Larry A. Nelson , Carl E. Youngmann , Keith L. Frost
发明人： Shih-Jong J. Lee , Alan C. Nelson , Larry A. Nelson , Carl E. Youngmann , Keith L. Frost
IPC分类号： G01N15/14 , G06K9/00 , G06K9/38
CPC分类号： G01N15/1475
摘要： A cytological system dynamic normalization of a normal threshold. An analysis score from a slide is compared against a threshold to determine whether or not the slide is normal or requires microscopy review. The normal threshold is dynamically adjusted using a three step process. The process is implemented on an automatic cytology system. The first step is initial calibration of the system to determine an initial threshold. The second step is a running adjustment of the normal threshold in response to the presentation of new slides to the automatic cytology system. The third step is the batch certification of every slide. The threshold may be adjusted for an analysis score, a quality control score, or a screening score.
摘要翻译：细胞学系统动态归一化正常阈值。将幻灯片的分析得分与阈值进行比较，以确定幻灯片是否正常或需要显微镜检查。使用三步过程动态调整正常阈值。该过程在自动细胞学系统上实现。第一步是系统的初始校准，以确定初始阈值。第二步是响应于向自动细胞学系统呈现新幻灯片而正常阈值的运行调整。第三步是每张幻灯片的批量认证。可以针对分析得分，质量控制评分或筛选分数调整阈值。

23. 发明授权

US08572480B1 Editing the sequential flow of a page 有权
标题翻译：编辑页面的顺序流程
公开(公告)号：US08572480B1
公开(公告)日：2013-10-29
申请号：US12241352
申请日：2008-09-30
申请人： Robert L. Goodwin , C. Brandon Forehand , Keith L. Frost
发明人： Robert L. Goodwin , C. Brandon Forehand , Keith L. Frost
IPC分类号： G06F17/00
CPC分类号： G06F17/2229 , G06F17/212
摘要： Editing the sequential flow of objects of a page is disclosed. The objects may have intended correct sequential order for processing or viewing, which may be difficult to detect by a computer algorithm. An initial flow may be created using an initial flow algorithm to provide an initial order of the objects. The initial flow may be visually represented on a page, such as by a curve drawn through the objects. A human editor may reorder the objects if the initial flow is not correct. In some aspects, the editor may trace a new order of the objects by controlling an input device to sequentially order the objects in an editor-assigned flow. In other aspects, the editor may sequentially select objects to create the editor-assigned flow. In response to the editor-assigned flow, a validation flow may be created, which may assist the editor in confirming accuracy of the edited flow. In other aspects, heuristics may learn from the editor-assigned flow to improve the initial flow over time.
摘要翻译：公开了编辑页面对象的顺序流。对象可能具有用于处理或查看的正确顺序，这可能难以通过计算机算法检测。可以使用初始流算法创建初始流程以提供对象的初始顺序。初始流程可以在页面上可视地表示，例如通过通过对象绘制的曲线。如果初始流程不正确，人类编辑器可能会重新排序对象。在某些方面，编辑者可以通过控制输入设备在编辑器分配的流程中顺序排列对象来跟踪对象的新顺序。在其他方面，编辑者可以依次选择对象来创建编辑器分配的流。响应于编辑器分配的流程，可以创建验证流程，这可以帮助编辑器确认编辑的流程的准确性。在其他方面，启发式可以从编辑器分配的流程中学习，以改善初始流量随时间的变化。

24. 发明授权

US07286719B2 Method and apparatus for correcting crosstalk and spatial resolution for multichannel imaging 有权
标题翻译：用于校正多声道成像的串扰和空间分辨率的方法和装置
公开(公告)号：US07286719B2
公开(公告)日：2007-10-23
申请号：US11419138
申请日：2006-05-18
申请人： James K. Riley , Keith L. Frost
发明人： James K. Riley , Keith L. Frost
IPC分类号： G06K9/32 , G01N21/00
CPC分类号： G06K9/00503 , G01J3/28 , G01J3/2803 , G01J3/32 , G01J3/36 , G01N15/147 , G01N15/1475 , G06K9/00127 , G06T5/50 , G06T7/32 , G06T7/33 , G06T2207/10036
摘要： A multi-channel imaging system generates an ensemble of images for each field of view of an object. Each image in the ensemble is intended to contain information from only one source among a plurality of sources for the object. However, due to crosstalk, at least a portion of the signal from a first source appears in a channel intended for a second source. Because the accuracy of the correction will be degraded if the images in an ensemble are spatially misaligned with respect to one another, the spatial offset between images is determined and a correction is applied to substantially eliminate the offset. Then, a correction to the signals is determined to substantially reduce the contributions to the signal in a channel from the signals in other channels. The signal processing can be employed to process the output signals for each of a plurality of different disclosed imaging systems.
摘要翻译：多通道成像系统为对象的每个视野生成图像集合。集合中的每个图像旨在包含来自对象的多个源中的一个源的信息。然而，由于串扰，来自第一源的信号的至少一部分出现在用于第二源的通道中。因为如果一个组合中的图像相对于彼此在空间上不对准，校正的精度将会降低，所以确定图像之间的空间偏移并且应用校正以基本上消除偏移。然后，确定对信号的校正，以从其它通道中的信号基本上减少对信道中的信号的贡献。信号处理可用于处理多个不同公开的成像系统中的每一个的输出信号。

25. 发明授权

US5862265A Separation apparatus and method for measuring focal plane 失效
标题翻译：用于测量焦平面的分离装置和方法
公开(公告)号：US5862265A
公开(公告)日：1999-01-19
申请号：US57924
申请日：1998-04-09
申请人： James K. Riley , Keith L. Frost , William C. Lindow , Kim J. Hansen , Tuan Phan , James A. Stephanick
发明人： James K. Riley , Keith L. Frost , William C. Lindow , Kim J. Hansen , Tuan Phan , James A. Stephanick
IPC分类号： G01B11/00 , G01M11/02 , G06T1/00 , G06K9/36
CPC分类号： G01M11/0264 , G01M11/0242
摘要： A computer receives image data from a star-shaped optical target in the object plane and calculates angle-dependent boundary sharpness. The horizontal, x-direction, amplitude derivative and the vertical, y-direction, amplitude derivative are computed over a portion of each star pattern image from a Z panning sequence. A microscope slide stage, carrying the target, is moved vertically from a level just below where the target is in focus to a level just above where the target is in focus. For each small increment of vertical motion, Z panning, an image of the star pattern is captured for analysis. Computations are performed on the differentiated images to search for evidence of elongation of the point spread function and variation with stage Z position of the angle of long axis of such an out-of-round point spread function. The presence of a distorted point spread function that varies along the optical axis indicates astigmatism.
摘要翻译：计算机从对象平面中的星形光学目标接收图像数据，并计算与角度相关的边界锐度。在Z平移序列的每个星型图像的一部分上计算水平，x方向，幅度导数和垂直，y方向，幅度导数。携带目标的显微镜载物台从目标对焦点正下方的水平垂直移动到目标对焦点正上方的水平位置。对于垂直运动的每个小增量，Z平移，捕获星形图案的图像用于分析。对差分图像进行计算，以搜索点扩散函数的伸长的证据以及这种外向点扩散函数的长轴角度的Z位置的变化。沿着光轴变化的失真点扩散函数的存在表示散光。

26. 发明授权

US5642441A Separation apparatus and method for measuring focal plane 失效
标题翻译：测量焦平面分离的装置和方法
公开(公告)号：US5642441A
公开(公告)日：1997-06-24
申请号：US547653
申请日：1995-10-24
申请人： James K. Riley , Keith L. Frost , William C. Lindow , Kim J. Hansen , Tuan Phan , James A. Stephanick
发明人： James K. Riley , Keith L. Frost , William C. Lindow , Kim J. Hansen , Tuan Phan , James A. Stephanick
IPC分类号： G01B11/00 , G01M11/02 , G06T1/00 , G06K9/36
CPC分类号： G01M11/0264 , G01M11/0242
摘要： A computer receives image data from a star-shaped optical target in the object plane and calculates angle-dependent boundary sharpness. The horizontal, x-direction, amplitude derivative and the vertical, y-direction, amplitude derivative are computed over a portion of each star pattern image from a Z panning sequence. A microscope slide stage, carrying the target, is moved vertically from a level just below where the target is in focus to a level just above where the target is in focus. For each small increment of vertical motion, Z panning, an image of the star pattern is captured for analysis. Computations are performed on the differentiated images to search for evidence of elongation of the point spread function and variation with stage Z position of the angle of long axis of such an out-of-round point spread function. The presence of a distorted point spread function that varies along the optical axis indicates astigmatism.
摘要翻译：计算机从对象平面中的星形光学目标接收图像数据，并计算与角度相关的边界锐度。在Z平移序列的每个星型图像的一部分上计算水平，x方向，幅度导数和垂直，y方向，幅度导数。携带目标的显微镜载物台从目标对焦点正下方的水平垂直移动到目标对焦点正上方的水平位置。对于垂直运动的每个小增量，Z平移，捕获星形图案的图像用于分析。对差分图像进行计算，以搜索点扩散函数的伸长的证据以及这种外向点扩散函数的长轴角度的Z位置的变化。沿着光轴变化的失真点扩散函数的存在表示散光。

27. 发明授权

US06763149B2 Method and apparatus for correcting crosstalk and spatial resolution for multichannel imaging 有权
标题翻译：用于校正多声道成像的串扰和空间分辨率的方法和装置
公开(公告)号：US06763149B2
公开(公告)日：2004-07-13
申请号：US10132059
申请日：2002-04-24
申请人： James K. Riley , Keith L. Frost
发明人： James K. Riley , Keith L. Frost
IPC分类号： G06K932
CPC分类号： G06K9/00503 , G01J3/28 , G01J3/2803 , G01J3/32 , G01J3/36 , G01N15/147 , G01N15/1475 , G06K9/00127 , G06T5/50 , G06T7/32 , G06T7/33 , G06T2207/10036
摘要： A multichannel imaging system generates an ensemble of images for each field of view of an object. Each image in the ensemble is intended to contain information from only one source among a plurality of sources for the object. However, due to crosstalk, at least a portion of the signal from a first source appears in a channel intended for a second source. Because the accuracy of the correction will be degraded if the images in an ensemble are spatially misaligned with respect to one another, the spatial offset between images is determined and a correction is applied to substantially eliminate the offset. Then, a correction to the signals is determined to substantially reduce the contributions to the signal in a channel from the signals in other channels. The signal processing can be employed to process the output signals for each of a plurality of different disclosed imaging systems.
摘要翻译：多通道成像系统为对象的每个视场生成图像集合。集合中的每个图像旨在包含来自对象的多个源中的一个源的信息。然而，由于串扰，来自第一源的信号的至少一部分出现在用于第二源的通道中。因为如果一个组合中的图像相对于彼此在空间上不对准，校正的精度将会降低，所以确定图像之间的空间偏移并且应用校正以基本上消除偏移。然后，确定对信号的校正，以从其它通道中的信号基本上减少对信道中的信号的贡献。信号处理可用于处理多个不同公开的成像系统中的每一个的输出信号。

28. 发明授权

US5937103A Method and apparatus for alias free measurement of optical transfer function 失效
标题翻译：用于别名自由测量光学传递函数的方法和装置
公开(公告)号：US5937103A
公开(公告)日：1999-08-10
申请号：US788239
申请日：1997-01-25
申请人： Seho Oh , Keith L. Frost , Michael J. Seo , James K. Riley , Chih-Chau L. Kuan
发明人： Seho Oh , Keith L. Frost , Michael J. Seo , James K. Riley , Chih-Chau L. Kuan
IPC分类号： G01J9/02 , G06K7/14 , G06K9/36
CPC分类号： G06K7/14 , G01J9/02
摘要： Measurement of the optical transfer function of an optical system imaging a bar pattern. A one dimensional fast Fourier transform processes sampled image data from the bar pattern. A model of the system utilizes robust measurements of the period, duty cycle and center of each stripe in the pattern. A signal alias free optical transfer function is estimated from the plurality of one dimensional frequency representation of the signal. An idealized bar pattern synthesized from the measured parameters of period, duty cycle and the center of each stripe in the pattern generates an ideal optical transfer function. The noise reduced optical transfer function, OTF, is estimated from OTF of the signal and OTF of the synthesized bar pattern.
摘要翻译：测量条形图案的光学系统的光学传递函数。一维快速傅立叶变换处理来自条形图案的采样图像数据。该系统的模型利用对图案中每个条带的周期，占空比和中心的鲁棒测量。从信号的多个一维频率表示估计信号无别名的光学传递函数。从图案中的每个条纹的周期，占空比和中心的测量参数合成的理想条形图形产生理想的光学传递函数。通过信号的OTF和合成的条形图的OTF估计噪声降低的光传输函数OTF。

29. 发明授权

US5883982A Astigmatism measurement apparatus and method based on a focal plane separation measurement 失效
标题翻译：基于焦平面分离测量的散光测量装置和方法
公开(公告)号：US5883982A
公开(公告)日：1999-03-16
申请号：US816837
申请日：1997-03-13
申请人： James K. Riley , Keith L. Frost , William C. Lindow , Kim J. Hansen , Tuan Phan , James A. Stephanick
发明人： James K. Riley , Keith L. Frost , William C. Lindow , Kim J. Hansen , Tuan Phan , James A. Stephanick
IPC分类号： G01B11/00 , G01M11/02 , G06T1/00 , G06K9/36
CPC分类号： G01M11/0264 , G01M11/0242
摘要： A computer receives image data from a star-shaped optical target in the object plane and calculates angle-dependent boundary sharpness. The horizontal, x-direction, amplitude derivative and the vertical, y-direction, amplitude derivative are computed over a portion of each star pattern image from a Z panning sequence. A microscope slide stage, carrying the target, is moved vertically from a level just below where the target is in focus to a level just above where the target is in focus. For each small increment of vertical motion, Z panning, an image of the star pattern is captured for analysis. Computations are performed on the differentiated images to search for evidence of elongation of the point spread function and variation with stage Z position of the angle of long axis of such an out-of-round point spread function. The presence of a distorted point spread function that varies along the optical axis indicates astigmatism.
摘要翻译：计算机从对象平面中的星形光学目标接收图像数据，并计算与角度相关的边界锐度。在Z平移序列的每个星型图像的一部分上计算水平，x方向，幅度导数和垂直，y方向，幅度导数。携带目标的显微镜载物台从目标对焦点正下方的水平垂直移动到目标对焦点正上方的水平位置。对于垂直运动的每个小增量，Z平移，捕获星形图案的图像用于分析。对差分图像进行计算，以搜索点扩散函数的伸长的证据以及这种外向点扩散函数的长轴角度的Z位置的变化。沿着光轴变化的失真点扩散函数的存在表示散光。

30. 发明授权

US5046827A Optical reconstruction filter for color mosaic displays 失效
标题翻译：彩色拼接显示器的光学重构滤波器
公开(公告)号：US5046827A
公开(公告)日：1991-09-10
申请号：US382514
申请日：1989-07-20
申请人： Keith L. Frost , Karen E. Jachimowicz , Michael J. Johnson
发明人： Keith L. Frost , Karen E. Jachimowicz , Michael J. Johnson
IPC分类号： G02B27/42 , G02B5/18 , G02B27/46 , G02F1/1335
CPC分类号： G02F1/133504 , G02B5/1842 , G02F2201/305
摘要： An optical reconstruction filter in the form of a phase diffraction grating (that is, a diffractive diffuser) placed between a flat panel liquid crystal color matrix display and a viewer to optically filter flat panel images and present a higher quality image to the viewer.

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