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21. 发明授权

US09610243B2 Clonidine compounds in a biodegradable polymer 有权
公开(公告)号：US09610243B2
公开(公告)日：2017-04-04
申请号：US13841481
申请日：2013-03-15
申请人： Warsaw Orthopedic, Inc. , Medtronic, Inc.
发明人： Danielle L. Clay , Josee Roy , William F. McKay
IPC分类号： A01N43/50 , A61K31/415 , A61K9/00 , A61K9/20 , A61K31/4162
CPC分类号： A61K9/0002 , A61K9/0024 , A61K9/0085 , A61K9/204 , A61K31/4162
摘要： Effective treatments of pain for extended periods of time are provided. Through the administration of an effective amount of clonidine in a drug depot at or near a target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain. When appropriate drug depot formulations are provided within biodegradable polymers, this pain relief can be continued for at least fourteen days.

22. 发明申请

US20150342964A1 DEXAMETHASONE POLYMER IMPLANT FOR PAIN 审中-公开
标题翻译： DEXAMETHASONE聚合物植入物
公开(公告)号：US20150342964A1
公开(公告)日：2015-12-03
申请号：US14291131
申请日：2014-05-30
申请人： Warsaw Orthopedic, Inc.
发明人： Jonathan Gray , Jeffrey C. Marx , William F. McKay , Josee Roy , Jared T. Wilsey
IPC分类号： A61K31/573 , A61K45/06 , A61K31/4168 , A61K47/34
CPC分类号： A61K31/573 , A61K9/0024 , A61K31/4168 , A61K45/06 , A61K47/34 , A61K2300/00
摘要： A biodegradable drug implant for reducing, preventing or treating pain and/or inflammation in a patient is provided. The biodegradable drug implant comprises dexamethasone and a polylactic acid polyglycolic acid (PLGA) copolymer matrix, wherein the dexamethasone comprises from about 50% to about 80% by weight of the drug implant. Methods of treating pain in a patient are also provided.
摘要翻译：提供了用于减少，预防或治疗患者的疼痛和/或炎症的可生物降解的药物植入物。可生物降解的药物植入物包括地塞米松和聚乳酸聚乙醇酸（PLGA）共聚物基质，其中地塞米松占药物植入物重量的约50％至约80％。还提供了治疗患者疼痛的方法。

23. 发明授权

US09198707B2 Nerve and soft tissue ablation device and method 有权
标题翻译：神经和软组织消融装置及方法
公开(公告)号：US09198707B2
公开(公告)日：2015-12-01
申请号：US13835424
申请日：2013-03-15
申请人： Warsaw Orthopedic, Inc.
发明人： William F. McKay , Josee Roy
IPC分类号： A61B18/02 , A61B19/00 , A61B18/00
CPC分类号： A61B18/02 , A61B34/20 , A61B90/37 , A61B2018/00577 , A61B2018/0262 , A61B2090/064
摘要： An ablation device and method for monitoring and controlling temperature, pressure and position of an ablation probe for precise destruction of unwanted one of nerve tissue and soft tissue. The ablation device includes a probe configured to generate pressure and temperature for ablating the unwanted soft tissue and nerve tissue The device can also include a monitoring device, an imaging device, and a computer system. The probe includes at least two prongs, the at least two prongs each including distal ends, the distal ends being configured to define, in combination, a probe geometry substantially matching an anatomical tissue geometry of the unwanted one of nerve tissue and soft tissue.
摘要翻译：一种消融装置和方法，用于监测和控制消融探针的温度，压力和位置，以精确地破坏神经组织和软组织中不必要的一种。消融装置包括被配置为产生压力和温度以用于烧蚀不想要的软组织和神经组织的探针。该装置还可以包括监测装置，成像装置和计算机系统。所述探针包括至少两个插脚，所述至少两个插脚各自包括远端，所述远端构造成组合地限定基本匹配神经组织和软组织中不想要的一个的解剖组织几何形状的探针几何形状。

24. 发明申请

US20150030703A1 COMPOSITIONS AND METHODS FOR PREFERENTIAL DISTRIBUTION OF ACTIVE AGENTS TO INJURY SITES 审中-公开
标题翻译：用于优先分配活性药剂至伤口的组合物和方法
公开(公告)号：US20150030703A1
公开(公告)日：2015-01-29
申请号：US14506140
申请日：2014-10-03
申请人： Warsaw Orthopedic, Inc.
发明人： Josee Roy , Toya Kimble
IPC分类号： A61K33/06 , A61K47/10
CPC分类号： A61K33/06 , A61K9/0019 , A61K45/06 , A61K47/10
摘要： Compositions are provided for preferential distribution of active agents to injury sites. Such compositions may comprise a ligand with hydrophilic properties and one or more active agents, such as compounds comprising hydrophilic metal ions. Because the delivery ligand and the active agent are specifically selected so the interactions between them are mainly of an ionic nature so that binding of the active agent to the delivery ligand and release of the active agent into the target site are not dependent on enzymatic activity. Methods of using such compositions are also disclosed.
摘要翻译：提供组合物用于将活性剂优先分配到损伤部位。这样的组合物可以包含具有亲水性质的配体和一种或多种活性剂，例如包含亲水金属离子的化合物。因为递送配体和活性剂被特异选择，所以它们之间的相互作用主要是离子性质的，使得活性剂与递送配体的结合和活性剂向靶位点的释放不依赖于酶活性。还公开了使用这些组合物的方法。

25. 再颁专利

USRE48948E1 Clonidine compounds in a biodegradable polymer 有权
公开(公告)号：USRE48948E1
公开(公告)日：2022-03-01
申请号：US16374300
申请日：2019-04-03
申请人： Warsaw Orthopedic, Inc.
发明人： Danielle L. Clay , Josee Roy , William F. McKay
IPC分类号： A61K9/00 , A61K9/20 , A61K31/4162
摘要： Effective treatments of pain for extended periods of time are provided. Through the administration of an effective amount of clonidine in a drug depot at or near a target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain. When appropriate drug depot formulations are provided within biodegradable polymers, this pain relief can be continued for at least fourteen days.

26. 发明授权

US10517930B2 Methods for treating back or neck pain caused by NGF using a therapeutic agent comprising REN-1820, ALE-0540 and capsaicin 有权
公开(公告)号：US10517930B2
公开(公告)日：2019-12-31
申请号：US15720907
申请日：2017-09-29
申请人： Warsaw Orthopedic, Inc.
发明人： Josee Roy , Susan J. Drapeau , Jeffrey C. Marx
IPC分类号： C07K14/00 , A61K38/00 , A61K38/18 , C07K14/47 , A61K38/19 , A61K38/20 , A61K38/21 , A61K38/17 , G01N33/53 , A61K39/395 , A61K39/00 , C07K16/22 , A61K31/225 , A61K38/48 , C07K14/48 , C07K16/28
摘要： The invention provides a method for alleviating discogenic pain by administering a therapeutic agent that disrupts neuronal and/or vascular elements in the disc, which is typically a degenerated disc. Disruption of neuronal elements in the disk includes destroying nerve endings without substantially affecting the central body of the nerve, suppressing activation of the nerve endings, and inhibiting the growth of nerve endings into the disk. Disruption of vascular elements includes causing the vascular extensions to retract from the disk, or suppressing the formation of such extensions. The therapeutic agent may be administered locally via an interbody pump, a bolus or a depot, or may be administered systemically.

27. 发明申请

US20180021406A1 PHARMACEUTICAL REMOVAL OF VASCULAR AND/OR NEURONAL EXTENSIONS FROM A DEGENERATING DISC 审中-公开
公开(公告)号：US20180021406A1
公开(公告)日：2018-01-25
申请号：US15720907
申请日：2017-09-29
申请人： Warsaw Orthopedic, Inc.
发明人： Josee Roy , Susan J. Drapeau , Jeffrey C. Marx
IPC分类号： A61K38/18 , A61K38/20 , A61K38/21
摘要： The invention provides a method for alleviating discogenic pain by administering a therapeutic agent that disrupts neuronal and/or vascular elements in the disc, which is typically a degenerated disc. Disruption of neuronal elements in the disk includes destroying nerve endings without substantially affecting the central body of the nerve, suppressing activation of the nerve endings, and inhibiting the growth of nerve endings into the disk. Disruption of vascular elements includes causing the vascular extensions to retract from the disk, or suppressing the formation of such extensions. The therapeutic agent may be administered locally via an interbody pump, a bolus or a depot, or may be administered systemically.

28. 发明授权

US09486478B2 Compositions and methods for preferential distribution of active agents to injury sites 有权
标题翻译：将活性剂优先分配到损伤部位的组合物和方法
公开(公告)号：US09486478B2
公开(公告)日：2016-11-08
申请号：US14506140
申请日：2014-10-03
申请人： Warsaw Orthopedic, Inc.
发明人： Josee Roy , Toya Kimble
IPC分类号： A61K33/06 , A61K9/00 , A61K45/06 , A61K47/10
CPC分类号： A61K33/06 , A61K9/0019 , A61K45/06 , A61K47/10
摘要： Compositions are provided for preferential distribution of active agents to injury sites. Such compositions may comprise a ligand with hydrophilic properties and one or more active agents, such as compounds comprising hydrophilic metal ions. Because the delivery ligand and the active agent are specifically selected so the interactions between them are mainly of an ionic nature so that binding of the active agent to the delivery ligand and release of the active agent into the target site are not dependent on enzymatic activity. Methods of using such compositions are also disclosed.
摘要翻译：提供组合物用于将活性剂优先分配到损伤部位。这样的组合物可以包含具有亲水性质的配体和一种或多种活性剂，例如包含亲水金属离子的化合物。因为递送配体和活性剂被特异选择，所以它们之间的相互作用主要是离子性质的，使得活性剂与递送配体的结合和活性剂向靶位点的释放不依赖于酶活性。还公开了使用这些组合物的方法。

29. 发明授权

US09452183B2 Compositions and methods for treatment of hemorrhage 有权
标题翻译：用于治疗出血的组合物和方法
公开(公告)号：US09452183B2
公开(公告)日：2016-09-27
申请号：US14511789
申请日：2014-10-10
申请人： Warsaw Orthopedic, Inc.
发明人： Josee Roy
IPC分类号： A61K33/06 , A61K9/00 , A61K31/74 , A61K31/08 , A61K31/77 , A61K45/06 , A61K47/10
CPC分类号： A61K33/06 , A61K9/0019 , A61K31/08 , A61K31/74 , A61K31/77 , A61K45/06 , A61K47/10 , A61K2300/00
摘要： Methods of treating hemorrhage are provided, comprising diagnosing one or more hemorrhaging or potentially hemorrhaging vessels in a patient and administering to the patient a therapeutically effective amount of a composition comprising a vessel closing compound at a concentration between about 0.1% and about 45%. The vessel closing compound may comprise a polymer with hydrophilic properties, such as polyethylene glycol (PEG). The composition may also comprise one or more active agent such as a blood flow modifier with a potential to form ionic bonds with the vessel closing agent.
摘要翻译：提供治疗出血的方法，包括诊断患者中的一种或多种出血或潜在的出血血管，并向患者施用治疗有效量的组合物，其包含浓度在约0.1％至约45％之间的血管封闭化合物。容器封闭化合物可以包含具有亲水性质的聚合物，例如聚乙二醇（PEG）。组合物还可以包含一种或多种活性剂，例如具有与容器封闭剂形成离子键的潜力的血液流动改性剂。

30. 发明申请

US20150153318A1 METHODS OF IDENTIFYING POTENTIAL COMPONENTS FOR TARGETED DRUG DELIVERY COMPOSITIONS 审中-公开
标题翻译：识别针对药物组合物的潜在成分的方法
公开(公告)号：US20150153318A1
公开(公告)日：2015-06-04
申请号：US14621004
申请日：2015-02-12
申请人： Warsaw Orthopedic, Inc.
发明人： Josee Roy , Victor Kelley , Roger E. Harrington
IPC分类号： G01N33/15
CPC分类号： G01N33/15 , A61K33/06 , A61K47/60
摘要： Methods of preparing compositions for preferential distribution of active agents to injury sites are provided. The compositions may comprise a polymer with hydrophilic properties and one or more active agents, such as compounds comprising hydrophilic metal ions. Because the delivery ligand and the active agent are specifically selected so the interactions between them are mainly of an ionic nature. Methods of identifying suitable components for such compositions are also disclosed.
摘要翻译：提供了将活性剂优先分配给损伤部位的组合物的制备方法。组合物可以包含具有亲水性质的聚合物和一种或多种活性剂，例如包含亲水金属离子的化合物。因为递送配体和活性剂被特异选择，所以它们之间的相互作用主要是离子性质的。还公开了用于鉴定这些组合物的合适组分的方法。

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