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21. 发明授权

US08080229B2 Water soluble nanocrystalline quantum dots 有权
标题翻译：水溶性纳米晶体量子点
公开(公告)号：US08080229B2
公开(公告)日：2011-12-20
申请号：US13155141
申请日：2011-06-07
申请人： Wei-Heng Shih , Wan Y. Shih , Hui Li , Melissa Colleen Schillo
发明人： Wei-Heng Shih , Wan Y. Shih , Hui Li , Melissa Colleen Schillo
IPC分类号： C01B17/20 , C01G21/21 , C01G11/02 , C01G9/08 , C01G45/00
CPC分类号： C09K11/565 , B82Y5/00 , B82Y10/00 , B82Y30/00 , C09K11/883 , Y10S977/774
摘要： An economic, direct synthetic method for producing water soluble QDs that are ready for bioconjugation is provided. The method can produce aqueous QDs with emission wavelengths varying from 400 nm to 700 nm. Highly luminescent metal sulfide (MS) QDs are produced via an aqueous synthesis route. MS QDs are capped with thiol-containing charged molecules in a single step. The resultant MS QDs exhibit the distinctive excitonic photoluminescence desired of QDs and can be fabricated to avoid undesirable broadband emissions at higher wavelengths. This provides a significant improvement over the present complex and expensive commercial processes for the production of QDs. The aqueous QDs are stable in biological fluids over a long period of time. In addition, nontoxic ZnS QDs have been produced with good photoluminescence properties by refluxing the ZnS QD suspensions over a period of time.
摘要翻译：提供了一种用于生产水溶性量子点的经济，直接的合成方法，可用于生物共轭。该方法可以产生发射波长从400nm到700nm变化的含水量子点。高度发光的金属硫化物（MS）量子点通过水性合成路线生产。在一个步骤中，MS量子点被含硫醇的带电分子封盖。所得的MS量子点显示量子点所需的独特的激子光致发光，并且可以被制造以避免在较高波长处的不期望的宽带发射。这提供了相对于目前用于生产量子点的复杂和昂贵的商业过程的显着改进。水质量子在长时间内在生物体液中是稳定的。此外，通过在一段时间内回流ZnS QD悬浮液，已经生产出具有良好光致发光性质的无毒ZnS量子点。

22. 发明授权

US08033185B2 All electric piezoelectric finger sensor (PEFS) for soft material stiffness measurement 有权
标题翻译：所有电动压电手指传感器（PEFS）用于软质材料刚度测量
公开(公告)号：US08033185B2
公开(公告)日：2011-10-11
申请号：US12837590
申请日：2010-07-16
申请人： Wan Y. Shih , Wei-Heng Shih , Anna Markidou , Steven T. Szweczyk , Hakki Yegingil
发明人： Wan Y. Shih , Wei-Heng Shih , Anna Markidou , Steven T. Szweczyk , Hakki Yegingil
IPC分类号： G01L1/04
CPC分类号： G01N33/4833 , A61B5/0053 , A61B5/0057 , A61B5/4312 , A61B5/441 , A61B5/442 , A61B5/444 , A61B2562/0247 , A61B2562/046 , G01L1/16 , G01N3/08 , G01N3/24 , G01N19/00 , G01N2203/0025 , G01N2203/0089 , G01N2203/0094
摘要： A PEFS (Piezoelectric Finger Sensor) acts as an “electronic finger” capable of accurately and non-destructively measuring both the Young's compression modulus and shear modulus of tissues with gentle touches to the surface. The PEFS measures both the Young's compression modulus and shear modulus variations in tissue generating a less than one-millimeter spatial resolution up to a depth of several centimeters. This offers great potential for in-vivo early detection of diseases. A portable hand-held device is also disclosed. The PEF offers superior sensitivity.
摘要翻译： PEFS（压电手指传感器）充当“电子手指”，可以对表面轻柔的接触的组织的杨氏压缩模量和剪切模量进行精确和非破坏性的测量。 PEFS测量组织中的杨氏压缩模量和剪切模量变化，产生小于1毫米的空间分辨率，直到几厘米的深度。这为疾病的体内早期检测提供了巨大的潜力。还公开了便携式手持装置。 PEF提供卓越的灵敏度。

23. 发明授权

US07992431B2 Piezoelectric microcantilevers and uses in atomic force microscopy 有权
标题翻译：压电微悬臂梁和原子力显微镜的应用
公开(公告)号：US07992431B2
公开(公告)日：2011-08-09
申请号：US11946534
申请日：2007-11-28
申请人： Wan Y. Shih , Wei-Heng Shih , Zuyan Shen , Qing Zhu
发明人： Wan Y. Shih , Wei-Heng Shih , Zuyan Shen , Qing Zhu
IPC分类号： G01B5/28
CPC分类号： G01Q60/38 , B82Y35/00 , G01B9/04 , G01Q10/045 , G01Q20/04 , Y10T29/42
摘要： The invention is direct to a piezoelectric microcantilever for static contact and dynamic noncontact atomic force microscopy which may be carried out in solution. The piezoelectric microcantilever, which includes a piezoelectric layer and a non-piezoelectric layer is capable of self actuation and detection. The piezoelectric layer may be constructed from a lead magnesium niobate-lead titanate (Pb(Mg1/3Nb2/3)O3)0.65—(PbTiO3)0.35(PMN0.65-PT0.35)(PMN-PT), zirconate titanate (PZT)/SiO2 or from any lead-free piezoelectric materials such as doped sodium-potassium niobate-lithium niobate. The piezoelectric layers of the microcantilevers may have dielectric constants of from 1600-3000 and thicknesses below 10 μm. Also disclosed are methods for fabricating microcantilever sensors and methods for atomic force microscopy employing the microcantilevers.
摘要翻译：本发明直接用于静态接触和动态非接触原子力显微镜的压电微悬臂梁，其可以在溶液中进行。包括压电层和非压电层的压电微悬臂梁能够自动启动和检测。压电层可以由铌酸铅镁酸铅（Pb（Mg1 / 3Nb2 / 3）O3）0.65-（PbTiO3）0.35（PMN0.65-PT0.35）（PMN-PT），锆钛酸铅（PZT））/ SiO 2或来自任何无铅压电材料如掺杂的铌酸钠 - 铌酸锂 - 铌酸锂。微悬臂梁的压电层可以具有1600-3000的介电常数和低于10μm的厚度。还公开了用于制造微悬臂梁传感器的方法和使用微悬臂梁的原子力显微镜的方法。

24. 发明授权

US07824653B2 Water soluble quantum dots 有权
标题翻译：水溶性量子点
公开(公告)号：US07824653B2
公开(公告)日：2010-11-02
申请号：US12552970
申请日：2009-09-02
申请人： Wei-Heng Shih , Wan Y. Shih , Hui Li , Melissa Colleen Schillo
发明人： Wei-Heng Shih , Wan Y. Shih , Hui Li , Melissa Colleen Schillo
IPC分类号： C01B17/20 , C01G21/21 , C01G11/02 , C01G9/08 , C01G45/00
CPC分类号： C09K11/565 , B82Y5/00 , B82Y10/00 , B82Y30/00 , C09K11/883 , Y10S977/774
摘要： An economic, direct synthetic method for producing water soluble QDs that are ready for bioconjugation is provided. The method can produce aqueous QDs with emission wavelengths varying from 400 nm to 700 nm. Highly luminescent metal sulfide (MS) QDs are produced via an aqueous synthesis route. MS QDs are capped with thiol-containing charged molecules in a single step. The resultant MS QDs exhibit the distinctive excitonic photoluminescence desired of QDs and can be fabricated to avoid undesirable broadband emissions at higher wavelengths. This provides a significant improvement over the present complex and expensive commercial processes for the production of QDs. The aqueous QDs are stable in biological fluids over a long period of time. In addition, nontoxic ZnS QDs have been produced with good photoluminescence properties by refluxing the ZnS QD suspensions over a period of time.
摘要翻译：提供了一种用于生产水溶性量子点的经济，直接的合成方法，可用于生物共轭。该方法可以产生发射波长从400nm到700nm变化的含水量子点。高度发光的金属硫化物（MS）量子点通过水性合成路线生产。在一个步骤中，MS量子点被含硫醇的带电分子封盖。所得的MS量子点显示量子点所需的独特的激子光致发光，并且可以被制造以避免在较高波长处的不期望的宽带发射。这提供了相对于目前用于生产量子点的复杂和昂贵的商业过程的显着改进。水质量子在长时间内在生物体液中是稳定的。此外，通过在一段时间内回流ZnS QD悬浮液，已经生产出具有良好光致发光性质的无毒ZnS量子点。

25. 发明申请

US20100051447A1 SOL-GEL PRECURSORS AND METHODS FOR MAKING LEAD-BASED PEROVSKITE FILMS 有权
标题翻译： SOL-GEL前身和制备基于铅的PEROVSKITE膜的方法
公开(公告)号：US20100051447A1
公开(公告)日：2010-03-04
申请号：US12513308
申请日：2007-11-06
申请人： Wei-Heng Shih , Wan Y. Shih , Zuyan Shen , Huidong Li , Xiaotong Gao
发明人： Wei-Heng Shih , Wan Y. Shih , Zuyan Shen , Huidong Li , Xiaotong Gao
IPC分类号： C23C14/08 , B05D3/02
CPC分类号： H01L41/318 , H01L41/094 , H01L41/0973 , H01L41/1875
摘要： A simple, economical sol-gel method was invented to produce thick and dense lead zirconate titanate (PZT) thin films that exhibit the stoichiometric chemical composition and unprecedented electrical and dielectric properties. The PZT films are the foundation of many microelectromechanical systems (MEMS) and nanoelectromechanical systems (NEMS) for micro/nano sensors and actuators applications.
摘要翻译：发明了一种简单经济的溶胶 - 凝胶法，以生产厚而致密的锆钛酸铅（PZT）薄膜，其表现出化学计量的化学成分和前所未有的电和介电性能。 PZT薄膜是用于微/纳米传感器和致动器应用的许多微机电系统（MEMS）和纳米机电系统（NEMS）的基础。

26. 发明授权

US07597870B2 Water soluble quantum dots 有权
标题翻译：水溶性量子点
公开(公告)号：US07597870B2
公开(公告)日：2009-10-06
申请号：US11968228
申请日：2008-01-02
申请人： Wei-Heng Shih , Wan Y. Shih , Hui Li , Melissa Colleen Schillo
发明人： Wei-Heng Shih , Wan Y. Shih , Hui Li , Melissa Colleen Schillo
IPC分类号： C01B17/20 , C01G21/21 , C01G11/02 , C01G9/08 , C01G45/00
CPC分类号： C09K11/565 , B82Y5/00 , B82Y10/00 , B82Y30/00 , C09K11/883 , Y10S977/774
摘要： An economic, direct synthetic method for producing water soluble QDs that are ready for bioconjugation is provided. The method can produce aqueous QDs with emission wavelengths varying from 400 nm to 700 nm. Highly luminescent metal sulfide (MS) QDs are produced via an aqueous synthesis route. MS QDs are capped with thiol-containing charged molecules in a single step. The resultant MS QDs exhibit the distinctive excitonic photoluminescence desired of QDs and can be fabricated to avoid undesirable broadband emissions at higher wavelengths. This provides a significant improvement over the present complex and expensive commercial processes for the production of QDs. The aqueous QDs are stable in biological fluids over a long period of time. In addition, nontoxic ZnS QDs have been produced with good photoluminescence properties by refluxing the ZnS QD suspensions over a period of time.
摘要翻译：提供了一种用于生产水溶性量子点的经济，直接的合成方法，可用于生物共轭。该方法可以产生发射波长从400nm到700nm变化的含水量子点。高度发光的金属硫化物（MS）量子点通过水性合成路线生产。在一个步骤中，MS量子点被含硫醇的带电分子封盖。所得的MS量子点显示量子点所需的独特的激子光致发光，并且可以被制造以避免在较高波长处的不期望的宽带发射。这提供了相对于目前用于生产量子点的复杂和昂贵的商业过程的显着改进。水质量子在长时间内在生物体液中是稳定的。此外，通过在一段时间内回流ZnS QD悬浮液，已经生产出具有良好光致发光性质的无毒ZnS量子点。

27. 发明授权

US07497133B2 All electric piezoelectric finger sensor (PEFS) for soft material stiffness measurement 有权
标题翻译：所有电动压电手指传感器（PEFS）用于软质材料刚度测量
公开(公告)号：US07497133B2
公开(公告)日：2009-03-03
申请号：US11136173
申请日：2005-05-23
申请人： Wan Y. Shih , Wei-Heng Shih , Anna Markidou , Steven T. Szweczyk , Hakki Yegingil
发明人： Wan Y. Shih , Wei-Heng Shih , Anna Markidou , Steven T. Szweczyk , Hakki Yegingil
IPC分类号： G01L1/04
CPC分类号： G01N33/4833 , A61B5/0053 , A61B5/0057 , A61B5/4312 , A61B5/441 , A61B5/442 , A61B5/444 , A61B2562/0247 , A61B2562/046 , G01L1/16 , G01N3/08 , G01N3/24 , G01N19/00 , G01N2203/0025 , G01N2203/0089 , G01N2203/0094
摘要： A PEFS (Piezoelectric Finger Sensor) acts as an “electronic finger” capable of accurately and non-destructively measuring both the Young's compression modulus and shear modulus of tissues with gentle touches to the surface. The PEFS measures both the Young's compression modulus and shear modulus variations in tissue generating a less than one-millimeter spatial resolution up to a depth of several centimeters. This offers great potential for in-vivo early detection of diseases. A portable hand-held device is also disclosed. The PEF offers superior sensitivity.
摘要翻译： PEFS（压电手指传感器）充当“电子手指”，可以对表面轻柔的接触的组织的杨氏压缩模量和剪切模量进行精确和非破坏性的测量。 PEFS测量组织中的杨氏压缩模量和剪切模量变化，产生小于1毫米的空间分辨率，直到几厘米的深度。这为疾病的体内早期检测提供了巨大的潜力。还公开了便携式手持装置。 PEF提供卓越的灵敏度。

28. 发明授权

US10076247B2 System and method for evaluating tissue 有权
公开(公告)号：US10076247B2
公开(公告)日：2018-09-18
申请号：US14465520
申请日：2014-08-21
申请人： Wan Y. Shih , Wei-Heng Shih , Hakki Yegingil , Ari D. Brooks
发明人： Wan Y. Shih , Wei-Heng Shih , Hakki Yegingil , Ari D. Brooks
IPC分类号： A61B5/103 , A61B5/00 , G01N29/06 , A61B8/08 , A61B8/00
CPC分类号： A61B5/0053 , A61B5/4244 , A61B5/4312 , A61B5/4381 , A61B5/441 , A61B5/442 , A61B8/085 , A61B8/403 , A61B8/485 , G01N29/0672 , G01N2291/02475 , G01N2291/02827
摘要： A sensor system for measuring an elastic modulus and a shear modulus and a method for evaluating a tissue. The invention pertains to a method for determining the presence of and/or characterizing abnormal growths, using a piezoelectric finger sensor (PEFS) system. The PEFS system may be particularly useful for screening for tumors and various forms of cancer. Additionally, the PEFS system may be useful for various dermatological applications.

29. 发明申请

US20160297839A1 TIN SULFIDE QUANTUM DOTS FOR IN VIVO NEAR INFRARED IMAGING 有权
标题翻译： TIN SULFIDE QUANTUM DOTS FOR VIVO NEAR INFRARED IMAGING
公开(公告)号：US20160297839A1
公开(公告)日：2016-10-13
申请号：US15092865
申请日：2016-04-07
申请人： Wei-Heng Shih , Wan Y. Shih , Song Han , Xiaomin Niu , Shi Fang
发明人： Wei-Heng Shih , Wan Y. Shih , Song Han , Xiaomin Niu , Shi Fang
IPC分类号： C07F7/22 , A61K49/18
CPC分类号： A61K49/1836 , A61K49/0067 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C09K11/02 , C09K11/661 , Y10S977/774 , Y10S977/896 , Y10S977/927
摘要： An aqueous approach to synthesize capped SnS quantum dots (QDs) followed by optional capping molecule extension by attaching one or more extending molecules to the capping molecule via peptide bond formation at elevated temperature. The capped SnS QDs may have a capping molecule:Sn:S molar ratio of 16:3:1 to 16:12:1. A suspension of SnS QDs was heat-treated at 200° C. for 0.5-4 hrs. The obtained SnS QDs showed an NIR emission peak at 820-835 nm with an excitation wavelength at 690 nm. The as synthesized SnS QDs were found to have high positive zeta potential of ˜30 mV and thus were toxic to cells. By neutralizing the SnS QDs the cytotoxicity was reduced to an accepted level. The heat-treatment step can be obviated by adding a glycerol solution containing S2− anions and capping molecule to a glycerol solution of Sn2+ ions.
摘要翻译：通过在升高的温度下通过肽键形成将一个或多个延伸分子连接到封端分子，合成封端的SnS量子点（QD），然后通过任选的封端分子延伸的水性方法。封端的SnS量子点可以具有封端分子：Sn:S摩尔比为16:3:1至16:12:1。 SnS量子点的悬浮液在200℃下热处理0.5-4小时。所获得的SnS量子点在820-835nm处显示出具有690nm激发波长的NIR发射峰。发现合成的SnS量子点具有约30mV的高ζ电位，因此对细胞有毒性。通过中和SnS量子点，细胞毒性降低到可接受的水平。通过向Sn2 +离子的甘油溶液中加入含有S2-阴离子和封端分子的甘油溶液可以消除热处理步骤。

30. 发明授权

US08722427B2 Determination of dissociation constants using piezoelectric microcantilevers 失效
标题翻译：使用压电微悬臂梁测定解离常数
公开(公告)号：US08722427B2
公开(公告)日：2014-05-13
申请号：US12900160
申请日：2010-10-07
申请人： Wan Y. Shih , Joseph Capobianco , Wei-Heng Shih
发明人： Wan Y. Shih , Joseph Capobianco , Wei-Heng Shih
IPC分类号： G01N33/551
CPC分类号： G01N33/54373
摘要： A method for determining the dissociation constant (Kd) by plotting resonance frequency shift as a function of time for various target analyte concentrations. From this graph, the fraction of saturation, i.e. equilibrium fraction of bound binding sites out of all available binding sites on the sensor surface may be estimated by taking the ratio of the equilibrium resonance frequency shift at a selected concentration to the equilibrium frequency shift of the sensor. The dissociation constant is the inverse slope of the line produced by graphing the fraction of saturation as a function of concentration. This method is particularly useful for the study of protein-protein and protein-mRNA interactions.
摘要翻译：通过绘制各种目标分析物浓度作为时间的函数的共振频移来确定解离常数（Kd）的方法。从该图中可以通过将选定浓度下的平衡共振频移与平衡频移的比值来估计饱和度的分数，即在传感器表面上所有可用结合位点之间的结合结合位点的平衡分数传感器。解离常数是通过绘制作为浓度的函数的饱和分数而产生的线的反斜率。这种方法对于研究蛋白质和蛋白质 - mRNA相互作用特别有用。

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