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21. 发明授权

US11786581B2 Directed stem cell recruitment 有权
公开(公告)号：US11786581B2
公开(公告)日：2023-10-17
申请号：US17105156
申请日：2020-11-25
申请人： Wake Forest University Health Sciences
发明人： James Yoo , Sang Jin Lee , Anthony Atala , Mark Van Dyke
IPC分类号： A61K9/00 , A61K38/39 , A61K38/48 , A61L27/24 , A61L27/52 , A61L27/54
CPC分类号： A61K38/39 , A61K9/0024 , A61K38/4886 , A61L27/24 , A61L27/52 , A61L27/54 , A61L2300/41 , A61L2300/434 , A61L2400/06 , A61L2430/26 , A61K38/39 , A61K2300/00 , A61K38/4886 , A61K2300/00
摘要： The invention is directed to methods of inducing cell recruitment and tissue regeneration at a target site in a subject. It is also based, in part, on the discovery that a subject's own biologic resources and environmental conditions can be used for in situ tissue regeneration and thereby reduce or eliminate the need for donor cell procurement and ex vivo manipulation of such donor cells. Methods are disclosed for recruitment of a subject's own stem cells to a target region by inducing a sustained positive pressure at a target site, such as the kidney, thereby increasing the number of pluripotent cells capable of differentiating to regenerate the target tissue.

22. 发明申请

US20210252188A1 INTEGRATED ORGAN AND TISSUE PRINTING METHODS, SYSTEM AND APPARATUS 有权
公开(公告)号：US20210252188A1
公开(公告)日：2021-08-19
申请号：US17237116
申请日：2021-04-22
申请人： Wake Forest University Health Sciences
发明人： Hyun-Wook Kang , Sang Jin Lee , Anthony Atala , James J. Yoo
IPC分类号： A61L27/20 , B29C64/393 , B29C64/112 , A61L27/22 , A61L27/38 , A61L27/52 , B29C64/124 , A61L27/26
摘要： A method of making an organ or tissue comprises: (a) providing a first dispenser containing a structural support polymer and a second dispenser containing a live cell-containing composition; (b) depositing a layer on said support from said first and second dispenser, said layer comprising a structural support polymer and said cell-containing composition; and then (c) iteratively repeating said depositing step a plurality of times to form a plurality of layers one on another, with separate and discrete regions in each of said layers comprising one or the other of said support polymer or said cell-containing composition, to thereby produce provide a composite three dimensional structure containing both structural support regions and cell-containing regions. Apparatus for carrying out the method and composite products produced by the method are also described.

23. 发明申请

US20200345899A1 MULTI-LAYER SKIN SUBSTITUTE PRODUCTS AND METHODS OF MAKING AND USING THE SAME 审中-公开
公开(公告)号：US20200345899A1
公开(公告)日：2020-11-05
申请号：US16947053
申请日：2020-07-16
申请人： Wake Forest University Health Sciences
发明人： Anthony Atala , Gayoung Jeong , James J. Yoo , Sang Jin Lee , Young-Joon Seol
IPC分类号： A61L27/60 , A61F2/10 , B33Y80/00 , B33Y70/00 , C08L5/08 , A61L27/20 , C08L89/06 , C12N5/071 , B33Y10/00 , A61L27/18 , A61L27/38 , A61L27/52 , G01N33/50
摘要： Provided are live, artificial, skin substitute products and methods of making and using the same, such as for wound treatment and compound testing, including compound testing for efficacy, toxicity, penetration, irritation and/or metabolism testing of drug candidates or compositions such as cosmetics.

24. 发明申请

US20170354763A1 MULTI-LAYER SKIN SUBSTITUTE PRODUCTS AND METHODS OF MAKING AND USING THE SAME 审中-公开
公开(公告)号：US20170354763A1
公开(公告)日：2017-12-14
申请号：US15542095
申请日：2016-01-11
申请人： Wake Forest University Health Sciences
发明人： Anthony Atala , Gayoung Jeong , James J. Yoo , Sang Jin Lee , Young-Joon Seol
IPC分类号： A61L27/60 , B33Y80/00 , G01N33/50 , B33Y70/00 , B29C64/106 , A61F2/10 , B33Y10/00 , A61L27/18 , A61L27/38 , A61L27/52 , B29K75/00 , B29K105/00
摘要： Provided are live, artificial, skin substitute products and methods of making and using the same, such as for wound treatment and compound testing, including compound testing for efficacy, toxicity, penetration, irritation and/or metabolism testing of drug candidates or compositions such as cosmetics. Described herein is an artificial mammalian skin substitute product, comprising: (a) optionally, but in some embodiments preferably, a first (“hypodermis-like”) layer comprising live mammalian adipocytes (e.g., induced pre-adipocytes) in a first hydrogel carrier; (b) a second (“dermis-like”) layer contacting or directly contacting the first layer and comprising live mammalian fibroblast cells and' live mammalian follicle dermal papilla cells in combination in a second hydrogel carrier; (c) a third (“epidermis-like”) layer contacting or directly contacting the second layer (i.e., on the opposite side thereof as the first layer, so that the second layer is sandwiched between the first and third layers when the first layer is present), the third layer comprising live mammalian keratinocytes and live mammalian melanocytes in combination in a third hydrogel carrier.

25. 发明申请

US20150025031A1 METABOLIC DOWNREGULATION FOR CELL SURVIVAL 审中-公开
标题翻译：细胞生存的代谢下调
公开(公告)号：US20150025031A1
公开(公告)日：2015-01-22
申请号：US14382921
申请日：2013-03-05
申请人： WAKE FOREST UNIVERSITY HEALTH SCIENCES
发明人： James Yoo , Sang Jin Lee , Jachyun Kim , Anthony Atala
IPC分类号： A61K31/7076
CPC分类号： A61K31/7076 , C12N5/0018 , C12N2500/40 , C12N2501/73
摘要： The present invention provides a system and method of maintaining and/or increasing cell viability by downregulating cellular metabolic rate under hypoxic conditions, wherein the availability of adenosine or derivatives thereof in the cell is increased and/or prolonged. The present invention also relates to a system and method of prolonging the survival of implanted cells that are under hypoxic condition until host neovascularization is achieved, wherein the availability of adenosine or derivatives thereof in the cell is increased and/or prolonged. The present invention also provides a system and method of maintaining and/or increasing cell viability by downregulating cellular metabolic rate under hypoxic conditions, wherein at least one purine metabolism enzyme inhibitor is applied to the cell.
摘要翻译：本发明提供通过在低氧条件下下调细胞代谢速率来维持和/或增加细胞活力的系统和方法，其中细胞中腺苷或其衍生物的可用性增加和/或延长。本发明还涉及延长在缺氧条件下进行宿主新生血管形成的植入细胞的存活的系统和方法，其中细胞中腺苷或其衍生物的可用性增加和/或延长。本发明还提供了通过在缺氧条件下下调细胞代谢速率来维持和/或增加细胞活力的系统和方法，其中至少一种嘌呤代谢酶抑制剂被施用于细胞。

26. 发明申请

US20150018948A1 ORBICULAR TISSUE EXPANDER 有权
标题翻译： ORBICULAR TISSUE扩展器
公开(公告)号：US20150018948A1
公开(公告)日：2015-01-15
申请号：US14325908
申请日：2014-07-08
申请人： Wake Forest University Health Sciences , North Carolina State University
发明人： Rohan A. Shirwaiker , Caroline Elsie Webster , John D. Jackson , Richard A. Wysk , Sang Jin Lee , Ola L.A. Harrysson , James J. Yoo , Anthony Atala , Paul H. Cohen , Yuan-Shin Lee , Peter M. Prim , Molly F. Purser , Katie L. Basinger
IPC分类号： A61B19/00 , A61B17/322
CPC分类号： A61B90/02 , A61B17/322 , A61B2017/3225
摘要： Provided herein is a tissue stretching device configured for orbicular expansion of a tissue placed therein. Methods of use of the device to stretch a tissue as well as for culturing organized tissues are also provided. Stretched and/or cultured tissues produced by these processes are also provided, as well as methods making use of the same.
摘要翻译：本文提供了构造成用于放置在其中的组织的轮状膨胀的组织拉伸装置。还提供了使用该装置拉伸组织以及培养有组织的组织的方法。还提供了通过这些方法生产的拉伸和/或培养的组织，以及使用它们的方法。

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