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21. 发明授权

US08532769B2 Heart rate variability distinction 有权
标题翻译：心率变异性区别
公开(公告)号：US08532769B2
公开(公告)日：2013-09-10
申请号：US12610009
申请日：2009-10-30
申请人： Lilian Kornet , Hans-Juergen Bruns , Raphael Schneider
发明人： Lilian Kornet , Hans-Juergen Bruns , Raphael Schneider
IPC分类号： A61N1/00
CPC分类号： A61B5/0452 , A61B5/02405 , A61B5/0464 , A61N1/36514 , A61N1/36578 , A61N1/36592
摘要： Systems, methods and devices for monitoring, analyzing, and processing a patient's heart rate signal for HRV characteristics are described herein. A first heart rate signal is acquired. The first heart rate signal includes at least one indication of an interval duration of cardiac activity. At least one accelerating portion and at least one decelerating portion of the first heart rate signal are identified. An average heart rate signal is acquired. The accelerating portion or the decelerating portion of the first heart rate signal is replaced with the average heart rate signal to produce a second heart rate signal. A frequency spectrum of the second heart rate signal may be obtained and utilized to predict or detect one or more autonomic conditions of a patient. Therapy may initiated or titrated in response to prediction or detection of the autonomic condition.
摘要翻译：本文描述了用于监测，分析和处理HRV特征的患者心率信号的系统，方法和装置。获取第一个心率信号。第一心率信号包括心脏活动的间隔持续时间的至少一个指示。识别出第一心率信号的至少一个加速部分和至少一个减速部分。获取平均心率信号。将第一心率信号的加速部分或减速部分替换为平均心率信号以产生第二心率信号。第二心率信号的频谱可以被获得并用于预测或检测患者的一个或多个自主状况。治疗可以根据对自主神经病症的预测或检测而启动或滴定。

22. 发明授权

US08457739B2 Automatic enabling of post long pause overdrive pacing 有权
标题翻译：自动启用后期长暂停超速起搏
公开(公告)号：US08457739B2
公开(公告)日：2013-06-04
申请号：US12844531
申请日：2010-07-27
申请人： Lilian Kornet , Roger Kessels
发明人： Lilian Kornet , Roger Kessels
IPC分类号： A61N1/00 , A61B5/04
CPC分类号： A61N1/3621 , A61N1/3624 , A61N1/395 , A61N1/3962
摘要： A method and apparatus for controlling an atrial overdrive pacing therapy include detecting an atrial arrhythmia episode and determining if the atrial arrhythmia episode is an early recurring episode. Delivery of the atrial overdrive pacing therapy is enabled in response to the early recurring episode and commences upon detection of an atrial arrhythmia episode or a long pause.
摘要翻译：用于控制心房超速起搏治疗的方法和装置包括检测心房心律失常发作并确定房性心律失常发作是否是早期的复发发作。心房超速起搏治疗的交付是为了响应早期的复发性发作，并且在检测到心房心律失常发作或长时间停顿时开始。

23. 发明申请

US20110270332A1 THERAPY USING PERTURBATION AND EFFECT OF PHYSIOLOGICAL SYSTEMS 有权
公开(公告)号：US20110270332A1
公开(公告)日：2011-11-03
申请号：US13094392
申请日：2011-04-26
申请人： Hendrik Peter Johan Buschman , John Edward Burnes , Richard N.M. Cornelussen , Michael Roland Scott Hill , Lilian Kornet , Simone Cornelia Maria Anna Ordelman , Petrus Hemanus Veltink
发明人： Hendrik Peter Johan Buschman , John Edward Burnes , Richard N.M. Cornelussen , Michael Roland Scott Hill , Lilian Kornet , Simone Cornelia Maria Anna Ordelman , Petrus Hemanus Veltink
IPC分类号： A61N1/36 , A61M37/00 , A61N1/365
CPC分类号： A61N1/36114 , A61N1/365
摘要： Methods for treating a patient and further to devices for performing such treatment, e.g., methods and devices to perturb at least one physiological system and deliver therapy to the patient based on the effects of such perturbation. For example, a method for using an implantable medical device is disclosed that involves delivering electrical stimuli to an efferent nerve associated with the selected organ. Afferent electrical activity is monitored during delivery of electrical stimuli to the efferent nerve, the monitored afferent electrical activity includes an indirect component of a compound action potential (CAP). A status of the selected organ is assessed based upon the indirect component. A determination is made as to whether to deliver therapy to the selected organ in response to assessing the status of the selected organ.

24. 发明申请

US20070270910A1 Post Long Pause Overdrive Pacing in Response to Atrial Tachyarrhythmia Episode 失效
标题翻译：发布长时间暂停高速起搏响应心房快速性心律失常发作
公开(公告)号：US20070270910A1
公开(公告)日：2007-11-22
申请号：US11554727
申请日：2006-10-31
申请人： Lilian Kornet , Maurits Allessie , Jaak M.O. Minten
发明人： Lilian Kornet , Maurits Allessie , Jaak M.O. Minten
IPC分类号： A61N1/00
CPC分类号： A61N1/3962 , A61N1/3621 , A61N1/3624 , A61N1/395
摘要： This disclosure provides for methods and apparatus for preventing an early recurring atrial fibrillation and atrial flutter (AF) episode (herein “ERAF”). Some aspects of the foregoing involve commencing atrial overdrive pacing therapy delivery at an overdrive pacing rate upon detection of one of: (i) an AF episode and (ii) a relatively long pause between successive sensed P-waves during an AF episode. The AF episode typically has a cycle length interval of between about 100 ms and 300 ms, and the relatively long pause has a duration of between about 40 ms and 100 ms longer than the cycle length of the AF episode. Atrial overdrive pacing is delivered for a relatively short period of time after successful termination of the AF episode. Subsequently, the atrial pacing rate is rapidly decreased until either normal sinus rhythm or a lower programmed pacing rate is reached.
摘要翻译：本公开提供了用于预防早期复发性心房颤动和心房扑动（AF）发作（本文为“ERAF”）的方法和装置。上述的某些方面涉及在检测到以下之一时以超速起搏速率开始心房超速起搏治疗递送：（i）AF发作和（ii）在AF发作期间连续感测的P波之间的相对长的暂停。 AF发作通常具有在约100ms和300ms之间的周期长度间隔，并且相对长的暂停具有比AF发作的周期长度大约40ms和100ms之间的持续时间。心房超速起搏在AF事件成功终止后相对较短的一段时间内交付。随后，心房起搏速度快速降低，直到达到正常窦性心律或较低程序起搏速率。

25. 发明申请

US20070156200A1 System and method for regulating blood pressure and electrolyte balance 审中-公开
标题翻译：用于调节血压和电解质平衡的系统和方法
公开(公告)号：US20070156200A1
公开(公告)日：2007-07-05
申请号：US11321947
申请日：2005-12-29
申请人： Lilian Kornet , Pierre Grandjean
发明人： Lilian Kornet , Pierre Grandjean
IPC分类号： A61N1/00
CPC分类号： A61B5/021 , A61B5/4035 , A61B5/4047 , A61N1/36114 , A61N1/36117 , A61N1/36564
摘要： The present invention is an apparatus and method for controlling blood pressure by stimulating the cardiac afferent sympathetic nerves. The invention may be implemented in a medical device having a pressure sensor for sensing blood pressure, an electrode for providing electrical signals to the cardiac afferent sympathetic nerves, and a controller for providing signals to the electrode as a function of blood pressure signals received from the pressure sensor.
摘要翻译：本发明是通过刺激心脏传入交感神经来控制血压的装置和方法。本发明可以在具有用于感测血压的压力传感器的医疗装置中实现，用于向心脏传入交感神经提供电信号的电极以及用于向电极提供信号的控制器作为从第压力传感器。

26. 发明授权

US08744548B2 Lead apparatus 有权
标题翻译：铅装置
公开(公告)号：US08744548B2
公开(公告)日：2014-06-03
申请号：US12795236
申请日：2010-06-07
申请人： Rogier Receveur , Jean Joseph Gerardus Rutten , Karel F. A. A. Smits , Nicolaas M Lokhoff , Sylvia Weijzen-Engels , Didier Billy , Tim Dirk Jan Jongen , Lilian Kornet
发明人： Rogier Receveur , Jean Joseph Gerardus Rutten , Karel F. A. A. Smits , Nicolaas M Lokhoff , Sylvia Weijzen-Engels , Didier Billy , Tim Dirk Jan Jongen , Lilian Kornet
IPC分类号： A61B5/042 , A61N1/05
CPC分类号： A61N1/056 , A61N1/3756
摘要： A lead including one or more electrodes having circuitry associated therewith. Each such electrode includes a circuit extending along and conforming to at least a portion of an inner surface of the electrode. The circuit includes an isolation substrate contacting at least a portion of the inner surface of the cylindrical electrode portion, a first contact electrically isolated from the electrode portion by the isolation substrate and an integrated circuit electrically coupled to the first contact and the electrode.
摘要翻译：包括具有与其相关的电路的一个或多个电极的引线。每个这样的电极包括沿着电极的内表面的至少一部分延伸并且与电极的内表面的至少一部分一致的电路。电路包括与圆柱形电极部分的内表面的至少一部分接触的隔离衬底，通过隔离衬底与电极部分电隔离的第一接触和电耦合到第一接触和电极的集成电路。

27. 发明授权

US08504161B1 Modulate vagal signals to reduce inflammation 有权
标题翻译：调制迷走神经信号以减轻炎症
公开(公告)号：US08504161B1
公开(公告)日：2013-08-06
申请号：US13568281
申请日：2012-08-07
申请人： Lilian Kornet , Sergio Valsecchi
发明人： Lilian Kornet , Sergio Valsecchi
IPC分类号： A61N1/36
CPC分类号： A61N1/36139 , A61N1/36053 , A61N1/36185
摘要： A medical device is configured to perform a method for modulating vagal nerve signals to reduce inflammation. A sensing module of the medical device is enabled to receive an electrical signal from selected electrodes electrically coupled to the medical device. A controller coupled to the sensing module is configured to determine an inflammation metric from the sensed electrical signal. The metric is compared to an inflammation detection threshold. A pulse generator is controlled to selectively deliver electrical stimulation pulses via the plurality of electrodes in response to the metric meeting the inflammation detection threshold to modulate vagal nerve signals to cause an anti-inflammatory response.
摘要翻译：医疗装置被配置为执行调节迷走神经信号以减少炎症的方法。医疗装置的感测模块能够从电耦合到医疗装置的所选择的电极接收电信号。耦合到感测模块的控制器被配置为从所感测的电信号确定炎症度量。将度量与炎症检测阈值进行比较。控制脉冲发生器以响应于满足炎症检测阈值的量度，经由多个电极选择性地递送电刺激脉冲，以调制迷走神经信号以引起抗炎反应。

28. 发明申请

US20110106195A1 ARRHYTHMIA PREDICTION BASED ON HEART RATE TURBULENCE 有权
标题翻译：基于心率波动的ARRHYTHMIA预测
公开(公告)号：US20110106195A1
公开(公告)日：2011-05-05
申请号：US12608855
申请日：2009-10-29
申请人： Lilian Kornet , Raphael Schneider
发明人： Lilian Kornet , Raphael Schneider
IPC分类号： A61N1/365 , A61B5/02
CPC分类号： A61N1/3621 , A61B5/02 , A61B5/02405 , A61B5/0402 , A61B5/046 , A61B5/6801 , A61B5/686 , A61N1/36592
摘要： In general, the disclosure describes techniques for predicting the occurrence of an arrhythmia based on an indication of heart rate turbulence. An example method comprises sensing a parameter indicative of heart rate turbulence, measuring heart rate turbulence based on the sensed parameter, and predicting an occurrence of an arrhythmia based on the measured heart rate turbulence.
摘要翻译：通常，本公开描述了基于心率湍流指示来预测心律失常发生的技术。示例性方法包括感测指示心率湍流的参数，基于所感测的参数来测量心率湍流，以及基于所测量的心率湍流来预测心律不齐的发生。

29. 发明申请

US20110024186A1 LEAD APPARATUS 有权
标题翻译：铅装置
公开(公告)号：US20110024186A1
公开(公告)日：2011-02-03
申请号：US12795236
申请日：2010-06-07
申请人： Rogier Receveur , Jean Joseph Gerardus Rutten , Karel F.A.A. Smits , Nicolaas M. Lokhoff , Sylvia Weijzen-Engels , Didier Billy , Tim Dirk Jan Jongen , Lilian Kornet
发明人： Rogier Receveur , Jean Joseph Gerardus Rutten , Karel F.A.A. Smits , Nicolaas M. Lokhoff , Sylvia Weijzen-Engels , Didier Billy , Tim Dirk Jan Jongen , Lilian Kornet
IPC分类号： H01B5/00 , H01R43/00
CPC分类号： A61N1/056 , A61N1/3756
摘要： A lead including one or more electrodes (e.g., electrodes, such as those having circuitry associated therewith).
摘要翻译：包括一个或多个电极（例如，电极，例如具有与其相关联的电路的电极）的引线。

30. 发明申请

US20110022107A1 AUTOMATIC ENABLING OF POST LONG PAUSE OVERDRIVE PACING 有权
标题翻译：自动启动后期长暂停过滤
公开(公告)号：US20110022107A1
公开(公告)日：2011-01-27
申请号：US12844531
申请日：2010-07-27
申请人： Lilian Kornet , Roger Kessels
发明人： Lilian Kornet , Roger Kessels
IPC分类号： A61N1/365
CPC分类号： A61N1/3621 , A61N1/3624 , A61N1/395 , A61N1/3962
摘要： A method and apparatus for controlling an atrial overdrive pacing therapy include detecting an atrial arrhythmia episode and determining if the atrial arrhythmia episode is an early recurring episode. Delivery of the atrial overdrive pacing therapy is enabled in response to the early recurring episode and commences upon detection of an atrial arrhythmia episode or a long pause.
摘要翻译：用于控制心房超速起搏治疗的方法和装置包括检测心房心律失常发作并确定房性心律失常发作是否是早期的复发发作。心房超速起搏治疗的交付是为了响应早期的复发性发作，并且在检测到心房心律失常发作或长时间停顿时开始。

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