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    • 23. 发明申请
    • Novel alkoxylactones, alkoxylactams and alkoxythiolactams for controlling processes based on microbial interaction
    • 用于控制基于微生物相互作用的方法的新型烷氧基内酯,烷氧基内酰胺和烷氧基硫醇内酰胺
    • US20080207734A1
    • 2008-08-28
    • US11473795
    • 2006-06-22
    • Stefan StumpeRoland BrevesUrsula HuchelFrank JanssenAndre Hatzelt
    • Stefan StumpeRoland BrevesUrsula HuchelFrank JanssenAndre Hatzelt
    • A61K31/4015C07D207/46A61K31/341C07D307/33
    • C07D307/33A61L2/0082A61L2/16
    • Compounds of the Formula I, wherein A1 is O or NH; A2 is O or S; each of R1 and R2 is independently hydrogen, a methyl or C2-C8-saturated or mono- or doubly unsaturated, branched or linear hydrocarbon group; and R3 is a C1-C18-saturated or mono- or doubly unsaturated, branched or linear hydrocarbon group wherein, each of R1, R2 and R3 comprises a heteroatom selected from the group consisting of O and S in the chain and/or is mono- or multiply-substituted by a substituent selected from the group consisting of halogen, hydroxy, C1-C6-alkyl, trifluoromethyl, C1-C6-alkoxy, C6-C10-aryl, and C1-C6-alkyl-C6-C10-aryl are useful for controlling the interaction process between microorganisms such as in the development and/or maturation of biofilms; multicellular swarm behavior; the concerted development of antibiotic resistances; the concerted synthesis of antibiotics; the concerted synthesis of pigments; the concerted production of extracellular enzymes; or the concerted production of virulence factors.
    • 式I的化合物,其中A 1是O或NH; A 2是O或S; R 1和R 2中的每一个独立地是氢,甲基或C 2 -C 8 - 饱和或 单或双不饱和,支链或直链烃基; 和R 3是C 1 -C 18 - 饱和或单或双不饱和,支链或直链烃基,其中R R 1,R 2和R 3都包含选自链和O中的O和S的杂原子和/或是单 - 或 被选自卤素,羟基,C 1 -C 6 - 烷基,三氟甲基,C 1 -C 6烷基的取代基多取代, C 6 - 烷氧基,C 6 -C 10 - 芳基和C 1 -C 6 C 1-6烷基-C 6 -C 10 - 芳基可用于控制微生物之间的相互作用过程,例如生物膜的显影和/或成熟; 多细胞群体行为 抗生素抗药性的协调发展; 协同合成抗生素; 色素的协同合成; 协同生产细胞外酶; 或协同生产的毒力因素。