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    • 21. 发明申请
    • Radio-Over-Fiber (RoF) System for Protocol-Independent Wired and/or Wireless Communication
    • 用于无协议无线和/或无线通信的无线光纤(RoF)系统
    • US20110116794A1
    • 2011-05-19
    • US12618613
    • 2009-11-13
    • Jacob GeorgeMichael SauerDean M. Thelen
    • Jacob GeorgeMichael SauerDean M. Thelen
    • H04J14/00
    • H04B10/25751H04B10/25754H04N7/15H04Q11/0067H04W16/26H04W76/10H04W84/12H04W88/08H04W88/085H04W92/20
    • An optically-switched fiber optic communication system, such as a Radio-over-Fiber (RoF) based optical fiber link system, may be used to increase the range of peer-to-peer communications. The optically-switched fiber optic communication system may include a head-end unit (HEU) having an optical switch bank. Fiber optic cables comprising optical fibers optically couple the HEU to one or more remote access points in different coverage areas. The optical switch bank in the HEU provides a link between the remote access points in the different coverage areas such that devices in the different cellular coverage areas can communicate with each other over the optical fibers through the HEU. By using the optically-switched fiber optic communication system, the range and coverage of communication between devices may be extended such that devices in different coverage areas and devices using different communication protocols can communicate.
    • 可以使用诸如基于光纤无线光纤链路系统的光交换光纤通信系统来增加对等通信的范围。 光交换光纤通信系统可以包括具有光开关组的头端单元(HEU)。 包含光纤的光纤光缆将HEU光学地耦合到不同覆盖区域中的一个或多个远程接入点。 HEU中的光开关组提供不同覆盖区域中的远程接入点之间的链路,使得不同蜂窝覆盖区域中的设备可以通过HEU通过光纤彼此通信。 通过使用光交换光纤通信系统,可以扩展设备之间的通信的范围和覆盖范围,使得不同覆盖区域中的设备和使用不同通信协议的设备可以通信。
    • 22. 发明申请
    • Location Tracking Using Fiber Optic Array Cables and Related Systems and Methods
    • 使用光纤阵列电缆和相关系统和方法进行位置跟踪
    • US20110019999A1
    • 2011-01-27
    • US12509099
    • 2009-07-24
    • Jacob GeorgeMichael SauerDean M. Thelen
    • Jacob GeorgeMichael SauerDean M. Thelen
    • H04B10/20
    • H04W4/023G01S5/14H04B10/25754H04B10/25756H04B10/808H04W16/26H04W84/12
    • Fiber optic array cables and related systems and methods to determine and/or track locations of objects are disclosed. The fiber optic array cables can be employed in an optical-fiber-based communication system, including a centralized optical-fiber based communication system. In one embodiment, the fiber optic array cable is configured to carry optical RF or radio-over-fiber (RoF) signals to establish communications with objects. The fiber optic array cable includes multiple reference units along the length of the cable. The reference units can be configured to convert received optical RF signals into electrical RF signals to establish RF communications with objects capable of receiving electrical RF signals. The reference units are also configured to convert received electrical RF signals from the objects into optical RF signals, which are then used to determine the location of the object. Having the availability of the multiple reference units on one or more the fiber optic array cables can provide enhanced reliability in tracking objects.
    • 公开了用于确定和/或跟踪物体位置的光纤阵列电缆及相关系统和方法。 光纤阵列电缆可以用在基于光纤的通信系统中,包括基于集中式光纤的通信系统。 在一个实施例中,光纤阵列电缆被配置为承载光学RF或无线电光纤(RoF)信号以建立与对象的通信。 光纤阵列电缆包括沿电缆长度的多个参考单元。 参考单元可以被配置为将接收的光学RF信号转换成电RF信号,以与能够接收电RF信号的对象建立RF通信。 参考单元还被配置为将来自物体的接收的电RF信号转换成光RF信号,然后将其用于确定物体的位置。 在一个或多个光纤阵列电缆上具有多个参考单元的可用性可以提供跟踪对象的增强的可靠性。
    • 23. 发明申请
    • Medical Instrument With A Flexible Sealing System
    • 具有柔性密封系统的医疗器械
    • US20100049145A1
    • 2010-02-25
    • US12507476
    • 2009-07-22
    • Elmar TeichtmannMichael Sauer
    • Elmar TeichtmannMichael Sauer
    • A61B17/34
    • A61B17/3462A61B2017/3464
    • A medical instrument has a cannula, a seal disposed in said cannula. An expansion device serves for expanding said opening in said seal for guiding shafts of other instruments of greater diameter in a sealed manner through the expanded opening. The expansion device has an expansion cone comprising a plurality of slats mounted pivotably on an annular body at a first end thereof, a second end of said slats, being connected to said seal in an area of said opening. The slats can either be connected at its first ends to said annular body via spherical heads engaged into corresponding openings in said annular body or said slats are connected at their ends via film hinges to said annular body.
    • 医疗器械具有插管,设置在所述套管中的密封件。 膨胀装置用于在所述密封件中膨胀所述开口,用于通过膨胀的开口以密封的方式引导具有较大直径的其它器械的轴。 膨胀装置具有膨胀锥体,该膨胀锥体包括在其第一端处可枢转地安装在环形体上的多个板条,所述板条的第二端在所述开口的区域中连接到所述密封件。 板条可以在其第一端处通过与所述环形体接合到相应开口中的球形头连接到所述环形体,或者所述板条的端部通过薄膜铰链连接到所述环形体。
    • 24. 发明授权
    • Ascorbic acid production from yeast
    • 酵母抗坏血酸生产
    • US07579171B2
    • 2009-08-25
    • US10606302
    • 2003-06-25
    • Danilo PorroMichael Sauer
    • Danilo PorroMichael Sauer
    • C12P21/00C12P7/00C12N1/15C12N15/63
    • C12N9/001C12N9/0006C12N9/18C12N15/52C12P17/04
    • Herein is disclosed a method of generating ascorbic acid from yeast. In one embodiment, the yeast is a Zygosaccharomyces spp. or a Kluyveromyces spp. growing in a medium comprising an ascorbic acid precursor. In a second embodiment the yeast is a recombinant yeast growing in a medium comprising an ascorbic acid precursor. Preferably the recombinant yeast is transformed with a coding region encoding an enzyme selected from L-galactose dehydrogenase (LGDH), L-galactono-1,4-lactone dehydrogenase (AGD), D-arabinose dehydrogenase (ARA), D-arabinono-1,4-lactone oxidase (ALO) or L-gulono-1,4-lactone oxidase (RGLO). The ascorbic acid precursor is preferably D-glucose, L-galactose, L-galactono-1,4-lactone, or L-gulono-1,4-lactone. In another preferred embodiment the ascorbic acid is accumulated in the medium at levels greater than background. Preferably, the yield of the conversion of the precursor to ascorbic acid is preferably at least about 35%.
    • 本文公开了从酵母产生抗坏血酸的方法。 在一个实施方案中,酵母是接合酵母属(Zygosaccharomyces spp)。 或克鲁维链霉菌属 在包含抗坏血酸前体的培养基中生长。 在第二个实施方案中,酵母是在包含抗坏血酸前体的培养基中生长的重组酵母。 优选地,用编码选自L-半乳糖脱氢酶(LGDH),L-半乳糖内酰-1,4-内酯脱氢酶(AGD),D-阿拉伯糖脱氢酶(ARA),D-阿拉伯聚糖-1 ,4-内酯氧化酶(ALO)或L-古洛酮-1,4-内酯氧化酶(RGLO)。 抗坏血酸前体优选为D-葡萄糖,L-半乳糖,L-半乳糖-1,4-内酯或L-古洛宁-1,4-内酯。 在另一个优选的实施方案中,抗坏血酸以大于背景的水平积累在培养基中。 优选地,前体转化成抗坏血酸的产率优选至少为约35%。
    • 28. 发明申请
    • Strains for the Production of Organic Acids
    • 有机酸生产菌株
    • US20070065899A1
    • 2007-03-22
    • US11533507
    • 2006-09-20
    • Minoska ValliMichael SauerDanilo PorroPaola BranduardiDiethard Mattanovich
    • Minoska ValliMichael SauerDanilo PorroPaola BranduardiDiethard Mattanovich
    • C12Q1/04C12P7/40
    • C12Q1/04C12P7/40C12P7/56G01N33/569G01N2333/395
    • A method of producing an organic acid by staining a yeast population with a stain capable of internal pH (pHi)-dependent fluorescence, to yield a stained yeast population; determining a gate pH and a corresponding fluorescence parameter of the stained yeast population; and sorting the cells of the stained yeast population such that the cells having a pHi above the gate pH are retained and the cells having a pHi below the gate pH are discarded, to yield a yeast population for the production of the organic acid. Also, a method of producing an organic acid by performing the above steps, followed by isolating individual cells of the yeast population, to yield individual yeast cells for the production of an organic acid; culturing an individual yeast cell, to yield a cloned yeast population for the production of an organic acid; and incubating the cloned yeast population for the production of an organic acid in a medium containing an organic acid precursor, to produce the organic acid.
    • 通过用能够内部pH(pH <! - SIPO - >依赖性荧光的染色剂)染色酵母菌群来产生有机酸的方法,以产生染色的酵母菌群; 确定染色酵母菌群的门pH和相应的荧光参数; 并且分选染色的酵母菌群的细胞,使得具有高于门pH的pH <0.01的细胞被保留,并且将具有低于门pH的pH < ,以产生用于生产有机酸的酵母菌种。 另外,通过上述步骤生产有机酸的方法,然后分离出酵母菌群的各个细胞,得到用于生产有机酸的单独的酵母细胞; 培养单独的酵母细胞,产生用于生产有机酸的克隆酵母菌群; 并将克隆的酵母菌群培养在含有机酸前体的培养基中生产有机酸,生产有机酸。