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21. 发明授权

US07465815B2 Cannabinoid receptor modulator 失效
标题翻译：大麻素受体调节剂
公开(公告)号：US07465815B2
公开(公告)日：2008-12-16
申请号：US10561483
申请日：2004-06-25
申请人： Shigenori Ohkawa , Tetsuya Tsukamoto , Yoshihiro Kiyota , Mika Goto , Shouzou Yamamoto , Masato Shimojou , Masaki Setou
发明人： Shigenori Ohkawa , Tetsuya Tsukamoto , Yoshihiro Kiyota , Mika Goto , Shouzou Yamamoto , Masato Shimojou , Masaki Setou
IPC分类号： C07D307/78
CPC分类号： C07D307/83 , A61K31/343 , A61K31/357 , A61K31/381 , A61K31/4025 , A61K31/4178 , A61K31/426 , A61K31/443 , A61K31/453 , A61K31/506 , C07D307/79 , C07D307/86 , C07D333/54 , C07D405/04
摘要： A cannabinoid receptor modulator containing a compound represented by Formula (I0) wherein, X is an oxygen atom, etc., R0 is an optionally substituted acylamino group, ring A0 is a benzene ring which may further have a substituent in addition to R0, and ring B is an optionally substituted 5-membered heterocycle, or a salt thereof or a prodrug thereof.
摘要翻译：含有由式（I0）表示的化合物的大麻素受体调节剂，其中X是氧原子等，R 0是任选取代的酰基氨基，环A 0是除了R 0之外还可以具有取代基的苯环，和环B是任选取代的5元杂环，或其盐或其前药。

22. 发明授权

US08722662B2 Heterocyclic compounds 失效
标题翻译：杂环化合物
公开(公告)号：US08722662B2
公开(公告)日：2014-05-13
申请号：US13253293
申请日：2011-10-05
申请人： Yuji Ishichi , Masami Yamada , Taku Kamei , Ikuo Fujimori , Yoshihisa Nakada , Tomoya Yukawa , Nobuki Sakauchi , Yusuke Ohba , Tetsuya Tsukamoto
发明人： Yuji Ishichi , Masami Yamada , Taku Kamei , Ikuo Fujimori , Yoshihisa Nakada , Tomoya Yukawa , Nobuki Sakauchi , Yusuke Ohba , Tetsuya Tsukamoto
IPC分类号： A61K31/55 , C07D267/10 , C07D413/04 , C07D413/06 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/14
CPC分类号： C07D267/10 , C07D413/04 , C07D413/06 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D498/08
摘要： Provided is a compound having a monoamine reuptake inhibitory activity, which is represented by the formula (I) wherein ring A is an optionally substituted 6-membered aromatic ring, ring B is the substituents on ring A are optionally bonded to form, together with ring A, an optionally substituted 9- or 10-membered aromatic fused ring, and other symbols are as defined in the specification, or a salt thereof.
摘要翻译：提供具有单胺再摄取抑制活性的化合物，其由式（I）表示，其中环A是任选取代的6元芳环，环B是环A上的取代基任选地键合以与环一起形成 A，任选取代的9元或10元芳族稠环，以及其它符号如说明书中所定义，或其盐。

23. 发明申请

US20130005710A1 AMINOPYRIDINE DERIVATIVE 审中-公开
标题翻译：氨基吡啶衍生物
公开(公告)号：US20130005710A1
公开(公告)日：2013-01-03
申请号：US13509668
申请日：2010-11-17
申请人： Tetsuya Tsukamoto , Takeshi Wakabayashi , Norihito Tokunaga , Yuhei Miyanohana
发明人： Tetsuya Tsukamoto , Takeshi Wakabayashi , Norihito Tokunaga , Yuhei Miyanohana
IPC分类号： A61K31/496 , A61K31/5377 , C07D417/14 , C07D401/04 , A61P25/28 , C07D405/14 , A61K31/4545 , A61K31/551 , C07D413/14 , C07D409/14 , C07D413/04 , C07D401/14
CPC分类号： C07D213/74 , A61K31/496 , A61K31/5377 , A61K31/551 , C07D213/76 , C07D401/04 , C07D405/04 , C07D409/04 , C07D413/04
摘要： The present invention provides a novel aminopyridine derivative that is excellent in pharmaceutical effects such as a neuroprotective effect, a neurogenesis or nerve regeneration promoting effect, and a cognitive function improving effect and, preferably, is low toxic and delivered at a high rate to the central nervous system. Specifically, the present invention provides a compound represented by the formula (I), wherein ring A represents a monocyclic aromatic hydrocarbon ring or the like; ring B may further have a substituent(s); ring D represents a monocyclic aromatic hydrocarbon ring or the like; L represents a bond, or a methylene group or the like; X represents —NRa- or the like, wherein Ra represents a hydrogen atom or the like; n represents 1 or 2; and R1 to R3 each represent a hydrogen atom or the like, wherein ring A and ring D each may be condensed with another ring to form a condensed ring which may have a substituent(s), and ring A-L- in the formula (I) may be bonded to X, provided that when ring A is pyrazole which may be substituted and ring D is benzene which may be substituted, L is a bond; or a salt thereof.
摘要翻译：本发明提供一种新颖的氨基吡啶衍生物，其具有优异的药效，如神经保护作用，神经发生或神经再生促进作用，以及认知功能改善作用，优选为低毒性，高速递送至中枢神经系统。具体地，本发明提供式（I）表示的化合物，其中环A表示单环芳香烃环等; 环B还可以具有取代基; 环D表示单环芳香烃环等; L表示键或亚甲基等; X表示-NR a等，其中R a表示氢原子等; n表示1或2; 并且R 1至R 3各自表示氢原子等，其中环A和环D各自可与另一个环缩合形成可具有取代基的稠环，式（I）中的环 - 可以与X键合，条件是当环A是可被取代的吡唑时，环D是可被取代的苯，L是一个键; 或其盐。

24. 发明授权

US08288390B2 Benzofuran derivatives 有权
标题翻译：苯并呋喃衍生物
公开(公告)号：US08288390B2
公开(公告)日：2012-10-16
申请号：US12659447
申请日：2010-03-09
申请人： Tetsuya Tsukamoto , Takeshi Wakabayashi , Taiichi Ohra
发明人： Tetsuya Tsukamoto , Takeshi Wakabayashi , Taiichi Ohra
IPC分类号： A61K31/496 , C07D405/02
CPC分类号： C07D307/79 , C07D307/80 , C07D307/81 , C07D405/04 , C07D405/12 , C07D405/14 , C07D407/04 , C07D407/12 , C07D413/04 , C07D413/12 , C07D417/12 , C07D493/10
摘要： The present invention provides a compound represented by the following formula (I): wherein: Ring A represents an optionally substituted piperazine ring, an optionally substituted morpholine ring, or an optionally substituted homopiperazine ring; R1 and R2 are the same or different from each other, and represent a hydrogen atom or optionally substituted lower alkyl; R3 and R4 are the same or different from each other, and represent a hydrogen atom or halogenated or non-halogenated lower alkyl; R5 to R7 are the same or different from each other, and represent a hydrogen atom, hydroxy, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkoxy, optionally substituted cycloalkyl, optionally substituted aryl, an optionally substituted aromatic heterocyclic ring, optionally substituted amino, or acyl; and represents a single bond or double bond, or a salt thereof.
摘要翻译：本发明提供由下式（I）表示的化合物：其中：环A表示任选取代的哌嗪环，任选取代的吗啉环或任选取代的高哌嗪环; R1和R2彼此相同或不同，表示氢原子或任选取代的低级烷基; R3和R4彼此相同或不同，表示氢原子或卤代或非卤代低级烷基; R 5至R 7彼此相同或不同，并且表示氢原子，羟基，任选取代的低级烷基，任选取代的低级烯基，任选取代的低级烷氧基，任选取代的环烷基，任选取代的芳基，任选取代的芳族杂环，任选取代的氨基或酰基; 并且表示单键或双键，或其盐。

25. 发明申请

US20120232096A1 BENZOFURAN DERIVATIVES 审中-公开
标题翻译： BENZOFURAN衍生物
公开(公告)号：US20120232096A1
公开(公告)日：2012-09-13
申请号：US13479981
申请日：2012-05-24
申请人： Tetsuya Tsukamoto , Takeshi Wakabayashi , Taiichi Ohra
发明人： Tetsuya Tsukamoto , Takeshi Wakabayashi , Taiichi Ohra
IPC分类号： A61K31/496 , A61P25/24 , A61P25/22 , A61P25/18 , A61P25/00 , A61P9/00 , A61P25/16 , A61P25/14 , A61P9/10 , A61P3/10 , A61P9/12 , C07D405/10 , A61P25/28
CPC分类号： C07D307/79 , C07D307/80 , C07D307/81 , C07D405/04 , C07D405/12 , C07D405/14 , C07D407/04 , C07D407/12 , C07D413/04 , C07D413/12 , C07D417/12 , C07D493/10
摘要： The present invention provides a compound represented by the following formula (I): wherein: Ring A represents an optionally substituted piperazine ring, an optionally substituted morpholine ring, or an optionally substituted homopiperazine ring; R1 and R2 are the same or different from each other, and represent a hydrogen atom or optionally substituted lower alkyl; R3 and R4 are the same or different from each other, and represent a hydrogen atom or halogenated or non-halogenated lower alkyl; R5 to R7 are the same or different from each other, and represent a hydrogen atom, hydroxy, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkoxy, optionally substituted cycloalkyl, optionally substituted aryl, an optionally substituted aromatic heterocyclic ring, optionally substituted amino, or acyl; and represents a single bond or double bond, or a salt thereof.
摘要翻译：本发明提供由下式（I）表示的化合物：其中：环A表示任选取代的哌嗪环，任选取代的吗啉环或任选取代的高哌嗪环; R1和R2彼此相同或不同，表示氢原子或任选取代的低级烷基; R3和R4彼此相同或不同，表示氢原子或卤代或非卤代低级烷基; R 5至R 7彼此相同或不同，并且表示氢原子，羟基，任选取代的低级烷基，任选取代的低级烯基，任选取代的低级烷氧基，任选取代的环烷基，任选取代的芳基，任选取代的芳族杂环，任选取代的氨基或酰基; 并且表示单键或双键，或其盐。

26. 发明申请

US20110039893A1 GSK-3BETA INHIBITOR 审中-公开
标题翻译： GSK-3BETA抑制剂
公开(公告)号：US20110039893A1
公开(公告)日：2011-02-17
申请号：US12311653
申请日：2007-10-10
申请人： Masakuni Kori , Hideyuki Oki , Tetsuya Tsukamoto , Masashi Takahashi , Masaki Setoh , Takehiro Hirano
发明人： Masakuni Kori , Hideyuki Oki , Tetsuya Tsukamoto , Masashi Takahashi , Masaki Setoh , Takehiro Hirano
IPC分类号： A61K31/444 , C07D401/14 , A61P25/00 , A61P3/10
CPC分类号： C07D213/75 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/538 , C07D401/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： For the purpose of providing a GSK-3β inhibitor containing a 2-aminopyridine compound or a salt thereof or a prodrug thereof useful as an agent for the prophylaxis or treatment of a GSK-3β-related pathology or disease, the present invention provides a GSK-3β inhibitor containing a compound represented by the formula (IA): wherein each symbol is as defined in the specification. or a salt thereof or a prodrug thereof.
摘要翻译：为了提供GSK-3＆bgr; 含有2-氨基吡啶化合物或其盐或其前药的抑制剂可用作预防或治疗GSK-3相关病理或疾病的药物，本发明提供了GSK-3＆bgr; 含有式（IA）表示的化合物的抑制剂：其中每个符号如说明书中所定义。或其盐或其前药。

27. 发明授权

US07507841B2 Cannabinoid receptor modulator 有权
标题翻译：大麻素受体调节剂
公开(公告)号：US07507841B2
公开(公告)日：2009-03-24
申请号：US11822941
申请日：2007-07-11
申请人： Shigenori Ohkawa , Tetsuya Tsukamoto , Yoshihiro Kiyota , Mika Goto , Shouzou Yamamoto , Masato Shimojou , Masaki Setou
发明人： Shigenori Ohkawa , Tetsuya Tsukamoto , Yoshihiro Kiyota , Mika Goto , Shouzou Yamamoto , Masato Shimojou , Masaki Setou
IPC分类号： C07D307/76
CPC分类号： C07D307/83 , A61K31/343 , A61K31/357 , A61K31/381 , A61K31/4025 , A61K31/4178 , A61K31/426 , A61K31/443 , A61K31/453 , A61K31/506 , C07D307/79 , C07D307/86 , C07D333/54 , C07D405/04
摘要： A cannabinoid receptor modulator containing a compound represented by Formula (I0) wherein, X is an oxygen atom, etc., R0 is an optionally substituted acylamino group, ring A0 is a benzene ring which may further have a substituent in addition to R0, and ring B is an optionally substituted 5-membered heterocycle, or a salt thereof or a prodrug thereof.
摘要翻译：含有由式（I0）表示的化合物的大麻素受体调节剂，其中X是氧原子等，R 0是任选取代的酰基氨基，环A 0是除了R 0之外还可以具有取代基的苯环，和环B是任选取代的5元杂环，或其盐或其前药。

28. 发明申请

US20080021087A1 Cannabinoid receptor modulator 有权
标题翻译：大麻素受体调节剂
公开(公告)号：US20080021087A1
公开(公告)日：2008-01-24
申请号：US11822941
申请日：2007-07-11
申请人： Shigenori Ohkawa , Tetsuya Tsukamoto , Yoshihiro Kiyota , Mika Goto , Shouzou Yamamoto , Masato Shimojou , Masaki Setou
发明人： Shigenori Ohkawa , Tetsuya Tsukamoto , Yoshihiro Kiyota , Mika Goto , Shouzou Yamamoto , Masato Shimojou , Masaki Setou
IPC分类号： A61K31/34 , A61K31/381 , A61K31/40 , A61K31/4427 , A61P1/00 , A61P1/04 , A61P11/00 , A61P11/06 , A61P17/00 , A61P19/02 , A61P25/00 , A61P25/16 , A61P25/34 , A61P27/00 , A61P31/22 , C07D209/56 , C07D307/00 , C07D333/52 , C07D401/00 , C07D409/02 , C07D409/14 , C07D497/00
CPC分类号： C07D307/83 , A61K31/343 , A61K31/357 , A61K31/381 , A61K31/4025 , A61K31/4178 , A61K31/426 , A61K31/443 , A61K31/453 , A61K31/506 , C07D307/79 , C07D307/86 , C07D333/54 , C07D405/04
摘要： A cannabinoid receptor modulator containing a compound represented by Formula (I0) wherein, X is an oxygen atom, etc., R0 is an optionally substituted acylamino group, ring A0 is a benzene ring which may further have a substituent in addition to R0, and ring B is an optionally substituted 5-membered heterocycle, or a salt thereof or a prodrug thereof.
摘要翻译：含有由式（I ）表示的化合物的大麻素受体调节剂，其中X是氧原子等，R 0是任选取代的酰基氨基，环A 除了R 0 O以外，还可以具有取代基的苯环，环B是任选取代的5元杂环，或其盐或前药其中。

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