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21. 发明授权

US07286870B2 Optical system for measuring metabolism in a body and imaging method 有权
标题翻译：用于测量身体代谢的光学系统和成像方法
公开(公告)号：US07286870B2
公开(公告)日：2007-10-23
申请号：US09900144
申请日：2001-07-09
申请人： Atsushi Maki , Hideaki Koizumi , Fumio Kawaguchi , Yuichi Yamashita , Yoshitoshi Ito
发明人： Atsushi Maki , Hideaki Koizumi , Fumio Kawaguchi , Yuichi Yamashita , Yoshitoshi Ito
IPC分类号： A61B6/00
CPC分类号： A61B5/0059 , A61B5/0042 , A61B5/055 , A61B5/14552 , A61B5/14553 , A61B5/18 , A61B5/6814 , A61B5/7207 , A61B5/7228 , A61B6/03 , A61B6/507 , A61B2562/0219 , A61B2562/0233 , A61B2562/046
摘要： In an optical measurement system and imaging method adapted to measure in vivo information in a living body without harming the living body, light rays of a plurality of wavelengths which are modulated in intensity with a plurality of different frequencies are irradiated on a plurality of irradiation positions on the surface of a living body, and time-variable changes in living body transmitting light intensity levels corresponding to the respective wavelengths and the respective irradiation positions are measured at different positions on the surface of the living body. Light is utilized to image the results of the measurements, in which the measuring time is shortened by estimating fluctuation attributable to the living body, and the presence or absence of a change in measured signal can be decided easily by displaying an estimation signal and a measured signal at a time.
摘要翻译：在适于测量活体内的体内信息而不损害生物体的光学测量系统和成像方法中，以多个不同频率强度调制的多个波长的光线照射在多个照射位置在生物体的表面上，在生物体的表面的不同位置测量发射对应于各个波长和各个照射位置的光强度水平的生物体的随时间变化。光被用于对测量结果进行成像，其中通过估计归因于生物体的波动来缩短测量时间，并且可以通过显示估计信号和测量的信号来容易地确定测量信号的变化的存在或不存在信号一次。

22. 发明授权

US07280859B2 Biological measurement probe, biological optical measurement instrument using the same, and brain function measurement instrument 有权
标题翻译：生物测量探头，使用相同的生物光学测量仪器和脑功能测量仪器
公开(公告)号：US07280859B2
公开(公告)日：2007-10-09
申请号：US10484258
申请日：2002-05-24
申请人： Atsushi Maki , Michiyuki Fujiwara
发明人： Atsushi Maki , Michiyuki Fujiwara
IPC分类号： A61B5/00
CPC分类号： A61B5/6814 , A61B5/0261 , A61B5/0476 , A61B5/14553 , A61B5/702 , A61B2562/0233 , A61B2562/046
摘要： The present invention provides a biological measurement probe readily wearable on a biological surface having a large curvature and a measurement technique of simultaneously measuring the blood circulation dynamic change accompanying the auditory/language/visual function activities of a subject (especially baby) and brain waves. A biological measurement probe having illuminating means for illuminating a subject through a first optical waveguide and light collecting means for collecting light illuminated from the illuminating means and propagated through the subject through a second optical waveguide, has first and second guide members having passages through which the first and second optical waveguides are passed and fixing the first and second optical waveguides, and a base member connecting the first guide member to the second one, holding them, and forming a portion brought into contact with the subject.
摘要翻译：本发明提供一种在具有大曲率的生物学表面上易于佩戴的生物测量探针和同时测量伴随对象（特别是婴儿）和脑波的听觉/语言/视觉功能活动的血液循环动态变化的测量技术。一种具有用于通过第一光波导照射被摄体的照明装置的生物测量探针和用于收集从照明装置照射并通过第二光波导传播通过被摄体的光的聚光装置，具有第一和第二引导构件，第一和第二光波导通过并固定第一和第二光波导，以及将第一引导构件连接到第二导波构件的基座，保持它们，并形成与被摄体接触的部分。

23. 发明申请

US20060184046A1 Optical measurement instrument for living body 审中-公开
标题翻译：生物体光学测量仪器
公开(公告)号：US20060184046A1
公开(公告)日：2006-08-17
申请号：US11371918
申请日：2006-03-10
申请人： Yuichi Yamashita , Atsushi Maki , Hideaki Koizumi
发明人： Yuichi Yamashita , Atsushi Maki , Hideaki Koizumi
IPC分类号： A61B6/00
CPC分类号： A61B5/14546 , A61B5/14553 , A61B2562/0233 , A61B2562/0242 , A61B2562/046 , G01N21/35 , G01N21/4795
摘要： An optical measurement instrument for a living body including a first light irradiator for irradiating light from a first irradiation position in a small region as considered as a plan on the surface of a head of a subject into the inside of the head in the region in the direction of depth, a second light irradiator for irradiating light from a second irradiation position in the region into the inside of the head, a first detecting for detecting the first irradiated light to pass through the head in a first detection position in the region, a second detector for detecting the second irradiated light to pass through the head in a second detection position in the region, and a calculator for multiplication or addition of a first signal and a second signal in a calculator.
摘要翻译：一种用于生物体的光学测量仪器，包括：第一光照射器，用于将来自被摄体头部的表面上所考虑的小区域的第一照射位置的光照射到头部的内部，深度方向，用于将来自该区域内的第二照射位置的光照射到头部内部的第二光照射器，在该区域中的第一检测位置检测第一照射光通过头部的第一检测，第二检测器，用于检测第二照射光在区域中的第二检测位置中通过头部;以及计算器，用于在计算器中乘法或相加第一信号和第二信号。

24. 发明申请

US20060184045A1 Optical measurement instrument for living body 有权
标题翻译：生物体光学测量仪器
公开(公告)号：US20060184045A1
公开(公告)日：2006-08-17
申请号：US11371916
申请日：2006-03-10
申请人： Yuichi Yamashita , Atsushi Maki , Hideaki Koizumi
发明人： Yuichi Yamashita , Atsushi Maki , Hideaki Koizumi
IPC分类号： A61B6/00
CPC分类号： A61B5/14546 , A61B5/14553 , A61B2562/0233 , A61B2562/0242 , A61B2562/046 , G01N21/35 , G01N21/4795
摘要： An optical measurement instrument for a living body to measure dynamic change of blood of a brain includes light incident units for irradiating light on a head of a subject, a light detector for detecting a light irradiated from the light incident units and reflected within the subject, a signal processing unit for calculating a spacious distribution of signals from the subject to be measured from a signal detected by the light detector, and a display for displaying the spacious distribution of signals from the subject to be measured. Measurement points are arranged about a middle of the light incident units and the light detector, and the light incident units and the light detector are arranged such that the measurement points are arranged to form a lattice whose circumference is square.
摘要翻译：用于测量脑的血液动态变化的生物体的光学测量仪器包括用于照射被检体头部的光入射单元，用于检测从光入射单元照射并在被检体内反射的光的光检测器，信号处理单元，用于根据由光检测器检测到的信号计算来自待测对象的信号的宽敞分布;以及显示器，用于显示来自待测对象的信号的宽敞分布。测量点围绕光入射单元和光检测器的中间布置，并且光入射单元和光检测器被布置成使得测量点被布置成形成圆周为正方形的格子。

25. 发明申请

US20060178839A1 Optical measurement instrument and optical measurement method 有权
标题翻译：光学测量仪器和光学测量方法
公开(公告)号：US20060178839A1
公开(公告)日：2006-08-10
申请号：US11378448
申请日：2006-03-20
申请人： Atsushi Maki , Yuuichi Yamashita , Tsuyoshi Yamamoto , Hideaki Koizumi
发明人： Atsushi Maki , Yuuichi Yamashita , Tsuyoshi Yamamoto , Hideaki Koizumi
IPC分类号： G06F19/00
CPC分类号： G01N21/49 , A61B5/0042 , A61B5/14553 , A61B5/7435
摘要： In order to provide an optical measurement system and an optical measurement method which is suitable for optically measuring a body to be inspected and easily obtaining an image of a desired item based on information obtained by the measurement, an optical measurement method comprising an initial display process for selectively instructing any one of selection of optical measurement, analysis of said optical measurement result and completion of a program (S1); a process for inputting items of condition including a measurement mode (S2); a process for displaying a light irradiation position and a light detection position and a state expressing measurement position relationship together with said mode (S4); a process for instructing to form a file for storing said optical measurement result; a process for instructing a measurement condition to detect light signals from the inside of a body to be inspected which is irradiated by a multi-wavelength multi-channel (S10); and a process for displaying said signals for each channel detected according to said instructed result (S11).
摘要翻译：为了提供一种光学测量系统和光学测量方法，该光学测量系统和光学测量方法适合于光学测量待检查的物体，并且基于通过测量获得的信息容易地获得所需物品的图像，光学测量方法包括初始显示处理用于选择性地指示光学测量的选择，所述光学测量结果的分析和程序的完成中的任何一个（S1）; 用于输入包括测量模式的条件项目的处理（S 2）; 用于显示光照射位置和光检测位置的处理以及表示测量位置关系的状态与所述模式（S 4）。用于指示形成用于存储所述光学测量结果的文件的处理; 用于指示测量条件以从多波长多通道照射的被检体的内部检测光信号的步骤（S10）; 以及根据所述指示结果显示针对每个通道的所述信号的处理（S11）。

26. 发明授权

US06723047B1 Volition induction apparatus and input/output apparatus which use optical measuring instrument, and recording medium 有权
标题翻译：使用光学测量仪器和记录介质的感应装置和输入/输出装置
公开(公告)号：US06723047B1
公开(公告)日：2004-04-20
申请号：US10009187
申请日：2001-12-07
申请人： Tsuyoshi Yamamoto , Atsushi Maki , Yoshitoshi Ito , Yuichi Yamashita , Hideaki Koizumi
发明人： Tsuyoshi Yamamoto , Atsushi Maki , Yoshitoshi Ito , Yuichi Yamashita , Hideaki Koizumi
IPC分类号： A61B500
CPC分类号： G06F3/015 , A61B5/486 , A63F2250/26 , Y10S128/905
摘要： It has long been unclear in what degree the brain should be activated and how much the blood volume should be varied for controlling a signal by measuring the concentration of metabolic substance in the tissue or change of concentration thereof using the light and by using the result of measurement. The present invention provides an optical measuring system which can present the concentration of metabolic substance in the tissue which may be detected with a subject by itself or the target value of change of the concentration. Thereby, it is now possible for the subject by itself to more easily detect and control the concentration of metabolic substance in the tissue or change of concentration thereof. As a result, cerebral information can be extracted in direct to realize various applications such as control of the game machines and welfare facilities.
摘要翻译：长期以来，不清楚大脑应该被激活的程度以及通过使用光测量组织中代谢物质的浓度或其浓度的变化来控制信号来改变血容量，并且通过使用测量。本发明提供一种光学测量系统，其可以呈现组织中代谢物质的浓度，其可以由受试者自身检测或目标浓度变化值。因此，现在可以使受试者本身更容易地检测和控制组织中代谢物质的浓度或其浓度的变化。因此，可以直接提取脑信息，实现游戏机和福利设施的控制等各种应用。

27. 发明授权

US06611698B1 Optical measuring instrument 有权
标题翻译：光学测量仪器
公开(公告)号：US06611698B1
公开(公告)日：2003-08-26
申请号：US09807478
申请日：2001-05-24
申请人： Yuichi Yamashita , Atsushi Maki , Fumio Kawaguchi
发明人： Yuichi Yamashita , Atsushi Maki , Fumio Kawaguchi
IPC分类号： A61B500
CPC分类号： A61B5/14553 , A61B5/00 , A61B2562/02 , A61B2562/046 , G01N21/49
摘要： A highly reliable optical measuring instrument for multi-channel simultaneous measurement has an intensity of light emitted from a light source modulated at different frequencies and the light is applied to multiple positions of a test object. The light which is detected from the test object is converted into electric signals by a photodiode, and modulation signals are detected by a lock-in amplifier module. The signals are processed as information on the test object interior by a processing unit. Light is applied sequentially from a light source in a preparatory measurement step prior to final measuring, and the signal level of the detection light is measured for each light applied position. A control unit controls light intensity and detection signal level to ensure that the difference in detection light levels is kept within a specified range.
摘要翻译：用于多通道同时测量的高度可靠的光学测量仪器具有从以不同频率调制的光源发射的光的强度，并且将光施加到测试对象的多个位置。从测试对象检测到的光由光电二极管转换为电信号，调制信号由锁定放大器模块检测。这些信号由处理单元作为测试对象内部的信息进行处理。在最终测量之前的准备测量步骤中从光源顺序地施加光，并且针对每个施加位置测量检测光的信号电平。控制单元控制光强度和检测信号电平，以确保检测光水平的差异保持在指定范围内。

28. 发明授权

US06321110B1 Device for controlling equipment by using signals from a living body 失效
标题翻译：通过使用生物体信号控制设备的装置
公开(公告)号：US06321110B1
公开(公告)日：2001-11-20
申请号：US09385419
申请日：1999-08-30
申请人： Yoshitoshi Ito , Hideaki Koizumi , Atsushi Maki , Yuichi Yamashita , Tsuyoshi Yamamoto
发明人： Yoshitoshi Ito , Hideaki Koizumi , Atsushi Maki , Yuichi Yamashita , Tsuyoshi Yamamoto
IPC分类号： A61B600
CPC分类号： G06F3/015
摘要： A device for controlling equipment includes a light projector adapted to project light onto a head of a living body, a light collecting device for collecting the light having passed through the head from the light projector, a light measuring device for measuring an intensity of the light collected by the light collecting device, a memory device for storing a previous history of changes of the intensity of the light measured by the light measuring device, a signal judging circuit for judging if both the intensity of the light measured by the light measuring device and the previous history of changes of the intensity of the light satisfy a predetermined condition, a display device for displaying the intensity of the light measured by the light measuring device and a result obtained by the signal judging circuit, and a control signal generating circuit for generating a control signal to be supplied to an external equipment if the predetermined condition is satisfied.
摘要翻译：一种用于控制设备的装置，包括适用于将光投射到生物体的头部上的光投射器，用于收集从光投影仪通过头部的光的光收集装置，用于测量光强度的光测量装置由光收集装置收集的存储装置，用于存储由光测量装置测量的光的强度变化的先前历史的存储装置，用于判断由光测量装置测量的光的强度和光的强度变化的先前历史满足预定条件，用于显示由光测量装置测量的光的强度的显示装置和由信号判断电路获得的结果的控制信号产生电路，如果满足预定条件，则提供给外部设备的控制信号。

29. 发明授权

US5586554A Optical system for measuring metabolism in a body 失效
标题翻译：用于测量身体新陈代谢的光学系统
公开(公告)号：US5586554A
公开(公告)日：1996-12-24
申请号：US197749
申请日：1994-02-16
申请人： Atsushi Maki , Fumio Kawaguchi , Yuichi Yamashita , Yoshitoshi Ito
发明人： Atsushi Maki , Fumio Kawaguchi , Yuichi Yamashita , Yoshitoshi Ito
IPC分类号： A61B10/00 , A61B5/00 , A61B5/145 , G01N21/17 , A61B5/05
CPC分类号： A61B5/0073 , A61B5/0059
摘要： An optical system is arranged to irradiate light to the inside of a test subject and detect the light passed through the test subject for obtaining information about the inside of the test subject. The optical system includes a light source for generating rays of light having different wavelengths, an apparatus for irradiating the rays of light to corresponding spots on the test subject, an apparatus for detecting the light passed through the test subject at plural detecting spots on the test subject, and an apparatus for dispersing the detected light. The rays of light to be irradiated to the test subject have a visible wavelength to a near infrared one. The apparatus for irradiating light operates to irradiate the rays of light of each of the wavelengths to the test subject substantially at one time or by shifting the irradiating times according to each of the wavelengths. The apparatus for irradiating light contains the apparatus for dispersing the irradiated light into respective wavelengths. The rays of light dispersed by the dispersing apparatus are irradiated to the test subject.
摘要翻译：光学系统被布置成将光照射到测试对象的内部，并检测通过测试对象的光以获得关于测试对象内部的信息。光学系统包括用于产生具有不同波长的光线的光源，用于将光线照射到测试对象上的相应点的设备，用于检测在测试中的多个检测点处通过测试对象的光的设备主体和用于分散检测到的光的装置。要照射到受试对象的光线具有近红外线的可见波长。用于照射光的装置基本上一次照射每个波长的光线到测试对象，或者根据每个波长移动照射时间。用于照射光的装置包含用于将照射的光分散到各个波长的装置。将由分散装置分散的光线照射到测试对象。

30. 发明授权

US07890270B2 Optical system for measuring metabolism in a body, method and program 有权
标题翻译：用于测量身体代谢的光学系统，方法和程序
公开(公告)号：US07890270B2
公开(公告)日：2011-02-15
申请号：US12392207
申请日：2009-02-25
申请人： Hiroki Sato , Atsushi Maki , Tsuyoshi Yamamoto , Masashi Kiguchi
发明人： Hiroki Sato , Atsushi Maki , Tsuyoshi Yamamoto , Masashi Kiguchi
IPC分类号： G01N31/00
CPC分类号： A61B5/7264 , A61B5/0059 , A61B5/7425 , A61B5/743 , G06F19/00 , G16H40/63
摘要： A living body light measuring device including plural light-radiating devices for radiating light to a head of a subject, plural light-receiving devices for detecting light which is transmitted through the head of the subject after radiation from the light-radiating devices, a calculator for calculating a change of concentration of oxidized and deoxidized hemoglobin in the head of the subject at a measurement point using a pair of each of the plural light-radiating devices and corresponding ones of the light-receiving devices. The calculator decides whether the oxidized hemoglobin concentration change and the deoxidized hemoglobin concentration change are statistically significant at each of the measurement points, and the display displays the decisions regarding the individual measurement points.
摘要翻译：一种生物体光测量装置，包括：多个用于将光照射到被检体的头部的光辐射装置;多个光检测装置，用于检测从所述光辐射装置辐射后透过所述被检体的头部的光;计算器用于使用多个光辐射装置和对应的光接收装置中的每一个来计算测量点处的受试者头部中的氧化和脱氧血红蛋白的浓度的变化。计算器确定每个测量点氧化血红蛋白浓度变化和脱氧血红蛋白浓度变化是否具有统计学意义，显示显示各个测量点的决定。

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