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21. 发明申请

US20110244460A1 METHOD FOR DETECTING CONTROLS FOR NUCLEIC ACID AMPLIFICATION AND USE THEREOF 审中-公开
标题翻译：用于检测核酸扩增控制的方法及其用途
公开(公告)号：US20110244460A1
公开(公告)日：2011-10-06
申请号：US13139290
申请日：2009-12-16
申请人： Mitsuharu Hirai , Satoshi Majima , Shinya Nakajima , Tatsuo Kamata
发明人： Mitsuharu Hirai , Satoshi Majima , Shinya Nakajima , Tatsuo Kamata
IPC分类号： C12Q1/68 , C07H21/00 , G06G7/58
CPC分类号： C12Q1/6848 , C12Q2545/107 , C12Q2527/107 , C12Q2545/101
摘要： The present invention provides a control detection method for easily detecting a positive control and a negative control simultaneously in one reaction system. An amplification reaction is carried out by adding a control template nucleic acid to a reaction system for detecting controls. The template nucleic acid can be amplified by a primer capable of amplifying an objective target sequence. An amplification region of the control template nucleic acid amplified by the primer can be hybridized with a detection probe capable of hybridizing to the target sequence. A Tm value (TmC) of a double-stranded nucleic acid composed of the amplification region of the control template nucleic acid amplified by the primer and the detection probe is set different from a Tm value (TmA) of a double-stranded nucleic acid composed of the target sequence and the detection probe. Thereby, it can be determined whether or not amplification occurs in a reaction system on the basis of the presence or absence of a peak at the TmC and it can be determined whether or not a reaction system is contaminated with undesired nucleic acid on the basis of the presence or absence of a peak at a temperature other than TmC.
摘要翻译：本发明提供一种用于在一个反应系统中同时容易地检测阳性对照和阴性对照的控制检测方法。通过将对照模板核酸加入到用于检测对照的反应系统中进行扩增反应。模板核酸可以通过能够扩增目的靶序列的引物扩增。由引物扩增的对照模板核酸的扩增区可以与能够与靶序列杂交的检测探针杂交。将由引物扩增的对照模板核酸的扩增区和检测用探针构成的双链核酸的Tm值（TmC）设定为与构成的双链核酸的Tm值（TmA）不同的目标序列和检测探针。因此，可以基于在TmC的峰的存在或不存在来确定反应体系中是否发生扩增，并且可以基于以下方式确定反应体系是否被不期望的核酸污染在TmC以外的温度下存在或不存在峰。

22. 发明申请

US20110103800A1 RADIO-ON-FIBER UNIT AND RADIO-ON-FIBER SYSTEM 有权
标题翻译：射频光纤单元和光纤光纤系统
公开(公告)号：US20110103800A1
公开(公告)日：2011-05-05
申请号：US13001883
申请日：2008-07-03
申请人： Satoshi Shinada , Tetsuya Kawanishi , Shinya Nakajima
发明人： Satoshi Shinada , Tetsuya Kawanishi , Shinya Nakajima
IPC分类号： H04B10/00 , H01Q21/08
CPC分类号： H01Q21/061 , H01Q21/0006 , H04B10/25756
摘要： An object of the present invention is to provide a radio-on-fiber unit and a radio-on-fiber system which can transmit/receive signals at adequate rates especially, to/from a mobile device. A first aspect of the present invention relates to a radio-on-fiber unit (3) which includes an antenna array (1) and a light modulator array (2). The light modulator array (2) comprises antenna elements (5) and light modulators (7) that are connected with the respective antenna elements via electric circuits. The optical waveguide (13) is composed of linear optical waveguides (13) that are arranged along the light modulators (7) included in certain lines among the light modulators (7). The light modulator array (2) comprises reflection units (17) for connecting two adjacent linear optical waveguides with each other. Consequently, a signal light inputted to a light input unit (11) is outputted from a light output unit (15) via each linear optical waveguide (13).
摘要翻译：本发明的一个目的是提供一种无线光纤单元和光纤无线电系统，其可以以适当的速率发送/接收来自移动设备的信号。本发明的第一方面涉及一种包括天线阵列（1）和光调制器阵列（2）的光纤上单元（3）。光调制器阵列（2）包括经由电路与各个天线元件连接的天线元件（5）和光调制器（7）。光波导（13）由沿光调制器（7）中的某些线路中包括的光调制器（7）布置的线性光波导（13）组成。光调制器阵列（2）包括用于将两个相邻的线性光波导彼此连接的反射单元（17）。因此，输入到光输入单元（11）的信号光经由每个线性光波导（13）从光输出单元（15）输出。

23. 发明授权

US07256892B2 Measuring instrument and fluorometric method 有权
标题翻译：测量仪器和荧光测定法
公开(公告)号：US07256892B2
公开(公告)日：2007-08-14
申请号：US10534182
申请日：2003-11-13
申请人： Shinya Nakajima
发明人： Shinya Nakajima
IPC分类号： G01N21/25 , F21V9/16 , B32B5/02
CPC分类号： G01N21/6428 , G01N21/645 , G01N2021/6441 , G01N2021/6463 , G01N2021/6471 , G01N2021/6482
摘要： A measuring instrument that comprises a light source unit 1 capable of emitting light having different wavelengths, a light receiving unit 2 that outputs an electrical signal corresponding to an intensity of transmitted light or radiated light from a sample 6 mixed with a plurality of coloring matters, and a calculation section 3, is used. The calculation section 3 uses a previously calculated correction coefficient to calculate the fluorescence intensity of transmitted light or radiated light for each coloring matter. The correction coefficient is calculated based on an electrical signal output by the light receiving unit 2 when a plurality of correction samples are irradiated with light having different wavelengths, each correction sample being mixed with any one of the coloring matters and the respective mixed coloring matters being different from one another.
摘要翻译：一种测量仪器，包括能够发射具有不同波长的光的光源单元1，光接收单元2，其输出与来自与多种着色物质混合的样品6的透射光或辐射光的强度对应的电信号，并使用计算部3。计算部分3使用先前计算的校正系数来计算每种色素的透射光或辐射光的荧光强度。当使用不同波长的光照射多个校正样本时，基于由光接收单元2输出的电信号来计算校正系数，每个校正样品与任何一个着色剂和各个混合着色剂混合为彼此不同

24. 发明申请

US20060134773A1 Device for pretreating specimen 审中-公开
标题翻译：预处理试样的装置
公开(公告)号：US20060134773A1
公开(公告)日：2006-06-22
申请号：US10536827
申请日：2003-11-27
申请人： Ken Inose , Shinya Nakajima , Satoshi Hashiguchi , Jun Murakami
发明人： Ken Inose , Shinya Nakajima , Satoshi Hashiguchi , Jun Murakami
IPC分类号： C12M1/34
CPC分类号： B01L3/5027 , B01L2200/0631 , B01L2300/0681 , B01L2300/0803 , B01L2300/0816 , B01L2300/087 , B01L2300/0874 , B01L2300/0877 , B01L2300/1827 , B01L2400/0406 , B01L2400/0421 , B01L2400/0487 , B01L2400/0644
摘要： Due to the recent decipherment of the human genome, various relations between life processes and genes have been analyzed. Consequently, medical importance shifts from pathology to etiology, and from medical treatment to prevention. Hereupon, the gene test technology becomes an important basis. A pretreatment device for pretreating a specimen comprises a specimen introducing portion, a holding portion, a wash storage, an elute storage, and a discharging portion in order to prevent a loss of sensitivity during a pretreatment process of the nucleic acid test, to easily automate the pretreatment process, and to decrease the cost thereof, thereby serving as a familiar system for the gene test.
摘要翻译：由于人类基因组最近的解密，人们分析了生命过程和基因之间的各种关系。因此，医学重要性从病理学转变为病因学，从医疗转向预防。因此，基因检测技术成为重要的依据。用于预处理样品的预处理装置包括样品导入部分，保持部分，洗涤储存器，洗脱储存器和排出部分，以便防止在核酸测试的预处理过程中的敏感性损失，以便容易地自动化预处理过程，并降低成本，从而作为基因测试的熟悉系统。

25. 发明授权

US08884766B2 Analysis system, analysis method and analysis program 有权
标题翻译：分析系统，分析方法和分析程序
公开(公告)号：US08884766B2
公开(公告)日：2014-11-11
申请号：US13455395
申请日：2012-04-25
申请人： Shinya Nakajima
发明人： Shinya Nakajima
IPC分类号： G08B21/22 , G01N33/493
CPC分类号： G01N33/493
摘要： An analysis system includes: a creatinine information acquiring section to input creatinine measurement data that indicate a measurement quantity of creatinine in a urine sample; a material ingredient information acquiring section to input material ingredient data that indicate a measured quantity of a material ingredient in the urine sample; and a correcting section to correct the measured quantity of the material ingredient indicated as the material ingredient data, by use of the measured quantity of creatinine indicated as the creatinine measurement data.
摘要翻译：分析系统包括：肌酸酐信息获取部，其输入表示尿样中肌酸酐的测定量的肌酐测定数据; 材料成分信息获取部，输入表示尿样中的原料成分的测定量的材料成分数据; 以及校正部，其通过使用表示为肌酐测定数据的测定肌酐量来校正表示为材料成分数据的材料成分的测定量。

26. 发明申请

US20110204139A1 Data output method in analysis of sample, analytical device, and analytical system 有权
标题翻译：分析样品，分析装置和分析系统的数据输出方法
公开(公告)号：US20110204139A1
公开(公告)日：2011-08-25
申请号：US12929676
申请日：2011-02-08
申请人： Shinya Nakajima
发明人： Shinya Nakajima
IPC分类号： G06Q50/00
CPC分类号： G01N35/00732 , G01N2035/00831
摘要： An analytical device is provided that can easily determine whether analysis results are affected by drug administration for the test subject when a sample such as urine or blood is analyzed. The analytical device includes reading means capable of reading test subject identification information recorded on an information recording portion of a sample container, and data output means capable of outputting data on analysis results of a sample contained in the sample container, the analytical device further having: information acquiring means capable of acquiring, from a source external to the analytical device, drug administration information on the test subject corresponding to the test subject identification information read by the reading means, wherein when the data on analysis results of a sample are outputted by the data output means, data on the drug administration information on the test subject corresponding thereto are also outputted.
摘要翻译：提供了一种分析装置，其可以容易地确定分析结果是否在分析诸如尿液或血液的样品时受试者的药物施用影响。分析装置包括能够读取记录在样本容器的信息记录部分上的测试对象识别信息的读取装置和能够输出包含在样本容器中的样本的分析结果的数据的数据输出装置，该分析装置还具有：信息获取装置，其能够从分析装置外部的来源获取与由读取装置读取的测试对象识别信息相对应的测试对象的药物管理信息，其中当样本的分析结果的数据由数据输出装置也输出与其对应的与被检者对应的药物管理信息的数据。

27. 发明授权

US07867344B2 Hot pressing method for high strength member using steel sheet and hot pressed parts 有权
标题翻译：使用钢板和热压部件的高强度部件的热压方法
公开(公告)号：US07867344B2
公开(公告)日：2011-01-11
申请号：US11572020
申请日：2005-07-15
申请人： Kazuhisa Kusumi , Jun Maki , Masayuki Abe , Masahiro Ohgami , Norihiro Fujita , Shinya Nakajima
发明人： Kazuhisa Kusumi , Jun Maki , Masayuki Abe , Masahiro Ohgami , Norihiro Fujita , Shinya Nakajima
IPC分类号： C21D8/02 , B32B15/18
CPC分类号： C23C2/26 , C21D1/673 , C23C2/28 , C23C26/00 , Y10T428/12757 , Y10T428/12799
摘要： A method is proved for hot pressing hot rolled steel sheet, cold rolled steel sheet, Al-based plated steel sheet or Zn-based plated steel sheet, where the hot pressed sheet can exhibit a strength of at least about 1200 Mpa, and my be prevented from exhibiting hydrogen embrittlement. The steel sheet may include between about 0.05 to 0.5 wt % C, and/or it may be plated with an Al-based or Zn-based plating material. The steel sheet may be heating to a temperature greater than an Ac3 temperature and not more than about 1100° C. before pressing. An atmosphere can be provided during heating which contains not more than about 6 vol % of hydrogen and a dew point of not more than about 10° C. The exemplary methods may be used to form high strength parts which may be used, e.g., in automobiles.
摘要翻译：证明了热压热轧钢板，冷轧钢板，Al系镀钢板或Zn系镀层钢板的热压板的强度至少为约1200Mpa的方法，防止氢脆化。钢板可以包括约0.05至0.5重量％的C，和/或其可以镀有Al基或Zn基镀层材料。在压制之前，钢板可能被加热到大于Ac 3温度且不大于约1100℃的温度。可以在加热期间提供含有不超过约6体积％氢气和露点不超过约10℃的气氛。示例性方法可用于形成高强度部件，其可以用于例如汽车

28. 发明申请

US20060108540A1 Measuring instrument and fluoremetric method 有权
标题翻译：测量仪和荧光法
公开(公告)号：US20060108540A1
公开(公告)日：2006-05-25
申请号：US10534182
申请日：2003-11-13
申请人： Shinya Nakajima
发明人： Shinya Nakajima
IPC分类号： G01N21/64
CPC分类号： G01N21/6428 , G01N21/645 , G01N2021/6441 , G01N2021/6463 , G01N2021/6471 , G01N2021/6482
摘要： A measuring instrument that comprises a light source unit 1 capable of emitting light having different wavelengths, a light receiving unit 2 that outputs an electrical signal corresponding to an intensity of transmitted light or radiated light from a sample 6 mixed with a plurality of coloring matters, and a calculation section 3, is used. The calculation section 3 uses a previously calculated correction coefficient to calculate the fluorescence intensity of transmitted light or radiated light for each coloring matter. The correction coefficient is calculated based on an electrical signal output by the light receiving unit 2 when a plurality of correction samples are irradiated with light having different wavelengths, each correction sample being mixed with any one of the coloring matters and the respective mixed coloring matters being different from one another.
摘要翻译：一种测量仪器，包括能够发射具有不同波长的光的光源单元1，光接收单元2，其输出与来自与多种着色物质混合的样品6的透射光或辐射光的强度对应的电信号，并使用计算部3。计算部分3使用先前计算的校正系数来计算每种色素的透射光或辐射光的荧光强度。当使用不同波长的光照射多个校正样本时，基于由光接收单元2输出的电信号来计算校正系数，每个校正样品与任何一个着色剂和各个混合着色剂混合为彼此不同

29. 发明申请

US20060099176A1 Medicines including interferon and administering system thereof 审中-公开
标题翻译：药物，包括干扰素及其给药系统
公开(公告)号：US20060099176A1
公开(公告)日：2006-05-11
申请号：US11320052
申请日：2005-12-28
申请人： Shinya Nakajima
发明人： Shinya Nakajima
IPC分类号： A61K38/21
CPC分类号： A61K38/212 , A61K38/21 , A61K38/215
摘要： The present invention discloses medicines including interferon and administering systems thereof, which have characteristics of the preparation according to the number of interferon on the surface of the cell and/or 2-5AS activity induced in the cell. The administering system of the present invention includes the first step of detecting the number of interferon receptors which are prepared so that the interferon dosage is determined according to the extent of interferon receptors on the surface of the cell.
摘要翻译：本发明公开了包含干扰素及其给药系统的药物，其具有根据细胞表面上的干扰素数目和/或细胞中诱导的2-5AS活性制备的特征。本发明的给药系统包括检测干扰素受体数量的第一步骤，所述干扰素受体的制备使得根据细胞表面上的干扰素受体的程度确定干扰素剂量。

30. 发明授权

US06683900B2 Solid state laser apparatus 有权
标题翻译：固态激光装置
公开(公告)号：US06683900B2
公开(公告)日：2004-01-27
申请号：US09892643
申请日：2001-06-28
申请人： Yoshihisa Yamanouchi , Fumio Matsuzaka , Akihiro Nishimi , Minoru Uehara , Shinya Nakajima , Koichi Mori
发明人： Yoshihisa Yamanouchi , Fumio Matsuzaka , Akihiro Nishimi , Minoru Uehara , Shinya Nakajima , Koichi Mori
IPC分类号： H01S304
CPC分类号： H01S3/025 , H01S3/0407 , H01S3/042
摘要： A cavity has a longitudinal hollow having opposite open ends. An excitation source, such as a YAG rod, is accommodated in the hollow of the cavity. A hollow, cylindrical rod holder is inserted into each of the opposite open ends of the hollow and is fitted over a corresponding end of the YAG rod. A seal is fitted into a hollow of the rod holder adjacent to a portion of the rod holder fitted over the end of the YAG rod. The seal includes an annular seal body with a U-shaped section, e.g. made from Teflon®, and fitted over an outer periphery of the YAG rod to grip the YAG rod, as well as a spring fitted in a groove of the seal body provided by the U-shaped section so as to circumferentially surround a gripped portion of the YAG rod.
摘要翻译：空腔具有相对开口端的纵向中空孔。诸如YAG杆的激发源容纳在腔的中空部分中。中空的圆柱形杆保持器被插入到空心的每个相对的开口端中并且装配在YAG杆的相应的端部上。密封件装配到杆保持器的中空部分中，邻近安装在YAG杆端部上的杆保持器的一部分。密封件包括具有U形截面的环形密封体，例如。由特氟龙制成，并且装配在YAG杆的外周上以夹持YAG杆，以及装配在由U形部分设置的密封体的槽中的弹簧，以便周向地围绕夹持的 YAG棒的一部分。

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