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    • 25. 发明授权
    • Terminal amino prostaglandin analogues
    • 末端氨基前列腺素类似物
    • US4315022A
    • 1982-02-09
    • US152766
    • 1980-05-23
    • Gordon WoottonStephen A. Smith
    • Gordon WoottonStephen A. Smith
    • A61K31/415A61K31/4166A61P43/00C07D233/32C07D233/76C07D233/78C07D233/86
    • C07C255/00C07C309/00C07D233/32C07D233/76C07D233/86
    • Compounds of the formula (I): ##STR1## having pharmacological activities similar to those of natural prostaglandins wherein:n is 0 to 5;X is CO, CS or CH.sub.2 ;Y is --CH.sub.2 --CH.sub.2 --; or, when n is 1 to 5, --CH.dbd.CH-- or --C.tbd.C--;R.sub.1 is either CH.sub.2 NR.sub.5 R.sub.6, wherein R.sub.5 and R.sub.6 are separately hydrogen or C.sub.1-6 alkyl, or R.sub.5 is hydrogen and R.sub.6 is (CH.sub.2).sub.m CO.sub.2 R.sup.1.sub.9 wherein m is 0 to 4 and R.sup.1.sub.9 is optionally substituted C.sub.1-6 alkyl or benzyl, optionally substituted in the phenyl ring by chlorine or bromine atoms or by nitro or CF.sub.3 groups; or R.sub.5 and R.sub.6 are both the same (CH.sub.2).sub.m CO.sub.2 R.sup.1.sub.9 as hereinbefore defined; or C(NH.sub.2).dbd.NOH; or C(OR.sub.7).dbd.NH.sub.2.sup.+ B.sup.- wherein R.sub.7 is C.sub.1-6 alkyl and B.sup.- is a salting ion; or CH.sub.2 NHR.sub.8, wherein R.sub.8 is SO.sub.2 R.sup.1.sub.9, COR.sup.1.sub.9 or CZNHR.sub.9 and R.sup.1.sub.9 is as hereinbefore defined, R.sub.9 is hydrogen or C.sub.1-6 alkyl and Z is oxygen or sulphur; or CZNH.sub.2 wherein Z is as hereinbefore defined:R.sub.2 is hydrogen or C.sub.1-4 alkyl;R.sub.3 is C.sub.1-9 alkyl, C.sub.5-8 cycloalkyl or C.sub.5-8 cycloalkyl --C.sub.1-6 alkyl; orR.sub.2 and R.sub.3 taken with the carbon atom to which they are joined represent a C.sub.5-8 cycloalkyl group; andR.sub.4 is hydrogen or C.sub.1-6 alkyl; and salts thereof; with the provisos (i) that when X is CH.sub.2 then Y must be --CH.sub.2 --CH.sub.2 --, and (ii) when R.sub.1 is CH.sub.2 NR.sub.5 R.sub.6 or CH.sub.2 NHR.sub.8 then Y must be --CH.sub.2 --CH.sub.2 --, pharmaceutical compositions containing them and processes for their preparation.
    • 具有与天然前列腺素类似的药理活性的式(I)化合物:其中:n为0至5; X为CO,CS或CH2; Y是-CH 2 -CH 2 - ; 或当n为1至5时,-CH = CH-或-CB 3 -C-; R1是CH2NR5R6,其中R5和R6分别是氢或C1-6烷基,或R5是氢,R6是(CH2)mCO2R19,其中m是0-4,R19是任选被取代的C 1-6烷基或苄基, 苯环由氯或溴原子或硝基或CF 3基团组成; 或者R 5和R 6与上述定义相同(CH2)mCO2R19; 或C(NH 2)= NOH; 或C(OR 7)= NH 2 + B-,其中R 7为C 1-6烷基,B为盐析离子; 或CH2NHR8,其中R8是SO2R19,COR19或CZNHR9,R19如上所定义,R9是氢或C1-6烷基,Z是氧或硫; 或CZNH 2,其中Z如上所定义:R 2是氢或C 1-4烷基; R3是C1-9烷基,C5-8环烷基或C5-8环烷基-C 1-6烷基; 或与其连接的碳原子取代的R 2和R 3表示C 5-8环烷基; 并且R 4是氢或C 1-6烷基; 及其盐; 条件是(i)当X是CH 2时,Y必须是-CH 2 -CH 2 - ,和(ii)当R 1是CH 2 NR 5 R 6或CH 2 NHR 8时,Y必须是-CH 2 -CH 2 - ,含有它们的药物组合物及其制备方法 。
    • 29. 发明授权
    • Telecommunications service control point with code blocking
    • 电信业务控制点与代码阻塞
    • US06741694B1
    • 2004-05-25
    • US10414393
    • 2003-04-15
    • Stephen A. SmithJoseph B. DonelanDale H. Foshe
    • Stephen A. SmithJoseph B. DonelanDale H. Foshe
    • H04M700
    • H04Q3/0029H04Q3/0091
    • A telecommunications service control point having call blocking logic configured to block a percentage of call attempts to a called number and route a percentage of call attempts to the called number. The SCP comprises a processing system coupled to an interface. The processing system is configured to a process a plurality of query messages to generate a plurality of response messages containing call handling information for a plurality of call attempts to a called number. A first percentage of the call handling information includes instructions to block a corresponding first percentage of the plurality of call attempts to the called number. A second percentage of the call handling information includes instructions to route a corresponding second percentage of the plurality of call attempts to the called number. The interface is configured to receive the plurality of query messages and transmit the plurality of response messages.
    • 具有呼叫阻塞逻辑的电信服务控制点被配置为阻止对被叫号码的呼叫尝试的百分比并且将呼叫尝试的百分比路由到被叫号码。 SCP包括耦合到接口的处理系统。 处理系统被配置为处理多个查询消息以生成包含用于对被叫号码的多次呼叫尝试的呼叫处理信息的多个响应消息。 呼叫处理信息的第一百分比包括阻止对被叫号码的多次呼叫尝试的对应的第一百分比的指令。 呼叫处理信息的第二百分比包括将多个呼叫尝试的对应的第二百分比路由到被叫号码的指令。 接口被配置为接收多个查询消息并发送多个响应消息。