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21. 发明授权

US08389541B2 Inhibitors of protein tyrosine kinase activity 有权
标题翻译：抑制蛋白酪氨酸激酶活性
公开(公告)号：US08389541B2
公开(公告)日：2013-03-05
申请号：US13341604
申请日：2011-12-30
申请人： Stephen William Claridge , Ljubomir Isakovic , Michael Mannion , Stephane Raeppel , Oscar Mario Saavedra , Frederic Gaudette , Lijie Zhan , Arkadii Vaisburg
发明人： Stephen William Claridge , Ljubomir Isakovic , Michael Mannion , Stephane Raeppel , Oscar Mario Saavedra , Frederic Gaudette , Lijie Zhan , Arkadii Vaisburg
IPC分类号： A01N43/42 , C07D413/00
CPC分类号： C07D495/04
摘要： This invention relates to compounds that inhibit protein tyrosine kinase activity. In particular the invention relates to compounds that inhibit the protein tyrosine kinase activity of growth factor receptors, resulting in the inhibition of receptor signaling, for example, the inhibition of VEGF receptor signaling and HGF receptor signaling. More particularly, the invention relates to compounds, compositions and methods for the inhibition of VEGF receptor signaling and HGF receptor signaling. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.
摘要翻译：本发明涉及抑制蛋白酪氨酸激酶活性的化合物。特别地，本发明涉及抑制生长因子受体的蛋白酪氨酸激酶活性的化合物，导致受体信号传导的抑制，例如VEGF受体信号传导和HGF受体信号传导的抑制。更具体地，本发明涉及用于抑制VEGF受体信号传导和HGF受体信号传导的化合物，组合物和方法。本发明还提供了治疗细胞增殖性疾病和病症的组合物和方法。

22. 发明申请

US20080004273A1 Inhibitors of protein tyrosine kinase activity 审中-公开
标题翻译：抑制蛋白酪氨酸激酶活性
公开(公告)号：US20080004273A1
公开(公告)日：2008-01-03
申请号：US11807907
申请日：2007-05-30
申请人： Stephane Raeppel , Stephen Claridge , Oscar Saavedra , Arkadii Vaisburg , Robert Deziel , Lijie Zhan , Michael Mannion , Frederic Gaudette , Nancy Zhou , Ljubomir Isakovic
发明人： Stephane Raeppel , Stephen Claridge , Oscar Saavedra , Arkadii Vaisburg , Robert Deziel , Lijie Zhan , Michael Mannion , Frederic Gaudette , Nancy Zhou , Ljubomir Isakovic
IPC分类号： A61K31/47 , A61K31/517 , A61K31/5375 , A61P37/00 , C07D215/00 , C07D239/72 , C07D265/30 , C12N5/00 , C12N9/99
CPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D413/14 , C12N9/1205
摘要： This invention relates to compounds that inhibit protein tyrosine kinase activity. In particular the invention relates to compounds that inhibit the protein tyrosine kinase activity of growth factor receptors, resulting in the inhibition of receptor signaling, for example, the inhibition of VEGF receptor signaling and HGF receptor signaling. More particularly, the invention relates to compounds, compositions and methods for the inhibition of VEGF receptor signaling and HGF receptor signaling. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.
摘要翻译：本发明涉及抑制蛋白酪氨酸激酶活性的化合物。特别地，本发明涉及抑制生长因子受体的蛋白酪氨酸激酶活性的化合物，导致受体信号传导的抑制，例如VEGF受体信号传导和HGF受体信号传导的抑制。更具体地，本发明涉及用于抑制VEGF受体信号传导和HGF受体信号传导的化合物，组合物和方法。本发明还提供了治疗细胞增殖性疾病和病症的组合物和方法。

23. 发明申请

US20100279983A1 NOVEL INHIBITORS OF BETA-LACTAMASE 失效
标题翻译： β-LACTAMASE的新型抑制剂
公开(公告)号：US20100279983A1
公开(公告)日：2010-11-04
申请号：US12301797
申请日：2007-05-21
申请人： Frank Dininno , Milton L. Hammond , Kevin Dykstra , Seongkon Kim , Qiang Tan , Katherine Young , Jeffrey Donald Hermes , Helen Chen , Stephane Raeppel , Michael Mannion , Frederic Gaudette , Arkadii Vaisburg , Jubrail Rahil , Nafsika Georgopapadakou , Nancy Z. Zhou
发明人： Frank Dininno , Milton L. Hammond , Kevin Dykstra , Seongkon Kim , Qiang Tan , Katherine Young , Jeffrey Donald Hermes , Helen Chen , Stephane Raeppel , Michael Mannion , Frederic Gaudette , Arkadii Vaisburg , Jubrail Rahil , Nafsika Georgopapadakou , Nancy Z. Zhou
IPC分类号： A61K31/675 , A61K31/67 , A61K31/665 , C07D409/12 , C07D277/80 , C07D277/36 , C07D333/72 , C07D307/83 , A61P31/04
CPC分类号： C07F9/655354 , C07F9/65395 , C07F9/6541 , C07F9/6553 , C07F9/6558 , C07F9/6561
摘要： This invention provides novel β-lactamase inhibitors of the aryl- and heteroarylsulfonamidomethylphosphonate monoester class having nitrogen-based cations or quarternary ammonium groups. The compounds inhibit three classes of β-lactamases and synergize the antibacterial effects of β-lactam antibiotics (e.g., imipenem and ceftazidime) against those micro-organisms normally resistant to the β-lactam antibiotics as a result of the presence of the β-lactamases. Formula (I) or pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供具有氮基阳离子或季铵基团的芳基 - 和杂芳基磺酰氨基甲基膦酸酯单酯类的新颖的β-内酰胺酶抑制剂。这些化合物抑制三种类型的β-内酰胺酶，并且与通常对β-内酰胺抗生素具有抗性的那些微生物相互作用可促进β-内酰胺类抗生素（如亚胺培南和头孢他啶）对抗生素的抗菌作用。＆bgr;内酰胺酶。式（I）或其药学上可接受的盐。

24. 发明授权

US08440643B2 Inhibitors of beta-lactamase 失效
标题翻译： β-内酰胺酶抑制剂
公开(公告)号：US08440643B2
公开(公告)日：2013-05-14
申请号：US12301797
申请日：2007-05-21
申请人： Frank Dininno , Milton L. Hammond , Kevin Dykstra , Seongkon Kim , Qiang Tan , Katherine Young , Jeffrey Donald Hermes , Helen Chen , Stephane Raeppel , Michael Mannion , Frederic Gaudette , Arkadii Vaisburg , Jubrail Rahil , Nafsika Georgopapadakou , Nancy Z. Zhou
发明人： Frank Dininno , Milton L. Hammond , Kevin Dykstra , Seongkon Kim , Qiang Tan , Katherine Young , Jeffrey Donald Hermes , Helen Chen , Stephane Raeppel , Michael Mannion , Frederic Gaudette , Arkadii Vaisburg , Jubrail Rahil , Nafsika Georgopapadakou , Nancy Z. Zhou
IPC分类号： A61K31/675 , A61K31/67 , A61K31/665
CPC分类号： C07F9/655354 , C07F9/65395 , C07F9/6541 , C07F9/6553 , C07F9/6558 , C07F9/6561
摘要： This invention provides novel β-lactamase inhibitors of the aryl- and heteroaryl-sulfonamidomethylphosphonate monoester class having nitrogen-based cations or quarternary ammomium groups. The compounds inhibit three classes of β-lactamases and synergize the antibacterial effects of β-lactam antibiotics (e.g., imipenem and ceftazimdime) against those micro-organisms normally resistant to the β-lactam antibiotics as a result of the presence of the β-lactamases.
摘要翻译：本发明提供具有氮基阳离子或季铵基团的芳基 - 和杂芳基 - 磺酰氨基甲基膦酸酯单酯类的新型β-内酰胺酶抑制剂。这些化合物抑制三类β-内酰胺酶，并与β-内酰胺类抗生素（如亚胺培南和头孢他啶）的抗菌作用协同作用，因为β-内酰胺酶的存在对通常对β-内酰胺抗生素有抗性的微生物。

25. 发明申请

US20100317625A1 NOVEL SULFONAMIDOMETHYLPHOSPHONATE INHIBITORS OF BETA-LACTAMASE 审中-公开
标题翻译： β-乳酸酶的新型磺酰亚胺磷酸盐抑制剂
公开(公告)号：US20100317625A1
公开(公告)日：2010-12-16
申请号：US12301793
申请日：2007-05-21
申请人： Frank Dininno , Milton L. Hammond , Kevin Dykstra , Seongkon Kim , Qiang Tan , Katherine Young , Jeffrey Donald Hermes , Stephane Raeppel , Michael Mannion , Nancy Z. Zhou , Frederic Gaudette , Arkadii Vaisburg , Jubrail Rahil , Nafsika Georgopapadakou
发明人： Frank Dininno , Milton L. Hammond , Kevin Dykstra , Seongkon Kim , Qiang Tan , Katherine Young , Jeffrey Donald Hermes , Stephane Raeppel , Michael Mannion , Nancy Z. Zhou , Frederic Gaudette , Arkadii Vaisburg , Jubrail Rahil , Nafsika Georgopapadakou
IPC分类号： A61K31/675 , C07F9/6553 , A61K31/67 , C07F9/6561 , C07F9/6539 , C07F9/655 , A61K31/665 , A61P31/04
CPC分类号： C07F9/655354 , C07F9/6539 , C07F9/65517 , C07F9/655345 , C07F9/65586
摘要： This invention provides novel β-lactamase inhibitors of the aryl- and heteroaryl-sulfonamidomethylphosphonate monoester class. The compounds inhibit three classes of β-lactamases and synergize the antibacterial effects of β-lactam antibiotics (e.g., imipenem and ceftazimdime) against those micro-organisms normally resistant to the β-lactam antibiotics as a result of the presence of the β-lactamases.
摘要翻译：本发明提供芳基 - 和杂芳基 - 磺酰氨基甲基膦酸酯单酯类的新颖的β-内酰胺酶抑制剂。这些化合物抑制三种类型的β-内酰胺酶，并且协同抗生素（例如，亚胺培南和头孢他啶）与通常对抗β-生物抗生素抗性的那些微生物的抗菌作用是由于存在＆bgr;内酰胺酶。

26. 发明授权

US07861238B2 Configuration tool and method of updating an archive file property relating to at least one point-of-sale peripheral 有权
标题翻译：配置工具和更新与至少一个销售点外围设备相关的归档文件属性的方法
公开(公告)号：US07861238B2
公开(公告)日：2010-12-28
申请号：US11610331
申请日：2006-12-13
申请人： Brian Al Saadi , Michael Mannion
发明人： Brian Al Saadi , Michael Mannion
IPC分类号： G06F9/44 , G06F9/00
CPC分类号： G06F8/658
摘要： A configuration tool and method of updating a pointer entry in a Java archive (JAR) file pointing to a peripheral configuration file comprises generally continuously listening for an event signifying deployment of a peripheral configuration file and in response to the event, automatically updating the pointer entry in the JAR file that points to the deployed peripheral configuration file.
摘要翻译：更新指向外围设备配置文件的Java存档（JAR）文件中的指针条目的配置工具和方法包括通常连续地监听表示外围设备配置文件的部署的事件，并响应该事件自动更新指针条目在指向所部署的外围设备配置文件的JAR文件中。

27. 发明授权

US07940744B2 System, apparatus and method for automated wireless device configuration 有权
标题翻译：用于自动化无线设备配置的系统，设备和方法
公开(公告)号：US07940744B2
公开(公告)日：2011-05-10
申请号：US11681078
申请日：2007-03-01
申请人： Daniel Adolf Lehotsky , Michael Mannion , Tsutomu Nobutani
发明人： Daniel Adolf Lehotsky , Michael Mannion , Tsutomu Nobutani
IPC分类号： H04L12/28
CPC分类号： H04L41/26 , H04L41/0803 , H04L41/0886 , H04W8/20 , H04W28/18
摘要： A method and system for automatically configuring a plurality of wireless peripheral devices within a network environment. The method includes identifying a plurality of wireless peripheral devices, including one existing networked wireless device. The existing networked wireless device is configured to function as a master device. The master device identifies one of the remaining wireless peripheral devices that has yet to be configured. The master device replicates itself by wirelessly transmitting the configuration data to the identified wireless peripheral device. The configuration data enables the identified peripheral wireless device to assume network operation and to assume functionality of the master device so as to be capable of automatically causing the configuration of additional peripheral devices.
摘要翻译：一种用于在网络环境内自动配置多个无线外围设备的方法和系统。该方法包括识别多个无线外围设备，包括一个现有的联网无线设备。现有的联网无线设备被配置为用作主设备。主设备识别尚未配置的剩余无线外设之一。主设备通过将配置数据无线发送到所识别的无线外围设备来复制自身。配置数据使得所识别的外围无线设备能够承担网络操作并且承担主设备的功能，以便能够自动地引起附加的外围设备的配置。

28. 发明授权

US07474446B2 Color reduction processing apparatus, printer control device, color reduction method, and printer control method 有权
标题翻译：减色处理装置，打印机控制装置，减色方法和打印机控制方法
公开(公告)号：US07474446B2
公开(公告)日：2009-01-06
申请号：US11000475
申请日：2004-11-30
申请人： Yukiharu Horiuchi , Michael Mannion
发明人： Yukiharu Horiuchi , Michael Mannion
IPC分类号： G03F3/08
CPC分类号： H04N1/6005 , H04N1/56 , H04N1/6075
摘要： A color reduction processing apparatus and method reduce an original image containing many colors to a printable image containing few colors according to human color sensation. A conversion processing unit converts the pixel data for each pixel in an RGB color image (original image) to HLS data. A color reduction processor then generates print image data (the reduced-color image) reduced to a first color, second color, and a non-printing color by calculating the hue H, lightness L, and saturation S values of the HLS data based on specific parameters. These parameters can be set from an operating screen presented on a display. The original image and reduced-color image are presented on the display for verification by the user.
摘要翻译：减色处理装置和方法根据人的颜色感将减少包含许多颜色的原始图像到包含少量颜色的可打印图像。转换处理单元将RGB彩色图像（原始图像）中的每个像素的像素数据转换为HLS数据。然后，通过计算基于HLS数据的色调H，亮度L和饱和度S值，减色处理器生成缩小为第一颜色，第二颜色和非打印色的打印图像数据（缩小颜色图像）具体参数。这些参数可以从显示器上显示的操作画面进行设置。原始图像和简化图像显示在显示屏上，供用户验证。

29. 发明申请

US20070169097A1 Configuration tool and method of updating an archive file property relating to at least one point-of-sale peripheral 有权
标题翻译：配置工具和更新与至少一个销售点外围设备相关的归档文件属性的方法
公开(公告)号：US20070169097A1
公开(公告)日：2007-07-19
申请号：US11610331
申请日：2006-12-13
申请人： Brian Al Saadi , Michael Mannion
发明人： Brian Al Saadi , Michael Mannion
IPC分类号： G06F9/44
CPC分类号： G06F8/658
摘要： A configuration tool and method of updating a pointer entry in a Java archive (JAR) file pointing to a peripheral configuration file comprises generally continuously listening for an event signifying deployment of a peripheral configuration file and in response to the event, automatically updating the pointer entry in the JAR file that points to the deployed peripheral configuration file.
摘要翻译：更新指向外围设备配置文件的Java存档（JAR）文件中的指针条目的配置工具和方法包括通常连续地监听表示外围设备配置文件的部署的事件，并响应该事件自动更新指针条目在指向所部署的外围设备配置文件的JAR文件中。

30. 发明申请

US20070146782A1 System, Apparatus and Method for Automated Wireless Device Configuration 有权
标题翻译：自动无线设备配置的系统，设备和方法
公开(公告)号：US20070146782A1
公开(公告)日：2007-06-28
申请号：US11681078
申请日：2007-03-01
申请人： Daniel Lehotsky , Michael Mannion , Tsutomu Nobutani
发明人： Daniel Lehotsky , Michael Mannion , Tsutomu Nobutani
IPC分类号： G06K1/00
CPC分类号： H04L41/26 , H04L41/0803 , H04L41/0886 , H04W8/20 , H04W28/18
摘要： A method and system for automatically configuring a plurality of wireless peripheral devices within a network environment. The method includes identifying a plurality of wireless peripheral devices, including one existing networked wireless device. The existing networked wireless device is configured to function as a master device. The master device identifies one of the remaining wireless peripheral devices that has yet to be configured. The master device replicates itself by wirelessly transmitting the configuration data to the identified wireless peripheral device. The configuration data enables the identified peripheral wireless device to assume network operation and to assume functionality of the master device so as to be capable of automatically causing the configuration of additional peripheral devices.
摘要翻译：一种用于在网络环境内自动配置多个无线外围设备的方法和系统。该方法包括识别多个无线外围设备，包括一个现有的联网无线设备。现有的联网无线设备被配置为用作主设备。主设备识别尚未配置的剩余无线外设之一。主设备通过将配置数据无线发送到所识别的无线外围设备来复制自身。配置数据使得所识别的外围无线设备能够承担网络操作并且承担主设备的功能，以便能够自动地引起附加的外围设备的配置。

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