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21. 发明授权

US4983624A Novel prolinal derivatives 失效
标题翻译：新颖的流涎衍生物
公开(公告)号：US4983624A
公开(公告)日：1991-01-08
申请号：US139231
申请日：1987-12-29
申请人： Masaaki Toda , Shuichi Ohuchida , Hiroyuki Ohno
发明人： Masaaki Toda , Shuichi Ohuchida , Hiroyuki Ohno
IPC分类号： C07D207/08
CPC分类号： C07D207/08
摘要： A novel prolinal derivative of general formula: ##STR1## [whereinA represents a group of the general formula: ##STR2## (wherein one of R.sup.1 and R.sup.2 represents hydrogen atom and the other represents alkyl group of from 2 to 5 carbon atoms, alkoxy group of from 1 to 5 carbon atom(s), phenyl group, benzyl group, cycloalkyl group of from 4 to 6 carbon atoms or (cycloalkyl group of from 4 to 6 carbon atoms) - methyl group or R.sup.1 and R.sup.2 each represents, same or different, alkyl group of from 1 to 4 carbon atom(s).)or a group of the general formula: ##STR3## (wherein m represents an integer of from 3 to 6.) n represents an integer of from 3 to 10.D represents carbocyclic or heterocyclic ring unsubstituted or substituted by from one to three of halogen atom, nitro group, trifluoromethyl group, alkyl or akloxy group of from 1 to 4 carbon atom(s).]possess inhibitory activity on prolyl endopeptidase, and therefore be useful for treating and/or preventing agent for amnesia.

22. 发明授权

US4857537A Novel thiazolidine derivatives 失效
标题翻译：新型噻唑烷衍生物
公开(公告)号：US4857537A
公开(公告)日：1989-08-15
申请号：US159073
申请日：1988-02-23
申请人： Masaaki Toda , Shuichi Ohuchida , Hiroyuki Ohno
发明人： Masaaki Toda , Shuichi Ohuchida , Hiroyuki Ohno
IPC分类号： C07D277/04 , C07D417/06
CPC分类号： C07D417/06 , C07D277/04
摘要： A novel thiazolidine derivative of general formula: ##STR1## [wherein R represents a group of general formula:G-E-D-B-A-(wherein A represents single bond, alkylene group of from 1 to 6 carbon atom(s), alkylene group of from 2 to 6 carbon atoms, a group of general formula: ##STR2## or saturated hydrocarbon ring of from 4 to 7 carbon atoms or single heterocyclic ring.Y represents alkylene group of from 1 to 4 carbon atom(s) or alkenylene group of from 2 to 4 carbon atoms.B represents single bond or alkylene group of from 1 to 6 carbon atom(s).D represents single bond, oxygen atom, carbonyl group or a group of general formula: ##STR3## R.sup.1 represents hydrogen atom, alkyl group of from 1 to 4 carbon atom(s), phenyl group or benzyl group.E represents single bond, alkylene group of from 1 to 8 carbon atom(s) or alkylene group of from 1 to 8 carbon atom(s) substituted by phenyl group or benzyl group.G represents carbocyclic or heterocyclic ring unsubstituted or substituted by from one to three of alkyl group of from 1 to 6 carbon atom(s), alkoxy group of from 1 to 6 carbon atom(s), halogen atom, trifluoromethyl group or nitro group.)With the proviso that, A and B do not represent mono-bonds at the same time.]possess inhibitory activity on prolyl endopeptidase, and therefore be useful for treating and/or preventing agent for amnesia.

23. 发明申请

US20090228183A1 Slip detection and traction control for a vehicle 有权
标题翻译：车辆的滑移检测和牵引力控制
公开(公告)号：US20090228183A1
公开(公告)日：2009-09-10
申请号：US12074726
申请日：2008-03-05
申请人： Satoru Watabe , Hiroyuki Ohno
发明人： Satoru Watabe , Hiroyuki Ohno
IPC分类号： B60W40/12
CPC分类号： B60K28/16 , B60T8/1706 , B60T8/175 , B60W2510/0638 , B60W2510/0652 , B60W2510/1005 , B60W2520/10 , B60W2710/0616 , B60W2710/0666 , Y10T477/755
摘要： A slip detection system for a vehicle comprises an engine speed detector configured to detect an engine speed of an engine mounted in the vehicle, an engine speed increase rate detector configured to detect an increase rate in a predetermined time of the engine speed detected by the engine speed detector, and a slip determiner configured to integrate values of increase rates in respective predetermined times, from when the increase rate detected by the engine speed increase rate detector becomes larger than a first threshold until the increase rate becomes smaller than the first threshold, and to determine that a drive wheel of the vehicle is in a slip-state when an integrated value resulting from integration of the values of the increase rates becomes larger than a second threshold.
摘要翻译：一种用于车辆的滑动检测系统包括：发动机速度检测器，被配置为检测安装在车辆中的发动机的发动机转速;发动机速度增加率检测器，被配置为检测在发动机检测到的发动机转速的预定时间内的增加率速度检测器和滑动判定器，其被配置为在从发动机速度增加率检测器检测到的增加率变得大于第一阈值直到增加速率变得小于第一阈值时，在各个预定时间内积分增加率的值，以及当由增加率的值的积分导致的积分值变得大于第二阈值时，确定车辆的驱动轮处于滑动状态。

24. 发明授权

US07385035B2 Cytotoxic protein and utilization thereof 失效
标题翻译：细胞毒性蛋白及其利用
公开(公告)号：US07385035B2
公开(公告)日：2008-06-10
申请号：US10496384
申请日：2002-12-05
申请人： Hiroyuki Ohno , Hiromitsu Saisho , Hideki Tanzawa
发明人： Hiroyuki Ohno , Hiromitsu Saisho , Hideki Tanzawa
IPC分类号： C07K5/10
CPC分类号： C07K14/205 , A61K38/164 , C07K16/121 , C12P21/02 , G01N2333/205 , Y10S435/81
摘要： This invention relates to a new cytotoxic protein (M toxin, mucous layer devastating toxin) produced by Helicobacter pylori and the use.This invention provides a cytotoxic protein (M toxin) produced by Helicobacter pylori, a partial peptide, and an antitumor agent containing the cytotoxic protein. The protein is obtained by culturing a transformant which is transformed with a recombination vector containing DNA coding the cytotoxin protein. This invention provides further the use of the protein.
摘要翻译：本发明涉及由幽门螺杆菌产生的新的细胞毒素蛋白（M毒素，粘液层破坏性毒素）及其用途。本发明提供由幽门螺杆菌，部分肽和含有细胞毒性蛋白质的抗肿瘤剂产生的细胞毒性蛋白（M毒素）。通过培养用含有编码细胞毒素蛋白的DNA的重组载体转化的转化体获得蛋白质。本发明进一步提供了蛋白质的用途。

25. 发明申请

US20060210575A1 Cytotoxic protein and utilization thereof 失效
标题翻译：细胞毒性蛋白及其利用
公开(公告)号：US20060210575A1
公开(公告)日：2006-09-21
申请号：US10496384
申请日：2002-12-05
申请人： Hiroyuki Ohno , Hiromitsu Saisho , Hideki Tanzawa
发明人： Hiroyuki Ohno , Hiromitsu Saisho , Hideki Tanzawa
IPC分类号： G01N33/53 , A61K39/395 , A61K39/00 , C07K14/47
CPC分类号： C07K14/205 , A61K38/164 , C07K16/121 , C12P21/02 , G01N2333/205 , Y10S435/81
摘要： This invention relates to a new cytotoxic protein (M toxin, mucous layer devastating toxin) produced by Helicobacter pylori and the use. This invention provides a cytotoxic protein (M toxin) produced by Helicobacter pylori, a partial peptide, and an antitumor agent containing the cytotoxic protein. The protein is obtained by culturing a transformant which is transformed with a recombination vector containing DNA coding the cytotoxin protein. This invention provides further the use of the protein.
摘要翻译：本发明涉及由幽门螺杆菌产生的新的细胞毒素蛋白（M毒素，粘液层破坏性毒素）及其用途。本发明提供由幽门螺杆菌，部分肽和含有细胞毒性蛋白质的抗肿瘤剂产生的细胞毒性蛋白（M毒素）。通过培养用含有编码细胞毒素蛋白的DNA的重组载体转化的转化体获得蛋白质。本发明进一步提供了蛋白质的用途。

26. 发明授权

US6048639A Thin type sealed cell and producing method thereof 失效
标题翻译：薄型密封电池及其制造方法
公开(公告)号：US6048639A
公开(公告)日：2000-04-11
申请号：US232655
申请日：1999-01-19
申请人： Tsutomu Sonozaki , Hiroyuki Ohno , Ikuro Nakane , Satoshi Narukawa
发明人： Tsutomu Sonozaki , Hiroyuki Ohno , Ikuro Nakane , Satoshi Narukawa
IPC分类号： H01M2/02 , H01M10/04 , H01M6/00 , H01M2/00
CPC分类号： H01M10/0436 , H01M2/021 , H01M2/0275 , H01M10/0525 , H01M2/0287
摘要： In a thin type sealed cell utilizing a cell case made of a laminated material, a storage life and reliability of the cell is increased by preventing a sectional surface at an end of the laminated material from being exposed in the cell case, and thereby a leakage of an electrolyte out of the cell and a short circuit in the cell are avoided. This is achieved by disposing a resin layer on the inner surface of the cell case composed of a sheet type laminated material, and covering the sectional surface existing inside the cell case with resin.
摘要翻译：在使用由层压材料制成的电池壳体的薄型密封电池中，通过防止层叠材料的端部的截面被暴露在电池壳体中，从而提高电池的储存寿命和可靠性，从而泄漏的电解液，并避免了电池中的短路。这是通过在由片状层压材料构成的电池壳体的内表面上设置树脂层，并且用树脂覆盖存在于电池壳体内的截面来实现的。

27. 发明授权

US5712391A Silicone derivatives, their production and use 失效
公开(公告)号：US5712391A
公开(公告)日：1998-01-27
申请号：US671001
申请日：1996-06-28
申请人： Hiroyuki Ohno , Natsue Kawahara , Isaburo Amano , Takanao Suzuki , Koji Chiba
发明人： Hiroyuki Ohno , Natsue Kawahara , Isaburo Amano , Takanao Suzuki , Koji Chiba
IPC分类号： A61K8/895 , A61K8/898 , A61K47/34 , A61Q1/00 , A61Q19/00 , C08G77/388 , C07D251/00 , C07D251/40 , C07D251/54 , C07F7/04
CPC分类号： A61K8/898 , A61K47/34 , A61Q19/00 , C08G77/388 , A61K2800/57
摘要： Disclosed are amino silicone derivatives having triazinyl groups or pyrimidinyl groups bound to amino groups of amino silicones, their production and use, said silicone derivatives being able to gel silicone oil or to increase the viscosity thereof stably and homogeneously, and therefore being useful as bases for cosmetics, pharmaceutical preparations and industrial materials.

28. 发明授权

US4975464A Treatment of diseases caused by abnormal action of elastase 失效
标题翻译：治疗由弹性蛋白酶异常作用引起的疾病
公开(公告)号：US4975464A
公开(公告)日：1990-12-04
申请号：US337812
申请日：1989-04-14
申请人： Katsuhiro Imaki , Yoshinobu Arai , Hiroyuki Ohno
发明人： Katsuhiro Imaki , Yoshinobu Arai , Hiroyuki Ohno
IPC分类号： A61K31/255 , C07C279/18 , C07C309/63 , C07C309/65 , C07C309/66 , C07C311/00 , C07C311/08 , C07C311/29 , C07C311/46 , C07C327/16 , C07C329/10 , C07D213/65 , C07D213/75 , C07D277/04 , C07D277/22 , C07D295/26 , C07D521/00 , A61K31/24
CPC分类号： C07D213/75 , C07C279/18 , C07C309/65 , C07C309/66 , C07C311/08 , C07C311/29 , C07C311/46 , C07C329/10 , C07D213/65 , C07D277/04 , C07D277/22 , C07D295/26
摘要： Compounds presented by the general formula: ##STR1## wherein Y is oxygen, R.sup.2 is H, alkyl, alkoxy, alkoxymethyl, --COOR.sup.3, --CH.sub.2 COOR.sup.3, --CH.dbd.CH--COOR.sup.3, halogen, --CF.sub.3, --COR.sup.4, --OCOR.sup.4, --CH.sub.2 OCOR.sup.4, --SO.sub.2 R.sup.4, --OSO.sub.2 R.sup.4, --CONR.sup.5 R.sup.6, --OCONR.sup.5 R.sup.6, --SO.sub.2 NR.sup.5 R.sup.6, --COHN-- SO.sub.2 NR.sup.5 R.sup.6, --NHSO.sub.2 R.sup.7, --NO.sub.2, --OH, --CH.sub.2 OH, guanidino, benzyloxy, guanidinophenylthiomethyl, morpholinosulfonylphenoxymethyl, pyridyloxymethyl, or (1,1-dioxothiazol-3-yl)carbonyl, or when Y is sulfur, R.sup.2 is H, alkyl, alkoxy, halogen, --COOR.sup.3, --CH.sub.2 COOR.sup.3, --NO.sub.2, or --SO.sub.2 NR.sup.5 R.sup.6, and n represents an integer of one to five, and when n represents more than two, each or R.sup.2 may be the same group or the different group and acid addition salts thereof have inhibitory effect on elastase, and, therefore, are useful for the treatment and/or prevention of diseases induced by abnormal enhancing of degradation of proteins such as elastin and the like, by the action of elastase in mammals, especially in human beings.
摘要翻译：由以下通式表示的化合物：其中Y是氧，R2是H，烷基，烷氧基，烷氧基甲基，-COOR3，-CH2COOR3，-CH = CH-COOR3，卤素，-CF3，-COR4， - OCOR4，-CH2OCOR4，-SO2R4，-OSO2R4，-CONR5R6，-OCONR5R6，-SO2NR5R6，-COHN-SO2NR5R6，-NHSO2R7，-NO2，-OH，-CH2OH，胍基，苄氧基，胍基苯硫基甲基，吗啉代磺酰基苯氧基甲基，吡啶氧基甲基或（1 ，1-二氧代噻唑-3-基）羰基，或当Y为硫时，R 2为H，烷基，烷氧基，卤素，-COOR 3，-CH 2 COOR 3，-NO 2或-SO 2 NR 5 R 6，n为1至5的整数，当n表示2以上时，各个或R2可以是相同的基团，也可以是不同的基团，其酸加成盐对弹性蛋白酶具有抑制作用，因此可用于治疗和/或预防由异常增强引起的疾病蛋白质如弹性蛋白等的降解，通过弹性蛋白酶在哺乳动物，特别是人类中的作用。

29. 发明授权

US4843094A Derivatives of p-guantidinobenzoic acid and pharmaceutical agents containing them as active ingredient 失效
标题翻译：对胍丁基苯甲酸的衍生物和含有它们作为活性成分的药剂
公开(公告)号：US4843094A
公开(公告)日：1989-06-27
申请号：US929317
申请日：1986-11-12
申请人： Katsuhiro Imaki , Yoshinobu Arai , Hiroyuki Ohno
发明人： Katsuhiro Imaki , Yoshinobu Arai , Hiroyuki Ohno
IPC分类号： C07C279/18 , C07C309/65 , C07C309/66 , C07C311/08 , C07C311/29 , C07C311/46 , C07C329/10 , C07D213/65 , C07D213/75 , C07D277/04 , C07D277/22 , C07D295/26
CPC分类号： C07D213/75 , C07C279/18 , C07C309/65 , C07C309/66 , C07C311/08 , C07C311/29 , C07C311/46 , C07C329/10 , C07D213/65 , C07D277/04 , C07D277/22 , C07D295/26
摘要： Compounds presented by the general formula: ##STR1## [wherein when Y is oxygen, R.sup.2 is H, alkyl, alkoxy, alkoxymethyl, --COOR.sup.3, --CH.sub.2 COOR.sup.3, --CH.dbd.CH--COOR.sup.3, halogen, --CF.sub.3, --COR.sup.4, --OCOR.sup.4, --CH.sub.2 OCOR.sup.4, --SO.sub.2 R.sup.4, --OSO.sub.2 R.sup.4, --CONR.sup.5 R.sup.6, --SO.sub.2 NR.sup.5 R.sup.6, --CONH--SO.sub.2 NR.sup.5 R.sup.6, --NHSO.sub.2 R.sup.7, --NO.sub.2, --OH, --CH.sub.2 OH, guanidino, benzyloxy, guanidinophenylthiomethyl, morpholinosulfonylphenoxymethyl, pyridyloxymethyl, or (1,1-dioxothiazol-3-yl)carbonyl, or when Y is sulfur, R.sup.2 is H, alkyl, alkoxy, halogen, --COOR.sup.3, --CH.sub.2 COOR.sup.3, --NO.sub.2, or --SO.sub.2 NR.sup.5 R.sup.6, and n represents an integer of one to five, and when n represents more than two, each of R.sup.2 may be the same group or the different group.] and acid addition salts thereof have inhibitory effect on elastase, and, therefore, are useful for the treatment and/or prevention of diseases induced by abnormal enhancing of degradation of proteins such as elastin and the like, by the action of elastase in mammals, especially in human beings.
摘要翻译：由以下通式表示的化合物：其中当Y为氧时，R 2为H，烷基，烷氧基，烷氧基甲基，-COOR 3，-CH 2 COOR 3，-CH = CH-COOR 3，卤素，-CF 3，-COR 4 ，-OCOR4，-CH2OCOR4，-SO2R4，-OSO2R4，-CONR5R6，-SO2NR5R6，-CONH-SO2NR5R6，-NHSO2R7，-NO2，-OH，-CH2OH，胍基，苄氧基，胍基苯硫基甲基，吗啉代磺酰基苯氧基甲基，吡啶氧基甲基，或（1，或者当Y为硫时，R 2为H，烷基，烷氧基，卤素，-COOR 3，-CH 2 COOR 3，-NO 2或-SO 2 NR 5 R 6，n为1〜5的整数，当n表示两个以上时，R2各自可以是相同的基团或不同的基团。]及其酸加成盐对弹性蛋白酶具有抑制作用，因此可用于治疗和/或预防由异常引起的疾病通过弹性蛋白酶在哺乳动物，特别是人类中的作用，增强蛋白质如弹性蛋白等的降解。

30. 发明申请

US20070231647A1 Proton Conductor and Fuel Cell Using the Same 有权
标题翻译：质子导体和使用它的燃料电池
公开(公告)号：US20070231647A1
公开(公告)日：2007-10-04
申请号：US11574699
申请日：2005-09-01
申请人： Hiroyuki Ohno
发明人： Hiroyuki Ohno
IPC分类号： H01M8/02 , C07C311/48 , C07D233/60 , H01B1/06
CPC分类号： H01M8/04291 , C07C311/48 , H01B1/122 , H01M8/0289 , H01M8/1048 , H01M2300/0025
摘要： The present invention is to provide a novel proton conductor comprising a zwitterionic type ionic liquid that can solve a problem of a complicated and enlarged system caused by installing a system of a humidifying device, a recovering device and a resupplying device that are necessary to keep proton transportation stably in an operation environment of a fuel cell. A proton conductor comprising an ionic liquid having a zwitterion wherein an anion and a cation coexist in one molecule, and a proton donor is provided.
摘要翻译：本发明提供一种包含两性离子型离子液体的新型质子导体，其可以解决由于安装加湿装置，恢复装置和恢复装置系统而引起的复杂和扩大的系统的问题，这些系统是保持质子所必需的在燃料电池的操作环境中稳定地运输。包括具有两性离子的离子液体的质子导体，其中阴离子和阳离子在一个分子中共存，并且提供质子供体。

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