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21. 发明授权

US08815867B2 Inhibitors of c-fms kinase 有权
标题翻译： c-fms激酶抑制剂
公开(公告)号：US08815867B2
公开(公告)日：2014-08-26
申请号：US11736653
申请日：2007-04-18
申请人： Carl R. Illig , Shelley K. Ballentine , Jinsheng Chen , Renee Louise DesJarlais , Sanath K. Meegalla , Mark Wall , Kenneth Wilson
发明人： Carl R. Illig , Shelley K. Ballentine , Jinsheng Chen , Renee Louise DesJarlais , Sanath K. Meegalla , Mark Wall , Kenneth Wilson
IPC分类号： A61K31/496 , C07D403/10
CPC分类号： C07D409/12 , C07D207/34 , C07D233/90 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D493/08 , C12N9/99
摘要： The invention is directed to compounds of Formula I: wherein Z, X, J, R2 and W are set forth in the specification, as well as solvates, hydrates, tautomers and pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase. Methods of treating autoimmune diseases; and diseases with an inflammatory component; treating metastasis from ovarian cancer, uterine cancer, breast cancer, prostate cancer, lung cancer, colon cancer, stomach cancer, hairy cell leukemia; and treating pain, including skeletal pain caused by tumor metastasis or osteoarthritis, or visceral, inflammatory, and neurogenic pain; as well as osteoporosis, Paget's disease, and other diseases in which bone resorption mediates morbidity including rheumatoid arthritis, and other forms of inflammatory arthritis, osteoarthritis, prosthesis failure, osteolytic sarcoma, myeloma, and tumor metastasis to bone with the compounds of Formula I, are also provided.
摘要翻译：本发明涉及式I化合物：其中Z，X，J，R 2和W在本说明书中列出，以及其抑制蛋白酪氨酸激酶，特别是c-型的溶剂化物，水合物，互变异构体和药学上可接受的盐， fms激酶。治疗自身免疫性疾病的方法和具有炎症成分的疾病; 治疗卵巢癌，子宫癌，乳腺癌，前列腺癌，肺癌，结肠癌，胃癌，毛细胞白血病的转移; 并治疗疼痛，包括由肿瘤转移或骨关节炎引起的骨骼疼痛，或内脏，炎症和神经源性疼痛; 骨质疏松症，佩吉特氏病和其他疾病，其中骨吸收介导包括类风湿性关节炎和其它形式的炎症性关节炎，骨关节炎，假体衰竭，溶骨性肉瘤，骨髓瘤和肿瘤转移至骨骼的发病率与式I化合物，也提供。

22. 发明申请

US20070249680A1 INHIBITORS OF C-FMS KINASE 有权
公开(公告)号：US20070249680A1
公开(公告)日：2007-10-25
申请号：US11736644
申请日：2007-04-18
申请人： Carl R. Illig , Shelley K. Ballentine , Jinsheng Chen , Renee Louise DesJarlais , Sanath K. Meegalla , Bruce E. Tomczuk , Mark Wall , Kenneth Wilson
发明人： Carl R. Illig , Shelley K. Ballentine , Jinsheng Chen , Renee Louise DesJarlais , Sanath K. Meegalla , Bruce E. Tomczuk , Mark Wall , Kenneth Wilson
IPC分类号： A61K31/445 , A61K31/12 , A61K31/4164
CPC分类号： C07D409/12 , C07D207/34 , C07D233/90 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D493/08 , C12N9/99
摘要： The invention is directed to compounds of Formula I: wherein Z, X, J, R2 and W are set forth in the specification, as well as solvates, hydrates, tautomers and pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase. Methods of treating autoimmune diseases; and diseases with an inflammatory component; treating metastasis from ovarian cancer, uterine cancer, breast cancer, prostate cancer, lung cancer, colon cancer, stomach cancer, hairy cell leukemia; and treating pain, including skeletal pain caused by tumor metastasis or osteoarthritis, or visceral, inflammatory, and neurogenic pain; as well as osteoporosis, Paget's disease, and other diseases in which bone resorption mediates morbidity including rheumatoid arthritis, and other forms of inflammatory arthritis, osteoarthritis, prosthesis failure, osteolytic sarcoma, myeloma, and tumor metastasis to bone with the compounds of Formula I, are also provided.

23. 发明申请

US20070249649A1 INHIBITORS OF C-FMS KINASE 有权
标题翻译： C-FMS激酶抑制剂
公开(公告)号：US20070249649A1
公开(公告)日：2007-10-25
申请号：US11736635
申请日：2007-04-18
申请人： Carl R. Illig , Shelley K. Ballentine , Jinsheng Chen , Renee Louise DesJarlais , Sanath K. Meegalla , Mark Wall , Kenneth Wilson
发明人： Carl R. Illig , Shelley K. Ballentine , Jinsheng Chen , Renee Louise DesJarlais , Sanath K. Meegalla , Mark Wall , Kenneth Wilson
IPC分类号： A61K31/4747 , A61K31/4545 , A61K31/4439 , C07D403/02
CPC分类号： C07D401/12 , C07C53/18 , C07D233/90 , C07D235/24 , C07D307/68 , C07D401/14 , C07D403/12 , C07D405/12 , C07D491/056
摘要： The invention is directed to compounds of Formula I: wherein Z, X, J, R2 and W are set forth in the specification, as well as solvates, hydrates, tautomers and pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase. Methods of treating autoimmune diseases; and diseases with an inflammatory component; treating metastasis from ovarian cancer, uterine cancer, breast cancer, colon cancer, stomach cancer, hairy cell leukemia and non-small lung carcinoma; and treating pain, including skeletal pain caused by tumor metastasis or osteoarthritis, or visceral, inflammatory, and neurogenic pain; as well as osteoporosis, Paget's disease, and other diseases in which bone resorption mediates morbidity including arthritis, prosthesis failure, osteolytic sarcoma, myeloma, and tumor metastasis to bone with the compounds of Formula I, are also provided.
摘要翻译：本发明涉及式I化合物：其中Z，X，J，R 2和W在本说明书中列出，以及溶剂合物，水合物，互变异构体及其药学上可接受的盐，其中抑制蛋白酪氨酸激酶，特别是c-fms激酶。治疗自身免疫性疾病的方法和具有炎症成分的疾病; 治疗卵巢癌，子宫癌，乳腺癌，结肠癌，胃癌，毛细胞白血病和非小细胞肺癌的转移; 并治疗疼痛，包括由肿瘤转移或骨关节炎引起的骨骼疼痛，或内脏，炎症和神经源性疼痛; 还提供了骨质疏松症，佩吉特氏病和其它骨吸收介导包括关节炎，假体失败，溶骨性骨肉瘤，骨髓瘤以及与式I化合物对骨的肿瘤转移的其它疾病。

24. 发明申请

US20070249608A1 INHIBITORS OF C-FMS KINASE 有权
公开(公告)号：US20070249608A1
公开(公告)日：2007-10-25
申请号：US11736653
申请日：2007-04-18
申请人： Carl R. Illig , Shelley K. Ballentine , Jinsheng Chen , Renee Louise DesJarlais , Sanath K. Meegalla , Mark Wall , Kenneth Wilson
发明人： Carl R. Illig , Shelley K. Ballentine , Jinsheng Chen , Renee Louise DesJarlais , Sanath K. Meegalla , Mark Wall , Kenneth Wilson
IPC分类号： A61K31/415 , A61K31/497 , A61K31/535 , C07D251/54
CPC分类号： C07D409/12 , C07D207/34 , C07D233/90 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D493/08 , C12N9/99
摘要： The invention is directed to compounds of Formula I: wherein Z, X, J, R2 and W are set forth in the specification, as well as solvates, hydrates, tautomers and pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase. Methods of treating autoimmune diseases; and diseases with an inflammatory component; treating metastasis from ovarian cancer, uterine cancer, breast cancer, prostate cancer, lung cancer, colon cancer, stomach cancer, hairy cell leukemia; and treating pain, including skeletal pain caused by tumor metastasis or osteoarthritis, or visceral, inflammatory, and neurogenic pain; as well as osteoporosis, Paget's disease, and other diseases in which bone resorption mediates morbidity including rheumatoid arthritis, and other forms of inflammatory arthritis, osteoarthritis, prosthesis failure, osteolytic sarcoma, myeloma, and tumor metastasis to bone with the compounds of Formula I, are also provided.

25. 发明授权

US08680098B2 Substituted aza-bicyclic imidazole derivatives useful as TRPM8 receptor modulators 有权
标题翻译：用作TRPM8受体调节剂的取代的氮杂 - 双环咪唑衍生物
公开(公告)号：US08680098B2
公开(公告)日：2014-03-25
申请号：US13034922
申请日：2011-02-25
申请人： Mark R. Player , Raul Calvo , Jinsheng Chen , Sanath Meegalla , Daniel Parks , William Parsons , Scott Ballentine , Shawn Branum
发明人： Mark R. Player , Raul Calvo , Jinsheng Chen , Sanath Meegalla , Daniel Parks , William Parsons , Scott Ballentine , Shawn Branum
IPC分类号： C07D471/04 , A61K31/5377 , A61K31/437 , A61K31/52 , A61K31/4985 , A61P29/00 , C07D487/04
CPC分类号： C07D471/04 , C07B2200/13 , C07C53/18 , C07C309/04 , C07D473/00 , C07D487/04
摘要： The present invention is directed to substituted aza-bicyclic imidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by TRP M8, including for example, inflammatory pain, inflammatory hyperalgesia, inflammatory hypersensitivity condition, neuropathic pain, neuropathic cold allodynia, inflammatory somatic hyperalgesia, inflammatory visceral hyperalgesia, cardiovascular disease aggravated by cold and pulmonary disease aggravated by cold.
摘要翻译：本发明涉及取代的氮杂 - 双环咪唑衍生物，含有它们的药物组合物及其用于治疗由TRP M8调节的病症和状况的用途，包括例如炎症性疼痛，炎性痛觉过敏，炎症性超敏反应性病症，神经性疼痛，神经性冷异常性疼痛，炎性体痛痛觉过敏，炎性内脏痛觉过敏，由寒冷和肺部疾病加重的心血管疾病加重。

26. 发明授权

US07795279B2 Method of inhibiting FLT3 kinase 有权
标题翻译：抑制FLT3激酶的方法
公开(公告)号：US07795279B2
公开(公告)日：2010-09-14
申请号：US11550077
申请日：2006-10-17
申请人： Shelley K. Ballentine , Christian Andrew Baumann , Jinsheng Chen , Carl R. Illig , Sanath K. Meegalla , M. Jonathan Rudolph , Robert W. Tuman , Mark J. Wall , Kenneth Wilson , Dana L. Johnson
发明人： Shelley K. Ballentine , Christian Andrew Baumann , Jinsheng Chen , Carl R. Illig , Sanath K. Meegalla , M. Jonathan Rudolph , Robert W. Tuman , Mark J. Wall , Kenneth Wilson , Dana L. Johnson
IPC分类号： A61K31/445 , C07D293/10
CPC分类号： A61K31/4439 , A61K31/454 , A61K31/497 , A61K31/5355 , Y10S514/908
摘要： A method of reducing or inhibiting kinase activity of FLT3 in a cell or a subject, and the use of such compounds for preventing or treating in a subject a cell proliferative disorder and/or disorders related to FLT3 using a compound of the present invention: or a solvate, hydrate, tautomer or pharmaceutically acceptable salt thereof. The present invention is further directed to methods for treating conditions such as cancers and other cell proliferative disorders.
摘要翻译：降低或抑制细胞或受试者中FLT3的激酶活性的方法，以及使用本发明的化合物，在受试者中预防或治疗细胞增殖性病症和/或与FLT3有关的病症的用途：或其溶剂合物，水合物，互变异构体或其药学上可接受的盐。本发明还涉及治疗诸如癌症和其它细胞增殖性疾病的病症的方法。

27. 发明申请

US20070249685A1 INHIBITORS OF C-FMS KINASE 有权
公开(公告)号：US20070249685A1
公开(公告)日：2007-10-25
申请号：US11736650
申请日：2007-04-18
申请人： Carl R. Illig , Jinsheng Chen , Renee Louise DesJarlais , Kenneth Wilson
发明人： Carl R. Illig , Jinsheng Chen , Renee Louise DesJarlais , Kenneth Wilson
IPC分类号： A61K31/44
CPC分类号： C07D409/12 , C07D207/34 , C07D233/90 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D493/08 , C12N9/99
摘要： The invention is directed to compounds of Formula I: wherein Z, X, J, R2 and W are set forth in the specification, as well as solvates, hydrates, tautomers and pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase. Methods of treating autoimmune diseases; and diseases with an inflammatory component; treating metastasis from ovarian cancer, uterine cancer, breast cancer, prostate cancer, lung cancer, colon cancer, stomach cancer, hairy cell leukemia; and treating pain, including skeletal pain caused by tumor metastasis or osteoarthritis, or visceral, inflammatory, and neurogenic pain; as well as osteoporosis, Paget's disease, and other diseases in which bone resorption mediates morbidity including rheumatoid arthritis, and other forms of inflammatory arthritis, osteoarthritis, prosthesis failure, osteolytic sarcoma, myeloma, and tumor metastasis to bone with the compounds of Formula I, are also provided.

28. 发明授权

US08722718B2 Inhibitors of C-FMS kinase 有权
标题翻译： C-FMS激酶抑制剂
公开(公告)号：US08722718B2
公开(公告)日：2014-05-13
申请号：US11736650
申请日：2007-04-18
申请人： Carl R. Illig , Jinsheng Chen , Renee Louise DesJarlais , Kenneth Wilson
发明人： Carl R. Illig , Jinsheng Chen , Renee Louise DesJarlais , Kenneth Wilson
IPC分类号： A61K31/4178 , C07D407/12
CPC分类号： C07D409/12 , C07D207/34 , C07D233/90 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D493/08 , C12N9/99
摘要： The invention is directed to compounds of Formula I: wherein Z, X, J, R2 and W are set forth in the specification, as well as solvates, hydrates, tautomers and pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase. Methods of treating autoimmune diseases; and diseases with an inflammatory component; treating metastasis from ovarian cancer, uterine cancer, breast cancer, prostate cancer, lung cancer, colon cancer, stomach cancer, hairy cell leukemia; and treating pain, including skeletal pain caused by tumor metastasis or osteoarthritis, or visceral, inflammatory, and neurogenic pain; as well as osteoporosis, Paget's disease, and other diseases in which bone resorption mediates morbidity including rheumatoid arthritis, and other forms of inflammatory arthritis, osteoarthritis, prosthesis failure, osteolytic sarcoma, myeloma, and tumor metastasis to bone with the compounds of Formula I, are also provided.
摘要翻译：本发明涉及式I化合物：其中Z，X，J，R 2和W在本说明书中列出，以及其抑制蛋白酪氨酸激酶，特别是c-型的溶剂化物，水合物，互变异构体和药学上可接受的盐， fms激酶。治疗自身免疫性疾病的方法和具有炎症成分的疾病; 治疗卵巢癌，子宫癌，乳腺癌，前列腺癌，肺癌，结肠癌，胃癌，毛细胞白血病的转移; 并治疗疼痛，包括由肿瘤转移或骨关节炎引起的骨骼疼痛，或内脏，炎症和神经源性疼痛; 骨质疏松症，佩吉特氏病和其他疾病，其中骨吸收介导包括类风湿性关节炎和其它形式的炎症性关节炎，骨关节炎，假体衰竭，溶骨性肉瘤，骨髓瘤和肿瘤转移至骨骼的发病率与式I化合物，也提供。

29. 发明授权

US07030112B2 Pyrrolopyridazine compounds and methods of use thereof for the treatment of proliferative disorders 有权
标题翻译：吡咯并哒嗪化合物及其用于治疗增殖性疾病的方法
公开(公告)号：US07030112B2
公开(公告)日：2006-04-18
申请号：US10672850
申请日：2003-09-26
申请人： Mark E. Salvati , Carl R. Illig , Kenneth Jerome Wilson , Jinsheng Chen , Sanath K. Meegalla , Mark James Wall
发明人： Mark E. Salvati , Carl R. Illig , Kenneth Jerome Wilson , Jinsheng Chen , Sanath K. Meegalla , Mark James Wall
IPC分类号： C07D487/04 , C07D487/14 , A61K31/5025 , A61P5/28 , A61P35/00
CPC分类号： C07D487/04 , A61K31/5025 , A61K45/06 , C07D519/00 , A61K2300/00
摘要： Disclosed are pyrrolopyridazine compounds of the formula, wherein the substituents are defined herein, methods of preparing such compounds, and their use for the treatment of proliferative, inflammatory, and other disorders.
摘要翻译：公开了下式的吡咯并哒嗪化合物，其中取代基在本文中定义，制备此类化合物的方法及其用于治疗增殖性，炎症性和其它障碍的用途。

30. 发明授权

US08497376B2 Inhibitors of c-fms kinase 有权
标题翻译： c-fms激酶抑制剂
公开(公告)号：US08497376B2
公开(公告)日：2013-07-30
申请号：US12252439
申请日：2008-10-16
申请人： Carl R. Illig , Jinsheng Chen , Sanath K. Meegalia , Mark J. Wall
发明人： Carl R. Illig , Jinsheng Chen , Sanath K. Meegalia , Mark J. Wall
IPC分类号： C07D405/14 , C07D471/04 , C07D493/08
CPC分类号： C07D401/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D471/08 , C07D493/08
摘要： The invention is directed to compounds of Formula I: wherein Z, X, J, R2 and W are set forth in the specification, as well as solvates, hydrates, tautomers and pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase. Methods of treating autoimmune diseases; and diseases with an inflammatory component; treating metastasis from ovarian cancer, uterine cancer, breast cancer, prostate cancer, lung cancer, colon cancer, stomach cancer, hairy cell leukemia; and treating pain, including skeletal pain caused by tumor metastasis or osteoarthritis, or visceral, inflammatory, and neurogenic pain; as well as osteoporosis, Paget's disease, and other diseases in which bone resorption mediates morbidity including rheumatoid arthritis, and other forms of inflammatory arthritis, osteoarthritis, prosthesis failure, osteolytic sarcoma, myeloma, and tumor metastasis to bone with the compounds of Formula I, are also provided.
摘要翻译：本发明涉及式I化合物：其中Z，X，J，R 2和W在本说明书中列出，以及其抑制蛋白酪氨酸激酶，特别是c-型的溶剂化物，水合物，互变异构体和药学上可接受的盐， fms激酶。治疗自身免疫性疾病的方法和具有炎症成分的疾病; 治疗卵巢癌，子宫癌，乳腺癌，前列腺癌，肺癌，结肠癌，胃癌，毛细胞白血病的转移; 并治疗疼痛，包括由肿瘤转移或骨关节炎引起的骨骼疼痛，或内脏，炎症和神经源性疼痛; 骨质疏松症，佩吉特氏病和其他疾病，其中骨吸收介导包括类风湿性关节炎和其它形式的炎症性关节炎，骨关节炎，假体衰竭，溶骨性肉瘤，骨髓瘤和肿瘤转移至骨骼的发病率与式I化合物，也提供。

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