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21. 发明申请

US20100069290A1 EJECTION LIQUID AND EJECTION METHOD 审中-公开
标题翻译：喷射液体和喷射方法
公开(公告)号：US20100069290A1
公开(公告)日：2010-03-18
申请号：US12517056
申请日：2007-11-09
申请人： Yohei Masada , Masaru Sugita , Hideki Kaneko , Naoko Sakurada
发明人： Yohei Masada , Masaru Sugita , Hideki Kaneko , Naoko Sakurada
IPC分类号： A61K47/18 , A61K38/02 , C07C309/02 , C07C279/04 , A61M16/10 , A61M15/00
CPC分类号： B65D83/00 , A61K9/0073 , A61K38/00 , A61K47/183 , A61M11/001 , A61M15/025
摘要： The ejection liquid of the present invention includes a compound having a guanidine group, and a carboxyl group or a sulfonic acid group in one molecule, and being represented by the general formula (1), or a salt of the compound, for the purpose of stably ejecting a solution including at least one of a protein and a peptide by imparting thermal energy to the solution.
摘要翻译：本发明的喷射液体包括在一个分子中具有胍基，羧基或磺酸基的化合物，并且由通式（1）表示，或化合物的盐，为了通过向溶液赋予热能来稳定地喷射包含蛋白质和肽中的至少一种的溶液。

22. 发明申请

US20080011292A1 METHOD FOR CONTROLLING EJECTION OF MEDICINES AND MEDICINE EJECTION APPARATUS 审中-公开
标题翻译：用于控制药物和药物喷射装置的控制方法
公开(公告)号：US20080011292A1
公开(公告)日：2008-01-17
申请号：US11768305
申请日：2007-06-26
申请人： Masaru Sugita , Soji Hamano , Shinji Watanabe , Mitsuru Imai
发明人： Masaru Sugita , Soji Hamano , Shinji Watanabe , Mitsuru Imai
IPC分类号： A61M11/06
CPC分类号： A61M15/00 , A61M5/16827 , A61M15/0003 , A61M15/0085 , A61M15/025 , A61M2205/12 , A61M2205/3569 , A61M2205/3592 , A61M2205/50 , A61M2205/581 , A61M2205/582 , A61M2205/583 , A61M2205/587 , A61M2205/60 , A61M2205/6072
摘要： A medicine ejection apparatus ejecting a plurality of medicines contained in a plurality of reservoirs includes a medicine identification section that identifies the medicines. A decision section is also provided to decide an ejection order in which the medicines are ejected, according to the combination of the identified medicines. In a medicine ejection section, the medicines are ejected in the ejection order decided by the decision section.
摘要翻译：一种喷射多个储存器中所含的多种药物的药物喷射装置，其特征在于，具备鉴定上述药剂的药物识别部。还提供决定部分，根据所鉴定的药物的组合来决定喷射药物的排出顺序。在药物喷射部中，以由决定部决定的喷射顺序喷射药品。

23. 发明授权

US08833363B2 Ejection liquid, ejection method, method for forming liquid droplets, liquid ejection cartridge and ejection apparatus 有权
标题翻译：喷射液体，喷射方法，液滴形成方法，液体喷射盒和喷射装置
公开(公告)号：US08833363B2
公开(公告)日：2014-09-16
申请号：US12968088
申请日：2010-12-14
申请人： Yohei Masada , Masaru Sugita , Hideki Kaneko , Takeshi Miyazaki
发明人： Yohei Masada , Masaru Sugita , Hideki Kaneko , Takeshi Miyazaki
IPC分类号： A61M11/00 , B41J2/06 , A61K38/00 , A61M15/00 , B41J2/05 , C12N5/00 , C11D10/00
CPC分类号： A61K9/0073 , A61M15/025 , B01J2219/00378
摘要： An ejection liquid capable of being stably ejected based on a system using thermal energy even if the liquid contains at least one selected from the group consisting of proteins and peptides, and a method and an apparatus for ejecting the liquid containing at least one selected from the group consisting of proteins and peptides using this system are provided. The applicability of the liquid for use in an inkjet system using thermal energy is improved by adding at least one selected from the group consisting of amino acids and salts thereof and a surfactant to an aqueous solution containing at least one selected from the group consisting of proteins and peptides.
摘要翻译：即使液体含有选自蛋白质和肽的组中的至少一种，能够基于使用热能的系统稳定地喷射的喷射液，以及用于喷射含有选自以下的至少一种的液体的方法和装置：提供了使用该系统的由蛋白质和肽组成的组。使用热能的喷墨系统中使用的液体的适用性通过将选自氨基酸及其盐和表面活性剂中的至少一种添加到含有选自蛋白质组中的至少一种的水溶液中而得到改善和肽。

24. 发明申请

US20110104113A1 EJECTION LIQUID, EJECTION METHOD, METHOD OF MAKING DROPLETS FROM LIQUID, CARTRIDGE AND EJECTION DEVICE 失效
标题翻译：喷射液体，喷射方法，从液体，喷射和喷射装置制造液滴的方法
公开(公告)号：US20110104113A1
公开(公告)日：2011-05-05
申请号：US12987016
申请日：2011-01-07
申请人： Masaru Sugita , Yohei Masada , Hideki Kaneko
发明人： Masaru Sugita , Yohei Masada , Hideki Kaneko
IPC分类号： A61K38/21 , A61K38/00 , A61K38/23 , A61K38/28 , A61K38/26 , A61K38/18 , A61K39/395 , A61K38/19 , A61P11/00
CPC分类号： A61M15/0065 , A61K9/0009 , A61K9/007 , A61K9/0073 , A61M11/005 , A61M11/042 , A61M15/0003 , A61M15/025 , B01L3/0268 , G01N35/1002 , G01N2035/1041
摘要： The present invention provides a liquid composition, as an ejection liquid used for stably ejecting liquid droplets, including at least one kind of a protein and a peptide, and a compound having a betaine skeleton by application of thermal energy to the liquid; a method of making droplets form the liquid; and an ejection method and an ejection device suitable for utilizing protein liquid droplets. By adding a compound having a betaine skeleton to an aqueous solution of at least one kind of a protein and a peptide, the liquid composition is improved in stability for ejection by application of thermal energy. Further, a surfactant may be further added to the liquid composition containing the compound having a betaine skeleton, and in this case the effect of stable ejection can be obtained.
摘要翻译：本发明提供一种液体组合物，作为用于稳定地喷射液滴的液体组合物，包括至少一种蛋白质和肽，以及通过向液体施加热能而具有甜菜碱骨架的化合物; 使液滴形成液体的方法; 以及适于利用蛋白质液滴的喷射方法和喷射装置。通过向至少一种蛋白质和肽的水溶液中加入具有甜菜碱骨架的化合物，通过施加热能提高了液体组合物的喷射稳定性。此外，还可以在含有具有甜菜碱骨架的化合物的液体组合物中进一步添加表面活性剂，在这种情况下，可以获得稳定的喷射效果。

25. 发明授权

US07827982B2 Ejection liquid and ejection method 有权
标题翻译：喷射液和喷射方法
公开(公告)号：US07827982B2
公开(公告)日：2010-11-09
申请号：US11724299
申请日：2007-03-15
申请人： Yohei Masada , Masaru Sugita , Hideki Kaneko , Takeshi Miyazaki
发明人： Yohei Masada , Masaru Sugita , Hideki Kaneko , Takeshi Miyazaki
IPC分类号： A61M11/00
CPC分类号： A61K47/16 , A61K9/0078 , A61K38/00 , A61K47/26 , A61M15/025 , A61M2205/123 , A61M2205/8206 , B41J29/13 , C09D11/30 , Y10S514/866
摘要： There is provided an ejection liquid which can be ejected stably by an inkjet method even in the case of containing at least one of proteins and peptides and is provided a method and device of discharging a liquid containing at least one of proteins and peptides, which use the ejection liquid. The ejection liquid to be ejected from ejection orifice by an inkjet method contains at least one selected from proteins and peptides, a benzalkonium chloride and a liquid medium.
摘要翻译：提供了即使在含有蛋白质和肽中的至少一种的情况下也可以通过喷墨法稳定喷射的喷射液体，并且提供了一种排出含有至少一种蛋白质和肽的液体的方法和装置，其使用喷射液体。通过喷墨方法从喷射口喷射的喷射液体含有选自蛋白质和肽，苯扎氯铵和液体介质中的至少一种。

26. 发明申请

US20100089394A1 INHALER AND DRIVING METHOD FOR SAME 审中-公开
标题翻译：吸入和驱动方法
公开(公告)号：US20100089394A1
公开(公告)日：2010-04-15
申请号：US12598121
申请日：2008-05-30
申请人： Naoko Sakurada , Masaru Sugita , Hideki Kaneko , Yohei Masada
发明人： Naoko Sakurada , Masaru Sugita , Hideki Kaneko , Yohei Masada
IPC分类号： A61M15/00
CPC分类号： A61B5/087 , A61B5/411 , A61B5/4839 , A61M11/001 , A61M15/0065 , A61M15/025 , A61M2016/0036 , A61M2205/123 , A61M2205/502 , A61M2205/52 , A61M2205/70 , A61M2205/8206 , A61M2230/46 , A61M2230/005
摘要： The present invention provides an inhaler capable of measuring lung function, feeding back the measurements, and administering medicine suitable for a lung condition in a single use. The inhaler 1 of the present invention includes a lung function measuring unit 2 having a spirometer for measuring lung function, and, using a computing unit 5, compares the lung function measurements with a medication pattern table stored in a storage unit 7 and determines a disease severity and a diseased region of the lung. Based on the determination results, the computing unit further selects types and particle diameters of medicines suitable for the lung condition, and controls an ejection unit 3 including a plurality of ejection portions to eject the medicines required for treatment in a single use.
摘要翻译：本发明提供一种能够测量肺功能，反馈测量值，以及一次使用适用于肺部病症的药物的吸入器。本发明的吸入器1包括具有用于测量肺功能的肺活量计的肺功能测量单元2，并且使用计算单元5将肺功能测量与存储在存储单元7中的药物模式表进行比较并确定疾病严重程度和肺部疾病区域。基于判定结果，计算单元进一步选择适合于肺部状态的药物的种类和粒径，并且控制包括多个喷射部的喷射单元3，以一次性地喷射治疗所需的药剂。

27. 发明申请

US20090060869A1 EJECTION LIQUID, EJECTION METHOD, METHOD OF MAKING DROPLETS FROM LIQUID, CARTRIDGE AND EJECTION DEVICE 审中-公开
标题翻译：喷射液体，喷射方法，从液体，喷射和喷射装置制造液滴的方法
公开(公告)号：US20090060869A1
公开(公告)日：2009-03-05
申请号：US11908600
申请日：2006-03-28
申请人： Masaru Sugita , Yohei Masada , Hideki Kaneko
发明人： Masaru Sugita , Yohei Masada , Hideki Kaneko
IPC分类号： A61K38/21 , A61K38/02 , A61K38/23 , A61K39/395 , A61K38/28 , A61K38/26
CPC分类号： A61M15/0065 , A61K9/0009 , A61K9/007 , A61K9/0073 , A61M11/005 , A61M11/042 , A61M15/0003 , A61M15/025 , B01L3/0268 , G01N35/1002 , G01N2035/1041
摘要： The present invention provides a liquid composition, as an ejection liquid used for stably ejecting liquid droplets, including at least one kind of a protein and a peptide, and a compound having a betaine skeleton by application of thermal energy to the liquid; a method of making droplets form the liquid; and an ejection method and an ejection device suitable for utilizing protein liquid droplets. By adding a compound having a betaine skeleton to an aqueous solution of at least one kind of a protein and a peptide, the liquid composition is improved in stability for ejection by application of thermal energy. Further, a surfactant may be further added to the liquid composition containing the compound having a betaine skeleton, and in this case the effect of stable ejection can be obtained.
摘要翻译：本发明提供一种液体组合物，作为用于稳定地喷射液滴的液体组合物，包括至少一种蛋白质和肽，以及通过向液体施加热能而具有甜菜碱骨架的化合物; 使液滴形成液体的方法; 以及适于利用蛋白质液滴的喷射方法和喷射装置。通过向至少一种蛋白质和肽的水溶液中加入具有甜菜碱骨架的化合物，通过施加热能提高了液体组合物的喷射稳定性。此外，还可以在含有具有甜菜碱骨架的化合物的液体组合物中进一步添加表面活性剂，在这种情况下，可以获得稳定的喷射效果。

28. 发明申请

US20090053174A1 EJECTION LIQUID, EJECTION METHOD, METHOD FOR FORMING LIQUID DROPLETS, LIQUID EJECTION CARTRIDGE AND EJECTION APPARATUS 审中-公开
标题翻译：喷射液体，喷射方法，形成液体滴液的方法，液体喷射装置和喷射装置
公开(公告)号：US20090053174A1
公开(公告)日：2009-02-26
申请号：US11909249
申请日：2006-04-27
申请人： Hideki Kaneko , Masaru Sugita , Yohei Masada , Takeshi Miyazaki
发明人： Hideki Kaneko , Masaru Sugita , Yohei Masada , Takeshi Miyazaki
IPC分类号： A61K38/21 , A61K38/00 , A61K39/395 , A61M15/00 , B41J2/175
CPC分类号： A61K9/0073 , A61K47/18 , C09D11/38
摘要： There are provided an ejection liquid that contains at least one of proteins and peptides and can be ejected stably by an ink jet system, and a method and apparatus for ejecting a liquid containing at least one of proteins and peptides using the ejection liquid. A specific amine is added to an aqueous solution of at least one of proteins and peptides to thereby improve the applicability to ejection by the ink jet system.
摘要翻译：提供了包含蛋白质和肽中的至少一种并且可以通过喷墨系统稳定喷射的喷射液体，以及使用喷射液体喷射含有至少一种蛋白质和肽的液体的方法和装置。将特定的胺加入到蛋白质和肽中的至少一种的水溶液中，从而提高由喷墨系统喷射的适用性。

29. 发明申请

US20060065755A1 Atomization method, atomizer based on atomization method, and atomization liquid composition 审中-公开
标题翻译：雾化法，雾化法雾化法和雾化液组成
公开(公告)号：US20060065755A1
公开(公告)日：2006-03-30
申请号：US11231782
申请日：2005-09-22
申请人： Masaru Sugita , Takeshi Miyazaki , Hideki Kaneko , Yohei Masada
发明人： Masaru Sugita , Takeshi Miyazaki , Hideki Kaneko , Yohei Masada
IPC分类号： A01G25/09 , A62C5/02 , B05B7/16 , B05B17/00
CPC分类号： A61M15/0065 , A61M15/025 , A61M2205/588 , B05B7/16
摘要： A liquid containing in an aqueous solvent a predetermined concentration of a drug compound used for therapeutic purposes is atomized. The liquid contains a scenting agent and/or a flavoring agent in an aqueous solvent, in addition to the drug compound. Fine droplets of the liquid are ejected through a thermal inkjet system as mist. The scenting agent or the flavoring agent is used for detection of atomization.
摘要翻译：将含有预定浓度的用于治疗目的的药物化合物的水溶液中的液体雾化。除了药物化合物之外，液体还含有水性溶剂中的香味剂和/或调味剂。液体的微小液滴通过热喷墨系统喷雾。香味剂或调味剂用于雾化检测。

30. 发明授权

US4462021A Digital-to-analog converter that compensates for integrated circuit resistor variations 失效
标题翻译：用于补偿集成电路电阻变化的数模转换器
公开(公告)号：US4462021A
公开(公告)日：1984-07-24
申请号：US347551
申请日：1982-02-10
申请人： Kazuo Watanabe , Masaru Sugita
发明人： Kazuo Watanabe , Masaru Sugita
IPC分类号： H03M1/76 , H03M1/00 , H03K13/02
CPC分类号： H03M1/74
摘要： A D/A converter is comprised of a string of resistors coupled to a voltage source with respective junctions formed between adjacent resistors, including a reference junction substantially at the mid-point of the resistor string. Plural switches are coupled to the junctions and are selectively operable to couple a potential produced at a respective junction. A subtracting circuit has one input coupled in common to a first set of the switches and another input coupled in common to a second set of the switches to subtract the potential coupled from one set from the potential coupled from the other set so as to produce an output analog signal. A switch control circuit is responsive to a multi-bit digital signal for operating predetermined switches in both the first and second sets and thereby couple to the subtracting circuit the potentials which are produced at corresponding junctions on either side of the reference junction.
摘要翻译： D / A转换器包括一组耦合到电压源的电阻器，其中相邻的电阻器之间形成相应的结，包括基本上在电阻器串的中点处的基准结。多个开关耦合到结点并且可选择性地可操作以耦合在相应结处产生的电位。减法电路具有一个共同连接到第一组开关的输入端，另一个输入端共同耦合到第二组开关，以减去从一组与从另一组耦合的电位耦合的电位，以产生一个输出模拟信号。开关控制电路响应于用于在第一和第二组中操作预定开关的多位数字信号，从而耦合到减法电路，在参考接点的任一侧上的相应接合处产生的电位。

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