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21. 发明授权

US09051590B2 Acetyl-CoA carboxylase 有权
标题翻译：乙酰CoA羧化酶
公开(公告)号：US09051590B2
公开(公告)日：2015-06-09
申请号：US13254512
申请日：2010-03-17
申请人： Misa Ochiai , Eiji Sakuradani , Sakayu Shimizu , Jun Ogawa
发明人： Misa Ochiai , Eiji Sakuradani , Sakayu Shimizu , Jun Ogawa
IPC分类号： C07H21/02 , C07H21/04 , C12Q1/68 , C12P21/06 , C12P21/04 , C12N15/00 , C12P7/64 , A23L1/30 , C12N9/00
CPC分类号： C12P7/6427 , A23L33/115 , A23V2002/00 , C12N9/93 , C12Y604/01002 , A23V2250/1882
摘要： The present invention provides a novel acetyl-CoA carboxylase.The object of the present invention is attained by the nucleotide sequence of SEQ ID NO: 1 and the amino acid sequence of SEQ ID NO: 2 of the present invention.
摘要翻译：本发明提供了一种新的乙酰辅酶A羧化酶。本发明的目的是通过本发明的SEQ ID NO：1的核苷酸序列和SEQ ID NO：2的氨基酸序列来实现的。

22. 发明授权

US08841097B2 Process for producing unsaturated fatty acid-containing oils 有权
标题翻译：用于生产不饱和脂肪酸的油的方法
公开(公告)号：US08841097B2
公开(公告)日：2014-09-23
申请号：US11407984
申请日：2006-04-21
申请人： Kenichi Higashiyama , Kengo Akimoto , Sakayu Shimizu
发明人： Kenichi Higashiyama , Kengo Akimoto , Sakayu Shimizu
IPC分类号： C12P7/64 , A61K31/20 , C07C53/00 , A23L1/30 , A23D9/00 , A23K1/16 , A23L1/29
CPC分类号： C12P7/6472 , A23D9/00 , A23K20/158 , A23L33/12 , A23L33/40 , A23V2002/00 , C12P7/64 , Y10S426/801 , Y10S426/807 , A23V2250/54252 , A23V2250/1874 , A23V2250/1868 , A23V2250/1862 , A23V2250/187 , A23V2250/612 , A23V2250/28 , A23V2250/70 , A23V2250/156
摘要： An edible oil obtained by culturing a microorganism belong to the genus Mortierella subgenus Mortierella in a medium containing a nitrogen source derived from soybean is discussed. The oils obtained have a low 24,25-methylenecholest-5-en-3β-ol content.
摘要翻译：通过在含有源自大豆的氮源的培养基中培养微生物而获得的食用油属于被孢霉属（Mortierella subgenus Mortidalla）属。获得的油具有低的24,25-亚甲基胆甾-5-烯-3β-醇含量。

23. 发明授权

US08367381B2 Method for producing 4-hydroxy-L-isoleucine 有权
标题翻译：生产4-羟基-L-异亮氨酸的方法
公开(公告)号：US08367381B2
公开(公告)日：2013-02-05
申请号：US13344170
申请日：2012-01-05
申请人： Tomohiro Kodera , Sergey Vasilievich Smirnov , Natalia Nikolaevna Samsonova , Veronika Aleksandrovna Kotliarova , Natalia Yurievna Rushkevich , Sakayu Shimizu , Jun Ogawa , Makoto Hibi , Vitaly Grigorievich Paraskevov
发明人： Tomohiro Kodera , Sergey Vasilievich Smirnov , Natalia Nikolaevna Samsonova , Veronika Aleksandrovna Kotliarova , Natalia Yurievna Rushkevich , Yury Ivanovich Kozlov , Sakayu Shimizu , Jun Ogawa , Makoto Hibi
IPC分类号： C12P13/06 , C12P21/06 , C12P21/04 , C12N9/02 , C12N1/20 , C12N15/00 , C12Q1/26 , C07H21/04
CPC分类号： C12N9/0069 , C12P13/06
摘要： A highly active L-isoleucine dioxygenase from Bacillus thuringiensis is provided. A method for manufacturing (2S,3R,4S)-4-hydroxy-L-isoleucine or a salt thereof by reacting L-isoleucine in an aqueous solvent in the presence of L-isoleucine dioxygenase and isolating (2S,3R,4S)-4-hydroxy-L-isoleucine is also provided.
摘要翻译：提供了一种来自苏云金芽孢杆菌的高活性L-异亮氨酸双加氧酶。在L-异亮氨酸双加氧酶存在下，通过使L-异亮氨酸在水性溶剂中反应，并分离（2S，3R，4S） - 还提供了4-羟基-L-异亮氨酸。

24. 发明申请

US20120107883A1 METHOD FOR PRODUCING 4-HYDROXY-L-ISOLEUCINE 有权
公开(公告)号：US20120107883A1
公开(公告)日：2012-05-03
申请号：US13344170
申请日：2012-01-05
申请人： Tomohiro Kodera , Sergey Vasilievich Smirnov , Natalia Nikolaevna Samsonova , Veronika Aleksandrovna Kotliarova , Natalia Yurievna Rushkevich , Yury Ivanovich Kozlov , Vitaly Grigorievich Paraskevov , Sakayu Shimizu , Jun Ogawa , Makoto Hibi
发明人： Tomohiro Kodera , Sergey Vasilievich Smirnov , Natalia Nikolaevna Samsonova , Veronika Aleksandrovna Kotliarova , Natalia Yurievna Rushkevich , Yury Ivanovich Kozlov , Vitaly Grigorievich Paraskevov , Sakayu Shimizu , Jun Ogawa , Makoto Hibi
IPC分类号： C12P13/06
CPC分类号： C12N9/0069 , C12P13/06
摘要： A highly active L-isoleucine dioxygenase from Bacillus thuringiensis is provided. A method for manufacturing (2S,3R,4S)-4-hydroxy-L-isoleucine or a salt thereof by reacting L-isoleucine in an aqueous solvent in the presence of L-isoleucine dioxygenase and isolating (2S,3R,4S)-4-hydroxy-L-isoleucine is also provided.

25. 发明授权

US07794993B2 Carbonyl reductase, gene thereof and method of using the same 有权
标题翻译：羰基还原酶，其基因及其使用方法
公开(公告)号：US07794993B2
公开(公告)日：2010-09-14
申请号：US11659481
申请日：2005-08-01
申请人： Noriyuki Kizaki , Miho Yano , Masahiro Funaki , Teruaki Takesue , Yoshihiko Yasohara , Souichi Morikawa , Takahisa Nakai , Michihiko Kataoka , Sakayu Shimizu
发明人： Noriyuki Kizaki , Miho Yano , Masahiro Funaki , Teruaki Takesue , Yoshihiko Yasohara , Souichi Morikawa , Takahisa Nakai , Michihiko Kataoka , Sakayu Shimizu
IPC分类号： C07H21/00 , C12N15/00 , C12N5/10 , C12N1/21 , C12P7/16 , C12P21/00 , C12N9/02 , C07K14/00
CPC分类号： C12P13/02 , C12N9/0006 , C12P41/002
摘要： The present invention relates to a polypeptide having an activity to asymmetrically reduce (3S)-1-chloro-3-tert-butoxycarbonylamino-4-phenyl-2-butanone to produce (2R,3S)-1-chloro-3-tert-butoxycarbonylamino-4-phenyl-2-butanol isolated from a microorganism belonging to the genus Ogataea, a DNA encoding the polypeptide and a transformant that produces the polypeptide. The present invention moreover relates to a method of producing (2R,3S)-1-chloro-3-tert-butoxycarbonylamino-4-phenyl-2-butanol utilizing the polypeptide or the transformant. Using the polypeptide or transformant of the present invention, optically active alcohols such as (2R,3S)-1-chloro-3-tert-butoxycarbonylamino-4-phenyl-2-butanol and the like can be produced efficiently.
摘要翻译：本发明涉及具有不对称还原（3S）-1-氯-3-叔丁氧基羰基氨基-4-苯基-2-丁酮的活性以产生（2R，3S）-1-氯-3-叔丁氧基羰基氨基-4- 从属于Ogataea的微生物分离的丁氧基羰基氨基-4-苯基-2-丁醇，编码多肽的DNA和产生多肽的转化体。本发明还涉及利用多肽或转化体制备（2R，3S）-1-氯-3-叔丁氧基羰基氨基-4-苯基-2-丁醇的方法。使用本发明的多肽或转化体，可以有效地制备光学活性醇如（2R，3S）-1-氯-3-叔丁氧基羰基氨基-4-苯基-2-丁醇等。

26. 发明申请

US20070298467A1 Method of preparing 2-deoxyribose 5-phosphate 有权
标题翻译： 2-脱氧核糖5-磷酸的制备方法
公开(公告)号：US20070298467A1
公开(公告)日：2007-12-27
申请号：US11878553
申请日：2007-07-25
申请人： Sakayu Shimizu , Jun Ogawa
发明人： Sakayu Shimizu , Jun Ogawa
IPC分类号： C12P19/02
CPC分类号： C12R1/22 , C12N9/88 , C12N9/90 , C12P19/02
摘要： The present invention discloses a method of preparing 2-deoxyribose 5-phosphate by reacting glyceraldehyde 3-phosphate and acetaldehyde in the presence of either a microorganism itself which contains 2-deoxyribose-5-phosphate aldolase but substantially no phosphatase or the enzyme derived from the microorganism. The present invention also discloses a method of preparing 2-deoxyribose 5-phosphate by reacting dihydroxyacetone phosphate and acetaldehyde in the presence of either a microorganism itself which contains 2-deoxyribose-5-phosphate aldolase and triose-phosphate isomerase but substantially no phosphatase or the enzymes derived from the microorganism.
摘要翻译：本发明公开了一种在含有2-脱氧核糖-5-磷酸醛缩酶但基本上不含磷酸酶的微生物本身存在下使甘油醛-3-磷酸和乙醛反应制备2-脱氧核糖-5-磷酸的方法，微生物。本发明还公开了在含有2-脱氧核糖-5-磷酸醛缩酶和丙糖磷酸异构酶但基本上不含磷酸酶的微生物本身的存在下使磷酸二羟丙酮和乙醛反应制备2-脱氧核糖-5-磷酸的方法，或者源于微生物的酶。

27. 发明授权

US07270992B2 Method of preparing 2-deoxyribose 5-phosphate 有权
公开(公告)号：US07270992B2
公开(公告)日：2007-09-18
申请号：US10652252
申请日：2003-09-02
申请人： Sakayu Shimizu , Jun Ogawa
发明人： Sakayu Shimizu , Jun Ogawa
IPC分类号： C12P19/02
CPC分类号： C12R1/22 , C12N9/88 , C12N9/90 , C12P19/02
摘要： The present invention discloses a method of preparing 2-deoxyribose 5-phosphate by reacting glyceraldehyde 3-phosphate and acetaldehyde in the presence of either a microorganism itself which contains 2-deoxyribose-5-phosphate aldolase but substantially no phosphatase or the enzyme derived from the microorganism. The present invention also discloses a method of preparing 2-deoxyribose 5-phosphate by reacting dihydroxyacetone phosphate and acetaldehyde in the presence of either a microorganism itself which contains 2-deoxyribose-5-phosphate aldolase and triose-phosphate isomerase but substantially no phosphatase or the enzymes derived from the microorganism.

28. 发明申请

US20070134775A1 Process for producing lactonase and utilization thereof 审中-公开
标题翻译：生产内酯酶的方法及其利用
公开(公告)号：US20070134775A1
公开(公告)日：2007-06-14
申请号：US10547424
申请日：2004-03-03
申请人： Sakayu Shimizu , Michihiko Kataoka , Keiji Sakamoto
发明人： Sakayu Shimizu , Michihiko Kataoka , Keiji Sakamoto
IPC分类号： C12P17/06 , C12N9/16 , C12N1/18
CPC分类号： C12P41/003 , C12N9/18 , C12P17/04
摘要： It has been required to economically produce a large amount of optically active γ-lactone derivatives (for example, pantolactone), which are useful as intermediates in synthesizing useful substances such as pharmaceutical drugs. To achieve this object, it is advantageous to employ an enzymatic technique of asymmetric hydrolysis with a hydrolyzing enzyme lactonase. However, it remains troublesome to prepare the enzyme or utilize a microorganism capable of producing the enzyme. Also, it is difficult to obtain a sufficient and stable enzymatic activity in the case of using recombination techniques. In producing lactonase, which asymmetrically hydrolyzes a γ-lactone derivative such as racemic pantolactone selectively, by a recombination technique, both mature lactonase DNA and signal peptide region DNA are transferred into a host. Thus, a stable lactonase activity comparable to naturally-occurring one can be achieved and a transformant sustaining a high enzyme activity in a stable manner can be acquired, thereby allowing the efficient and industrially advantageous asymmetric synthesis of γ-lactone derivatives.
摘要翻译：需要经济地生产大量的用作合成有用物质如药物的中间体的光学活性γ-内酯衍生物（例如泛酸内酯）。为了达到这个目的，使用水解酶内酯酶的不对称水解酶技术是有利的。然而，制备酶或利用能够产生酶的微生物仍然是麻烦的。此外，在使用重组技术的情况下，难以获得足够稳定的酶活性。在制备内含子选择性地水解γ-内酯衍生物如外消旋泛酸内酯的内切酶中，通过重组技术，将成熟内含酶DNA和信号肽区DNA两者转移到宿主中。因此，可以获得与天然存在的活性相当的稳定的内含酶活性，并且可以获得以稳定的方式维持高酶活性的转化体，从而允许有效和工业上有利的γ-内酯衍生物的不对称合成。

29. 发明申请

US20060252736A1 Process for producing unsaturated fatty acid-containing oils 有权
公开(公告)号：US20060252736A1
公开(公告)日：2006-11-09
申请号：US11482901
申请日：2006-07-10
申请人： Kenichi Higashiyama , Kengo Akimoto , Sakayu Shimizu
发明人： Kenichi Higashiyama , Kengo Akimoto , Sakayu Shimizu
IPC分类号： C12P7/64 , A61K31/56
CPC分类号： C12P7/6472 , A23D9/00 , A23K20/158 , A23L33/12 , A23L33/40 , A23V2002/00 , C12P7/64 , Y10S426/801 , Y10S426/807 , A23V2250/54252 , A23V2250/1874 , A23V2250/1868 , A23V2250/1862 , A23V2250/187 , A23V2250/612 , A23V2250/28 , A23V2250/70 , A23V2250/156
摘要： An edible oil obtained by culturing a microorganism belong to the genus Mortierella subgenus Mortierella in a medium containing a nitrogen source derived from soybean is discussed. The oils obtained have a low 24,25-methylenecholest-5-en-3β-ol content.

30. 发明授权

US06835559B2 Process for the production of optically active &bgr;-amino alcohols 失效
标题翻译：光学活性β-氨基醇的制备方法
公开(公告)号：US06835559B2
公开(公告)日：2004-12-28
申请号：US10240056
申请日：2003-01-22
申请人： Keiji Sakamoto , Shinji Kita , Kazuya Tsuzaki , Tadanori Morikawa , Sakayu Shimizu , Michihiko Kataoka
发明人： Keiji Sakamoto , Shinji Kita , Kazuya Tsuzaki , Tadanori Morikawa , Sakayu Shimizu , Michihiko Kataoka
IPC分类号： C12P1300
CPC分类号： C12P13/001 , C12P13/008 , C12P41/002 , Y10S435/822 , Y10S435/865 , Y10S435/877 , Y10S435/911 , Y10S435/914 , Y10S435/917 , Y10S435/918
摘要： A process for producing an optical active &bgr;-amino alcohol, the method comprising the step of allowing at least one microorganism selected from the group consisting of microorganisms belonging to the genus Morganella and others, to act on an enantiomeric mixture of an &agr;-aminoketone or a salt thereof having the general formula (I): to produce an optical active &bgr;-amino alcohol with the desired optical activity having the general formula (II) described below in a high yield as well as in a highly selective manner:
摘要翻译：一种制备光学活性β-氨基醇的方法，所述方法包括允许至少一种选自属于摩根氏菌属和其他微生物的微生物的微生物作用于α-氨基酮或其对映异构体混合物其具有通式（I）的盐：以高产率和高度选择性的方式制备具有下述通式（II）的具有所需光学活性的光学活性β-氨基醇：

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