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21. 发明授权

US07091012B2 Processes for obtaining sterols and polar lipids from vegetable oil lecithin fractions 失效
$Processes for obtaining sterols and polar lipids from vegetable oil lecithin fractions$
标题翻译：从植物油卵磷脂级分获得固醇和极性脂质的方法
公开(公告)号：US07091012B2
公开(公告)日：2006-08-15
申请号：US10988743
申请日：2004-11-15
申请人： Sabine Both , Teresa Alexandre , Bernhard Gutsche , Juergen Kray , Carsten Beverungen , Rainer Eickenberg
发明人： Sabine Both , Teresa Alexandre , Bernhard Gutsche , Juergen Kray , Carsten Beverungen , Rainer Eickenberg
IPC分类号： C12P7/40
CPC分类号： B01D61/145 , B01D61/142 , C11B1/00 , C11B1/025 , C11B1/10 , C11B3/008 , C12P33/00
摘要： Processes for the simultaneous production of sterols and polar lipids, in which preparations of vegetable oil lecithin fractions are subjected to ultrafiltration and, on the one hand, the sterols in the permeate and, on the other hand, the polar lipids in the retentate are enriched. The permeate and retentate can subsequently be worked up by methods known per se.
摘要翻译：用于同时生产甾醇和极性脂质的方法，其中植物油卵磷脂级分的制备物经过超滤，一方面是渗透物中的固醇，另一方面，渗余物中的极性脂质富集。渗透物和渗余物随后可以通过本身已知的方法来处理。

22. 发明申请

US20050255570A1 Method for producing conjugated linoleic acid 失效
标题翻译：共轭亚油酸的制备方法
公开(公告)号：US20050255570A1
公开(公告)日：2005-11-17
申请号：US10516987
申请日：2003-05-28
申请人： Lars Zander , Stefan Busch , Carolin Meyer , Sabine Both , Ulrich Schoerken
发明人： Lars Zander , Stefan Busch , Carolin Meyer , Sabine Both , Ulrich Schoerken
IPC分类号： C12P7/64 , C12R1/05
CPC分类号： C12P7/6427
摘要： Processes for preparing conjugated linoleic acid are described wherein a conjugated linoleic acid lower alkyl ester is subjected to hydrolysis in the presence of an enzyme to form a hydrolyzate comprising a conjugated linoleic acid and a lower alkanol, wherein at least a portion of the lower alkanol is continuously removed; the hydrolyzate is separated into an organic phase and an aqueous/alcoholic phase; and the conjugated linoleic acid is separated from the organic phase.
摘要翻译：描述制备共轭亚油酸的方法，其中共轭亚油酸低级烷基酯在酶存在下进行水解以形成包含共轭亚油酸和低级链烷醇的水解产物，其中至少一部分低级烷醇为连续删除将水解产物分离成有机相和水相/醇相; 共轭亚油酸与有机相分离。

23. 发明授权

US07638662B2 Emollients and cosmetic preparations 失效
标题翻译：润肤剂和化妆品
公开(公告)号：US07638662B2
公开(公告)日：2009-12-29
申请号：US10719588
申请日：2003-11-21
申请人： Achim Ansmann , Sabine Both , Daniela Prinz , Nicole Schoeffler , Alfred Westfechtel
发明人： Achim Ansmann , Sabine Both , Daniela Prinz , Nicole Schoeffler , Alfred Westfechtel
IPC分类号： C07C13/00 , C07C13/28
CPC分类号： C07C13/28 , A61K8/31 , A61Q19/00 , C07C2601/08 , C07C2601/14
摘要： Compounds of the formula (I): wherein each of R1-R12 is independently hydrogen or a linear C1-20 alkyl group each of A1 and A2 is a 1, 2 or 3 ring carbon atom wherein A1 is substituted by R9 and R10 and A2 is substituted by R11 and R12; and wherein at least one of R1-R12 is a linear alkyl group having from 1 to 20 carbon atoms are emollients for use in cosmetics, lubricants and pharmaceutical preparations.
摘要翻译：式（I）化合物：其中R 1 -R 12各自独立地为氢或各自为A 1和A 2的直链C 1-20烷基是其中A 1被R 9和R 10和A 2取代的1,2或3个环碳原子被R11和R12取代; 并且其中R 1 -R 12中的至少一个是具有1至20个碳原子的直链烷基是用于化妆品，润滑剂和药物制剂中的润肤剂。

24. 发明申请

US20070160554A1 Acyl ribonucleosides and acyl deoxyribonucleosides, compositions of, and methods of making same 审中-公开
标题翻译：酰基核糖核苷和酰基脱氧核糖核苷，组合物及其制备方法
公开(公告)号：US20070160554A1
公开(公告)日：2007-07-12
申请号：US10595656
申请日：2004-10-23
申请人： Peter Kempers , Philippe Moussou , Louis Danoux , Sabine Both , Carsten Beverungen
发明人： Peter Kempers , Philippe Moussou , Louis Danoux , Sabine Both , Carsten Beverungen
IPC分类号： A61K31/7076 , C07H19/16 , A61K8/73
CPC分类号： C07H19/04 , A61K8/606 , A61Q19/00 , A61Q19/004 , A61Q19/02
摘要： The present invention is concerned with acyl ribonucleosides and with acyl deoxyribonucleosides. It is furthermore concerned with an enzymatic process for the manufacture of acyl ribonucleosides and of acyl deoxyribonucleosides. It is furthermore concerned with the use of acyl ribonucleosides and of acyl deoxyribonucleosides for cosmetic and for pharmaceutical purposes and with their use as a food supplement for humans or animals. It is furthermore concerned with compositions containing acyl ribonucleosides and acyl deoxyribonucleosides, whereby these compositions are suitable for cosmetic or for pharmaceutical purposes or as food supplement.
摘要翻译：本发明涉及酰基核糖核苷和酰基脱氧核糖核苷。此外还涉及用于制备酰基核糖核苷和酰基脱氧核糖核苷的酶促方法。此外，还关注酰基核糖核苷和酰基脱氧核糖核苷用于化妆品和药物目的，并且用作人或动物的食品补充剂。此外，还涉及含有酰基核糖核苷和酰基脱氧核糖核苷的组合物，由此这些组合物适用于化妆品或用于制药目的或作为食品补充剂。

25. 发明授权

US07138256B2 Processes for preparing conjugated linoleic acid from conjugated linoleic acid esters 失效
标题翻译：从共轭亚油酸酯制备共轭亚油酸的方法
公开(公告)号：US07138256B2
公开(公告)日：2006-11-21
申请号：US10516987
申请日：2003-05-28
申请人： Lars Zander , Stefan Busch , Carolin Meyer , Sabine Both , Ulrich Schoerken
发明人： Lars Zander , Stefan Busch , Carolin Meyer , Sabine Both , Ulrich Schoerken
IPC分类号： C12P7/64
CPC分类号： C12P7/6427
摘要： Processes for preparing conjugated linoleic acid are described wherein a conjugated linoleic acid lower alkyl ester is subjected to hydrolysis in the presence of an enzyme to form a hydrolyzate comprising a conjugated linoleic acid and a lower alkanol, wherein at least a portion of the lower alkanol is continuously removed; the hydrolyzate is separated into an organic phase and an aqueous/alcoholic phase; and the conjugated linoleic acid is separated from the organic phase.
摘要翻译：描述制备共轭亚油酸的方法，其中共轭亚油酸低级烷基酯在酶存在下进行水解以形成包含共轭亚油酸和低级链烷醇的水解产物，其中至少一部分低级烷醇为连续删除将水解产物分离成有机相和水相/醇相; 共轭亚油酸与有机相分离。

26. 发明申请

US20050233426A1 Processes for the production of triglycerides of unsaturated fatty acids in the presence of enzymes 审中-公开
标题翻译：在酶存在下生产不饱和脂肪酸甘油三酸酯的方法
公开(公告)号：US20050233426A1
公开(公告)日：2005-10-20
申请号：US11093410
申请日：2005-03-30
申请人： Ulrich Schoerken , Sabine Both , Carolin Meyer , Peter Horlacher
发明人： Ulrich Schoerken , Sabine Both , Carolin Meyer , Peter Horlacher
IPC分类号： C11C3/06 , C11C3/10 , C12P7/64
CPC分类号： C12P7/6472
摘要： Processes for the enzyme-catalyzed production of triglycerides using polyunsaturated fatty acids, in which (a) the reaction of polyunsaturated fatty acids and/or C1-4 alkyl esters thereof with glycerol in vacuo in the presence of an immobilized enzyme to form their triglycerides is accelerated by addition of an additive from the group of weakly basic salts, complexing agents and ion exchangers and/or addition of a weakly basic salt and/or addition of an entraining agent in the form of a solvent or a gas and/or addition of glycerol-binding adsorbers and/or heat treatment of the partial glyceride intermediate product, (b) the immobilized enzymes are removed from the triglyceride by separation or filtration and (c) the remaining fatty acids and/or C1-4 alkyl esters thereof are removed from the triglyceride by distillation, refining or extraction.
摘要翻译：使用多不饱和脂肪酸酶催化生产甘油三酸酯的方法，其中（a）多不饱和脂肪酸和/或其中C 1-4烷基酯与甘油在真空中的存在下反应，通过从弱碱性盐，络合剂和离子交换剂组中加入添加剂和/或加入弱碱性盐和/或以溶剂形式加入夹带剂来加速形成它们的甘油三酯的固定化酶或甘油结合吸附剂的气体和/或加成物和/或热处理部分甘油酯中间产物，（b）通过分离或过滤从甘油三酯中除去固定化的酶，和（c）剩余的脂肪酸和/或通过蒸馏，精制或萃取，从甘油三酯中除去C 1-4烷基酯。

27. 发明申请

US20050220826A1 Oil bodies for cosmetic compositions containing cyclohexyl cyclohexane 失效
标题翻译：含有环己基环己烷的化妆品组合物的油体
公开(公告)号：US20050220826A1
公开(公告)日：2005-10-06
申请号：US10507674
申请日：2003-03-06
申请人： Rolf Kawa , Achim Ansmann , Daniel Prinz , Sabine Both
发明人： Rolf Kawa , Achim Ansmann , Daniel Prinz , Sabine Both
IPC分类号： A61K8/00 , A61K8/03 , A61K8/06 , A61K8/30 , A61K8/31 , A61K8/92 , A61Q17/04 , A61Q19/00 , C07C13/28 , A61K7/00
CPC分类号： C07C13/28 , A61K8/06 , A61K8/31 , A61Q17/04 , A61Q19/00 , C07C2601/08 , C07C2601/14
摘要： A cosmetic composition containing: (a) an aqueous phase; (b) an oil phase containing cyclohexyl cyclohexane; (c) optionally, a surfactant; and (d) optionally, an auxiliary oil component.
摘要翻译：一种化妆品组合物，其含有：（a）水相; （b）含有环己基环己烷的油相; （c）任选的表面活性剂; 和（d）任选的辅助油组分。

28. 发明授权

US07935508B2 Production and use of monoglycerides 有权
标题翻译：单酸甘油酯的生产和使用
公开(公告)号：US07935508B2
公开(公告)日：2011-05-03
申请号：US11813939
申请日：2006-01-10
申请人： Ulrich Schörken , Sabine Both , Frank Bongardt , Diana Stuhlmann
发明人： Ulrich Schörken , Sabine Both , Frank Bongardt , Diana Stuhlmann
IPC分类号： C12N9/00
CPC分类号： C10L1/191 , A61K47/44 , C10L10/08 , C10M129/76 , C10M2207/289 , C12P7/6445 , C12P7/6472 , C12P7/649 , Y02E50/13
摘要： A higher-yielding process for the production of monoglycerides in which triglycerides are enzymatically reacted with a catalytic amount of an esterase, preferably lipase, that has been activated by the addition of alkaline salts, in the presence of linear or branched alcohols containing 1 to 8 carbon atoms, then the esterase may be deactivated and it and the remaining alcohol removed, with the monoglycerides thus produced useful in lubricants, fuel additives, and emulsifying constituents in foods, and cosmetic and/or pharmaceutical formulations.
摘要翻译：用于生产甘油三酸酯的较高产量的方法，其中甘油三酸酯在催化量的酯酶（优选脂肪酶）中酶催化，其通过加入碱性盐在含有1至8个的直链或支链醇的存在下活化碳原子，那么酯酶可以失活，并且其和除去的剩余的醇与由此产生的单酸甘油酯可用于食品中的润滑剂，燃料添加剂和乳化成分，以及化妆品和/或药物制剂。

29. 发明申请

US20100159538A1 METHOD FOR THE CHEMOENZYMATIC PRODUCTION OF FATTY ACID ESTERS 审中-公开
标题翻译：脂肪酸酯的生产方法
公开(公告)号：US20100159538A1
公开(公告)日：2010-06-24
申请号：US12063547
申请日：2006-08-02
申请人： Sabine Both , Ulrich Schorken , Carolin Meyer
发明人： Sabine Both , Ulrich Schorken , Carolin Meyer
IPC分类号： C12P7/64
CPC分类号： B01J31/003 , B01J31/0225 , B01J31/08 , C12P7/62
摘要： A chemoenzymatic process for the production of fatty acid esters comprising partially esterifying one or more fatty acid esters, under mild temperatures with an enzymatic catalyst, and optionally in the presence of one or more inert solvents, with a 1- to 5-fold molar excess of one or more water-containing aliphatic alcohols with boiling points between 60° C. and 120° C., then removing the water and unreacted alcohol(s) from the resulting pre-esterification product, followed by additional esterification up to 99.7%, chemically-catalyzed with, e.g., an acid or tin salt at slightly higher temperatures, optionally using one or more inert solvents, with a 1- to 4-fold molar excess of the same one or more aliphatic alcohols as employed in the preliminary esterification step.
摘要翻译：一种用于生产脂肪酸酯的化学酶法，其包括在温和的温度下用酶促催化剂部分酯化一种或多种脂肪酸酯，并且任选地在一种或多种惰性溶剂的存在下，以1〜5倍摩尔过量的一种或多种沸点为60℃至120℃的含水脂族醇，然后从所得预酯化产物中除去水和未反应的醇，然后进一步酯化达99.7％，用稍高的温度下的酸或锡盐进行化学催化，任选地使用一种或多种惰性溶剂，与初步酯化步骤中使用的相同的一种或多种脂肪醇的1至4倍摩尔过量。

30. 发明申请

US20060057689A1 Method for producing c4-c12 fatty acids 审中-公开
标题翻译：生产c4-c12脂肪酸的方法
公开(公告)号：US20060057689A1
公开(公告)日：2006-03-16
申请号：US10513812
申请日：2003-04-29
申请人： Ralf Otto , Georg Fieg , Sabine Both , Ulrich Schoerken , Levent Yueksel , Ingomar Mrozek , Carolin Meyer , Norbert Klein , Albrecht Weiss
发明人： Ralf Otto , Georg Fieg , Sabine Both , Ulrich Schoerken , Levent Yueksel , Ingomar Mrozek , Carolin Meyer , Norbert Klein , Albrecht Weiss
IPC分类号： C12P7/64 , C12P7/40
CPC分类号： C12P7/6418 , C12P7/40
摘要： Processes for preparing fatty acids are described wherein a C4-C12 fatty acid methyl ester is subjected to hydrolysis in the presence of an enzyme to form an organic phase comprising a C4-C12 fatty acid and an aqueous phase comprising methanol, wherein at least a portion of the methanol is continuously removed; and the organic phase is subsequently separated from the aqueous phase, and optionally, where the organic phase further comprises an unhydrolyzed portion of the C4-C12 fatty acid methyl ester, the unhydrolyzed portion of the C4-C12 fatty acid methyl ester is separated from the C4-C12 fatty acid.
摘要翻译：描述了制备脂肪酸的方法，其中在酶的存在下使C 4 -C 12脂肪酸甲酯进行水解以形成包含C 脂肪酸和包含甲醇的水相，其中至少部分甲醇被连续除去; 随后将有机相与水相分离，任选地，当有机相进一步包含C 6-14脂肪酸甲酯的未水解部分时，将C 4 -C 12脂肪酸甲酯的未水解部分与C 4 -C 12脂肪酸甲酯分离 >脂肪酸。

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