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21. 发明授权

US08278088B2 Polynucleotide encoding a polypeptide having glycosylation activity on a flavonoid 有权
标题翻译：编码具有对类黄酮具有糖基化活性的多肽的多核苷酸
公开(公告)号：US08278088B2
公开(公告)日：2012-10-02
申请号：US12523068
申请日：2008-01-18
申请人： Misa Ochiai , Harukazu Fukami , Masahiro Nakao , Akio Noguchi
发明人： Misa Ochiai , Harukazu Fukami , Masahiro Nakao , Akio Noguchi
IPC分类号： C12N1/20 , C12N1/00 , C12N1/12 , C12N5/04 , C12N5/00 , C12N15/00 , C07H21/04
CPC分类号： C12N9/1048
摘要： The present invention provides novel glycosyltransferase proteins produced by ascomycetous filamentous fungi (preferably species belonging to the genus Trichoderma, more preferably Trichoderma viride), as well as genes encoding the same. Among novel enzyme proteins provided by the present invention, particularly preferred is an enzyme protein obtained from the culture supernatant of Trichoderma viride strain IAM5141. The novel enzymes of the present invention allow glycosylation of flavonoid compounds to thereby improve their water solubility.
摘要翻译：本发明提供了由Ascomycetoto丝状真菌（优选属于木霉属，更优选绿色木霉）的物质以及编码它们的基因产生的新的糖基转移酶蛋白质。在本发明提供的新型酶蛋白中，特别优选从绿色木霉菌株IAM5141的培养物上清液获得的酶蛋白质。本发明的新型酶可以使类黄酮化合物进行糖基化从而提高其水溶性。

22. 发明申请

US20110217768A1 NOVEL LIPASE 有权
标题翻译：新手
公开(公告)号：US20110217768A1
公开(公告)日：2011-09-08
申请号：US12981929
申请日：2010-12-30
申请人： Masahiro Nakao , Masaki Kanamori , Harukazu Fukami , Hiroaki Kasai , Misa Ochiai
发明人： Masahiro Nakao , Masaki Kanamori , Harukazu Fukami , Hiroaki Kasai , Misa Ochiai
IPC分类号： C12N5/10 , C12N15/63 , C07H21/04 , C12N1/00 , C07H21/00
CPC分类号： C12N9/20 , C12P7/6409 , C12P7/6436 , C12R1/01
摘要： The present invention provides a novel lipase with a molecular weight of about 32 kDa, which is produced by a strain belonging to the genus Tetrasphaera, as well as a gene encoding the same. This lipase has the ability to recognize a medium-chain fatty acid as a substrate. The present invention also provides a novel lipase with a molecular weight of about 40 kDa, which is produced by a strain belonging to the genus Tetrasphaera and has the ability to recognize both a medium-chain fatty acid and a long-chain fatty acid as substrates, as well as a polynucleotide encoding the same. The present invention further provides Tetrasphaera sp. strain NITE P-154. The lipase of the present invention can be used as an immobilized enzyme and is useful in fields such as production of digestants and/or flavorings, production of clinical laboratory reagents, detergent enzymes and/or fats, as well as production of optically active intermediates for agricultural chemicals and pharmaceutical preparations.
摘要翻译：本发明提供了一种分子量约32kDa的新型脂肪酶，其由属于四联属属的菌株产生，以及编码该脂肪酶的基因。该脂肪酶具有识别中链脂肪酸作为底物的能力。本发明还提供一种分子量约40kDa的新型脂肪酶，其由属于四孢属属的菌株产生，并且具有将中链脂肪酸和长链脂肪酸同时识别为底物的能力，以及编码该多核苷酸的多核苷酸。本发明进一步提供了Tetrasphaera sp。菌株NITE P-154。本发明的脂肪酶可以用作固定化酶，可用于生产消化剂和/或调味剂，生产临床实验室试剂，洗涤剂和/或脂肪等领域，以及生产光学活性中间体农药和药物制剂。

23. 发明申请

US20100075380A1 Novel Lipase 有权
标题翻译：新型脂肪酶
公开(公告)号：US20100075380A1
公开(公告)日：2010-03-25
申请号：US12096574
申请日：2006-12-08
申请人： Masahiro Nakao , Masaki Kanamori , Harukazu Fukami , Hiroaki Kasai , Misa Ochiai
发明人： Masahiro Nakao , Masaki Kanamori , Harukazu Fukami , Hiroaki Kasai , Misa Ochiai
IPC分类号： C07H21/04 , C12N15/63 , C12N1/21 , C07K14/195 , C12N9/20 , C12P7/64 , C12P21/00 , C12N5/10 , C12N1/19
CPC分类号： C12N9/20 , C12P7/6409 , C12P7/6436 , C12R1/01
摘要： The present invention provides a novel lipase with a molecular weight of about 32 kDa, which is produced by a strain belonging to the genus Tetrasphaera, as well as a gene encoding the same. This lipase has the ability to recognize a medium-chain fatty acid as a substrate. The present invention also provides a novel lipase with a molecular weight of about 40 kDa, which is produced by a strain belonging to the genus Tetrasphaera and has the ability to recognize both a medium-chain fatty acid and a long-chain fatty acid as substrates, as well as a polynucleotide encoding the same. The present invention further provides Tetrasphaera sp. strain NITE P-154. The lipase of the present invention can be used as an immobilized enzyme and is useful in fields such as production of digestants and/or flavorings, production of clinical laboratory reagents, detergent enzymes and/or fats, as well as production of optically active intermediates for agricultural chemicals and pharmaceutical preparations.
摘要翻译：本发明提供了一种分子量约32kDa的新型脂肪酶，其由属于四联属属的菌株产生，以及编码该脂肪酶的基因。该脂肪酶具有识别中链脂肪酸作为底物的能力。本发明还提供一种分子量约40kDa的新型脂肪酶，其由属于四孢属属的菌株产生，并且具有将中链脂肪酸和长链脂肪酸同时识别为底物的能力，以及编码该多核苷酸的多核苷酸。本发明进一步提供了Tetrasphaera sp。菌株NITE P-154。本发明的脂肪酶可以用作固定化酶，可用于生产消化剂和/或调味剂，生产临床实验室试剂，洗涤剂和/或脂肪等领域，以及生产光学活性中间体农药和药物制剂。

24. 发明申请

US20070065380A1 2-O-(beta-D-glucopyranosyl) ascorbic acid, process for its production, and foods cosmetics containing compositions comprising it 有权
标题翻译： 2-O-（β-D-吡喃葡萄糖基）抗坏血酸，其生产方法，以及含有组合物的食品化妆品
公开(公告)号：US20070065380A1
公开(公告)日：2007-03-22
申请号：US11501074
申请日：2006-08-09
申请人： Mitsuru Maeda , Masahiro Nakao , Harukazu Fukami
发明人： Mitsuru Maeda , Masahiro Nakao , Harukazu Fukami
IPC分类号： A61K31/7048 , A61K8/49
CPC分类号： A61K8/676 , A23L33/105 , A23L33/15 , A23V2002/00 , A61K8/602 , A61K31/375 , A61K2800/52 , A61Q17/04 , A61Q19/00 , A61Q19/02 , C07H1/08 , C07H17/04 , C12P19/60 , A23V2250/708
摘要： The present invention provides a novel ascorbic acid derivative as a provitamin C with improved stability in the body and prolonged life in the body compared to conventionally known 2-O-(α-D-glucopyranosyl)ascorbic acid. The composition comprising the novel compound 2-O-(β-D-glucopyranosyl)ascorbic acid has been extracted from plants such as from Ningxia Lycium barbarum L. and/or Lycium chinense Mill. The compositions comprising 2-O-(β-D-glucopyranosyl)ascorbic acid may be enzymatically synthesized using β-D-glucosyltransferase. Pure 2-O-(β-D-glucopyranosyl)ascorbic acid may be produced from such compositions. Alternatively, 2-O-(β-D-glucopyranosyl)ascorbic acid may be produced by chemical synthesis. The 2-O-(β-D-glucopyranosyl)ascorbic acid results in higher stability and a prolonged life of vitamin C when ingested in the body compared to the corresponding α-D-glucopyranosyl derivative, and is therefore highly suitable as a provitamin C to be used in cosmetics and foods.
摘要翻译：与常规已知的2-O-（α-D-吡喃葡萄糖基）抗坏血酸相比，本发明提供了一种新型抗坏血酸衍生物作为维生素C，其具有改善的身体稳定性和延长的身体寿命。含有新化合物2-O-（β-D-吡喃葡萄糖基）抗坏血酸的组合物已经从宁夏枸杞子和/或枸杞子等植物中提取出来。包含2-O-（β-D-吡喃葡萄糖基）抗坏血酸的组合物可以使用β-D-葡糖基转移酶酶促合成。可以从这样的组合物制备纯的2-O-（β-D-吡喃葡萄糖基）抗坏血酸。或者，可通过化学合成制备2-O-（β-D-吡喃葡萄糖基）抗坏血酸。与相应的α-D-吡喃葡萄糖基衍生物相比，2-O-（β-D-吡喃葡萄糖基）抗坏血酸产生更高的稳定性和摄取维生素C的寿命，因此非常适合作为维生素C 用于化妆品和食品。

25. 发明申请

US20060217441A1 Lipid-improving agent and composition containing lipid-improving agent 有权
标题翻译：脂质改善剂及含有脂质改善剂的组合物
公开(公告)号：US20060217441A1
公开(公告)日：2006-09-28
申请号：US10550711
申请日：2004-03-26
申请人： Kengo Akimoto , Harukazu Fukami , Toshinao Goda
发明人： Kengo Akimoto , Harukazu Fukami , Toshinao Goda
IPC分类号： A61K31/22
CPC分类号： C12P7/6472 , A23D9/00 , A23L33/115 , A23V2002/00 , A61K31/231 , A61K31/232 , C11C3/08 , A23V2250/5112 , A23V2250/1862
摘要： A lipid-improving agent containing a triglyceride(s) where a poly-unsaturated fatty acid is bonded to 2-position of a triglyceride(s).
摘要翻译：含有甘油三酯的脂质改进剂，其中多不饱和脂肪酸与甘油三酯的2-位结合。

26. 发明授权

US5198458A Pyrrolidineamide derivatives of acylamino acid and pharmaceutical composition containing the same 失效
标题翻译：酰氨基酸的吡咯烷酰胺衍生物和含有它们的药物组合物
公开(公告)号：US5198458A
公开(公告)日：1993-03-30
申请号：US638148
申请日：1991-01-09
申请人： Naoki Higuchi , Masayuki Saitoh , Masaki Hashimoto , Harukazu Fukami , Takaharu Tanaka
发明人： Naoki Higuchi , Masayuki Saitoh , Masaki Hashimoto , Harukazu Fukami , Takaharu Tanaka
IPC分类号： C07D207/16 , C07D295/185
CPC分类号： C07D295/185 , C07D207/16
摘要： A compound of the general formula: ##STR1## wherein m is an integer of 1 to 7,n is 0 or an integer of 1 to 5,R.sup.1 is the phenyl, a substituted phenyl, the phenoxy, a substituted phenoxy or a saturated or unsaturated straight alkyl having 5 to 18 carbon atoms,R.sup.2 is hydrogen atom,R.sup.3 is hydrogen atom, a branched or unbranched alkyl having 3 to 5 carbon atoms, the phenyl, hydroxyphenyl, benzyloxyphenyl, an alkylthio having 1 to 3 carbon atoms in its alkyl moiety, amino, carboxyl, hydroxy, benzyloxy, indolyl or imidazolyl, or R.sup.2 and R.sup.3 together form a single bond between the carbon atom and the nitrogen atom, and a pharmaceutical composition containing said compound are provided. The compound is effective in curing amnesia because of its anti-prolyl endopeptidase activity.
摘要翻译：一种通式如下的化合物：其中m为1〜7的整数，n为0或1〜5的整数，R 1为苯基，取代苯基，苯氧基，取代的苯氧基或具有5至18个碳原子的饱和或不饱和直链烷基，R 2是氢原子，R 3是氢原子，具有3至5个碳原子的支链或非支链烷基，苯基，羟基苯基，苄氧基苯基，具有1至3个碳原子的烷硫基在其烷基部分中，氨基，羧基，羟基，苄氧基，吲哚基或咪唑基，或R2和R3一起形成碳原子和氮原子之间的单键，并提供含有所述化合物的药物组合物。该化合物由于其抗脯氨酰内肽酶活性而有效地治愈健忘症。

27. 发明授权

US08207320B2 Lipase 有权
标题翻译：脂肪酶
公开(公告)号：US08207320B2
公开(公告)日：2012-06-26
申请号：US12981929
申请日：2010-12-30
申请人： Masahiro Nakao , Masaki Kanamori , Harukazu Fukami , Hiroaki Kasai , Misa Ochiai
发明人： Masahiro Nakao , Masaki Kanamori , Harukazu Fukami , Hiroaki Kasai , Misa Ochiai
IPC分类号： C07H21/02 , C12N1/20 , C12N15/00
CPC分类号： C12N9/20 , C12P7/6409 , C12P7/6436 , C12R1/01
摘要： The present invention provides a novel lipase with a molecular weight of about 32 kDa, which is produced by a strain belonging to the genus Tetrasphaera, as well as a gene encoding the same. This lipase has the ability to recognize a medium-chain fatty acid as a substrate. The present invention also provides a novel lipase with a molecular weight of about 40 kDa, which is produced by a strain belonging to the genus Tetrasphaera and has the ability to recognize both a medium-chain fatty acid and a long-chain fatty acid as substrates, as well as a polynucleotide encoding the same. The present invention further provides Tetrasphaera sp. strain NITE P-154. The lipase of the present invention can be used as an immobilized enzyme and is useful in fields such as production of digestants and/or flavorings, production of clinical laboratory reagents, detergent enzymes and/or fats, as well as production of optically active intermediates for agricultural chemicals and pharmaceutical preparations.
摘要翻译：本发明提供了一种分子量约32kDa的新型脂肪酶，其由属于四联属属的菌株产生，以及编码该脂肪酶的基因。该脂肪酶具有识别中链脂肪酸作为底物的能力。本发明还提供了一种分子量约40kDa的新型脂肪酶，其由属于四味子属的菌株产生，并且具有将中链脂肪酸和长链脂肪酸同时识别为底物的能力，以及编码该多核苷酸的多核苷酸。本发明进一步提供了Tetrasphaera sp。菌株NITE P-154。本发明的脂肪酶可以用作固定化酶，可用于生产消化剂和/或调味剂，生产临床实验室试剂，洗涤剂酶和/或脂肪等领域，以及生产光学活性中间体农药和药物制剂。

28. 发明授权

US07943583B2 2-O-(β-D-glucopyranosyl) ascorbic acid, process for its production, and foods cosmetics containing compositions comprising it 有权
标题翻译： 2-O-（＆bgr-D-吡喃葡萄糖基）抗坏血酸，其生产方法，以及含有组合物的食品化妆品
公开(公告)号：US07943583B2
公开(公告)日：2011-05-17
申请号：US11501074
申请日：2006-08-09
申请人： Mitsuru Maeda , Masahiro Nakao , Harukazu Fukami
发明人： Mitsuru Maeda , Masahiro Nakao , Harukazu Fukami
IPC分类号： A01N43/04 , A01N43/06
CPC分类号： A61K8/676 , A23L33/105 , A23L33/15 , A23V2002/00 , A61K8/602 , A61K31/375 , A61K2800/52 , A61Q17/04 , A61Q19/00 , A61Q19/02 , C07H1/08 , C07H17/04 , C12P19/60 , A23V2250/708
摘要： The present invention provides a novel ascorbic acid derivative as a provitamin C with improved stability in the body and prolonged life in the body compared to conventionally known 2-O-(β-D-glucopyranosyl)ascorbic acid. The composition comprising the novel compound 2-O- (β-D-glucopyranosyl)ascorbic acid has been extracted from plants such as from Ningxia Lycium barbarum L. and/or Lycium chinense Mill. The compositions comprising 2-O-(βD-glucopyranosyl) ascorbic acid may be enzymatically synthesized using β-D-glucosyltransferase. Pure 2-O-(β-D-glucopyranosyl)ascorbic acid may be produced from such compositions. Alternatively, 2-O-(β-D-glucopyranosyl)ascorbic acid may be produced by chemical synthesis. The 2-O-(β-D-glucopyranosyl)ascorbic acid results in higher stability and a prolonged life of vitamin C when ingested in the body compared to the corresponding α-D-glucopyranosyl derivative, and is therefore highly suitable as a provitamin C to be used in cosmetics and foods.
摘要翻译：本发明提供了一种新颖的抗坏血酸衍生物作为前维生素C，与常规已知的2-O-（β-葡萄糖-D-吡喃葡萄糖基）抗坏血酸相比，体内的稳定性和体内寿命延长。含有新化合物2-O-（＆bgr-D-吡喃葡萄糖基）抗坏血酸的组合物已经从宁夏枸杞子和/或枸杞子等植物中提取出来。包含2-O-（β-葡萄糖吡喃糖基）抗坏血酸的组合物可以使用β-葡糖基转移酶酶促合成。可以从这样的组合物制备纯2-O-（＆bgr-D-吡喃葡萄糖基）抗坏血酸。或者，可通过化学合成制备2-O-（＆bgr-D-吡喃葡萄糖基）抗坏血酸。与对应的α-D-吡喃葡萄糖基衍生物相比，2-O-（＆bgr-D-吡喃葡萄糖基）抗坏血酸在身体摄取时导致更高的稳定性和更长的维生素C的使用寿命，因此非常适合作为维生素 C用于化妆品和食品。

29. 发明授权

US07723386B2 Lipid-improving agent and composition containing lipid-improving agent 有权
标题翻译：脂质改善剂及含有脂质改善剂的组合物
公开(公告)号：US07723386B2
公开(公告)日：2010-05-25
申请号：US10550711
申请日：2004-03-26
申请人： Kengo Akimoto , Harukazu Fukami , Toshinao Goda
发明人： Kengo Akimoto , Harukazu Fukami , Toshinao Goda
IPC分类号： A01N37/06
CPC分类号： C12P7/6472 , A23D9/00 , A23L33/115 , A23V2002/00 , A61K31/231 , A61K31/232 , C11C3/08 , A23V2250/5112 , A23V2250/1862
摘要： A lipid-improving agent containing a triglyceride(s) where a poly-unsaturated fatty acid is bonded to 2-position of a triglyceride(s).
摘要翻译：含有甘油三酯的脂质改进剂，其中多不饱和脂肪酸与甘油三酯的2-位结合。

30. 发明申请

US20100029695A1 METHOD OF TREATING DERMATITIS COMPRISING ADMINISTERING A CHYMASE INHIBITOR 审中-公开
标题翻译：治疗包含乙型肝炎病毒抑制剂的药物治疗方法
公开(公告)号：US20100029695A1
公开(公告)日：2010-02-04
申请号：US12576829
申请日：2009-10-09
申请人： Harukazu Fukami , Yoshiaki Tomimori , Yoshiaki Fukuda , Naohiro Watanabe
发明人： Harukazu Fukami , Yoshiaki Tomimori , Yoshiaki Fukuda , Naohiro Watanabe
IPC分类号： A61K31/517 , A61P37/06 , A61P17/02
CPC分类号： C07D239/96 , A61K31/00 , A61K31/517
摘要： A medicament safe and free from side effects, for the prevention or treatment of dermatitis exhibiting a biphasic inflammation reaction or dermatitis induced by repeated exposure to an antigen, which suppresses the progress of the condition and improves the quality of life of the patient, which medicament treats dermatitis exhibiting a biphasic inflammation reaction or dermatitis induced by repeated exposure to an antigen by including a quiazoline derivative having the formula (I) or (II) or its pharmaceutically acceptable salt as an effective ingredient:
摘要翻译：一种安全且无副作用的药物，用于预防或治疗由于反复接触抗原而引起的双相炎症反应或皮炎，其抑制病症的进展并改善患者的生活质量，该药物通过包括具有式（I）或（II）的喹唑啉衍生物或其药学上可接受的盐作为有效成分，治疗通过重复暴露于抗原而引起的双相炎症反应或皮炎的皮炎，

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