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21. 发明授权

US08053463B2 PPAR active compounds 有权
标题翻译： PPAR活性化合物
公开(公告)号：US08053463B2
公开(公告)日：2011-11-08
申请号：US12043069
申请日：2008-03-05
申请人： Jack Lin , Byunghun Lee , Shenghua Shi , Chao Zhang , Dean R. Artis , Prabha N. Ibrahim , Weiru Wang , Rebecca Zuckerman
发明人： Jack Lin , Byunghun Lee , Shenghua Shi , Chao Zhang , Dean R. Artis , Prabha N. Ibrahim , Weiru Wang , Rebecca Zuckerman
IPC分类号： C07D209/04 , C07D401/02 , A61K31/454 , A61K31/404
CPC分类号： C07D401/12 , C07D209/18 , C07D403/12
摘要： Compounds are described that are active on at least one of PPARα, PPARδ, and PPARγ, which are useful for therapeutic and/or prophylactic methods involving modulation of at least one of PPARα, PPARδ, and PPARγ, wherein the compounds have the formula: wherein: X2 and X3 are independently CH or N; and one of X1 and X4 is N or CR4 and the other of X1 and X4 is N or CH.
摘要翻译：描述了对PPARα，PPARδ和PPARγ中的至少一种有活性的化合物，其可用于涉及调节PPARα，PPARδ和PPARγ中的至少一种的治疗和/或预防方法，其中所述化合物具有下式：其中：X2和X3独立地是CH或N; X1和X4之一是N或CR4，X1和X4中的另一个是N或CH。

22. 发明授权

US07702178B2 Method and apparatus for providing noise reduction 有权
标题翻译：用于提供降噪的方法和装置
公开(公告)号：US07702178B2
公开(公告)日：2010-04-20
申请号：US11081255
申请日：2005-03-15
申请人： James Bergen , Chao Zhang , Gooitzen Van Der Wal
发明人： James Bergen , Chao Zhang , Gooitzen Van Der Wal
IPC分类号： G06K9/40
CPC分类号： H04N5/144 , G06T5/002 , G06T5/30 , G06T5/50 , G06T2207/10016 , G06T2207/20016 , H04N5/21 , H04N5/213
摘要： A method and apparatus for reducing noise in at least one frame in an image sequence is disclosed. A minimum function is applied to the at least one frame to produce a plurality of minimum values. A mask is generated in accordance with the plurality of minimum values. The mask is applied to reduce the noise in the at least one frame. In one embodiment, impulse noise is reduced. In another embodiment wideband non-linear noise is reduced.
摘要翻译：公开了一种降低图像序列中的至少一帧中的噪声的方法和装置。最小功能被应用于至少一个帧以产生多个最小值。根据多个最小值生成掩模。应用掩模以减少至少一个帧中的噪声。在一个实施例中，脉冲噪声减小。在另一个实施例中，宽带非线性噪声减小。

23. 发明申请

US20090286793A1 PDE4B INHIBITORS AND USES THEREFOR 有权
标题翻译： PDE4B抑制剂及其用途
公开(公告)号：US20090286793A1
公开(公告)日：2009-11-19
申请号：US12506222
申请日：2009-07-20
申请人： Prabha N. Ibrahim , Hanna Cho , Bruce England , Sam Gillette , Dean R. Artis , Rebecca Zuckerman , Chao Zhang
发明人： Prabha N. Ibrahim , Hanna Cho , Bruce England , Sam Gillette , Dean R. Artis , Rebecca Zuckerman , Chao Zhang
IPC分类号： A61K31/4365 , C07D471/04 , C07D413/14 , A61K31/5377 , A61P11/00 , A61P25/00 , A61P35/00 , A61P19/00
CPC分类号： C07C311/48 , C07D215/36 , C07D215/40 , C07D231/12 , C07D239/18 , C07D239/46 , C07D275/04 , C07D277/42 , C07D277/62 , C07D333/36 , C07D333/38 , C07D333/40 , C07D401/12 , C07D405/06 , C07D405/14 , C07D409/04 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04
摘要： Compounds active on phosphodiesterase PDE4B are provided. Also provided herewith are compositions useful for treatment of PDE4B-mediated diseases or conditions, and methods for the use thereof.
摘要翻译：提供了磷酸二酯酶PDE4B活性的化合物。本文还提供了可用于治疗PDE4B介导的疾病或病症的组合物及其使用方法。

24. 发明授权

US07605168B2 PDE4B inhibitors 有权
标题翻译： PDE4B抑制剂
公开(公告)号：US07605168B2
公开(公告)日：2009-10-20
申请号：US11219635
申请日：2005-09-02
申请人： Prabha N. Ibrahim , Ryan Bremer , Sam Gillette , Hanna Cho , Marika Nespi , Shumeye Mamo , Chao Zhang , Dean R. Artis , Byunghun Lee , Rebecca Zuckerman
发明人： Prabha N. Ibrahim , Ryan Bremer , Sam Gillette , Hanna Cho , Marika Nespi , Shumeye Mamo , Chao Zhang , Dean R. Artis , Byunghun Lee , Rebecca Zuckerman
IPC分类号： A61K31/437 , A61K31/403 , C07D471/02 , C07D405/02
CPC分类号： C07D471/04 , C07D209/12 , C07D401/12 , C07D405/04 , G06F19/16 , G06F19/706
摘要： Compounds are described that are active on PDE4. Also described are crystal structures of PDE4B determined using X-ray crystallography, the use of PDE4B crystals and structural information for identifying molecular scaffolds, for developing ligands that bind to and modulate PDE4B, and for identifying improved ligands based on known ligands.
摘要翻译：描述了在PDE4上有活性的化合物。还描述了使用X射线晶体学测定的PDE4B的晶体结构，使用PDE4B晶体和用于鉴定分子支架的结构信息，用于开发结合和调节PDE4B的配体，以及基于已知配体鉴定改进的配体。

25. 发明申请

US20090181988A1 Pyrazolo Pyrimidine Derivatives and Methods of Use Thereof 审中-公开
标题翻译：吡唑并嘧啶衍生物及其使用方法
公开(公告)号：US20090181988A1
公开(公告)日：2009-07-16
申请号：US12194469
申请日：2008-08-19
申请人： Masahiro Tanaka , Chao Zhang , Kevan M. Shokat , Alma L. Burlingame , Kirk Hansen , Raynard L. Bateman , Stephen G. DiMagno
发明人： Masahiro Tanaka , Chao Zhang , Kevan M. Shokat , Alma L. Burlingame , Kirk Hansen , Raynard L. Bateman , Stephen G. DiMagno
IPC分类号： A61K31/522 , C12Q1/02 , C07D473/34 , A61K31/519 , C07D473/30 , A61K31/52 , C07D487/04 , A61P35/00
CPC分类号： C07D487/04
摘要： This invention generally relates to pyrazolo pyrimidine derivatives useful as, inter alia, inhibitors of short chain dehydrogenase/reductase (SDR) family of NAD(P)(H) dependent oxido-reductases. More specifically, the invention relates to pyrazolo pyrimidine derivatives, including derivatives and analogs of SDR inhibitors, pharmaceutical compositions containing derivatives and analogs of SDR inhibitors, methods of making derivatives and analogs of SDR inhibitors and methods of use thereof.
摘要翻译：本发明一般涉及用作特别是NAD（P）（H）依赖性氧化还原酶的短链脱氢酶/还原酶（SDR）家族的抑制剂的吡唑并嘧啶衍生物。更具体地，本发明涉及吡唑并嘧啶衍生物，包括SDR抑制剂的衍生物和类似物，含有SDR抑制剂的衍生物和类似物的药物组合物，制备SDR抑制剂的衍生物和类似物的方法及其使用方法。

26. 发明授权

US07429596B2 1H-pyrrolo [2,3-D] pyrimidine derivatives and methods of use thereof 有权
标题翻译： 1H-吡咯并[2,3-D]嘧啶衍生物及其使用方法
公开(公告)号：US07429596B2
公开(公告)日：2008-09-30
申请号：US10871732
申请日：2004-06-18
申请人： Masahiro Tanaka , Chao Zhang , Kevan M. Shokat , Alma L. Burlingame , Kirk Hansen , Raynard L. Bateman , Stephen G. DiMagno
发明人： Masahiro Tanaka , Chao Zhang , Kevan M. Shokat , Alma L. Burlingame , Kirk Hansen , Raynard L. Bateman , Stephen G. DiMagno
IPC分类号： C07D487/04 , C07D413/06 , A61K31/519 , A61K31/675 , A61K31/662 , A61K31/497 , A61K31/5355 , C07F9/38 , A61P35/04 , A61P35/02
CPC分类号： C07D487/04
摘要： This invention generally relates to pyrazolo pyrimidine derivatives useful as inhibitors of short chain dehydrogenase/reductase (SDR) family of NAD(P)(H) dependent oxido-reductases. The invention further relates to pharmaceutical compositions and methods of preventing or treating disease with 1H-Pyrrolo[2.3-d]pyrimidine derivatives. More specifically, the invention relates to a 1H-Pyrrolo[2.3-d]pyrimidine which is a compound of Formula I or II: or a pharmaceutically-acceptable salt or prodrug thereof; wherein: Y is N or CR5; Z is NR3R4, halo, H, OH, alkyl, alkyloxy, or haloalkyl; and R1a is indolyl, thiazolyl, benzyl, biphenylyl, thiophenyl, pyrrolyl, or phenyl, wherein said phenyl is substituted with at least one of OH, —NR3R4, —C(═O)NR6R7, —CN, NO2—C(═O)OH, —C(═O)O-alkyl, (C1-C4)alkyl, halo, haloalkyl or haloaryl; and wherein said indolyl, thiazolyl, benzyl, biphenylyl, thiophenyl, or pyrrolyl is optionally substituted with OH, —NR3R4, —C(═O)NR6R7, —CN, NO2, —C(═O)O—R3, (C1-C4)alkyl, halo, haloalkyl or haloaryl.
摘要翻译：本发明一般涉及可用作NAD（P）（H）依赖性氧化还原酶的短链脱氢酶/还原酶（SDR）家族的抑制剂的吡唑并嘧啶衍生物。本发明还涉及用1H-吡咯并[2,3-d]嘧啶衍生物预防或治疗疾病的药物组合物和方法。更具体地，本发明涉及作为式I或II化合物的1H-吡咯并[2,3-d]嘧啶或其药学上可接受的盐或前药; 其中：Y是N或CR 5; Z是NR 3 R 4，卤素，H，OH，烷基，烷氧基或卤代烷基; 并且R 1a是吲哚基，噻唑基，苄基，联苯基，噻吩基，吡咯基或苯基，其中所述苯基被OH，-NR 3 R 3中的至少一个取代， -C（-O）NR 6 R 7，-CN，NO 2 -C（-O（O））OH，-C（-O）O-烷基，（C 1 -C 4 -C 4）烷基，卤素，卤代烷基或卤代芳基; 并且其中所述吲哚基，噻唑基，苄基，联苯基，噻吩基或吡咯基任选被OH，-NR 3 R 4，-C（ - ）NR -C（O）OR 3，-C（-O）OR 3，（C 1 -C 6） C 1 -C 4烷基，卤素，卤代烷基或卤代芳基。

27. 发明申请

US20070082884A1 Selective serine/threonine kinase inhibitors 有权
标题翻译：选择性丝氨酸/苏氨酸激酶抑制剂
公开(公告)号：US20070082884A1
公开(公告)日：2007-04-12
申请号：US10552847
申请日：2004-04-12
申请人： Jack Taunton , Michael Cohen , Kevan Shokat , Chao Zhang
发明人： Jack Taunton , Michael Cohen , Kevan Shokat , Chao Zhang
IPC分类号： A61K31/55 , A61K31/519 , A61K31/517 , A61K31/407 , A61K31/404
CPC分类号： C07D487/04
摘要： Inhibition of protein kinases having one or more cysteine residues within the ATP binding site is effected by contacting the kinase, per se or in a cell or subject, with an inhibitory-effective amount of a compound having a heterocyclic core structure comprised of two or more fused rings containing at least one nitrogen ring atom, and an electrophilic substituent that is capable of reacting with a cysteine residue within the ATP binding site of a kinase. Preferred compounds include certain pyrrolopyrimidines and oxindoles having such an electrophilic substituent and optionally an aromatic or heteroaromatic substituent that is capable of interacting with a threonine or smaller residue located in the gatekeeper position of the kinase. Kinases lacking such cysteine residues may be engineered or modified so that they are capable of being inhibited by such compounds by replacing a valine or other amino acid residue within the ATP binding site by a cysteine residue.
摘要翻译：在ATP结合位点内具有一个或多个半胱氨酸残基的蛋白激酶的抑制通过使本身或细胞或受试者中的激酶与抑制有效量的具有由两个或更多个的杂环核心结构组成的化合物接触来实现含有至少一个氮环原子的稠环，以及能够与激酶的ATP结合位点内的半胱氨酸残基反应的亲电取代基。优选的化合物包括具有这样的亲电子取代基的某些吡咯并嘧啶和羟吲哚，以及任选的能够与位于激酶的关守位置的苏氨酸或更小残基相互作用的芳族或杂芳族取代基。缺乏这种半胱氨酸残基的激酶可以被改造或修饰，使得它们能够被这种化合物抑制，通过用半胱氨酸残基替换ATP结合位点内的缬氨酸或其它氨基酸残基。

28. 发明授权

US07183540B2 Apparatus for measuring photo diodes' temperature dependence 有权
标题翻译：用于测量光电二极管温度依赖性的设备
公开(公告)号：US07183540B2
公开(公告)日：2007-02-27
申请号：US11082357
申请日：2005-03-17
申请人： Chao Zhang , Xuefei Zeng , Zhong Yang , Yuanjun Huang , Zhiyong Jiang , Jun Cao
发明人： Chao Zhang , Xuefei Zeng , Zhong Yang , Yuanjun Huang , Zhiyong Jiang , Jun Cao
IPC分类号： H01J7/24
CPC分类号： G01J1/08 , G01J1/02 , G01J1/0252 , G01J1/04 , G01J1/0418 , G01J2001/4466 , G01R31/2635 , G01R31/2642
摘要： A system for measuring gains of a plurality of photo diodes includes a chamber adapted to host the plurality of photo diodes and a temperature control unit configured to control the temperature within the chamber to a predetermined temperature. A control unit selects at least one of the plurality of photo diodes. A hosting unit is configured to provide a bias voltage to the selected photo diode at the predetermined temperature. A light source transmits photo signals to the selected photo diode at the predetermined temperature. A measurement unit configured to measure current signals generated by the selected photo diode in response to the photo signals under the bias voltage at the predetermined temperature.
摘要翻译：用于测量多个光电二极管的增益的系统包括适于容纳多个光电二极管的室，以及被配置为将室内的温度控制在预定温度的温度控制单元。控制单元选择多个光电二极管中的至少一个。托管单元被配置为在预定温度下向所选择的光电二极管提供偏置电压。光源在预定温度下将光信号传输到选定的光电二极管。测量单元，被配置为响应于在预定温度下的偏置电压下的光信号来测量由所选择的光电二极管产生的电流信号。

29. 发明申请

US20060208180A1 Apparatus for measuring photo diodes' temperature dependence 有权
标题翻译：用于测量光电二极管温度依赖性的设备
公开(公告)号：US20060208180A1
公开(公告)日：2006-09-21
申请号：US11082357
申请日：2005-03-17
申请人： Chao Zhang , Xuefei Zeng , Zhong Yang , Yuanjun Huang , Zhiyong Jiang , Jun Cao
发明人： Chao Zhang , Xuefei Zeng , Zhong Yang , Yuanjun Huang , Zhiyong Jiang , Jun Cao
IPC分类号： H01J7/24
CPC分类号： G01J1/08 , G01J1/02 , G01J1/0252 , G01J1/04 , G01J1/0418 , G01J2001/4466 , G01R31/2635 , G01R31/2642
摘要： A system for measuring gains of a plurality of photo diodes includes a chamber adapted to host the plurality of photo diodes and a temperature control unit configured to control the temperature within the chamber to a predetermined temperature. A control unit selects at least one of the plurality of photo diodes. A hosting unit is configured to provide a bias voltage to the selected photo diode at the predetermined temperature. A light source transmits photo signals to the selected photo diode at the predetermined temperature. A measurement unit configured to measure current signals generated by the selected photo diode in response to the photo signals under the bias voltage at the predetermined temperature.
摘要翻译：用于测量多个光电二极管的增益的系统包括适于容纳多个光电二极管的室，以及被配置为将室内的温度控制在预定温度的温度控制单元。控制单元选择多个光电二极管中的至少一个。托管单元被配置为在预定温度下向所选择的光电二极管提供偏置电压。光源在预定温度下将光信号传输到选定的光电二极管。测量单元，被配置为响应于在预定温度下的偏置电压下的光信号来测量由所选择的光电二极管产生的电流信号。

30. 发明申请

US20050190990A1 Method and apparatus for combining a plurality of images 审中-公开
标题翻译：用于组合多个图像的方法和装置
公开(公告)号：US20050190990A1
公开(公告)日：2005-09-01
申请号：US11044155
申请日：2005-01-27
申请人： Peter Burt , Gooitzen Der Wal , Chao Zhang
发明人： Peter Burt , Gooitzen Der Wal , Chao Zhang
IPC分类号： G03G9/00 , G06K9/32 , G06K9/36
CPC分类号： G06T5/50
摘要： A method and apparatus for combining a plurality of images is disclosed. In one embodiment, at least one signal component is determined from a plurality of source images using feature selective fusion. At least one color component is determined from the plurality of source images using color fusion. An output image is formed from the at least one signal component and the at least one color component. In another embodiment, at least one image component is determined from a plurality of source images using feature selective fusion. An output image is formed from the at least one image component using color fusion.
摘要翻译：公开了一种用于组合多个图像的方法和装置。在一个实施例中，使用特征选择融合从多个源图像确定至少一个信号分量。使用颜色融合从多个源图像确定至少一个颜色分量。输出图像由至少一个信号分量和至少一个颜色分量形成。在另一实施例中，使用特征选择融合从多个源图像确定至少一个图像分量。使用颜色融合从至少一个图像分量形成输出图像。

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