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21. 发明授权

US5889025A Antidiabetic compounds having hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them 失效
标题翻译：具有降血脂，抗高血压特性的抗糖尿病化合物，其制备方法和含有它们的药物组合物
公开(公告)号：US5889025A
公开(公告)日：1999-03-30
申请号：US851450
申请日：1997-05-05
申请人： Vidya Bhushan Lohray , Braj Bhushan Lohray , Sekar Reddy Alla , Rajagopalan Ramanujam , Ranjan Chakrabarti
发明人： Vidya Bhushan Lohray , Braj Bhushan Lohray , Sekar Reddy Alla , Rajagopalan Ramanujam , Ranjan Chakrabarti
IPC分类号： A61K20060101 , C07D20060101 , C07D277/20 , C07D417/12 , A61K31/445 , C07D417/10
CPC分类号： C07D277/20 , C07D417/12
摘要： Novel antidiabetic compounds, their tautomeric forms, their derivatives, their steroisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutical acceptable compositions containing them: Methods for preparing the antidiabetic compounds and their uses.
摘要翻译：新型抗糖尿病化合物，其互变异构形式，其衍生物，其立体异构体，其多晶型物，其药学上可接受的盐，其药学上可接受的溶剂合物和含有它们的药学上可接受的组合物：制备抗糖尿病化合物的方法及其用途。

22. 发明授权

US07119198B2 Tricyclic compounds and their use in medicine; process for their preparation and pharmaceutical compositions containing them 失效
标题翻译：三环化合物及其在医药中的应用其制备方法和含有它们的药物组合物
公开(公告)号：US07119198B2
公开(公告)日：2006-10-10
申请号：US11182032
申请日：2005-07-14
申请人： Braj Bhushan Lohray , Vidya Bhushan Lohray , Ashok Channaveerappa Bajji , Shivaramayya Kalchar , Rajagopalan Ramanujam , Ranjan Chakrabarti
发明人： Braj Bhushan Lohray , Vidya Bhushan Lohray , Ashok Channaveerappa Bajji , Shivaramayya Kalchar , Rajagopalan Ramanujam , Ranjan Chakrabarti
IPC分类号： C07D265/38
CPC分类号： C07C59/64 , C07C69/734 , C07D265/28 , C07D265/38 , C07D279/22 , C07D279/24 , C07D279/26 , C07D413/06 , C07D417/06
摘要： Novel β-aryl-α-oxysubstituted alkylcarboxylic acids of the formula (I) and compositions containing them. The compounds have hypolipidemic, antihyperglycemic uses.
摘要翻译：式（I）的新型β-芳基-α-氧代取代的烷基羧酸和含有它们的组合物。这些化合物具有降血脂，抗高血糖的作用。

23. 发明授权

US06939988B1 Tricyclic compounds and their use in medicine process for their preparation and pharmaceutical compositions containing them 失效
标题翻译：三环化合物及其在药物制备中的应用及含有它们的药物组合物
公开(公告)号：US06939988B1
公开(公告)日：2005-09-06
申请号：US09448260
申请日：1999-11-23
申请人： Braj Bhushan Lohray , Vidya Bhushan Lohray , Ashok Channaveerappa Bajji , Shivaramayya Kalchar , Rajagopalan Ramanujam , Ranjan Chakrabarti
发明人： Braj Bhushan Lohray , Vidya Bhushan Lohray , Ashok Channaveerappa Bajji , Shivaramayya Kalchar , Rajagopalan Ramanujam , Ranjan Chakrabarti
IPC分类号： C07D279/22 , A61K20060101 , A61K31/535 , A61K31/538 , A61K31/54 , A61K31/5415 , A61P3/04 , A61P3/06 , A61P3/08 , A61P3/10 , A61P5/00 , A61P9/10 , A61P13/12 , A61P17/06 , A61P19/10 , A61P43/00 , C07C20060101 , C07C51/353 , C07C59/64 , C07C67/343 , C07C69/734 , C07D20060101 , C07D265/28 , C07D265/38 , C07D279/26 , C07D307/81 , C07D413/06 , C07D417/06
CPC分类号： C07C59/64 , C07C69/734 , C07D265/28 , C07D265/38 , C07D279/22 , C07D279/24 , C07D279/26 , C07D413/06 , C07D417/06
摘要： Novel β-aryl-α-oxysubstituted alkylcarboxylic acids of the formula (I) and compositions containing them. The compounds have hypolipidemic, antihyperglycemic uses.
摘要翻译：式（I）的新型β-芳基-α-氧代取代的烷基羧酸和含有它们的组合物。这些化合物具有降血脂，抗高血糖的作用。

24. 发明授权

US06846824B2 Bicyclic compounds and their use in medicine; process for their preparation and pharmaceutical compositions containing them 失效
标题翻译：双环化合物及其在药物中的用途; 其制备方法和含有它们的药物组合物
公开(公告)号：US06846824B2
公开(公告)日：2005-01-25
申请号：US09816584
申请日：2001-03-23
申请人： Braj Bhushan Lohray , Vidya Bhushan Lohray , Ashok Channaveerappa Bajji , Shivaramayya Kalchar , Rajagopalan Ramanujam , Ranjan Chakrabarti , Javed Iqbal , Ranga Madhavan Gurram
发明人： Braj Bhushan Lohray , Vidya Bhushan Lohray , Ashok Channaveerappa Bajji , Shivaramayya Kalchar , Rajagopalan Ramanujam , Ranjan Chakrabarti , Javed Iqbal , Ranga Madhavan Gurram
IPC分类号： A61K9/08 , A61K9/10 , A61K9/14 , A61K9/20 , A61K9/48 , A61K31/538 , A61K31/5415 , A61P3/04 , A61P3/06 , A61P3/10 , A61P5/00 , A61P9/10 , A61P13/12 , A61P17/06 , A61P19/10 , A61P25/28 , C07D265/36 , C07D279/16 , C07D413/06 , A61K31/495 , C07D241/38
CPC分类号： C07D413/06 , A61K31/5415 , C07D265/36 , C07D279/16
摘要： Compounds of formula (I) its tautomeric forms, its stereoisomers, its polymorphs, its pharmaceutically acceptable salts or its pharmaceutically acceptable solvates can be used to prevent or treat diabetes caused by insulin resistance or impaired glucose tolerance or complications of diabetes caused by insulin resistance or impaired glucose tolerance. The compounds can also be used to reduce cholesterol, body weight, blood glucose, triglycerides and free fatty acids in the blood.
摘要翻译：式（I）化合物其互变异构形式，其立体异构体，其多晶型物，其药学上可接受的盐或其药学上可接受的溶剂化物可用于预防或治疗由胰岛素抵抗或糖耐量受损或由胰岛素抵抗引起的糖尿病并发症引起的糖尿病，葡萄糖耐量降低。该化合物也可用于降低血液中的胆固醇，体重，血糖，甘油三酯和游离脂肪酸。

25. 发明授权

US06372750B2 Heterocyclic compounds, process for their preparation and pharmaceutical compounds containing them and their use in the treatment of diabetes and related diseases 有权
标题翻译：杂环化合物，其制备方法和含有它们的药物化合物及其在治疗糖尿病和相关疾病中的应用
公开(公告)号：US06372750B2
公开(公告)日：2002-04-16
申请号：US09827009
申请日：2001-04-05
申请人： Vidya Bhushan Lohray , Braj Bhushan Lohray , Rao Bheema Paraselli , Ranga Madhavan Gurram , Rajagopalan Ramanujam , Ranjan Chakrabarti , Sarma K. S. Pakala
发明人： Vidya Bhushan Lohray , Braj Bhushan Lohray , Rao Bheema Paraselli , Ranga Madhavan Gurram , Rajagopalan Ramanujam , Ranjan Chakrabarti , Sarma K. S. Pakala
IPC分类号： A61K31425
CPC分类号： C07D239/36 , C07D239/47 , C07D239/88 , C07D277/34 , C07D413/12 , C07D417/12 , C07D471/04 , C07D495/04
摘要： The present invention relates to novel antidiabetic compounds, their tautomeric forms, their derivatives, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them This invention particularly relates to novel azolidinedione derivatives of the general formula (I), and their pharmaceutically acceptable salts, pharmaceutically acceptable solvates and pharmaceutical compositions containing them
摘要翻译：本发明涉及新的抗糖尿病化合物，其互变异构形式，其衍生物，其立体异构体，其多晶型物，其药学上可接受的盐，其药学上可接受的溶剂合物和含有它们的药学上可接受的组合物。本发明特别涉及通式（ I）及其药学上可接受的盐，药学上可接受的溶剂合物和含有它们的药物组合物

26. 发明授权

US06331627B1 Intermediates of benzoxazinone derivatives and preparation thereof 失效
标题翻译：苯并恶嗪酮衍生物的中间体及其制备方法
公开(公告)号：US06331627B1
公开(公告)日：2001-12-18
申请号：US09610623
申请日：2000-07-05
申请人： Vidya Bhushan Lohray , Braj Bhushan Lohray , Rao Bheema Paraselli , Rajagopalan Ramanujam , Ranjan Chakrabarti
发明人： Vidya Bhushan Lohray , Braj Bhushan Lohray , Rao Bheema Paraselli , Rajagopalan Ramanujam , Ranjan Chakrabarti
IPC分类号： C07D27916
CPC分类号： C07C323/62 , C07C235/48 , C07C327/48 , C07D239/90 , C07D265/22 , C07D279/08
摘要： The present invention relates to novel antiobesity and hypocholesterolemic compounds, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. More particularly, the present invention relates to novel &bgr;-aryl-&agr;-oxysubstituted alkylcarboxylic acids of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereo-somers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. The present invention also relates to a process for the preparation of the above said novel compounds, their analogs, their derivatives, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, pharmaceutically acceptable solvates, novel intermediates and pharmaceutical compositions containing them.
摘要翻译：本发明涉及新型抗肥胖和低胆固醇血症化合物，其衍生物，其类似物，其互变异构形式，其立体异构体，其多晶型物，其药学上可接受的盐，其药学上可接受的溶剂合物和含有它们的药学上可接受的组合物。更具体地，本发明涉及通式（I）的新型β-芳基-α-氧代取代的烷基羧酸，其衍生物，它们的类似物，它们的互变异构形式，它们的立体异构体，它们的多晶型物，其药学上可接受的盐，它们的药学上可接受的溶剂合物和含有它们的药学上可接受的组合物。本发明还涉及制备上述新化合物，其类似物，其衍生物，其互变异构形式，其立体异构体，其多晶型物，其药学上可接受的盐，药学上可接受的盐可接受的溶剂合物，新型中间体和含有它们的药物组合物。

27. 发明授权

US06265401B1 Bicyclic compounds and their use in medicine, process for their preparation and pharmaceutical compositions containing them 失效
标题翻译：双环化合物及其在医药中的应用，其制备方法和含有它们的药物组合物
公开(公告)号：US06265401B1
公开(公告)日：2001-07-24
申请号：US09085292
申请日：1998-05-27
申请人： Braj Bhushan Lohray , Vidya Bhushan Lohray , Ashok Channaveerappa Bajji , Shivaramayya Kalchar , Rajagopalan Ramanujam , Ranjan Chakrabarti
发明人： Braj Bhushan Lohray , Vidya Bhushan Lohray , Ashok Channaveerappa Bajji , Shivaramayya Kalchar , Rajagopalan Ramanujam , Ranjan Chakrabarti
IPC分类号： A61K31538
CPC分类号： C07D265/36 , A61K31/5415 , C07D279/16
摘要： Compounds of formula (I) its tautomeric forms, its stereoisomers, its polymorphs, its pharmaceutically acceptable salts or its pharmaceutically acceptable solvates can be used to prevent or treat diabetes caused by insulin resistance or impaired glucose tolerance or complications of diabetes caused by insulin resistance or impaired glucose tolerance. The compounds can also be used to reduce cholesterol, body weight, blood glucose, triglycerides and free fatty acids in the blood.
摘要翻译：式（I）化合物其互变异构形式，其立体异构体，其多晶型物，其药学上可接受的盐或其药学上可接受的溶剂化物可用于预防或治疗由胰岛素抵抗或糖耐量受损或由胰岛素抵抗引起的糖尿病并发症引起的糖尿病，葡萄糖耐量降低。该化合物也可用于降低血液中的胆固醇，体重，血糖，甘油三酯和游离脂肪酸。

28. 发明授权

US6030973A Heterocyclic compounds having antidiabetic hypolipidemia and antihypertensive properties, process for their preparation and pharmaceutical compositions containing them 失效
标题翻译：具有抗糖尿病血脂异常和抗高血压性质的杂环化合物，其制备方法和含有它们的药物组合物
公开(公告)号：US6030973A
公开(公告)日：2000-02-29
申请号：US135566
申请日：1998-08-17
申请人： Vidya Bhushan Lohray , Braj Bhushan Lohray , Rao Bheema Paraselli , Rajagopalan Ramanujam , Ranjan Chakrabarti
发明人： Vidya Bhushan Lohray , Braj Bhushan Lohray , Rao Bheema Paraselli , Rajagopalan Ramanujam , Ranjan Chakrabarti
IPC分类号： C07D265/22 , C07D277/20 , C07D277/34 , C07D413/12 , C07D417/12 , A61K31/505 , C07D239/91 , C07D239/92 , C07D279/08
CPC分类号： C07D417/12 , C07D265/22 , C07D277/20 , C07D277/34 , C07D413/12
摘要： The present invention relates to novel antidiabetic compounds, their tautomeric forms, their derivatives, their analogues, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. This invention particularly relates to novel azolidinediones of the general formula (I), their analogues, their derivatives, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, pharmaceutically acceptable solvates and pharmaceutical compositions containing them. ##STR1##
摘要翻译：本发明涉及新型抗糖尿病化合物，其互变异构形式，其衍生物，其类似物，其立体异构体，其多晶型物，其药学上可接受的盐，其药学上可接受的溶剂化物和含有它们的药学上可接受的组合物。本发明特别涉及通式（I）的新型氮杂二醇，其类似物，其衍生物，其互变异构形式，其立体异构体，其多晶型物，其药学上可接受的盐，药学上可接受的溶剂合物和含有它们的药物组合物。

29. 发明授权

US5985884A Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases 失效
公开(公告)号：US5985884A
公开(公告)日：1999-11-16
申请号：US884816
申请日：1997-06-30
申请人： Vidya Bhushan Lohray , Braj Bhushan Lohray , Rao Bheema Paraselli , Ranga Madhavan Gurram , Rajagopalan Ramanujam , Ranjan Chakrabarti , Sarma K. S. Pakala
发明人： Vidya Bhushan Lohray , Braj Bhushan Lohray , Rao Bheema Paraselli , Ranga Madhavan Gurram , Rajagopalan Ramanujam , Ranjan Chakrabarti , Sarma K. S. Pakala
IPC分类号： A61K31/417 , A61K31/4178 , A61K31/422 , A61K31/4245 , A61K31/497 , A61K31/513 , A61K31/517 , A61K31/519 , A61P3/00 , A61P3/06 , A61P3/10 , C07D239/00 , C07D239/36 , C07D239/46 , C07D239/88 , C07D263/00 , C07D271/00 , C07D277/00 , C07D277/34 , C07D413/12 , C07D417/12 , C07D471/04 , C07D495/04 , A61K31/505 , C07D239/02 , C07D241/00
CPC分类号： C07D239/36 , C07D239/47 , C07D239/88 , C07D277/34 , C07D413/12 , C07D417/12 , C07D471/04 , C07D495/04
摘要： The present invention relates to novel antidiabetic compounds, their tautomeric forms, their derivatives, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. This invention particularly relates to novel azolidinedione derivatives of the general formula (I), and their pharmaceutically acceptable salts, pharmaceutically acceptable solvates and pharmaceutical compositions containing them. ##STR1##

30. 发明授权

US5919782A Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them 失效
标题翻译：具有抗糖尿病，降血脂血症，抗高血压性质的杂环化合物，其制备方法和含有它们的药物组合物
公开(公告)号：US5919782A
公开(公告)日：1999-07-06
申请号：US851447
申请日：1997-05-05
申请人： Vidya Bhushan Lohray , Braj Bhushan Lohray , Paraselli Bheema Rao , Sekar Reddy Alla , Rajagopalan Ramanujam , Ranjan Chakrabarti
发明人： Vidya Bhushan Lohray , Braj Bhushan Lohray , Paraselli Bheema Rao , Sekar Reddy Alla , Rajagopalan Ramanujam , Ranjan Chakrabarti
IPC分类号： C07D417/14 , C07D417/12 , A61K31/425
CPC分类号： C07D417/14
摘要： Novel antidiabetic compounds, their tautomeric forms, their derivatives, their steroisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceuticals acceptable compositions containing them; methods for preparing the antidiabetic compounds and their uses.
摘要翻译：新型抗糖尿病化合物，其互变异构形式，其衍生物，其立体异构体，其多晶型物，其药学上可接受的盐，其药学上可接受的溶剂化物和药物可接受的组合物含有它们; 制备抗糖尿病化合物的方法及其用途。

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