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21. 发明申请

US20080283474A1 BUOY SUSPENSION FRACTIONATION SYSTEM 有权
标题翻译： BUOY悬挂分拣系统
公开(公告)号：US20080283474A1
公开(公告)日：2008-11-20
申请号：US12101594
申请日：2008-04-11
申请人： Michael D. Leach , Randel Dorian , Jacy C. Hoeppner
发明人： Michael D. Leach , Randel Dorian , Jacy C. Hoeppner
IPC分类号： B01D21/26
CPC分类号： B01D21/262 , A61M1/029 , A61M1/3693 , B01D21/26 , B01L3/50215 , B01L2200/026 , B01L2400/0409 , G01N33/491
摘要： A separator that uses centrifugation to fractionate a suspension such as blood comprises a separation container and a buoy. The buoy is carried in the separation container and has a tuned density that is configured to reach an equilibrium position in a suspension. The guide surface is carried on the buoy upper surface and is inclined to an accumulation position near a buoy perimeter. The buoy suspension fractionation system can be used in a method of isolating a fraction from a suspension, and in a method for re-suspending particulates for withdrawal.
摘要翻译：使用离心分离悬浮液如血液的分离器包括分离容器和浮标。浮标被携带在分离容器中并且具有被配置为在悬浮液中达到平衡位置的调节密度。引导表面承载在浮标上表面上，并且倾斜于靠近浮标周界的积聚位置。浮标分级分离系统可用于从悬浮液中分离馏分的方法，以及用于再悬浮颗粒以进行萃取的方法。

22. 发明授权

US08105495B2 Method for preparing platelet rich plasma and concentrates thereof 有权
标题翻译：制备富血小板血浆及其浓缩物的方法
公开(公告)号：US08105495B2
公开(公告)日：2012-01-31
申请号：US12987605
申请日：2011-01-10
申请人： Randel Dorian , Michael D. Leach
发明人： Randel Dorian , Michael D. Leach
IPC分类号： B01D21/26 , B01D15/00 , B01D33/00 , B01D35/00 , B01D37/00 , B04B3/00 , B04B1/04
CPC分类号： A61M1/3496 , A61M1/3482 , A61M1/3633 , A61M1/3679 , A61M1/3693 , A61M1/3696 , A61M2202/0415 , B04B5/0442 , B04B2005/0478
摘要： A process for separating platelet rich plasma from a blood sample using a platelet rich plasma separator system is disclosed. The system includes an inner wall having a top edge and a central axis that is surrounded by a depth filter having a capacity to receive all of the erythrocytes in the blood sample, where an inner surface of the inner wall has an angle of about 0.2° from the central axis of the inner wall. The process includes spinning the inner cylinder at its central axis at a speed that separates the erythrocytes from plasma and platelets and causes the erythrocytes to collect against an inner surface of the depth filter. The cylinder is continually spun for a sufficient time to allow substantially all of the erythrocytes to flow up the inner surface and over the top edge into the depth filter, leaving platelet enriched plasma (PRP) in the inner cylinder, such that upon discontinuing the spinning, permits the platelet enriched plasma to flow to the bottom of the inner cylinder.
摘要翻译：公开了一种使用富血小板血浆分离器系统从血液样品中分离富血小板血浆的方法。该系统包括具有顶部边缘和中心轴线的内壁，该内壁被深度过滤器包围，该深度过滤器具有容纳血液样本中的所有红细胞的能力，其中内壁的内表面具有约0.2°的角度从内壁的中心轴线。该方法包括以将红细胞与血浆和血小板分离的速度在其中心轴处旋转内筒，并使红细胞收集在深度过滤器的内表面上。气瓶连续旋转足够的时间，以使基本上所有的红细胞都能从内表面上升到顶部边缘上方进入深度过滤器，从而在内筒中留下富含血小板的血浆（PRP），从而在停止纺丝时允许富含血小板的血浆流到内筒的底部。

23. 发明申请

US20110284460A1 Buoy Suspension Fractionation System 有权
公开(公告)号：US20110284460A1
公开(公告)日：2011-11-24
申请号：US13198038
申请日：2011-08-04
申请人： Michael D. Leach , Randel Dorian , Jacy C. Hoeppner
发明人： Michael D. Leach , Randel Dorian , Jacy C. Hoeppner
IPC分类号： B01D21/00
CPC分类号： B01D21/262 , A61M1/029 , A61M1/3693 , A61M2202/0427 , B01L3/50215 , B01L2200/026
摘要： A separator that uses centrifugation to fractionate a suspension such as blood comprises a separation container and a buoy. The buoy is carried in the separation container and has a tuned density that is configured to reach an equilibrium position in a suspension. The guide surface is carried on the buoy upper surface and is inclined to an accumulation position near a buoy perimeter. The buoy suspension fractionation system can be used in a method of isolating a fraction from a suspension, and in a method for re-suspending particulates for withdrawal.

24. 发明申请

US20110281714A1 Method and Apparatus for Preparing Platelet Rich Plasma and Concentrates Thereof 失效
标题翻译：制备富血小板血浆及其浓缩物的方法和装置
公开(公告)号：US20110281714A1
公开(公告)日：2011-11-17
申请号：US13193849
申请日：2011-07-29
申请人： Randel Dorian , Michael D. Leach
发明人： Randel Dorian , Michael D. Leach
IPC分类号： B04B7/18
CPC分类号： B01D63/02 , A61M1/0281 , A61M1/3482 , A61M1/3496 , A61M1/3633 , A61M1/3679 , A61M1/3693 , A61M1/3696 , A61M2202/0415 , A61M2202/0427 , B01D2313/44 , B01D2313/58 , B01F11/0005 , B01F13/0052 , B04B5/0442 , B04B2005/0478
摘要： The PRP separator-concentrator of this invention is suitable for office use or emergency use for trauma victims. The PRP separator comprises a motorized centrifugal separation assembly, and a concentrator assembly. The centrifugal separator assembly comprises a centrifugal drum separator that includes an erythrocyte capture module and a motor having a drive axis connected to the centrifugal drum separator. The concentrator assembly comprises a water-removal module for preparing PRP concentrate. The centrifugal drum separator has an erythrocyte trap. The water removal module can be a syringe device with water absorbing beads or it can be a pump-hollow fiber cartridge assembly. The hollow fibers are membranes with pores that allow the flow of water through the fiber membrane while excluding flow of clotting factors useful for sealing and adhering tissue and growth factors helpful for healing while avoiding activation of platelets and disruption of any trace erythrocytes present in the PRP.
摘要翻译：本发明的PRP分离器集中器适用于创伤受害者的办公用途或紧急用途。 PRP分离器包括电动离心分离组件和集中器组件。离心分离器组件包括离心鼓分离器，其包括红细胞捕获模块和具有连接到离心鼓分离器的驱动轴的马达。浓缩器组件包括用于制备PRP浓缩物的去水模块。离心鼓分离器具有红细胞捕集器。除水模块可以是具有吸水珠的注射器装置，或者其可以是泵中空纤维筒组件。中空纤维是具有孔的膜，其允许水流过纤维膜，同时排除可用于密封和粘附组织的凝血因子的流动和有助于愈合的生长因子，同时避免血小板的活化和PRP中存在的任何痕量红细胞的破坏。

25. 发明申请

US20110100919A1 Method for Preparing Platelet Rich Plasma and Concentrates Thereof 有权
标题翻译：制备富血小板血浆及其浓缩物的方法
公开(公告)号：US20110100919A1
公开(公告)日：2011-05-05
申请号：US12987605
申请日：2011-01-10
申请人： Randel Dorian , Michael D. Leach
发明人： Randel Dorian , Michael D. Leach
IPC分类号： B04B3/00 , B01D15/00
CPC分类号： A61M1/3496 , A61M1/3482 , A61M1/3633 , A61M1/3679 , A61M1/3693 , A61M1/3696 , A61M2202/0415 , B04B5/0442 , B04B2005/0478
摘要： A process for separating platelet rich plasma from a blood sample using a platelet rich plasma separator system is disclosed. The system includes an inner wall having a top edge and a central axis that is surrounded by a depth filter having a capacity to receive all of the erythrocytes in the blood sample, where an inner surface of the inner wall has an angle of about 0.2° from the central axis of the inner wall. The process includes spinning the inner cylinder at its central axis at a speed that separates the erythrocytes from plasma and platelets and causes the erythrocytes to collect against an inner surface of the depth filter. The cylinder is continually spun for a sufficient time to allow substantially all of the erythrocytes to flow up the inner surface and over the top edge into the depth filter, leaving platelet enriched plasma (PRP) in the inner cylinder, such that upon discontinuing the spinning, permits the platelet enriched plasma to flow to the bottom of the inner cylinder.
摘要翻译：公开了一种使用富血小板血浆分离器系统从血液样品中分离富血小板血浆的方法。该系统包括具有顶部边缘和中心轴线的内壁，该内壁被深度过滤器包围，该深度过滤器具有容纳血液样本中的所有红细胞的能力，其中内壁的内表面具有约0.2°的角度从内壁的中心轴线。该方法包括以将红细胞与血浆和血小板分离的速度在其中心轴处旋转内筒，并使红细胞收集在深度过滤器的内表面上。气瓶连续旋转足够的时间，以使得基本上所有的红细胞都能从内表面和顶部边缘上方流入深度过滤器，从而使血小板富集等离子体（PRP）留在内筒中，从而在停止纺丝时允许富含血小板的血浆流到内筒的底部。

26. 发明申请

US20110042296A1 APPARATUS AND METHOD FOR PREPARING PLATELET RICH PLASMA AND CONCENTRATES THEREOF 有权
标题翻译：制备稀土等离子体及其浓度的装置和方法
公开(公告)号：US20110042296A1
公开(公告)日：2011-02-24
申请号：US12917055
申请日：2010-11-01
申请人： Randel Dorian , Michael D. Leach
发明人： Randel Dorian , Michael D. Leach
IPC分类号： B01D36/02
CPC分类号： B01D63/02 , A61M1/0281 , A61M1/3482 , A61M1/3496 , A61M1/3633 , A61M1/3679 , A61M1/3693 , A61M1/3696 , A61M2202/0415 , A61M2202/0427 , B01D2313/44 , B01D2313/58 , B04B5/0442 , B04B2005/0478
摘要： Disclosed is a separator-concentrator, such as for separating and concentrating platelet-rich-plasma (PRP) from whole blood that is suitable for office use or emergency use for trauma victims. The PRP separator comprises a motorized centrifugal separation assembly and a concentrator assembly. The centrifugal separation assembly comprises a centrifugal drum separator and a motor having a drive axis connected to the centrifugal drum separator. The concentrator assembly comprises a water-removal module for preparing PRP concentrate.
摘要翻译：公开了一种分离器收集器，例如用于分离和浓缩富血小板血浆（PRP），全血适用于办公用途或紧急用于创伤受害者。 PRP分离器包括电动离心分离组件和集中器组件。离心分离组件包括离心鼓分离器和具有连接到离心鼓分离器的驱动轴的马达。浓缩器组件包括用于制备PRP浓缩物的去水模块。

27. 发明授权

US07806276B2 Buoy suspension fractionation system 有权
$Buoy suspension fractionation system$
标题翻译：浮标分离系统
公开(公告)号：US07806276B2
公开(公告)日：2010-10-05
申请号：US12101594
申请日：2008-04-11
申请人： Michael D. Leach , Randel Dorian , Jacy C. Hoeppner
发明人： Michael D. Leach , Randel Dorian , Jacy C. Hoeppner
IPC分类号： B01D21/26 , B01D17/02 , B01D17/038 , C02F1/38
CPC分类号： B01D21/262 , A61M1/029 , A61M1/3693 , B01D21/26 , B01L3/50215 , B01L2200/026 , B01L2400/0409 , G01N33/491
摘要： A separator that uses centrifugation to fractionate a suspension such as blood comprises a separation container and a buoy. The buoy is carried in the separation container and has a tuned density that is configured to reach an equilibrium position in a suspension. The guide surface is carried on the buoy upper surface and is inclined to an accumulation position near a buoy perimeter. The buoy suspension fractionation system can be used in a method of isolating a fraction from a suspension, and in a method for re-suspending particulates for withdrawal.
摘要翻译：使用离心分离悬浮液如血液的分离器包括分离容器和浮标。浮标被携带在分离容器中并且具有被配置为在悬浮液中达到平衡位置的调节密度。引导表面承载在浮标上表面上，并且倾斜于靠近浮标周界的积聚位置。浮标分级分离系统可用于从悬浮液中分离馏分的方法，以及用于再悬浮颗粒以进行萃取的方法。

28. 发明申请

US20090014391A1 Buoy Suspension Fractionation System 有权
标题翻译：浮标分离系统
公开(公告)号：US20090014391A1
公开(公告)日：2009-01-15
申请号：US12101586
申请日：2008-04-11
申请人： Michael D. Leach , Randel Dorian , Jacy C. Hoeppner
发明人： Michael D. Leach , Randel Dorian , Jacy C. Hoeppner
IPC分类号： B01D35/05
CPC分类号： A61M1/029 , A61K35/00 , A61M1/3693 , A61M2202/0427 , B01D21/0012 , B01D21/26 , B01D21/262 , B01D2221/10 , B01L3/50215 , B01L2200/026 , B01L2400/0633 , G01N33/49
摘要： A separator that uses centrifugation to fractionate a suspension such as blood comprises a separation container and a buoy. The buoy is carried in the separation container and has a tuned density that is configured to reach an equilibrium position in a suspension. The guide surface is carried on the buoy upper surface and is inclined to an accumulation position near a buoy perimeter. The buoy suspension fractionation system can be used in a method of isolating a fraction from a suspension, and in a method for re-suspending particulates for withdrawal.
摘要翻译：使用离心分离悬浮液如血液的分离器包括分离容器和浮标。浮标被携带在分离容器中并且具有被配置为在悬浮液中达到平衡位置的调节密度。引导表面承载在浮标上表面上，并且倾斜于靠近浮标周界的积聚位置。浮标分级分离系统可用于从悬浮液中分离馏分的方法，以及用于再悬浮颗粒以进行萃取的方法。

29. 发明授权

US09011800B2 Method and apparatus for separating biological materials 有权
标题翻译：用于分离生物材料的方法和装置
公开(公告)号：US09011800B2
公开(公告)日：2015-04-21
申请号：US12504413
申请日：2009-07-16
申请人： Michael D. Leach , Jason Chavarria
发明人： Michael D. Leach , Jason Chavarria
IPC分类号： B01D45/00 , A61M1/02 , A61M1/36 , B01D21/26 , B01D21/30
CPC分类号： A61M1/029 , A61M1/3693 , A61M2202/0437 , A61M2202/10 , B01D21/262 , B01D21/307 , B01D2221/10
摘要： According to various embodiments, a system can be provided to separate undifferentiated cells and/or stromal cells from a whole tissue sample. The whole tissue sample can be any appropriate tissue sample obtained directly from a patient. The tissue sample can be obtained during a selected operating procedure for immediate or quick application or re-application to the patient. Accordingly, autologous cells can be obtained intraoperatively for application to a patient substantially soon after obtaining a whole tissue sample.
摘要翻译：根据各种实施方案，可以提供系统以从整个组织样品中分离未分化的细胞和/或基质细胞。整个组织样本可以是直接从患者获得的任何合适的组织样本。可以在选择的操作程序期间获得组织样品，以立即或快速施用或重新施用于患者。因此，在获得整个组织样本之后，可以在术中基本上很快获得自体细胞以供给患者。

30. 发明授权

US08998949B2 Soft tissue conduit device 有权
标题翻译：软组织导管装置
公开(公告)号：US08998949B2
公开(公告)日：2015-04-07
申请号：US11504882
申请日：2006-08-16
申请人： Kevin T. Stone , Michael D. Leach
发明人： Kevin T. Stone , Michael D. Leach
IPC分类号： A61B17/08 , A61M31/00 , A61B17/04 , A61B17/064 , A61B17/34 , A61F2/08 , A61B17/88 , A61B17/06 , A61F2/28
CPC分类号： A61B17/0401 , A61B17/0469 , A61B17/0482 , A61B17/0642 , A61B17/3472 , A61B17/8875 , A61B2017/0404 , A61B2017/0406 , A61B2017/044 , A61B2017/0445 , A61B2017/0475 , A61B2017/0496 , A61B2017/06052 , A61B2017/0646 , A61B2017/0647 , A61B2017/0648 , A61F2/0805 , A61F2/0811 , A61F2002/0858 , A61F2002/0882 , A61F2002/2839
摘要： A method of conducting biological materials to soft tissue. The method includes loading a conduit device onto a delivery shaft of an inserter, inserting at least a portion of the delivery shaft into soft tissue, expelling the conduit device from the delivery shaft into the tissue, and delivering biological material through an access port of the inserter into at least one outer longitudinal channel of the conduit device.
摘要翻译：将生物材料导入软组织的方法。该方法包括将导管装置装载到插入器的输送轴上，将至少一部分输送轴插入软组织中，将导管装置从输送轴排出到组织中，以及通过生物材料的进入口输送生物材料插入到导管装置的至少一个外纵向通道中。

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