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21. 发明申请

US20060205053A1 27411, a novel human PGP synthase 审中-公开
公开(公告)号：US20060205053A1
公开(公告)日：2006-09-14
申请号：US11369106
申请日：2006-03-06
申请人： Rachel Meyers
发明人： Rachel Meyers
IPC分类号： C12N9/10 , C07H21/04 , C12P21/06
CPC分类号： C12N9/1288
摘要： The present invention relates to a newly identified human PGP synthase. The invention also relates to polynucleotides encoding the PGP synthase. The invention further relates to methods using the PGP synthase polypeptides and polynucleotides as a target for diagnosis and treatment in PGP synthase-mediated or -related disorders. The invention further relates to drug-screening methods using the PGP synthase polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the PGP synthase polypeptides and polynucleotides. The invention further relates to procedures for producing the PGP synthase polypeptides and polynucleotides.

22. 发明申请

US20060040357A1 Novel nucleic acid sequences encoding melanoma associated antigen molecules, aminotransferase molecules, ATPase molecules, acyltransferase molecules, pyridoxal-phosphate dependant enzyme molecules and uses therefor 失效
公开(公告)号：US20060040357A1
公开(公告)日：2006-02-23
申请号：US11245400
申请日：2005-10-06
申请人： Rajasekhar Bandaru , Maria Glucksmann , Rachel Meyers , Laura Rudolph-Owen
发明人： Rajasekhar Bandaru , Maria Glucksmann , Rachel Meyers , Laura Rudolph-Owen
IPC分类号： C07H21/04 , C12P21/06 , C12N9/10 , C12N9/12
CPC分类号： G01N33/5743 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/47 , C07K14/4748 , C07K2319/00 , C12N9/1029 , C12N9/1096 , C12N9/14 , C12N9/90
摘要： The invention provides isolated nucleic acids molecules that encode novel polypeptides. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a sequence of the invention has been introduced or disrupted. The invention still further provides isolated proteins, fusion proteins, antigenic peptides and antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

23. 发明申请

US20060035362A1 Novel human hydrolase family members and uses thereof 失效
标题翻译：新型人类水解酶家族成员及其用途
公开(公告)号：US20060035362A1
公开(公告)日：2006-02-16
申请号：US11244219
申请日：2005-10-05
申请人： Rachel Meyers
发明人： Rachel Meyers
IPC分类号： C12N9/64 , C07H21/04 , C12P21/06
CPC分类号： C07K14/705 , A01K2217/05 , A61K38/00 , A61K2039/505 , C07K14/82 , C07K2319/00 , C12N9/0083 , C12N9/14 , C12N9/16 , C12N9/18 , C12N9/6421 , C12N9/82 , C12N9/88 , C12N9/90
摘要： The invention provides isolated nucleic acids molecules, designated 26443 and 46873 nucleic acid molecules, which encode novel human hydrolase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 26443 and 46873 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 26443 and 46873 gene has been introduced or disrupted. The invention still further provides isolated 26443 and 46873 proteins, fusion proteins, antigenic peptides and anti-26443 or 46873 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供编码新的人水解酶家族成员的分离的核酸分子，命名为26443和46873核酸分子。本发明还提供了反义核酸分子，含有26443和46873核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及引入或破坏了26443和46873基因的非人类转基因动物。本发明还进一步提供分离的26443和46873蛋白，融合蛋白，抗原肽和抗26443或46873抗体。还提供了利用本发明组合物的诊断方法。

24. 发明申请

US20060014244A1 Novel nucleic acid sequences encoding adenylate kinase, phospholipid scramblase-like, DNA fragmentation factor-like, phosphatidylserine synthase-like, and ATPase-like molecules and uses therefor 审中-公开
公开(公告)号：US20060014244A1
公开(公告)日：2006-01-19
申请号：US11040595
申请日：2005-01-21
申请人： Miyoung Chun , Maria Glucksmann , Rosana Kapeller-Libermann , Rachel Meyers
发明人： Miyoung Chun , Maria Glucksmann , Rosana Kapeller-Libermann , Rachel Meyers
IPC分类号： C07H21/04 , C12P21/06 , C12N9/12
CPC分类号： C12N9/1229 , C07K14/47 , C12N9/1288 , C12N9/14 , G01N33/574 , G01N33/6896
摘要： The invention provides isolated nucleic acids molecules that encode novel polypeptides. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a sequence of the invention has been introduced or disrupted. The invention still further provides isolated proteins, fusion proteins, antigenic peptides and antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

25. 发明申请

US20050266470A1 25501, a human transferase family member and uses therefor 审中-公开
公开(公告)号：US20050266470A1
公开(公告)日：2005-12-01
申请号：US11139195
申请日：2005-05-27
申请人： Rachel Meyers
发明人： Rachel Meyers
IPC分类号： C07H21/04 , C07K14/82 , C07K16/30 , C12N5/06 , C12N9/00 , C12N9/10 , C12N15/54 , C12P21/02 , C12P21/06 , C12Q1/68 , G01N33/574
CPC分类号： C12N9/1007
摘要： The invention provides isolated nucleic acids molecules, designated 25501 nucleic acid molecules, which encode novel transferase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 25501 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 25501 gene has been introduced or disrupted. The invention still further provides isolated 25501 proteins, fusion proteins, antigenic peptides and anti-25501 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

26. 发明申请

US20050203049A1 47169 and 33935, novel human glycosyl transferases and uses therefor 审中-公开
标题翻译： 47169和33935，新型人糖基转移酶及其用途
公开(公告)号：US20050203049A1
公开(公告)日：2005-09-15
申请号：US11120749
申请日：2005-05-03
申请人： Rachel Meyers , Mark Williamson
发明人： Rachel Meyers , Mark Williamson
IPC分类号： A61K38/00 , C12N9/10 , A61K48/00 , C12N15/85
CPC分类号： C12N9/1048 , A61K38/00
摘要： The invention provides isolated nucleic acids molecules, designated 47169 and 33935 nucleic acid molecules, which encode novel glycosyl transferases. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 47169 and 33935 nucleic acid molecules, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a 47169 or 33935 gene has been introduced or disrupted. The invention still further provides isolated 47169 and 33935 proteins, fusion proteins, antigenic peptides and anti-47169 and anti-33935 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供编码新的糖基转移酶的分离的核酸分子，命名为47169和33935核酸分子。本发明还提供了反义核酸分子，含有47169和33935核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及引入或破坏了47169或33935基因的非人转基因动物。本发明还进一步提供分离的47169和33935蛋白，融合蛋白，抗原肽和抗-47169和抗-33935抗体。还提供了利用本发明组合物的诊断方法。

27. 发明授权

US06849437B2 47153, a human glycosyltransferase family member and uses therefor 失效
标题翻译：人类糖基转移酶家族成员47153及其用途
公开(公告)号：US06849437B2
公开(公告)日：2005-02-01
申请号：US10113709
申请日：2002-03-28
申请人： Rachel Meyers , Julie Beth Rosenfeld
发明人： Rachel Meyers , Julie Beth Rosenfeld
IPC分类号： C12N9/10 , C07H21/04 , C12N1/20 , C12N5/00 , C12N9/00
CPC分类号： C12N9/1048
摘要： The invention provides isolated nucleic acids molecules, designated 47153 nucleic acid molecules, which encode novel glycosyltransferase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 47153 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 47153 gene has been introduced or disrupted. The invention still further provides isolated 47153 proteins, fusion proteins, antigenic peptides and anti-47153 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供编码新的糖基转移酶家族成员的分离的核酸分子，命名为47153核酸分子。本发明还提供了反义核酸分子，含有47153个核酸分子的重组表达载体，已引入其中的表达载体的宿主细胞，以及引入或破坏了47153基因的非人转基因动物。本发明还进一步提供分离的47153蛋白，融合蛋白，抗原肽和抗47153抗体。还提供了利用本发明组合物的诊断和治疗方法。

28. 发明授权

US06569657B1 32140, a novel human aldehyde dehydrogenase and uses therefor 失效
标题翻译： 32140，一种新的人醛脱氢酶并用于此
公开(公告)号：US06569657B1
公开(公告)日：2003-05-27
申请号：US09717926
申请日：2000-11-21
申请人： Rachel Meyers , William J. Cook
发明人： Rachel Meyers , William J. Cook
IPC分类号： C12N904
CPC分类号： C12N9/0008 , A01K2217/05 , C07K2319/00
摘要： The invention provides isolated nucleic acids molecules, designated 32140 nucleic acid molecules, which encode novel aldehyde dehydrogenase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 32140 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 32140 gene has been introduced or disrupted. The invention still further provides isolated 32140 proteins, fusion proteins, antigenic peptides and anti-32140 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供编码新的醛脱氢酶家族成员的分离的核酸分子，命名为32140核酸分子。本发明还提供了反义核酸分子，含有32140个核酸分子的重组表达载体，其中引入了表达载体的宿主细胞以及其中32140基因被引入或破坏的非人类转基因动物。本发明还进一步提供了分离的32140蛋白，融合蛋白，抗原肽和抗32140抗体。还提供了利用本发明组合物的诊断方法。

29. 发明授权

US06489152B1 32670, novel human phosphatidylserine synthase-like molecules and uses thereof 失效
标题翻译： 32670，新型人磷脂酰丝氨酸合酶样分子及其用途
公开(公告)号：US06489152B1
公开(公告)日：2002-12-03
申请号：US09790838
申请日：2001-02-22
申请人： Rachel Meyers
发明人： Rachel Meyers
IPC分类号： C12N912
CPC分类号： C12N9/1288
摘要： Novel human phosphatidylserine synthase-like polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length human phosphatidylserine synthase-like proteins, the invention further provides isolated human phosphatidylserine synthase-like fusion proteins, antigenic peptides, and anti-human phosphatidylserine synthase-like antibodies. The invention also provides human phosphatidylserine synthase-like nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a human phosphatidylserine synthase-like gene has been introduced or disrupted. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：公开了新型人磷脂酰丝氨酸合酶样多肽，蛋白质和核酸分子。除了分离的全长人磷脂酰丝氨酸合酶样蛋白之外，本发明还提供了分离的人磷脂酰丝氨酸合酶样融合蛋白，抗原肽和抗人磷脂酰丝氨酸合酶样抗体。本发明还提供了人类磷脂酰丝氨酸合酶类核酸分子，含有本发明的核酸分子的重组表达载体，其中引入了表达载体的宿主细胞和其中人磷脂酰丝氨酸合酶样基因具有的非人类转基因动物被引入或中断。还提供了利用本发明组合物的诊断，筛选和治疗方法。

30. 发明申请

US20140323541A1 Methods And Compositions For Prevention Or Treatment Of RSV Infection Using Modified Duplex RNA Molecules 审中-公开
标题翻译：方法和组合物预防或使用修改的双相RNA分子治疗RSV感染
公开(公告)号：US20140323541A1
公开(公告)日：2014-10-30
申请号：US13604480
申请日：2012-09-05
申请人： Rachel Meyers , Rene Alvarez , Geoff Cole , Sayda Elbashir
发明人： Rachel Meyers , Rene Alvarez , Geoff Cole , Sayda Elbashir
IPC分类号： C12N15/113 , A61K9/00
CPC分类号： C12N15/1131 , A61K9/0073 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2320/30 , C12N2310/3521 , C12N2310/3533
摘要： Methods and compositions are provided for the prevention or treatment of RSV infection in a human. The methods include administering one or more doses of a composition comprising an siRNA. The dose can be formulated for topical or parenteral administration. Topical administration includes administration as a nasal spray, or by inhalation of respirable particles or droplets. The siRNA preferably comprises a sense strand and antisense strand with modified nucleotides.
摘要翻译：提供了用于预防或治疗人体RSV感染的方法和组合物。所述方法包括施用一种或多种剂量的包含siRNA的组合物。剂量可以配制用于局部或肠胃外给药。局部给药包括作为鼻喷雾给药，或通过吸入可吸入颗粒或液滴。 siRNA优选包含具有修饰的核苷酸的有义链和反义链。

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