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21. 发明授权

US07250120B2 Benzo-, naphtho- and phenanthrochromene substituted by carbamated or ureated phenyls, preparation thereof and compositions and articles containing them 有权
标题翻译：由氨基甲酸酯化或脲化苯基取代的苯并 - 萘并菲衍生物，其制备方法和含有它们的组合物和制品
公开(公告)号：US07250120B2
公开(公告)日：2007-07-31
申请号：US10867201
申请日：2004-06-14
申请人： You-Ping Chan , Olivier Breyne
发明人： You-Ping Chan , Olivier Breyne
IPC分类号： G02B5/23 , C07D311/60 , C07D311/78 , C07D311/92
CPC分类号： C07D311/78 , C07D311/92 , C08K5/1545 , C09K9/02 , C09K2211/1088
摘要： Disclosed are novel benzo-, naphtho- and phenanthrochromenes substituted by carbamated or ureated phenyls having the following general formula (I): wherein R1 represents a group their preparation, photochromic compositions and articles containing them. This family of compounds have interesting and useful photochromic properties, especially in terms of absorption band and discoloration speed.
摘要翻译：公开了由具有以下通式（I）的氨基甲酰化或脲化苯基取代的新型苯并，萘并菲和菲并苯系：其中R 1表示其制备物，光致变色组合物和含有它们的制品。该化合物族具有有趣和有用的光致变色性质，特别是在吸收带和变色速度方面。

22. 发明申请

US20070010652A1 Polyamino acids functionalised with at least one hydrophobic group and applications thereof particularly therapeutic applications 失效
标题翻译：用至少一个疏水基团官能化的聚氨基酸及其应用特别是治疗应用
公开(公告)号：US20070010652A1
公开(公告)日：2007-01-11
申请号：US10558617
申请日：2004-05-28
申请人： Stephanie Angot , Olivier Breyne , You-Ping Chan
发明人： Stephanie Angot , Olivier Breyne , You-Ping Chan
IPC分类号： C08G69/10
CPC分类号： A61K8/88 , A61K47/645 , A61K2800/57 , A61Q19/00 , C08G69/10 , C08G69/48
摘要： The invention relates to novel materials based on biodegradable polyamino acids, particularly useful for the vectorisation of active principals (PA). The invention further relates to novel, pharmaceutical, cosmetic, dietary or phytosanitary compositions based on said polyamino acids. The aim of the invention is to provide a novel polymeric raw material, for use in the vectorisation of PA and with an optimal match for all the requirements of the type: biocompatibility, biodegradability, stability, ability to easily associate with numerous active principals or to solubilise the same and to liberate said active principals in vivo. Said aim is achieved with polyamino acids comprising aspartic and/or glutamate units, some of which carry at least one graft, characterised in that at least one of said grafts is bonded to an aspartic or glutamate unit by means of an amino acids spacer based on Leu, and/or Ileu, and/or Val, and/or Phe and a hydrophobic group with C6-C30 is connected by an ester bond to the spacer. Said specific amino acid spacers guarantee an improved stability to hydrolysis and a higher association quotient with proteins when compared with conventional analogous products. Said polymers have the advantage of easily and economically being transformed into vectorisation particles for active principals said particles being themselves able to form stable aqueous colloidal suspensions.
摘要翻译：本发明涉及基于可生物降解的聚氨基酸的新型材料，特别适用于活性成分（PA）的向量化。本发明进一步涉及基于所述聚氨基酸的新型药物，化妆品，膳食或植物检疫组合物。本发明的目的是提供一种新型的聚合物原料，用于PA的向量化，并具有与以下类型的所有要求的最佳匹配：生物相容性，生物可降解性，稳定性，容易与许多活性成分相关的能力或溶解相同并在体内释放所述活性成分。所述目的通过包含天冬氨酸和/或谷氨酸单体的聚氨基酸实现，其中一些氨基酸携带至少一个接枝物，其特征在于至少一个所述移植物通过氨基酸间隔基与天冬氨酸或谷氨酸单元结合，基于 Leu和/或Ileu和/或Val，和/或Phe和具有C6-C30的疏水基团通过酯键连接到间隔物上。当与常规类似产物相比时，所述特异性氨基酸间隔物保证了水解的稳定性提高和与蛋白质的较高缔合商。所述聚合物具有容易且经济地转化成用于活性原料的载体化颗粒的优点，所述颗粒本身能够形成稳定的水性胶体悬浮液。

23. 发明授权

US06506322B1 Naphthopyrans annelated in C5-C6 with an indene- or dihydronaphthalene-type carbocycle, and compositions and (co)polymer matrices containing them 有权
标题翻译： Naphthopyrans在C5-C6中用茚或二氢萘型碳环，和包含它们的组合物和（共）聚合物基质）
公开(公告)号：US06506322B1
公开(公告)日：2003-01-14
申请号：US09712058
申请日：2000-11-14
申请人： Olivier Breyne , You-Ping Chan , Patrick Jean
发明人： Olivier Breyne , You-Ping Chan , Patrick Jean
IPC分类号： G02B523
CPC分类号： C07D311/92 , C07D311/78 , C07D311/94
摘要： The present invention relates to novel naphthopyran-type compounds, annelated in position C5-C6 by an indene- or dihydronaphthalene-type carbocycle, which are of the formulae (I) and (II) given below: These compounds (I) and (II) have interesting photochromic properties. The invention also relates to their preparation, to their applications as photochromes, as well as to the compositions and (co)polymer matrices containing them.
摘要翻译：本发明涉及由下式给出的式（I）和（II）的茚或二氢萘型碳环在C5-C6位置上取代的新型萘并吡喃型化合物：这些化合物（I）和（II ）具有有趣的光致变色性质。本发明还涉及它们作为光致变色剂的应用以及含有它们的组合物和（共）聚合物基质）的制备。

24. 发明授权

US06410754B1 Photochromic spiropyrans, and compositions and articles containing same 失效
标题翻译：光致变色螺吡喃，以及含有它们的组合物和制品
公开(公告)号：US06410754B1
公开(公告)日：2002-06-25
申请号：US08913620
申请日：1997-11-14
申请人： Gérard Soula , You-Ping Chan
发明人： Gérard Soula , You-Ping Chan
IPC分类号： C07D24136
CPC分类号： C07D311/96 , C08K5/1545 , C09K9/02
摘要： Novel spiropyran compounds, particularly with photochromic properties, are disclosed, as well as photochromic compositions and ophthalmic articles containing said compounds. The photochromes have been designed so as to have a high colorability, a high sensitivity to activating radiation breaking the pyran ring, to be entirely or practically free from coloration in a non activated non exposed state, to have an intense coloration following activation and a high coverage of the visible spectrum in combination with at least one other photochrome, and to have high rates of coloration/decoloration. The spiropyrans are easily produced and photochemically stable, and are, e.g., of formula (i), wherein L=(a); (b).
摘要翻译：公开了具有光致变色特性的新型螺吡喃化合物，以及含有所述化合物的光致变色组合物和眼用制品。光致变色器被设计成具有高的着色性，对于激活放射性破坏吡喃环的辐射的高灵敏度，在非活化的非曝光状态下完全或实际上没有着色，在激活后具有强烈的着色和高的可见光谱的覆盖与至少一种其它色素结合，并且具有高的着色/脱色速率。螺吡喃容易产生和光化学稳定，并且是例如式（i），其中L =（a）; （b）。

25. 发明授权

US5888432A 2-Adamantyl benzopyrans the compositions and (co)polymer matrices containing them 失效
标题翻译： 2-金刚烷基苯并吡喃衍生物含有它们的组合物和（共）聚合物基质
公开(公告)号：US5888432A
公开(公告)日：1999-03-30
申请号：US984278
申请日：1997-12-03
申请人： You-Ping Chan
发明人： You-Ping Chan
IPC分类号： G02B5/23 , C03C4/06 , C03C14/00 , C07D311/92 , C07D311/96 , C08F20/26 , C08F246/00 , C08K5/1545 , C08L101/06 , G09F9/30 , C07D311/78
CPC分类号： G02B5/23 , C07D311/92 , C07D311/96 , C08F246/00
摘要： The present invention has for subjects, novel benzopyran derivatives, substituted in position 2 with an adamantyl group as well as the compositions and (co)polymer matrices containing such derivatives. Said derivatives possess interesting photochromic properties.
摘要翻译：本发明对于具有金刚烷基的位置2取代的新的苯并吡喃衍生物以及含有这些衍生物的组合物和（共）聚合物基质。所述衍生物具有有趣的光致变色性质。

26. 发明授权

US5811507A Polyesterimides for use in linear and/or non-linear optics, and one method for preparing same 失效
标题翻译：用于线性和/或非线性光学的聚酰亚胺及其制备方法
公开(公告)号：US5811507A
公开(公告)日：1998-09-22
申请号：US628639
申请日：1996-11-14
申请人： You-Ping Chan , Gilles Tapolsky , Remi Meyrueix , Jean-Pierre Lecomte , Michael Dickens
发明人： You-Ping Chan , Gilles Tapolsky , Remi Meyrueix , Jean-Pierre Lecomte , Michael Dickens
IPC分类号： G02F1/01 , C08G63/685 , C08G73/16 , G02F1/35 , G02F1/355 , G02F1/361
CPC分类号： G02F1/3617 , C08G63/6856 , C08G73/16
摘要： The present invention relates to a new polyesterimide of the type containing ester repeat functional groups E=--CO--O--, imide repeat functional groups I: ##STR1## and at least one chromophore, characterized in that it contains a quantity of recurrent amide functional groups capable of ring closure to imides which is smaller than or equal to 5 mol % relative to the sum of the imide functional groups and of the amide functional groups capable of ring closure to imides, which are present, and in that the polymerization functional groups consist essentially of E functional groups. This polyesterimide is preferably free from amide functional groups capable of ring closure to imides. One of the processes for obtaining this polyesterimide constitutes another subject-matter of the invention. Such a polymer is advantageously capable of behaving like a material that is transparent and/or active in nonlinear optics. It therefore constitutes a raw material of choice for producing LO and/or NLO devices: filters, polarizers, waveguides, a modulator, directional coupler, optical flip-flop and photoconductive film.
摘要翻译： PCT No.PCT / FR94 / 01219 Sec。 371日期：1996年11月14日 102（e）日期1996年11月14日PCT 1994年10月20日PCT PCT。第WO95 / 11476号公报日期：1995年04月27日本发明涉及含有酯重复官能团的类型的新的聚酯酰亚胺E = -CO-O-，酰亚胺重复官能团I：＆lt; IMAGE＆gt;和至少一种发色团，其特征在于它含有能够闭环的酰胺官能团的量相对于酰亚胺官能团和能够闭合的酰胺官能团的总和小于或等于5摩尔％，其存在和存在于酰亚胺中聚合官能团基本上由E官能团组成。该聚酯酰亚胺优选不含能够闭合成酰亚胺的酰胺官能团。获得该聚酯酰亚胺的方法之一构成本发明的另一主题。这种聚合物有利地能够表现得像非线性光学中透明和/或有活性的材料。因此，它构成了生产LO和/或NLO器件的首选材料：滤波器，偏振器，波导，调制器，定向耦合器，光学触发器和光电导膜。

27. 发明授权

US5763511A Organic photochromic materials with high refractive index, their preparation and articles formed from these materials 失效
$Organic photochromic materials with high refractive index, their preparation and articles formed from these materials$
标题翻译：具有高折射率的有机光致变色材料，它们的制备和由这些材料形成的制品
公开(公告)号：US5763511A
公开(公告)日：1998-06-09
申请号：US817560
申请日：1997-04-21
申请人： You-Ping Chan , David Henry , Remy Meyrueix , Jacques Jean Vial
发明人： You-Ping Chan , David Henry , Remy Meyrueix , Jacques Jean Vial
IPC分类号： C09K9/02 , G02B5/23 , C08K5/35 , C08K5/34
CPC分类号： G02B5/23 , C09K9/02
摘要： The invention relates to organic photochromic materials consisting of a polymer matrix of optical quality and of at least one dye that imparts photochromic properties to the matrix, the dye being selected from spirooxazines, spiropyrans and chromenes. The polymer constituting the matrix is a copolymer of 30-95 wt % ethoxylated bisphenol A dimethacrylate and 5-70 wt % of a polyurethane oligomer having terminal di- or triacrylic or di- or trimethacrylic functionality. Such photochromic materials are most suitable for the production of ophthalmic and sun protection lenses.
摘要翻译： PCT No.PCT / US95 / 14585 Sec。 371日期1997年04月21日 102（e）日期1997年4月21日PCT提交1995年11月9日PCT公布。公开号WO96 / 19741 日期1996年6月27日本发明涉及由光学质量的聚合物基质和赋予基质的光致变色性质的至少一种染料组成的有机光致变色材料，染料选自螺恶嗪，螺吡喃和色烯。构成基质的聚合物是30-95重量％乙氧基化双酚A二甲基丙烯酸酯和5-70重量％具有末端二 - 或三丙烯酸或二 - 或三甲基丙烯酸官能团的聚氨酯低聚物的共聚物。这种光致变色材料最适用于生产眼镜和防晒镜片。

28. 发明授权

US08716217B2 Polyglutamic acids functionalized by cationic groups and hydrophobic groups and applications thereof, in particular therapeutic applications thereof 失效
标题翻译：由阳离子基团和疏水基团官能化的聚谷氨酸及其应用，特别是其治疗应用
公开(公告)号：US08716217B2
公开(公告)日：2014-05-06
申请号：US12149542
申请日：2008-05-05
申请人： You-Ping Chan , Cecile Bonnet-Gonnet , Olivier Breyne
发明人： You-Ping Chan , Cecile Bonnet-Gonnet , Olivier Breyne
IPC分类号： A61K38/00 , A61K47/30 , A61K48/00 , C08G63/00
CPC分类号： C08G69/10 , A61K9/10 , A61K47/34 , A61K47/645 , C08G69/48
摘要： The present invention relates to novel biodegradable materials based on modified polyamino acids that are useful in particular in the vectorization of active principle(s) (APs). The invention is also directed to novel pharmaceutical, cosmetic, health-food or plant-protection compositions based on these polyamino acids.The aim of the invention is to provide a novel polymeric starting material which can be used for AP vectorization and which satisfy all the requirements: biocompatibility, biodegradability, ability to easily associate with or dissolve numerous active principles and to release these active principles in vivo. This goal is achieved by the present invention, which relates to novel polyglutamates modified by cationic groups, which, if they can be deprotonated, exhibit a pKa equal to or greater than 7, and by hydrophobic groups comprising from 8 to 30 carbon atoms.These polyglutamates modified by cationic groups are easily and economically converted into particles for the vectorization of active principles, these particles being themselves capable of forming stable aqueous colloidal suspensions. These modified polyglutamates exhibit the advantage of being less viscous than other analogous polymers while retaining an ability to associate proteins, such as insulin. Some are soluble in water at acidic pH and become insoluble at physiological pH (7.4) and should thus, during subcutaneous injection, precipitate on the site of injection.
摘要翻译：本发明涉及基于改性聚氨基酸的新型可生物降解材料，其特别用于活性成分（AP）的向量化。本发明还涉及基于这些聚氨基酸的新型药物，化妆品，保健食品或植物保护组合物。本发明的目的是提供一种新颖的聚合起始材料，其可用于AP向量化，并且其满足所有要求：生物相容性，生物降解性，容易地与许多活性成分缔合或溶解的能力，并在体内释放这些活性成分。该目的通过本发明来实现，本发明涉及由阳离子基团修饰的新的聚谷氨酸，如果它们可以去质子化，表现出等于或大于7的pKa，以及含有8至30个碳原子的疏水基团。通过阳离子基团改性的这些聚谷氨酸可容易且经济地转化成用于活性成分载体化的颗粒，这些颗粒本身能够形成稳定的水性胶态悬浮液。这些改性的聚谷氨酸显示出比其它类似聚合物粘稠度较低的优点，同时保留了使蛋白质如胰岛素相关联的能力。一些在酸性pH下溶于水，在生理pH（7.4）下变得不溶，因此皮下注射时，在注射部位沉淀。

29. 发明授权

US07919572B2 Polyamino acids functionalised with at least one hydrophobic group and applications thereof particularly therapeutic applications 失效
标题翻译：用至少一个疏水基团官能化的聚氨基酸及其应用特别是治疗应用
公开(公告)号：US07919572B2
公开(公告)日：2011-04-05
申请号：US10558617
申请日：2004-05-28
申请人： Stéphanie Angot , Olivier Breyne , You-Ping Chan
发明人： Stéphanie Angot , Olivier Breyne , You-Ping Chan
IPC分类号： C08G69/10 , A01N25/00 , A61K47/00
CPC分类号： A61K8/88 , A61K47/645 , A61K2800/57 , A61Q19/00 , C08G69/10 , C08G69/48
摘要： The invention relates to novel materials based on biodegradable polyamino acids, particularly useful for the vectorisation of active principals (PA). The invention further relates to novel, pharmaceutical, cosmetic, dietary or phytosanitary compositions. The invention provides novel polymeric raw material, for use in the vectorisation of PA and with an optimal match for all the requirements of the type: biocompatibility, biodegradability, stability, ability to easily associate with numerous active principals or to solubilise the same and to liberate said active principals in vivo. Said aim is achieved with polyamino acids comprising aspartic and/or glutamate units, some of which carry at least one graft, characterised in that at least one of said grafts is bonded to an aspartic or glutamate unit by means of an amino acids spacer based on Leu, and/or Ileu, and/or Val, and/or Phe and a hydrophobic group with C6-C30 is connected by an ester bond to the spacer.
摘要翻译：本发明涉及基于可生物降解的聚氨基酸的新型材料，特别适用于活性成分（PA）的向量化。本发明进一步涉及新的，药物，化妆品，膳食或植物检疫组合物。本发明提供新颖的聚合物原料，用于PA的载体化和与所有类型的所有要求的最佳匹配：生物相容性，生物可降解性，稳定性，容易与许多活性成分相关联或溶解它并释放的能力活体检者在体内表示。所述目的通过包含天冬氨酸和/或谷氨酸单体的聚氨基酸实现，其中一些氨基酸携带至少一个接枝物，其特征在于至少一个所述移植物通过氨基酸间隔基与天冬氨酸或谷氨酸单元结合，基于 Leu和/或Ileu和/或Val，和/或Phe和具有C6-C30的疏水基团通过酯键连接到间隔物上。

30. 发明申请

US20060099264A1 Polyaminoacids functionalized by alpha tocopherol and uses thereof, particular for therapeutic applications 有权
标题翻译：由α-生育酚功能化的聚氨基酸及其用途，特别用于治疗应用
公开(公告)号：US20060099264A1
公开(公告)日：2006-05-11
申请号：US10516733
申请日：2003-06-03
申请人： You-Ping Chan , Stephanie Angot , Olivier Breyne
发明人： You-Ping Chan , Stephanie Angot , Olivier Breyne
IPC分类号： A61K48/00 , A61K38/00 , C07K14/00 , A61K9/14
CPC分类号： A61K8/88 , A61K8/678 , A61K9/5146 , A61K47/34 , A61K2800/57 , A61Q19/00 , C08G69/10 , C08G69/48
摘要： The invention concerns novel biodegradable polyaminoacid materials, useful in particular for vectoring active principle(s). The invention also concerns novel pharmaceutical, cosmetic, dietetic or phytosanitary compositions based on said polyaminoacids. The invention aims at providing a novel polymer raw material, capable of being used for vectoring active principles and enabling optimal fulfillment of all specified requirements: biocompatibility, biodegradability, easy and inexpensive transformation into particles vectoring active principles, said particles being themselves capable of forming colloidal suspensions, of being easily associated with numerous active principles, and of releasing said active principles in vivo. Therefor, the present invention concerns first of all amphiphilic polyaminoacids comprising aspartic acid units and/or glutamic acid units, characterized in that at least part of said units carry grafts including at least one alphα-tocopherol motif, for example (polyglutamate or polyaspartate grafted with alphα-tocopherol of synthetic or natural origin).
摘要翻译：本发明涉及新型可生物降解的聚氨基酸材料，特别适用于向量活性成分。本发明还涉及基于所述聚氨基酸的新型药物，化妆品，饮食或植物检疫组合物。本发明旨在提供一种新颖的聚合物原料，其能够用于向量活性成分的原理并且能够最佳地实现所有特定的要求：生物相容性，生物降解性，容易且便宜的转化成粒子的载体活性成分，所述颗粒本身能够形成胶体悬浮液，易于与许多活性成分相关联，并且在体内释放所述活性成分。因此，本发明涉及包含天冬氨酸单元和/或谷氨酸单元的所有两亲性聚氨基酸的首要问题，其特征在于至少部分所述单元携带包含至少一种α-生育酚基序的移植物，例如（聚谷氨酸盐或聚天冬氨酸嫁接合成或天然来源的α-生育酚）。

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