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21. 发明申请

US20110092836A1 METHOD AND APPARATUS FOR DETERMINING THE CORONARY SINUS VEIN BRANCH ACCESSED BY A CORONARY SINUS LEAD 有权
标题翻译：用于确定冠状动脉导管接收的冠状动脉支架的方法和装置
公开(公告)号：US20110092836A1
公开(公告)日：2011-04-21
申请号：US12976397
申请日：2010-12-22
申请人： Yinghong Yu , Jiang Ding , Jeng Mah , Julio Spinelli
发明人： Yinghong Yu , Jiang Ding , Jeng Mah , Julio Spinelli
IPC分类号： A61B5/0408
CPC分类号： A61B5/0452 , A61B5/0456 , A61B34/20 , A61B2034/2072 , A61N1/3627 , A61N1/3682
摘要： Systems and methods for determining the coronary sinus vein branch location of a left ventricle electrode are disclosed. The systems and methods involve detecting the occurrence of electrical events within the patient's heart including sensing one or more of the electrical events with the electrode and then analyzing the electrical events to determine the electrode's position. The determination of electrode position may be used to automatically adjust operating parameters of a VRT device. Furthermore, the determination of electrode position may be made in real-time during installation of the electrode and a visual indication of the electrode position may be provided on a display screen.
摘要翻译：公开了用于确定左心室电极的冠状静脉窦静脉分支位置的系统和方法。系统和方法涉及检测患者心脏内的电事件的发生，包括用电极感测一个或多个电事件，然后分析电气事件以确定电极的位置。电极位置的确定可用于自动调整VRT器件的工作参数。此外，可以在电极的安装期间实时地确定电极位置，并且可以在显示屏上提供电极位置的视觉指示。

22. 发明授权

US07856270B2 Cardiac pacing using adjustable atrio-ventricular delays 有权
标题翻译：心脏起搏使用可调节的心房延迟
公开(公告)号：US07856270B2
公开(公告)日：2010-12-21
申请号：US11049181
申请日：2005-02-02
申请人： Jiang Ding , Yinghong Yu , Andrew P. Kramer , Julio Spinelli
发明人： Jiang Ding , Yinghong Yu , Andrew P. Kramer , Julio Spinelli
IPC分类号： A61N1/365
CPC分类号： E21B17/01 , A61N1/3627 , A61N1/3682 , E21B43/36
摘要： A pacing system for providing optimal hemodynamic cardiac function for parameters such as contractility (peak left ventricle pressure change during systole or LV+dp/dt), or stroke volume (aortic pulse pressure) using system for calculating atrio-ventricular delays for optimal timing of a ventricular pacing pulse. The system providing an option for near optimal pacing of multiple hemodynamic parameters. The system deriving the proper timing using electrical or mechanical events having a predictable relationship with an optimal ventricular pacing timing signal.
摘要翻译：一种起搏系统，用于为诸如收缩性（收缩期峰值左心室压力变化或LV + dp / dt）之间的参数或行程体积（主动脉脉压）提供最佳血液动力学心脏功能，使用用于计算心室延迟的系统以获得最佳时机心室起搏脉搏。该系统为多个血液动力学参数的近似最佳起搏提供了选择。该系统使用与最佳心室起搏定时信号具有可预测关系的电或机械事件导出适当的定时。

23. 发明授权

US07260427B2 Method and apparatus for determining the coronary sinus vein branch accessed by a coronary sinus lead 有权
标题翻译：用于确定冠状静脉窦导管接近的冠状静脉窦静脉分支的方法和装置
公开(公告)号：US07260427B2
公开(公告)日：2007-08-21
申请号：US10729301
申请日：2003-12-05
申请人： Yinghong Yu , Jiang Ding , Jeng Mah , Julio Spinelli
发明人： Yinghong Yu , Jiang Ding , Jeng Mah , Julio Spinelli
IPC分类号： A61B5/0452
CPC分类号： A61B5/0452 , A61B5/0456 , A61B34/20 , A61B2034/2072 , A61N1/3627 , A61N1/3682
摘要： Systems and methods for determining the coronary sinus vein branch location of a left ventricle electrode are disclosed. The systems and methods involve detecting the occurrence of electrical events within the patient's heart including sensing one or more of the electrical events with the electrode and then analyzing the electrical events to determine the electrode's position. The determination of electrode position may be used to automatically adjust operating parameters of a VRT device. Furthermore, the determination of electrode position may be made in real-time during installation of the electrode and a visual indication of the electrode position may be provided on a display screen.
摘要翻译：公开了用于确定左心室电极的冠状静脉窦静脉分支位置的系统和方法。系统和方法涉及检测患者心脏内的电事件的发生，包括用电极感测一个或多个电事件，然后分析电气事件以确定电极的位置。电极位置的确定可用于自动调整VRT器件的工作参数。此外，可以在电极的安装期间实时地确定电极位置，并且可以在显示屏上提供电极位置的视觉指示。

24. 发明申请

US20060271121A1 Closed loop impedance-based cardiac resynchronization therapy systems, devices, and methods 审中-公开
公开(公告)号：US20060271121A1
公开(公告)日：2006-11-30
申请号：US11136894
申请日：2005-05-25
申请人： Jiang Ding , Julio Spinelli , Yinghong Yu , Jeffrey Stahmann
发明人： Jiang Ding , Julio Spinelli , Yinghong Yu , Jeffrey Stahmann
IPC分类号： A61N1/368
CPC分类号： A61N1/3627 , A61B5/053 , A61N1/36521 , A61N1/3682 , A61N1/3684
摘要： This document discusses, among other things, systems, devices, and methods measure an impedance and, in response, adjust an atrioventricular (AV) delay or other cardiac resynchronization therapy (CRT) parameter that synchronizes left and right ventricular contractions. A first example uses parameterizes a first ventricular volume against a second ventricular volume during a cardiac cycle, using a loop area to create a synchronization fraction (SF). The CRT parameter is adjusted in closed-loop fashion to increase the SF. A second example measures a septal-freewall phase difference (PD), and adjusts a CRT parameter to decrease the PD. A third example measures a peak-to-peak volume or maximum rate of change in ventricular volume, and adjusts a CRT parameter to increase the peak-to-peak volume or maximum rate of change in the ventricular volume.

25. 发明申请

US20060116727A1 AUTOMATIC SELECTION OF STIMULATION CHAMBER FOR VENTRICULAR RESYNCHRONIZATION THERAPY 有权
标题翻译：自体选择刺激室进行心脏再生治疗
公开(公告)号：US20060116727A1
公开(公告)日：2006-06-01
申请号：US11276007
申请日：2006-02-09
申请人： Jiang Ding , Julio Spinelli , Yinghong Yu , Andrew Kramer
发明人： Jiang Ding , Julio Spinelli , Yinghong Yu , Andrew Kramer
IPC分类号： A61N1/36
CPC分类号： A61N1/36592 , A61B5/0472 , A61N1/3627 , A61N1/3684
摘要： A method and apparatus for selection of one or more ventricular chambers to stimulate for ventricular resynchronization therapy. Intrinsic intracardia electrograms that include QRS complexes, are recorded from a left and right ventricle. A timing relationship between the intrinsic intracardia electrograms recorded from the left and right ventricle is then determined. In one embodiment, the timing relationship is determined using a delay between a left ventricular and a right ventricular sensed intrinsic ventricular depolarizations and a duration interval of one or more QRS complexes. In one embodiment, the duration of QRS complexes is determined from either intracardiac electrograms or from surface ECG recordings. One or more ventricular chambers in which to provide pacing pulses are then selected based on the timing relationship between intrinsic intracardia electrograms recorded from the right and left ventricle, and the duration of one or more QRS complexes.
摘要翻译：用于选择一个或多个心室以刺激心室再同步治疗的方法和装置。包括QRS复合物在内的心内电图从左心室和右心室记录。然后确定从左心室和右心室记录的内在心内电描记图之间的时间关系。在一个实施例中，使用左心室和右心室感测的内心室去极化之间的延迟和一个或多个QRS复合物的持续时间间隔来确定时间关系。在一个实施方案中，QRS复合物的持续时间由心脏内电刺激图或从表面心电图记录确定。然后基于从右心室和左心室记录的内在心内电描记图与一个或多个QRS复合物的持续时间之间的时间关系来选择其中提供起搏脉冲的一个或多个心室。

26. 发明申请

US20050131472A1 Cardiac pacing using adjustable atrio-ventricular delays 有权
标题翻译：心脏起搏使用可调节的心房延迟
公开(公告)号：US20050131472A1
公开(公告)日：2005-06-16
申请号：US11049181
申请日：2005-02-02
申请人： Jiang Ding , Yinghong Yu , Andrew Kramer , Julio Spinelli
发明人： Jiang Ding , Yinghong Yu , Andrew Kramer , Julio Spinelli
IPC分类号： A61N1/362 , A61N1/368 , A61N1/365
CPC分类号： E21B17/01 , A61N1/3627 , A61N1/3682 , E21B43/36
摘要： A pacing system for providing optimal hemodynamic cardiac function for parameters such as contractility (peak left ventricle pressure change during systole or LV+dp/dt), or stroke volume (aortic pulse pressure) using system for calculating atrio-ventricular delays for optimal timing of a ventricular pacing pulse. The system providing an option for near optimal pacing of multiple hemodynamic parameters. The system deriving the proper timing using electrical or mechanical events having a predictable relationship with an optimal ventricular pacing timing signal.
摘要翻译：一种起搏系统，用于为诸如收缩性（收缩期峰值左心室压力变化或LV + dp / dt）之间的参数或行程体积（主动脉脉压）提供最佳血液动力学心脏功能，使用用于计算心室延迟的系统以获得最佳时机心室起搏脉搏。该系统为多个血液动力学参数的近似最佳起搏提供了选择。该系统使用与最佳心室起搏定时信号具有可预测关系的电或机械事件导出适当的定时。

27. 发明授权

US06684103B2 Cardiac pacing using adjustable atrio-ventricular delays 有权
标题翻译：心脏起搏使用可调节的心房延迟
公开(公告)号：US06684103B2
公开(公告)日：2004-01-27
申请号：US10243811
申请日：2002-09-13
申请人： Jiang Ding , Yinghong Yu , Andrew P. Kramer , Julio Spinelli
发明人： Jiang Ding , Yinghong Yu , Andrew P. Kramer , Julio Spinelli
IPC分类号： A61N1365
CPC分类号： E21B17/01 , A61N1/3627 , A61N1/3682 , E21B43/36
摘要： A pacing system for providing optimal hemodynamic cardiac function for parameters such as contractility (peak left ventricle pressure change during systole or LV+dp/dt), or stroke volume (aortic pulse pressure) using system for calculating atrio-ventricular delays for optimal timing of a ventricular pacing pulse. The system providing an option for near optimal pacing of multiple hemodynamic parameters. The system deriving the proper timing using electrical or mechanical events having a predictable relationship with an optimal ventricular pacing timing signal.
摘要翻译：一种起搏系统，用于为诸如收缩性（收缩期峰值左心室压力变化或LV + dp / dt）之间的参数或行程体积（主动脉脉压）提供最佳血液动力学心脏功能，使用用于计算心室延迟的系统以获得最佳时机心室起搏脉搏。该系统为多个血液动力学参数的近似最佳起搏提供了选择。该系统使用与最佳心室起搏定时信号具有可预测关系的电或机械事件导出适当的定时。

28. 发明申请

US20130013018A1 IDENTIFYING HEART FAILURE PATIENTS SUITABLE FOR RESYNCHRONIZATION THERAPY USING QRS COMPLEX WIDTH FROM AN INTRACARDIAC ELECTROGRAM 有权
标题翻译：鉴定心脏衰竭患者适用于使用QRS复合宽度从内皮细胞电泳进行再生治疗
公开(公告)号：US20130013018A1
公开(公告)日：2013-01-10
申请号：US13615281
申请日：2012-09-13
申请人： Jiang Ding , Yinghong Yu , Julio Spinelli
发明人： Jiang Ding , Yinghong Yu , Julio Spinelli
IPC分类号： A61N1/365
CPC分类号： A61B5/053 , A61B5/0452 , A61B5/0456 , A61B5/0472 , A61B34/20 , A61B2034/2072 , A61N1/3627 , A61N1/36592 , A61N1/3682
摘要： Methods and systems are disclosed for determining whether a patient is a responder to cardiac resynchronization therapy. The beginning and ending of the intrinsic ventricular depolarization are determined through signals measured from one or more electrodes implanted in the patient's heart. An interval between the beginning and ending of the intrinsic ventricular depolarization is computed and is compared to a threshold. The threshold may be determined empirically. The pacing parameters of a heart stimulation device, such as a pacemaker, may then be configured, for example, by setting the paced atrio-ventricular delay based on whether the patient responds positively to cardiac resynchronization therapy.
摘要翻译：公开了用于确定患者是心脏再同步治疗的应答者的方法和系统。通过从植入患者心脏的一个或多个电极测量的信号来确定内在性心室去极化的开始和结束。计算内在心室去极化的开始和结束之间的间隔，并将其与阈值进行比较。阈值可以凭经验确定。然后可以例如通过基于患者是否对心脏再同步治疗作出积极响应来设定起搏心房延迟来配置诸如起搏器的心脏刺激装置的起搏参数。

29. 发明授权

US07881794B2 Method and apparatus for determining the coronary sinus vein branch accessed by a coronary sinus lead 有权
标题翻译：用于确定冠状静脉窦导管接近的冠状静脉窦静脉分支的方法和装置
公开(公告)号：US07881794B2
公开(公告)日：2011-02-01
申请号：US11834484
申请日：2007-08-06
申请人： Yinghong Yu , Jiang Ding , Jeng Mah , Julio Spinelli
发明人： Yinghong Yu , Jiang Ding , Jeng Mah , Julio Spinelli
IPC分类号： A61N1/00
CPC分类号： A61B5/0452 , A61B5/0456 , A61B34/20 , A61B2034/2072 , A61N1/3627 , A61N1/3682
摘要： Systems and methods for determining the coronary sinus vein branch location of a left ventricle electrode are disclosed. The systems and methods involve detecting the occurrence of electrical events within the patient's heart including sensing one or more of the electrical events with the electrode and then analyzing the electrical events to determine the electrode's position. The determination of electrode position may be used to automatically adjust operating parameters of a VRT device. Furthermore, the determination of electrode position may be made in real-time during installation of the electrode and a visual indication of the electrode position may be provided on a display screen.
摘要翻译：公开了用于确定左心室电极的冠状静脉窦静脉分支位置的系统和方法。系统和方法涉及检测患者心脏内的电事件的发生，包括用电极感测一个或多个电事件，然后分析电气事件以确定电极的位置。电极位置的确定可用于自动调整VRT器件的工作参数。此外，可以在电极的安装期间实时地确定电极位置，并且可以在显示屏上提供电极位置的视觉指示。

30. 发明授权

US07424324B2 Identifying heart failure patients suitable for resynchronization therapy using QRS complex width from an intracardiac electrogram 有权
标题翻译：确定适合于使用QRS复合宽度的心脏电图进行再同步治疗的心力衰竭患者
公开(公告)号：US07424324B2
公开(公告)日：2008-09-09
申请号：US11133526
申请日：2005-05-20
申请人： Jiang Ding , Yinghong Yu , Julio Spinelli
发明人： Jiang Ding , Yinghong Yu , Julio Spinelli
IPC分类号： A61N1/37
CPC分类号： A61B5/053 , A61B5/0452 , A61B5/0456 , A61B5/0472 , A61B34/20 , A61B2034/2072 , A61N1/3627 , A61N1/36592 , A61N1/3682
摘要： Methods and systems are disclosed for determining whether a patient is a responder to cardiac resynchronization therapy. The beginning and ending of the intrinsic ventricular depolarization are determined through signals measured from one or more electrodes implanted in the patient's heart. An interval between the beginning and ending of the intrinsic ventricular depolarization is computed and is compared to a threshold. The threshold may be determined empirically. The pacing parameters of a heart stimulation device, such as a pacemaker, may then be configured, for example, by setting the paced atrio-ventricular delay based on whether the patient responds positively to cardiac resynchronization therapy.
摘要翻译：公开了用于确定患者是心脏再同步治疗的应答者的方法和系统。通过从植入患者心脏的一个或多个电极测量的信号来确定内在性心室去极化的开始和结束。计算内在心室去极化的开始和结束之间的间隔，并将其与阈值进行比较。阈值可以凭经验确定。然后可以例如通过基于患者是否对心脏再同步治疗作出积极响应来设定起搏心房延迟来配置诸如起搏器的心脏刺激装置的起搏参数。

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