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21. 发明授权

US06551267B1 Medical article having blood-contacting surface 有权
标题翻译：医用制品具有接触血液的表面
公开(公告)号：US06551267B1
公开(公告)日：2003-04-22
申请号：US09691423
申请日：2000-10-18
申请人： Richmond R. Cohen , Preston Keusch
发明人： Richmond R. Cohen , Preston Keusch
IPC分类号： A61L3300
CPC分类号： B01L3/5082 , A61B5/15003 , A61B5/150351 , A61B5/150389 , A61B5/150503 , A61B5/150755 , A61L33/0064 , A61L33/064 , C08L39/06
摘要： A plastic medical article, such as a catheter or blood collection tube, is coated with a crosslinked hydrogel permanently bound to the inside wall of the tube. The hydrophilic surface provided by the hydrogel prevents adherence of blood components to the surface, and the permanent adherence of the hydrogel prevents its removal by blood.
摘要翻译：诸如导管或采血管的塑料医疗制品涂覆有永久地结合到管的内壁的交联水凝胶。由水凝胶提供的亲水表面防止血液成分粘附到表面，并且水凝胶的永久粘附防止其被血液除去。

22. 发明授权

US06377847B1 Iontophoretic drug delivery device and reservoir and method of making same 失效
标题翻译：离子电渗药物输送装置和储存器及其制作方法
公开(公告)号：US06377847B1
公开(公告)日：2002-04-23
申请号：US09328329
申请日：1999-06-09
申请人： Preston Keusch , NRK Vilambi , Bruce Michael Eliash
发明人： Preston Keusch , NRK Vilambi , Bruce Michael Eliash
IPC分类号： A61N130
CPC分类号： A61N1/0448 , A61F2013/0296 , A61N1/0436 , A61N1/044
摘要： A reservoir electrode assembly of the present invention for an iontophoretic drug delivery device includes an electrode and a hydrophilic reservoir situated in electrically conductive relation to the electrode. The hydrophilic reservoir is formed from a bibulous hydrophilic cross-linked polymeric material having a first surface and a second surface that is adhesively adherent to the electrode. The first surface of the polymeric material is releasably adhesively adherent when applied to an area of a patient's skin. The polymeric material has a cohesive strength forms an adhesive bond with a bond strength between the second surface of the polymeric material to the electrode that is greater than the cohesive strength of the polymeric material. Additionally, an adhesive bond strength of the first surface of the polymeric material to the applied area of the patient is less than the cohesive strength of the polymeric material so that upon removal of the reservoir assembly of the invention from the applied area of the patient, substantially no polymeric material remains on the applied area and the hydrophilic reservoir remains substantially intact and adhesively adherent to the electrode.
摘要翻译：用于离子电渗药物递送装置的本发明的储存器电极组件包括位于与电极导电关系的电极和亲水性储存器。亲水性储存器由具有第一表面和吸附在电极上的第二表面的吸水性亲水性交联聚合物材料形成。当应用于患者皮肤区域时，聚合物材料的第一表面可剥离地粘附。聚合物材料具有内聚强度，其形成粘合剂粘合，聚合物材料的第二表面与电极之间的粘合强度大于聚合物材料的内聚强度。此外，聚合物材料的第一表面与患者的施用区域的粘合粘合强度小于聚合材料的内聚强度，使得当从患者的施用区域移除本发明的储器组件时，基本上没有聚合物材料保留在施加的区域上，并且亲水性储存器保持基本上完整且粘附到电极上。

23. 发明授权

US5354790A Methods for the preparation of non-stringy adhesive hydrophilic gels 失效
标题翻译：非粘性亲水性凝胶的制备方法
公开(公告)号：US5354790A
公开(公告)日：1994-10-11
申请号：US938909
申请日：1992-08-31
申请人： Preston Keusch , Keith A. Murdock , Christine A. Czap , Linda Lennon
发明人： Preston Keusch , Keith A. Murdock , Christine A. Czap , Linda Lennon
IPC分类号： A61B5/0408 , A61B18/14 , A61L15/58 , A61L24/00 , C08J3/28 , C09J139/06 , C09J171/02 , H01M6/22 , C08K5/06
CPC分类号： C08J3/28 , A61B5/04087 , A61L15/58 , A61L24/001 , A61L24/0031 , C09J139/06 , C09J171/02 , H01M6/22 , A61B2018/00107 , C08J2300/10
摘要： A method is disclosed for the preparation of non-stringy hydrogels that are comprised of a homogeneous uniform mixture of water and at least one water-soluble high molecular weight polymer. Suitable mixtures may be derived from poly(ethylene oxide) and water or poly(vinyl pyrrolidone), a viscosity enhancing hydrophilic polymer and water, and further, may optionally contain an effective amount of a water-soluble electrolyte to provide conductive non-stringy materials. These polymeric mixtures are crosslinked by exposure to radiant energy to provide gel-like solids which are sufficiently tacky and adhesive to adhere to the subjects' skin and yet are substantially non-stringy and non-aggressive such that contact with such hydrogels imparts less discomfort to the user. In addition, the consumer utilizing the products of this invention would not experience the objectionable sticky, stringy sensation associated with existing adhesive gels.
摘要翻译：公开了用于制备由水和至少一种水溶性高分子量聚合物均匀均匀混合物组成的非串联水凝胶的方法。合适的混合物可以衍生自聚（环氧乙烷）和水或聚（乙烯基吡咯烷酮），增粘亲水性聚合物和水，并且还可以任选地含有有效量的水溶性电解质以提供导电非串联材料。这些聚合物混合物通过暴露于辐射能来交联，以提供凝胶状固体，其具有足够的粘性和粘合剂以粘附到受试者的皮肤上，但是基本上非丝质和非侵略性，使得与这种水凝胶的接触赋予较少的不适用户。此外，利用本发明产品的消费者不会遇到与现有粘合剂凝胶相关联的令人反感的粘性，串联感觉。

24. 发明授权

US4989607A Highly conductive non-stringy adhesive hydrophilic gels and medical electrode assemblies manufactured therefrom 失效
标题翻译：高导电性非粘性亲水凝胶和由其制造的医用电极组件
公开(公告)号：US4989607A
公开(公告)日：1991-02-05
申请号：US330669
申请日：1989-03-30
申请人： Preston Keusch , Christine A. Czap , Keith A. Murdock , Linda Lennon
发明人： Preston Keusch , Christine A. Czap , Keith A. Murdock , Linda Lennon
IPC分类号： A61B5/0408 , A61B18/14 , A61L15/58 , A61L24/00 , C08J3/28 , C09J139/06 , C09J171/02 , H01M6/22
CPC分类号： C08J3/28 , A61B5/04087 , A61L15/58 , A61L24/001 , A61L24/0031 , C09J139/06 , C09J171/02 , H01M6/22 , A61B2018/00107 , C08J2300/10
摘要： The highly conductive hydrogels of this invention are comprised of a cohesive uniform mixture of poly(vinyl pyrrolidone), a viscosity-enhancing hydrophilic polymer, and an effective amount of an electrolyte. This polymeric mixture which is crosslinked by exposure to radiant energy provides a gel-like solid which is sufficiently tacky and adhesive to adhere to the subjects' skin and yet is substantially non-stringy and non-aggressive such that the use of such hydrogel imparts less discomfort to the user. In addition, the consumer utilizing the product of this invention would not experience the objectionable sticky, stringy sensation associated with existing conductive adhesive gels.
摘要翻译：本发明的高导电性水凝胶由聚（乙烯基吡咯烷酮），增粘亲水性聚合物和有效量的电解质的内聚均匀混合物组成。通过暴露于辐射能量交联的这种聚合物混合物提供了一种凝胶状固体，其具有足够的粘性和粘合性以粘附到受试者的皮肤上，但是基本上是非串联和非侵略性的，使得使用这种水凝胶使得较少不舒服的用户。此外，利用本发明产品的消费者将不会遇到与现有导电粘合剂凝胶相关联的令人反感的粘性，紧张感。

25. 发明授权

US4706680A Conductive adhesive medical electrode assemblies 失效
标题翻译：导电胶医用电极组件
公开(公告)号：US4706680A
公开(公告)日：1987-11-17
申请号：US879877
申请日：1986-06-30
申请人： Preston Keusch , John L. Essmyer
发明人： Preston Keusch , John L. Essmyer
IPC分类号： C09J171/00 , A61B5/04 , A61B5/0408 , A61B5/0416 , A61B18/14 , A61N1/04
CPC分类号： A61B5/0408 , A61B5/0416 , A61B2018/00107
摘要： A medical electrode adapted for providing electrical contact with a patient's skin and comprising:(a) a conductive member including means for connecting the medical electrode to an external electrical apparatus; and(b) interfacing means comprising a solid sheet of a conductive viscoelastic hydrophilic gel which is a homogeneous aqueous mixture, substantially free of unbound water, monomers and cross-linking agents, consisting essentially of(i) water;(ii) an amount dissolved in the water of a water soluble electrolyte effective to reduce the transverse electrical resistance of the sheet to an impedance at 60 Hz of less than 1,000 ohms; and(iii) an amount dispersed uniformly throughout the water of from about 2 to 35 wt % of a cross-linked polyethylene oxide, effective to form with the water a tacky surface viscoelastic adhesive solid; which hydrophilic gel is produced by subjecting a liquid film of an aqueous solution having a viscosity of about 2-2,000.times.10.sup.3 cps of the electrolyte and a linear water soluble polyethylene oxide having a weight average molecular weight from about 0.05-10.times.10.sup.6 Daltons to an amount of high energy radiation effective to convert the liquid film to a sheet of adhesive viscoelastic solid.
摘要翻译：一种适于与患者皮肤电接触的医用电极，包括：（a）导电构件，包括用于将医用电极连接到外部电气设备的装置; 和（b）界面装置，其包含基本上不含未结合的水，单体和交联剂的基本上由（i）水组成的均匀含水混合物的导电粘弹性亲水凝胶的固体片; （ii）溶解在水溶性电解质的水中的量，其有效地将片材的横向电阻降低到小于1000欧姆的60Hz的阻抗; 和（iii）在整个水中均匀分散的量为约2-35重量％的交联聚环氧乙烷，有效地与水形成粘性表面粘弹性粘合剂固体; 该亲水凝胶通过将具有约2-2,000×10 3 cps的粘度的电解液的水溶液的液膜和重均分子量为约0.05-10×10 6道尔顿的线性水溶性聚环氧乙烷经过高能量辐射有效地将液膜转化成一片粘合剂粘弹性固体。

26. 发明申请

US20100106074A1 PHYSICAL, STRUCTURAL, MECHANICAL, ELECTRICAL AND ELECTROMECHANICAL FEATURES FOR USE IN ASSOCIATION WITH ELECTRICALLY ASSISTED DELIVERY DEVICES AND SYSTEMS 审中-公开
标题翻译：物理，结构，机械，电气和电气特性用于与电力辅助交付设备和系统的协调
公开(公告)号：US20100106074A1
公开(公告)日：2010-04-29
申请号：US12472140
申请日：2009-05-26
申请人： Vilambi NRK Reddy , Preston Keusch , Robert J. Strowe , Jeffrey Kapec , Kazuna Tanaka
发明人： Vilambi NRK Reddy , Preston Keusch , Robert J. Strowe , Jeffrey Kapec , Kazuna Tanaka
IPC分类号： A61N1/30
CPC分类号： A61N1/0448 , A61N1/044
摘要： Provided are various embodiments of integrated electrode devices, assemblies and systems structured for use in association with electrically assisted delivery devices configured for delivery of a composition to a membrane. The integrated electrode devices, assemblies and systems include one or more of a variety of structural, physical, mechanical, electrical and electromechanical enhancements.
摘要翻译：提供了集成电极装置，组件和系统的各种实施例，其被构造为与被配置为将组合物递送到膜的电辅助递送装置相关联地使用。集成电极装置，组件和系统包括各种结构，物理，机械，电和机电增强中的一种或多种。

27. 发明授权

US07043297B2 Iontophoretic drug delivery device and reservoir and method of making same 失效
公开(公告)号：US07043297B2
公开(公告)日：2006-05-09
申请号：US11039518
申请日：2005-01-19
申请人： Preston Keusch , NRK Vilambi , Bruce Michael Eliash
发明人： Preston Keusch , NRK Vilambi , Bruce Michael Eliash
IPC分类号： A61N1/30
CPC分类号： A61N1/0448 , A61N1/0436 , A61N1/044
摘要： A reservoir electrode assembly of the present invention for an iontophoretic drug delivery device includes an electrode and a hydrophilic reservoir situated in electrically conductive relation to the electrode. The hydrophilic reservoir is formed from a bibulous hydrophilic cross-linked polymeric material having a first surface and a second surface that is adhesively adherent to the electrode. The first surface of the polymeric material is releasably adhesively adherent when applied to an area of a patient's skin. The polymeric material has a cohesive strength forms an adhesive bond with a bond strength between the second surface of the polymeric material to the electrode that is greater than the cohesive strength of the polymeric material. Additionally, an adhesive bond strength of the first surface of the polymeric material to the applied area of the patient is less than the cohesive strength of the polymeric material so that upon removal of the reservoir assembly of the invention from the applied area of the patient, substantially no polymeric material remains on the applied area and the hydrophilic reservoir remains substantially intact and adhesively adherent to the electrode.

28. 发明申请

US20050131338A1 Iontophoretic drug delivery device and reservoir and method of making same 失效
公开(公告)号：US20050131338A1
公开(公告)日：2005-06-16
申请号：US11039518
申请日：2005-01-19
申请人： Preston Keusch , NRK Vilambi , Bruce Eliash
发明人： Preston Keusch , NRK Vilambi , Bruce Eliash
IPC分类号： A61N1/30 , A61B17/20
CPC分类号： A61N1/0448 , A61N1/0436 , A61N1/044
摘要： A reservoir electrode assembly of the present invention for an iontophoretic drug delivery device includes an electrode and a hydrophilic reservoir situated in electrically conductive relation to the electrode. The hydrophilic reservoir is formed from a bibulous hydrophilic cross-linked polymeric material having a first surface and a second surface that is adhesively adherent to the electrode. The first surface of the polymeric material is releasably adhesively adherent when applied to an area of a patient's skin. The polymeric material has a cohesive strength forms an adhesive bond with a bond strength between the second surface of the polymeric material to the electrode that is greater than the cohesive strength of the polymeric material. Additionally, an adhesive bond strength of the first surface of the polymeric material to the applied area of the patient is less than the cohesive strength of the polymeric material so that upon removal of the reservoir assembly of the invention from the applied area of the patient, substantially no polymeric material remains on the applied area and the hydrophilic reservoir remains substantially intact and adhesively adherent to the electrode.

29. 发明授权

US06496727B1 Medicament-loaded transdermal reservoir and method for its formation 有权
标题翻译：药物载体透皮储库及其形成方法
公开(公告)号：US06496727B1
公开(公告)日：2002-12-17
申请号：US09584453
申请日：2000-05-31
申请人： Michael I. Bernhard , Ralph Ewall , Curtis Karl , Preston Keusch , Gary Kupperblatt , Daniel O'Grady
发明人： Michael I. Bernhard , Ralph Ewall , Curtis Karl , Preston Keusch , Gary Kupperblatt , Daniel O'Grady
IPC分类号： A61N130
CPC分类号： A61N1/30
摘要： A transdermal reservoir and method for loading a material into a reservoir includes providing a bibulous reservoir blocking a backing with an interior surface having a patient contact surface with a shape disposed on the interior surface of the backing. A closure is sized and shaped to engage the backing for forming a releasable seal to isolate the bibulous reservoir from the ambient environment. The closure has an inside surface with a section of an absorbent material disposed thereon. When the closure is disposed on the backing, the absorbent material is positioned in intimate physical contact with the reservoir. The method includes applying an aliquot of a material to the absorbent material,. placing the closure on the backing so that the absorbent material is in intimate physical contact with the contact surface of the bibulous reservoir and the closure forms the releasable seal with the backing. The reservoir is allowed to stand for a sufficient time to allow the aliquot to be absorbed into the bibulous material thereby loading the reservoir.
摘要翻译：用于将材料装载到储存器中的透皮储存器和方法包括提供阻塞背衬的吸水储存器，其具有带有设置在背衬的内表面上的形状的患者接触表面的内表面。封闭件的尺寸和形状被设计成与背衬接合以形成可释放的密封，以将吸水容器与环境环境隔离。封闭件具有内表面，其上设置有一部分吸收材料。当封闭件设置在背衬上时，吸收材料定位成与贮存器紧密地物理接触。该方法包括将一种材料的等分试样施加到吸收材料上。将封闭物放置在背衬上，使得吸收材料与吸水容器的接触表面紧密地物理接触并且封闭物与背衬形成可释放的密封。允许储存器放置足够的时间以允许将等分试样吸收到吸水材料中，从而装载储存器。

30. 发明授权

US5622168A Conductive hydrogels and physiological electrodes and electrode assemblies therefrom 失效
标题翻译：导电水凝胶和生理电极及其电极组件
公开(公告)号：US5622168A
公开(公告)日：1997-04-22
申请号：US400273
申请日：1995-03-03
申请人： Preston Keusch , John L. Essmyer
发明人： Preston Keusch , John L. Essmyer
IPC分类号： A61B5/0408 , A61B5/0496 , A61N1/05 , A61B5/04 , A61N1/04
CPC分类号： A61B5/0496 , A61B5/04085 , A61N1/0551
摘要： A highly conductive hydrophilic gel comprising a uniform aqueous solution of a crosslinked water-soluble polymer, an amount of a water-soluble electrolyte effective to reduce the transverse electrical resistance of said aqueous mixture to an impedance at 60 Hz less than about 1,000 ohm, which hydrophilic gel also contains a humectant in an amount effective to retard the drying of the conductive hydrophilic gel when it is exposed to the atmosphere while being used. A physiological electrode adapted for providing electrical contact with a surface of a sentient creature and comprising a sheet of the conductive viscoelastic hydrophilic gel.
摘要翻译：一种高度导电的亲水性凝胶，其包含交联的水溶性聚合物的均匀水溶液，一定量的水溶性电解质，其有效地将所述水性混合物的横向电阻降低到小于约1,000欧姆的60Hz的阻抗，当亲水性凝胶在使用时暴露于大气中时，亲水凝胶还含有有效阻止导电亲水凝胶的干燥的湿润剂。生理电极，其适于与感知生物的表面提供电接触并且包括导电粘弹性亲水凝胶片。

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