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21. 发明授权

US09562104B2 Anti-CD40 antibodies 有权
公开(公告)号：US09562104B2
公开(公告)日：2017-02-07
申请号：US12718365
申请日：2010-03-05
申请人： Jacques F. Banchereau , Gerard Zurawski , Sandra Zurawski , SangKon Oh
发明人： Jacques F. Banchereau , Gerard Zurawski , Sandra Zurawski , SangKon Oh
IPC分类号： A61K39/395 , C07K16/28 , C07K14/005 , A61K39/00
CPC分类号： C07K16/2878 , A61K39/00 , A61K2039/6056 , C07K14/005 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/626 , C07K2317/74 , C07K2317/80 , C07K2319/00 , C12N2740/16222 , C12N2740/16322
摘要： The present invention includes compositions and methods for the expression, secretion and use of novel compositions for use as, e.g., vaccines and antigen delivery vectors, to delivery antigens to antigen presenting cells. In one embodiment, the vector is an anti-CD40 antibody, or fragments thereof, and one or more antigenic peptides linked to the anti-CD40 antibody or fragments thereof, including humanized antibodies.

22. 发明授权

US08728481B2 Agents that engage antigen-presenting cells through dendritic cell asialoglycoprotein receptor (DC-ASGPR) 有权
标题翻译：通过树突状细胞脱唾液酸糖蛋白受体（DC-ASGPR）与抗原呈递细胞接触的药剂
公开(公告)号：US08728481B2
公开(公告)日：2014-05-20
申请号：US13551198
申请日：2012-07-17
申请人： Jacques F. Banchereau , SangKOn Oh , Gerard Zurawski , Sandra Zurawski , Dapeng Li
发明人： Jacques F. Banchereau , SangKOn Oh , Gerard Zurawski , Sandra Zurawski , Dapeng Li
IPC分类号： A61K39/00 , A61K39/395 , A01N63/00
CPC分类号： A61K39/145 , A61K47/6849 , A61K51/1027 , A61K2039/5154 , C07K14/005 , C07K14/195 , C07K14/37 , C07K14/405 , C07K14/435 , C07K16/28 , C07K2317/24 , C07K2317/33 , C07K2317/56 , C07K2317/74 , C07K2317/75 , C07K2317/92 , C12N5/0639 , C12N7/00 , C12N2760/16122 , C12N2760/16134 , Y02A50/472
摘要： The present invention includes compositions and methods for making and using anti DC-ASGPR antibodies that can, e.g., activate DCs and other cells.
摘要翻译：本发明包括用于制备和使用可以例如激活DC和其他细胞的抗DC-ASGPR抗体的组合物和方法。

23. 发明申请

US20130183346A1 UNIQUE TRANSCRIPTIONAL SIGNATURES IN THE BLOOD OF CLINICAL RESPONDERS 审中-公开
标题翻译：临床反应人血液中的独特的转录信号
公开(公告)号：US20130183346A1
公开(公告)日：2013-07-18
申请号：US13614400
申请日：2012-09-13
申请人： Anna Karolina Palucka , Jose Rosello-Urgell , Jacques F. Banchereau , Joseph Fay , Damien Chaussabel
发明人： Anna Karolina Palucka , Jose Rosello-Urgell , Jacques F. Banchereau , Joseph Fay , Damien Chaussabel
IPC分类号： G06F19/12
CPC分类号： G16B5/00
摘要： A method for using the blood transcriptional profile of patients with stage IV melanoma to generate networks associated with the possibility of prolonged survival and networks associated with clinical responses to dendritic cell (DC) vaccination as measured by tumor regression are disclosed herein.
摘要翻译：本文公开了使用IV期黑素瘤患者的血液转录谱的方法，以生成与延长存活的可能性相关的网络，以及通过肿瘤消退测量的与树突状细胞（DC）接种的临床反应相关的网络。

24. 发明授权

US08449888B2 Vaccines based on targeting antigen to DCIR expressed on antigen-presenting cells 失效
公开(公告)号：US08449888B2
公开(公告)日：2013-05-28
申请号：US13234914
申请日：2011-09-16
申请人： Gerard Zurawski , Jacques F. Banchereau , Eynav Klechevsky , Sandra Zurawski , Anne-Laure Flamar
发明人： Gerard Zurawski , Jacques F. Banchereau , Eynav Klechevsky , Sandra Zurawski , Anne-Laure Flamar
IPC分类号： A61K39/395 , A61K39/12 , C07K16/46 , C07K16/28
CPC分类号： C07K16/2851 , A61K39/02 , A61K39/12 , A61K39/145 , A61K39/21 , A61K47/6897 , A61K47/6901 , A61K2039/505 , A61K2039/6056 , B82Y5/00 , C12N5/0639 , C12N2760/16134
摘要： The present invention includes compositions and methods for increasing the effectiveness of antigen presentation using a DCIR-specific antibody or fragment thereof to which an antigen is attached that forms an antibody-antigen complex, wherein the antigen is processed and presented by a dendritic cell that has been contacted with the antibody-antigen complex.

25. 发明申请

US20120231023A1 Novel Vaccine Adjuvants Based on Targeting Adjuvants to Antibodies Directly to Antigen-Presenting Cells 审中-公开
标题翻译：基于靶向抗体的抗体直接针对抗原呈递细胞的新型疫苗佐剂
公开(公告)号：US20120231023A1
公开(公告)日：2012-09-13
申请号：US13415564
申请日：2012-03-08
申请人： Gerard Zurawski , Jacques F. Banchereau , Anne-Laure Flamar , Robert R. Kane
发明人： Gerard Zurawski , Jacques F. Banchereau , Anne-Laure Flamar , Robert R. Kane
IPC分类号： A61K39/44 , A61K35/12 , A61P31/12 , C12N5/0784 , A61P31/10 , A61P33/00 , A61P33/02 , A61P37/08 , A61P35/00 , A61P31/04
CPC分类号： C07K16/2851 , A61K35/15 , A61K39/39 , A61K2039/55516 , A61K2039/6056 , C07K16/2878 , Y02A50/39
摘要： The present invention includes compositions and methods for enhancing an immune response with an adjuvant composition comprising: an anti-dendritic cell (DC)-specific antibody or fragment thereof conjugated to at least a portion of Toll-Like Receptor (TLR) agonist, more specifically a TLR7 ligand (TLR7L), and a pharmaceutically acceptable carrier, wherein the conjugate and agonist are each comprised in an amount such that, in combination with the other, are effective to produce the immune response in a human or animal subject in need of immunostimulation.
摘要翻译：本发明包括用佐剂组合物增强免疫应答的组合物和方法，其包含：与至少一部分Toll样受体（TLR）激动剂缀合的抗树突状细胞（DC）特异性抗体或其片段，更具体地 TLR7配体（TLR7L）和药学上可接受的载体，其中缀合物和激动剂各自包含的量使得与另一种组合有效地在需要免疫刺激的人或动物受试者中产生免疫应答。

26. 发明申请

US20120213768A1 Diagnostic and Therapeutic Uses for B Cell Maturation Antigen 审中-公开
标题翻译：诊断和治疗用于B细胞成熟抗原
公开(公告)号：US20120213768A1
公开(公告)日：2012-08-23
申请号：US13397932
申请日：2012-02-16
申请人： SangKon Oh , Maria Virginia Pascual , Gerard Zurawski , Jacques F. Banchereau
发明人： SangKon Oh , Maria Virginia Pascual , Gerard Zurawski , Jacques F. Banchereau
IPC分类号： A61K39/395 , G01N33/566 , G01N21/25 , G01N21/64 , G01N27/72 , A61K38/02 , A61P29/00 , A61P17/00 , A61P37/08 , A61P11/06 , A61P3/10 , A61P1/16 , A61P9/00 , A61P1/00 , A61P37/04 , A61K31/713 , C07H21/04 , C07K14/00 , A61P19/02 , C12Q1/68
CPC分类号： A61K31/713 , A61K45/06 , C12N15/1138 , C12N2310/14 , C12Q1/6883 , C12Q2600/158 , G01N33/5091 , G01N33/564 , G01N2333/70575 , G01N2800/104
摘要： Biomarkers and therapies against autoimmune diseases, including systemic lupus erythematosus (SLE) are described herein. The present invention is based on the discovery of B cell maturation antigen (BCMA) and BCMA variant expression on SLE monocytes that can be directly associated with disease activity. The findings of the present invention enable the design of monoclonal antibodies or recombinant proteins that can block BCMA and BCMA variants as well as BCMA-bound APRIL.
摘要翻译：包括系统性红斑狼疮（SLE）在内的生物标志物和抗自身免疫性疾病的疗法在本文中描述。本发明基于可以与疾病活动直接相关的SLE单核细胞上的B细胞成熟抗原（BCMA）和BCMA变体表达的发现。本发明的发现使得能够设计可以阻断BCMA和BCMA变体以及BCMA结合的APRIL的单克隆抗体或重组蛋白。

27. 发明授权

US07888481B2 Anti-interferon alpha monoclonal antibodies and methods for use 有权
标题翻译：抗干扰素α单克隆抗体及其使用方法
公开(公告)号：US07888481B2
公开(公告)日：2011-02-15
申请号：US12367030
申请日：2009-02-06
申请人： Jacques F. Banchereau , Kiley Prilliman , Virginia Pascual , Anna Karolina Palucka
发明人： Jacques F. Banchereau , Kiley Prilliman , Virginia Pascual , Anna Karolina Palucka
IPC分类号： C07K16/00 , A61K39/395
CPC分类号： C07K16/249 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The present invention includes compositions and methods that include antibodies that selectively neutralize a bioactivity of at least two interferon alpha (“IFNα”) protein subtypes for the protein subtypes A, 2, B2, C, F, G, H2, I, J1, K, 4a, 4b and WA, but does not neutralize at least one bioactivity of IFNα protein subtype D. Examples of bioactivity for measurement include activation of the MxA promoter or antiviral activity and variants, derivatives and fragments thereof. The invention also includes host cells, hybridomas and plasmacytomas that produce antibodies. Because of their unique selectivity and affinity, the antibodies of the present invention are useful to detect IFNα subtypes in sample or tissue and/or for therapeutic applications that include, but are not limited to the treatment and/or amelioration of an IFNα related disorder such as SLE, lupus, type I diabetes, psoriasis, AIDS and Graft versus Host Disease.
摘要翻译：本发明包括组合物和方法，其包括选择性中和至少两种干扰素α（“IFNα”）蛋白亚型对于蛋白质亚型A，2，B2，C，F，G，H2，I，J1的生物活性的抗体， K，4a，4b和WA，但不中和IFNα蛋白亚型D的至少一种生物活性。用于测量的生物活性的实例包括MxA启动子的活化或抗病毒活性及其变体，衍生物和片段。本发明还包括产生抗体的宿主细胞，杂交瘤和浆细胞瘤。由于其独特的选择性和亲和性，本发明的抗体可用于检测样品或组织和/或治疗应用中的IFNα亚型，包括但不限于IFNα相关病症的治疗和/或改善，例如如SLE，狼疮，I型糖尿病，牛皮癣，艾滋病和移植物抗宿主病。

28. 发明申请

US20100297114A1 ANTIGEN PRESENTING CELL TARGETED VACCINES 有权
标题翻译：抗原呈递细胞靶向疫苗
公开(公告)号：US20100297114A1
公开(公告)日：2010-11-25
申请号：US12717789
申请日：2010-03-04
申请人： Gerard Zurawski , Jacques F. Banchereau , Anne-Laure Flamar , Yves Levy , Monica Montes
发明人： Gerard Zurawski , Jacques F. Banchereau , Anne-Laure Flamar , Yves Levy , Monica Montes
IPC分类号： A61K39/395 , C07K16/28 , C12N15/63 , C12N5/10 , A61P37/04 , A61P31/12 , A61P35/00 , A61P31/00
CPC分类号： C07K16/2878 , A61K39/00 , A61K39/385 , A61K2039/6056 , A61K2039/627 , A61K2039/64 , C07K14/005 , C07K16/00 , C07K2317/41 , C07K2317/56 , C07K2317/565 , C07K2317/74 , C07K2317/77 , C07K2317/80 , C07K2319/00 , C07K2319/30 , C07K2319/40 , C07K2319/91 , C12N2740/16222 , C12N2740/16322 , C12N2760/16122 , C12N2770/24222 , C12N2770/24234 , G01N33/6863 , Y02A50/39 , Y02A50/464 , Y02A50/466
摘要： The present invention includes compositions and methods for the expression, secretion and use of novel compositions for use as, e.g., vaccines and antigen delivery vectors, to delivery antigens to antigen presenting cells. In one embodiment, the vector is an anti-CD40 antibody, or fragments thereof, and one or more antigenic peptides linked to the anti-CD40 antibody or fragments thereof, including humanized antibodies.
摘要翻译：本发明包括用于表达，分泌和使用用作例如疫苗和抗原递送载体的用于将抗原递送至抗原呈递细胞的组合物和方法。在一个实施方案中，载体是抗CD40抗体或其片段，以及与抗-CD40抗体或其片段（包括人源化抗体）连接的一个或多个抗原肽。

29. 发明申请

US20100113293A1 SYSTEMIC LUPUS ERYTHEMATOSUS DIAGNOSTIC ASSAY 审中-公开
标题翻译：系统性红斑狼疮诊断测定
公开(公告)号：US20100113293A1
公开(公告)日：2010-05-06
申请号：US12558334
申请日：2009-09-11
申请人： Maria Virginia Pascual , Jacques F. Banchereau , Lynda B. Bennett
发明人： Maria Virginia Pascual , Jacques F. Banchereau , Lynda B. Bennett
IPC分类号： C40B30/02 , C40B40/06
CPC分类号： C12Q1/6883 , C12Q2600/158
摘要： The present invention provides compositions and methods for aiding in the diagnosis, monitoring and prognosis of SLE in a subject and for identifying potential therapeutic agents to treat and/or ameliorate the symptoms associated with SLE. Accordingly, embodiments of the invention are directed to methods of identifying the gene expression profile of a suitable sample by screening for the presence of a differentially expressed SLE-associated gene isolated from a sample containing or suspected of containing a cell that can differentially express an SLE-associated gene.
摘要翻译：本发明提供了用于帮助受试者中SLE的诊断，监测和预后以及用于鉴定治疗和/或改善与SLE相关的症状的潜在治疗剂的组合物和方法。因此，本发明的实施方案涉及通过筛选从含有或怀疑含有可差异表达SLE的细胞的样品分离的差异表达的SLE相关基因的存在来鉴定合适样品的基因表达谱的方法相关基因。

30. 发明申请

US20100076691A1 Diagnosis of Metastatic Melanoma and Monitoring Indicators of Immunosuppression Through Blood Leukocyte Microarray Analysis 审中-公开
标题翻译：通过血液白细胞微阵列分析诊断转移性黑色素瘤和监测免疫抑制指标
公开(公告)号：US20100076691A1
公开(公告)日：2010-03-25
申请号：US12513344
申请日：2007-11-03
申请人： Anna Karolina Palucka , Jacques F. Banchereau , Damien Chaussabel
发明人： Anna Karolina Palucka , Jacques F. Banchereau , Damien Chaussabel
IPC分类号： C12Q1/68 , C40B30/00 , C40B40/06 , G06F19/00
CPC分类号： C12Q1/6886 , C12Q1/6837 , C12Q2600/158 , G16B20/00 , G16B25/00
摘要： The present invention includes compositions, systems and methods for the early detection and consistent determination of metastatic melanoma and/or immunosuppression using microarrays by calculating one or more expression vectors from the expression of one or more genes.
摘要翻译：本发明包括通过从一种或多种基因的表达计算一种或多种表达载体来使用微阵列进行早期检测和一致确定转移性黑素瘤和/或免疫抑制的组合物，系统和方法。

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