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21. 发明授权

US5294734A 4-substituted 2-aminoalk-3-enoic acids 失效
标题翻译： 4-取代的2-氨基-3-烯酸
公开(公告)号：US5294734A
公开(公告)日：1994-03-15
申请号：US851437
申请日：1992-03-16
申请人： Christof Angst , Hans Allgeier , Roland Heckendorn , Daniel Wallach
发明人： Christof Angst , Hans Allgeier , Roland Heckendorn , Daniel Wallach
IPC分类号： C07F9/38 , C07F9/59 , A61K31/66
CPC分类号： C07F9/592 , C07F9/3826
摘要： Substituted 2-aminoalk-3-enoic acid derivative of formula I ##STR1## wherein R.sub.1 is an aliphatic hydrocarbon radical that is substituted by optionally acylated or aliphatically or araliphatically etherified hydroxy, by halogen, by optionally acylated and/or aliphatically substituted amino or by an aza-, diaza-, azoxa- or oxa-cycloaliphatic radical, or is an oxacycloaliphatic hydrocarbon radical bonded via a carbon atom, or is an optionally aliphatically N-substituted or N-acylated azacycloaliphatic hydrocarbon radical, and R.sub.2 is free or esterified carboxy, and their salts exhibit NMDA-antagonistic properties and are useful as active ingredients of anticonvulsive medicaments.
摘要翻译：取代的式I的2-氨基-3-烯酸衍生物其中R 1是被任选被酰化或脂族或芳烷基醚化的羟基，被卤素任选被酰化和/或脂族取代的脂族烃基氨基或氮杂 - ，二氮杂 - 氮杂 - 或氧杂 - 脂环族基团，或是通过碳原子键合的氧杂环脂族烃基，或任选地是脂族N-取代或N-酰化氮杂环脂族烃基，R2是游离的或酯化的羧基，它们的盐表现出NMDA-拮抗性质，可用作抗惊厥药物的活性成分。

22. 发明授权

US4427590A Triazolobenzodiazepine derivatives 失效
标题翻译：三唑并苯并二氮杂衍生物
公开(公告)号：US4427590A
公开(公告)日：1984-01-24
申请号：US199770
申请日：1971-11-17
申请人： Hans Allgeier , Andre Gagneux
发明人： Hans Allgeier , Andre Gagneux
IPC分类号： C07D243/26 , A61K31/4985 , A61K31/55 , A61P25/08 , A61P25/20 , C07D243/16 , C07D309/12 , C07D487/04
CPC分类号： C07D487/04 , C07D309/12
摘要： Compounds of the class of 6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine-1-lower alkanols, and their ethers and esters, 1-(fluoro-lower alkyl)-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines and the 5-oxides and pharmaceutically acceptable acid addition salts thereof have central depressant properties, in particular antiaggressive and anticonvulsant actions, and are active ingredients for pharmaceutical compositions. Specific embodients are 6-phenyl-8-chloro-4H-s-triazolo[4,3-a][1,4]benzodiazepine-1-methanol and 1-(fluoromethyl)6-phenyl-8-chloro-4H-s-triazolo[4,3-a][1,4]benzodiazepine.
摘要翻译： 6-苯基-4H-3-三唑并[4,3-a] [1,4]苯并二氮杂-1-低级链烷醇类化合物及其醚和酯，1-（氟 - 低级烷基）-6- 苯并噻唑并[4,3-a] [1,4]苯并二氮杂及其5-氧化物及其药学上可接受的酸加成盐具有中枢抑制特性，特别是抗侵袭性和抗惊厥作用，并且是药物的活性成分组合物。具体实施方案是6-苯基-8-氯-4H-三唑并[4,3-a] [1,4]苯并二氮杂-1-甲醇和1-（氟甲基）-6-苯基-8-氯-4H- - 三唑并[4,3-a] [1,4]苯并二氮杂。

23. 发明授权

US4002764A Diazepine derivatives in the treatment of tension, agitation and epilepsy 失效
标题翻译：二氮衍生物治疗紧张，躁动和癫痫
公开(公告)号：US4002764A
公开(公告)日：1977-01-11
申请号：US634808
申请日：1975-11-24
申请人： Hans Allgeier , Andre Gagneux
发明人： Hans Allgeier , Andre Gagneux
IPC分类号： A61K31/41
摘要： Compounds of the class of 6-phenyl-4H-s-triazolo [4,3-a][1,4]benzodiazepine-1-carboxamides, their 5-oxides and their pharmaceutically acceptable acid addition salts have valuable pharmacological properties and are active ingredients for therapeutic compositions. In particular, these new compounds have an anti-convulsive and anti-aggressive action and potentiate the action of anaesthetics. Specific embodiments are N,N-dimethyl-6-phenyl-8-chloro-4H-s-triazolo[4,3-a][1,4]benzodiazepine-1-carboxamide, 6-phenyl-8-chloro-4H-s-triazolo[4,3-a][1,4]benzodiazepine-1-carboxamide, N,N-dimethyl-6-(o-chlorophenyl)-8-chloro-4H-s-triazolo[4,3-a][1,4]benzodiazepine-1-carboxamide and 6-(o-chlorophenyl)-8-chloro-4H-s-triazolo[4,3-a][1,4]benzodiazepine-1-carboxamide.
摘要翻译： 6-苯基-4H-s-三唑并[4,3-a] [1,4]苯并二氮杂-1-甲酰胺类化合物及其药学上可接受的酸加成盐具有有价值的药理学性质并且是有活性的治疗组合物的成分。特别地，这些新化合物具有抗惊厥和抗侵袭作用并且增强了麻醉剂的作用。具体实施方案是N，N-二甲基-6-苯基-8-氯-4H-三唑并[4,3-a] [1,4]苯并二氮杂_-甲酰胺，6-苯基-8-氯-4H- 三唑并[4,3-a] [1,4]苯并二氮杂-1-甲酰胺，N，N-二甲基-6-（邻氯苯基）-8-氯-4H-三唑并[4,3-a ] [1,4]苯并二氮杂-1-甲酰胺和6-（邻氯苯基）-8-氯-4H-吖唑并[4,3-a] [1,4]苯并二氮杂-1-甲酰胺。

24. 发明申请

US20140018376A1 Use of 1H-Quinazoline-2,4-Diones 审中-公开
标题翻译：使用1H-喹唑啉-2,4-二酮
公开(公告)号：US20140018376A1
公开(公告)日：2014-01-16
申请号：US13502765
申请日：2010-10-20
申请人： Hans Allgeier , Yves Auberson , Thomas Blaettler , David Carcache , Philipp Floersheim , Wolfgang Froestl , Christel Guibourdenche , Hans o Kalkman , Joerg Kallen , Manuel Koller , Kurt Lingenhohl , Henri Mattes , Joachim Nozulak , David Orain , Johanne Renaud , Christine Strohmaier
发明人： Hans Allgeier , Yves Auberson , Thomas Blaettler , David Carcache , Philipp Floersheim , Wolfgang Froestl , Christel Guibourdenche , Hans o Kalkman , Joerg Kallen , Manuel Koller , Kurt Lingenhohl , Henri Mattes , Joachim Nozulak , David Orain , Johanne Renaud , Christine Strohmaier
IPC分类号： C07D239/96 , C07D403/04 , C07D405/04
CPC分类号： C07D239/96 , C07D403/04 , C07D405/04
摘要： The invention concerns the use of competitive AMPA receptor antagonists for the treatment, prevention or delay of progression of Rasmussen's encephalitis and/or certain forms of epilepsy.
摘要翻译：本发明涉及竞争性AMPA受体拮抗剂用于治疗，预防或延缓拉斯穆森脑炎和/或某些形式的癫痫发展的用途。

25. 发明申请

US20130261130A1 NEUROTRYPSIN INHIBITORS 审中-公开
标题翻译：神经营养素抑制剂
公开(公告)号：US20130261130A1
公开(公告)日：2013-10-03
申请号：US13882351
申请日：2011-10-31
申请人： Shaheen Ahmed , Stefan Hettwer , Jan Willem Vrijbloed , Carlo Farina , Hans Allgeier
发明人： Shaheen Ahmed , Stefan Hettwer , Jan Willem Vrijbloed , Carlo Farina , Hans Allgeier
IPC分类号： C07D409/12 , C07D401/12 , C07D413/12 , C07D333/38 , C07D409/14 , C07D417/12 , C07D333/70 , C07D209/42
CPC分类号： C07D409/12 , C07C231/02 , C07C237/42 , C07C2601/06 , C07C2602/08 , C07D209/42 , C07D235/18 , C07D277/56 , C07D333/38 , C07D333/70 , C07D401/12 , C07D409/14 , C07D413/12 , C07D417/12
摘要： The invention relates to acylamino-phthalic acid amides and related compounds of formula (I) wherein A is —CON—R3R4, —NR5COR6, —NHR7, —OR8, —SR9, —CH2NR10R11, —(CH2)2-R12, —CH═CH—R12, —C≡C—R12, optionally substituted phenyl, optionally substituted thiophenyl, or optionally substituted 1,2,3-triazol-4-yl, W is hydrogen, hydroxy or carboxymethoxy, Y is carboxy, methoxycarbonyl or 2H-tetrazol-5-yl, and the various substituents R have the meanings indicated in the description. These compounds are useful for the treatment and/or prophylaxis of skeletal muscle atrophy, schizophrenia and Alzheimer's disease, and as cognitive enhancers.
摘要翻译：本发明涉及酰氨基 - 邻苯二甲酸酰胺及其相关的式（I）化合物，其中A为-CON-R 3 R 4，-NR 5 COR 6，-NHR 7，-OR 8，-SR 9，-CH 2 NR 10 R 11， - （CH 2）2 -R 12，-CH = CH-R 12，-C = C-R 12，任选取代的苯基，任选取代的噻吩基或任选取代的1,2,3-三唑-4-基，W是氢，羟基或羧基甲氧基，Y是羧基，甲氧基羰基或2H 四唑-5-基，各种取代基R具有说明书中所示的含义。这些化合物可用于治疗和/或预防骨骼肌萎缩，精神分裂症和阿尔茨海默氏病以及认知增强剂。

26. 发明申请

US20070208018A1 Quinazoline Derivatives 失效
标题翻译：喹唑啉衍生物
公开(公告)号：US20070208018A1
公开(公告)日：2007-09-06
申请号：US11572007
申请日：2005-07-26
申请人： Hans Allgeier , Wolfgang Froestl , Manuel Koller , Henri Mattes , Joachim Nozulak , Silvio Ofner , David Orain , Vittorio Rasetti , Johanne Renaud , Nicolas Soldermann , Philipp Floersheim
发明人： Hans Allgeier , Wolfgang Froestl , Manuel Koller , Henri Mattes , Joachim Nozulak , Silvio Ofner , David Orain , Vittorio Rasetti , Johanne Renaud , Nicolas Soldermann , Philipp Floersheim
IPC分类号： A61K31/5377 , A61K31/517 , C07D413/02 , C07D239/92
CPC分类号： C07D409/12 , C07D239/96 , C07D401/12 , C07D403/04
摘要： The present invention relates to 1H-Quinazoline-2,4-dione derivatives of formula(I) wherein the substituents are defined as in the specification, their preparation, their use as pharmaceuticals, and pharmaceutical compositions containing them.
摘要翻译：本发明涉及式（I）的1H-喹唑啉-2,4-二酮衍生物，其中取代基如说明书中所定义，它们的制备，它们作为药物的用途以及含有它们的药物组合物。

27. 发明授权

US06516960B1 Method for synchronously retracting and extending telescopic lengths of a crane 有权
标题翻译：一种用于同步缩回和延伸起重机伸缩长度的方法
公开(公告)号：US06516960B1
公开(公告)日：2003-02-11
申请号：US09980396
申请日：2001-11-16
申请人： Jürgen Schlachter , Hans Allgeier , Jürgen Appel
发明人： Jürgen Schlachter , Hans Allgeier , Jürgen Appel
IPC分类号： B66C2366
CPC分类号： B66C23/705
摘要： A method for synchronously retracting and extending a jib of a crane having a plurality of telescoping lengths, preferably in a vehicle crane, extending and retracting being with driving means which is one of a hydraulically-driven, multistage telescoping cylinder and a plurality of single-stage telescoping cylinders operated in parallel. A pre-control transmitter transmits an electrical signal to an input of regulating electronics, which reference signal serves as a reference value for the telescoping speed of a telescoping cylinder or stage which takes on the task of guiding, and the actual value for the current position of the telescoping cylinders or stages is reported to the regulating electronics, and the latter compares the actual value of the telescoping cylinder or stage assuming the guidance task to the actual value of the telescoping cylinders or stages to be controlled and, in the event that an impermissible deviation is determined, the telescoping speed of the rest of the telescoping cylinders is increased or reduced until a synchronous telescoping of all telescoping cylinders and stages occurs.
摘要翻译：一种用于同步地缩回和延伸具有多个伸缩长度的起重机的起重机的方法，优选地在车辆起重机中，其具有作为液压驱动的多级伸缩缸和多个单级伸缩缸之一的驱动装置而延伸和缩回，平台上的平台伸缩缸。预控制发射器将电信号发送到调节电子器件的输入端，该参考信号用作伸缩滚筒或负责引导任务的平台的伸缩速度的参考值，以及当前位置的实际值可伸缩气瓶或气缸的台阶报告给调节电子设备，后者将伸缩气缸或台架的实际值与引导任务相比较，以实现可伸缩气缸或待控制的气缸的实际值，确定不允许的偏差，伸缩气瓶的其余部分的伸缩速度增加或减小，直到所有伸缩气瓶和平台的同步伸缩发生。

28. 发明授权

US4851424A 1-Phenyl-lower alkyl-imidazole 4- or 5-carboxamide compounds which are useful in the treatment of epilepsy 失效
标题翻译：可用于治疗癫痫的1-苯基 - 低级烷基 - 咪唑4-或5-甲酰胺化合物
公开(公告)号：US4851424A
公开(公告)日：1989-07-25
申请号：US53913
申请日：1987-05-26
申请人： Hans Allgeier
发明人： Hans Allgeier
IPC分类号： C07D233/70 , C07D233/90
CPC分类号： C07D233/90
摘要： 1-Phenyl-lower alkylimidazole-4- and/or 5-carboxamides of the formula ##STR1## in which Ph represents phenyl substituted by lower alkyl and/or by halogen, alk represents lower alkylidene, one of the radicals R.sub.1 and R.sub.2 is carbamoyl optionally substituted by lower alkyl or by lower alkanoyl and the other is hydrogen, lower alkyl, or carbamoyl optionally substituted by lower alkyl or by lower alkanoyl, and R.sub.3 represents hydrogen or lower alkyl, have anticonvulsive properties and can be used as anticonvulsives. They are manufactured as follows: in a compound of the formula ##STR2## in which R.sub.1 ' represents a radical R.sub.1 or X and R.sub.2 ' represents a radical X, or R.sub.1 ' represents a radical X and R.sub.2 ' represents a radical R.sub.2, where X represents a group that can be converted into carbamoyl that optionally is mono- or di-substituted by lower alkyl or monosubstituted by lower alkanoyl, the radical X or the radicals X is/are converted into carbamoyl that optionally is mono- or di-substituted by lower alkyl or monosubstituted by lower alkanoyl.
摘要翻译：其中Ph表示被低级烷基取代的苯基和/或被卤素代表的苯基的1-苯基 - 低级烷基咪唑-4-和/或5-甲酰胺表示低级亚烷基，基团R1和 R2是任选被低级烷基或低级烷酰基取代的氨基甲酰基，另一个是任选被低级烷基或低级烷酰基取代的氢，低级烷基或氨基甲酰基，R3代表氢或低级烷基，具有抗惊厥性质，可用作抗惊厥药。它们制备如下：在式（III）的化合物中，其中R 1'表示基团R 1或X，且R 2'表示基团X，或R 1'表示基团X，并且R 2'表示基团R 2 其中X表示可以转化为氨基甲酰基的基团，其任选被低级烷基单取代或二取代或被低级烷酰基单取代，基团X或基团X被转化成氨基甲酰基，其任选为单或二被低级烷基取代或被低级烷酰基单取代。

29. 发明授权

US4076812A 10-Halogeno- or 10,11-dihalogeno derivatives of 5H-dibenz[b,f]azepine 失效
标题翻译： 5,5-二苯并[d，d]薁-9-基的10-卤代 - 或10,11-二卤代衍生物
公开(公告)号：US4076812A
公开(公告)日：1978-02-28
申请号：US615256
申请日：1975-09-22
申请人： Hans Allgeier , Erich Schmid
发明人： Hans Allgeier , Erich Schmid
IPC分类号： C07D223/26 , A61K31/55 , C07D223/22
CPC分类号： C07D223/26
摘要： The present invention relates to new derivatives of 5H-dibenz[b,f]azepine having the formula I ##STR1## wherein Hal represents halogen with an atomic number up to 35 and R represents hydrogen or halogen with an atomic number up to 35. These new compounds possess useful pharmacological properties, in particular a prolonged anticonvulsive action, and can be used for the treatment of states of convulsion, especially of epilepsy. A specific embodiment of the invention is 10-chloro-5H-dibenz[b,f]azepine-5-carboxamide.
摘要翻译：本发明涉及具有式I（I）的5H-二苯并[b，f]吖庚因的新衍生物，其中Hal表示原子数高达35的卤素，R表示氢或原子数最多为这些新化合物具有有用的药理学特性，特别是延长的抗惊厥作用，可用于治疗特别是癫痫的惊厥状态。本发明的具体实施方案是10-氯-5H-二苯并[b，f]吖庚因-5-甲酰胺。

30. 发明授权

US3948931A Triazolo benzodiazepine-1-carboxamides 失效
标题翻译：三唑并苯并二氮杂-1-甲酰胺
公开(公告)号：US3948931A
公开(公告)日：1976-04-06
申请号：US418137
申请日：1973-11-21
申请人： Hans Allgeier , Andre Gagneux
发明人： Hans Allgeier , Andre Gagneux
IPC分类号： A61K31/55 , A61P25/08 , A61P25/20 , C07D487/04
CPC分类号： C07D487/04 , Y10S514/96 , Y10S514/966
摘要： Compounds of the class of 6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine-1-carboxamides, their 5-oxides and their pharmaceutically acceptable acid addition salts have valuable pharmacological properties and are active ingredients for therapeutic compositions. In particular, these new compounds have an anti-convulsive and anti-aggressive action and potentiate the action of anaesthetics. Specific embodiments are N,N-dimethyl-6-phenyl-8-chloro-4H-s-triazolo[4,3-a][1,4]benzodiazepine-1-carboxamide, 6-phenyl-8-chloro-4H-s-triazolo[4,3-a][1,4]benzodiazepine-1-carboxamide, N,N-dimethyl-6-(o-chlorophenyl-8-chloro-4H-s-triazolo[4,3-a][1,4]benzodiazepine-1-carboxamide and 6-(o-chlorophenyl)-8-chloro-4H-s-triazolo[4,3-a][1,4]benzodiazepine-1-carboxamide.
摘要翻译： 6-苯基-4H-s-三唑并[4,3-a] [1,4]苯并二氮杂-1-甲酰胺类化合物及其药学上可接受的酸加成盐具有有价值的药理学性质并且是有活性的治疗组合物的成分。特别地，这些新化合物具有抗惊厥和抗侵袭作用并且增强了麻醉剂的作用。具体实施方案是N，N-二甲基-6-苯基-8-氯-4H-三唑并[4,3-a] [1,4]苯并二氮杂_-甲酰胺，6-苯基-8-氯-4H- 三唑并[4,3-a] [1,4]苯并二氮杂-1-甲酰胺，N，N-二甲基-6-（邻氯苯基-8-氯-4H-吖唑并[4,3-a] [1,4]苯并二氮杂-1-甲酰胺和6-（邻氯苯基）-8-氯-4H-三唑并[4,3-a] [1,4]苯并二氮杂-1-甲酰胺。

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