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21. 发明申请

US20150374807A1 Amyloid beta1-6 Antigen Arrays 审中-公开
标题翻译：淀粉样β1-6抗原阵列
公开(公告)号：US20150374807A1
公开(公告)日：2015-12-31
申请号：US14788896
申请日：2015-07-01
申请人： Martin F. Bachmann , Alain Tissot , Rainer Ortmann , Rainer Martin Lueoend , Matthias Staufenbiel , Peter Frey
发明人： Martin F. Bachmann , Alain Tissot , Rainer Ortmann , Rainer Martin Lueoend , Matthias Staufenbiel , Peter Frey
IPC分类号： A61K39/00
CPC分类号： A61K39/0007 , A61K2039/5256 , A61K2039/5258 , A61K2039/6075 , A61K2039/64
摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array, and in particular an Aβ1-peptide-VLP-composition. More specifically, the invention provides a composition comprising a virus-like particle and at least one Aβ1-6 peptide bound thereto. The invention also provides a process for producing the conjugates and the ordered and repetitive arrays, respectively. The compositions of the invention are useful in the production of vaccines for the treatment of Alzheimer's disease and as a pharmaccine to prevent or cure Alzheimer's disease and to efficiently induce immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune, responses within the indicated context.
摘要翻译：本发明涉及分子生物学，病毒学，免疫学和医学领域。本发明提供了包含有序和重复的抗原或抗原决定簇，特别是Aβ肽-VLP组合物的组合物。更具体地，本发明提供了包含病毒样颗粒和与其结合的至少一个Aβ1-6肽的组合物。本发明还提供了分别制备共轭物和有序和重复阵列的方法。本发明的组合物可用于生产用于治疗阿尔茨海默氏病的疫苗和作为预防或治愈阿尔茨海默氏病的药物，并有效诱导免疫应答，特别是抗体应答。此外，本发明的组合物特别可用于在指定的上下文中有效诱导自身特异性免疫，应答。

22. 发明申请

US20140027230A1 Starting Element With Hydrodynamic Torque Converter 有权
标题翻译：启动元件与流体力学转矩
公开(公告)号：US20140027230A1
公开(公告)日：2014-01-30
申请号：US13950374
申请日：2013-07-25
申请人： Georg Mencher , Peter Frey , Jörg Sudau
发明人： Georg Mencher , Peter Frey , Jörg Sudau
IPC分类号： F16H41/04
CPC分类号： F16H45/02 , F16H2041/246 , F16H2045/0226 , F16H2045/0263 , F16H2045/0284
摘要： A starting element for transmitting torque from a drive-side rotational input (14) of the starting element to a driven hub (8) includes a hydrodynamic torque converter (4) which has a turbine coupled to the driven hub (8) so as to be fixed with respect to rotation relative to it and which comprises a turbine shell (56) with turbine blades (22) arranged therein. A maximum extension of the turbine shell (56) opposite an axial direction (12) terminates at a first axial position (53), and an impeller (20) located opposite the turbine in the axial direction (12). A stator (24) is arranged between the turbine and the impeller (22) and is coupled via a stator flange (58) to a freewheel (52) adjoining the driven hub (8) in an axial direction (12). A center of the freewheel (52) is located at a second axial position (54). A difference between the first axial position (53) and the second axial position (54) is greater than a predetermined minimum value.
摘要翻译：用于将扭矩从起动元件的驱动侧旋转输入（14）传递到从动轮毂（8）的启动元件包括具有联接到从动轮毂（8）的涡轮的流体动力学变矩器（4），以便相对于其旋转而被固定，并且其包括具有布置在其中的涡轮叶片（22）的涡轮壳体（56）。涡轮壳体（56）的与轴向方向（12）相反的最大延伸部终止于第一轴向位置（53）和在轴向（12）处与涡轮机相对定位的叶轮（20）。定子（24）布置在涡轮机和叶轮（22）之间，并且经由定子凸缘（58）被耦合到沿着轴向方向（12）邻接从动轮毂（8）的自由轮（52）。自由轮（52）的中心位于第二轴向位置（54）。第一轴向位置（53）和第二轴向位置（54）之间的差异大于预定的最小值。

23. 发明申请

US20130125538A1 Torque Transmission Device With Electrical Insulation 审中-公开
标题翻译：带绝缘的扭矩传动装置
公开(公告)号：US20130125538A1
公开(公告)日：2013-05-23
申请号：US13670695
申请日：2012-11-07
申请人： Peter Frey , Michael Heuler , Georg Mencher
发明人： Peter Frey , Michael Heuler , Georg Mencher
IPC分类号： F16C33/02 , F16C33/30
CPC分类号： F16C33/02 , F02N11/08 , F16C17/04 , F16C17/24 , F16C19/30 , F16C19/52 , F16C33/30 , F16C2202/30 , F16H41/24 , F16H57/021
摘要： A torque transmission device, particularly for a motor vehicle, for the transmission of a torque from a driving unit, particularly from an internal combustion engine, to a driven unit, particularly a transmission, has at least one bearing location which has at least one bearing support acting in axial and/or radial direction, wherein an insulation element preventing a flow of electric current is provided in the region of the at least one bearing location.
摘要翻译：特别是用于机动车辆的扭矩传递装置用于将来自驱动单元，特别是内燃机的转矩传递到从动单元，特别是变速器的转矩传递装置具有至少一个轴承位置，其具有至少一个轴承支撑件在轴向和/或径向方向上作用，其中在所述至少一个轴承位置的区域中提供防止电流流动的绝缘元件。

24. 发明申请

US20100277941A1 LED HEADLIGHT 审中-公开
标题翻译： LED头灯
公开(公告)号：US20100277941A1
公开(公告)日：2010-11-04
申请号：US12743575
申请日：2008-11-17
申请人： Peter Frey , Christian Meier
发明人： Peter Frey , Christian Meier
IPC分类号： B60Q1/04
CPC分类号： F21V29/71 , F21S41/141 , F21S45/33 , F21S45/43 , F21S45/46 , F21S45/47 , F21S45/48 , F21V29/56 , F21V29/89 , F21Y2115/10
摘要： An LED headlight may include at least one heat-conducting element that extends from at least one heat source located in a headlight housing to at least one cooling element in such a way as to make thermal contact and which is arranged at least partially outside on the headlight housing, the heat-conducting element being movable.
摘要翻译： LED头灯可以包括至少一个导热元件，其从位于头灯壳体中的至少一个热源延伸到至少一个冷却元件，以便进行热接触并且至少部分地布置在头灯壳体，导热元件可移动。

25. 发明授权

US07581951B2 Dental treatment element 失效
标题翻译：牙科治疗元件
公开(公告)号：US07581951B2
公开(公告)日：2009-09-01
申请号：US10562939
申请日：2004-07-01
申请人： Karl-Heinz Lehmann , Peter Frey
发明人： Karl-Heinz Lehmann , Peter Frey
IPC分类号： A61G15/00
CPC分类号： A61G15/16
摘要： The invention relates to a treatment element which is used to receive dental hand instruments. Said treatment element comprises a base part (1) which is provided with connections (2; 39) and which is used to accommodate the instruments, and a instrument storage place (5; 15). Said treatment element comprises an exchangeable upper part (4; 12).
摘要翻译：本发明涉及一种用于接收牙科手术器械的治疗元件。所述治疗元件包括设置有连接件（2; 39）并用于容纳器械的基座部件（1），以及仪器存储部件（5; 15）。所述处理元件包括可更换的上部部分（4; 12）。

26. 发明授权

US07269541B1 System and method for supporting multi-rate simulation of a circuit having hierarchical data structure 有权
标题翻译：支持具有分层数据结构的电路的多速率仿真的系统和方法
公开(公告)号：US07269541B1
公开(公告)日：2007-09-11
申请号：US10713753
申请日：2003-11-13
申请人： Bruce W. McGaughy , Peter Frey , Jun Kong , Baolin Yang
发明人： Bruce W. McGaughy , Peter Frey , Jun Kong , Baolin Yang
IPC分类号： G06F17/50
CPC分类号： G06F17/5022
摘要： A system for supporting multi-rate simulation of a circuit having a hierarchical data structure includes a simulator module having one or more computer programs for 1) partitioning the circuit into a plurality of group circuits, each group circuit includes one or more leaf circuits, where each leaf circuit produces a predictable set of output signals with a given set of input signals, 2) storing the group circuits in a scheduled event queue in accordance with priority in time which the group circuits need to be simulated, 3) retrieving from the scheduled event queue a set of group circuits for simulation within a predetermined time period, 4) distributing the set of group circuits into a set of predefined event lists, where each of the predefined event list stores one or more group circuits of a corresponding event type, and 5) simulating the one or more group circuits in each of the predefined event list in accordance with a rate of change of signal conditions of each individual group circuit. Hence, the system provides an efficient way to support multi-rate simulation by dynamically scheduling and synchronizing multiple group simulation event types and by communicating corresponding isomorphic activities through an efficient port connectivity interface.
摘要翻译：一种用于支持具有分层数据结构的电路的多速率仿真的系统包括具有一个或多个计算机程序的模拟器模块，用于1）将电路划分为多个组电路，每个组电路包括一个或多个叶电路，其中每个叶片电路产生具有给定的一组输入信号的可预测的一组输出信号，2）根据组电路需要模拟的时间优先级将组电路存储在调度事件队列中; 3）从调度的事件队列一组用于在预定时间段内进行模拟的组电路，4）将所述组电路组分配成一组预定事件列表，其中每个预定事件列表存储相应事件类型的一个或多个组电路，以及5）根据每个单独组的信号条件的变化率来模拟每个预定事件列表中的一个或多个组电路电路。因此，该系统通过动态调度和同步多组模拟事件类型并通过有效的端口连接接口传达相应的同构活动来提供有效的方式来支持多速率模拟。

27. 发明授权

US07024652B1 System and method for adaptive partitioning of circuit components during simulation 有权
标题翻译：仿真期间电路元件自适应分配的系统和方法
公开(公告)号：US07024652B1
公开(公告)日：2006-04-04
申请号：US10713751
申请日：2003-11-13
申请人： Bruce W. McGaughy , Peter Frey , Jun Kong , Baolin Yang
发明人： Bruce W. McGaughy , Peter Frey , Jun Kong , Baolin Yang
IPC分类号： G06F17/50
CPC分类号： G06F17/5036
摘要： A system for adaptive partitioning of circuit components during simulating of a circuit having a hierarchical data structure includes a simulator module having one or more computer programs for 1) selecting a group of leaf circuits from the first branch and the second branch for simulation, where each leaf circuit is represented by a matrix comprising a set of equations, 2) determining a strength of coupling between two or more leaf circuits of the group in accordance with a set of predetermined electrical coupling criteria, 3) if two or more leaf circuits are deemed be strongly coupled, combining the corresponding matrix of each strongly coupled leaf circuit into a combined matrix, and 4) performing computation for the two or more strongly coupled leaf circuits in accordance with the combined matrix. The system adaptively adjusts the group circuit matrix for computing a group of circuits according to the strength of coupling between the circuits. Hence, it achieves higher simulation performance by reducing either the size of the solver matrix when the circuits are loosely connected to each other, or by reducing the number of computational repetitions due to the communication of changes of signal conditions between circuits by combining the individual circuit matrices when such circuits are closely coupled to each other.
摘要翻译：用于在具有分层数据结构的电路的仿真期间对电路组件进行自适应分配的系统包括具有一个或多个计算机程序的模拟器模块，用于1）从第一分支和第二分支中选择一组叶电路用于模拟，其中每个叶片电路由包括一组方程的矩阵表示，2）根据一组预定的电耦合标准确定该组的两个或更多叶片电路之间的耦合强度，3）如果认为两个或多个叶片电路强耦合，将每个强耦合叶电路的相应矩阵组合成组合矩阵，以及4）根据组合矩阵对两个或更多个强耦合叶电路执行计算。该系统根据电路之间的耦合强度自适应地调整用于计算一组电路的组电路矩阵。因此，通过在电路彼此松耦合时减小求解器矩阵的大小，或者通过将各个电路之间的信号状态的通信减少而导致的计算重复次数减少，从而实现更高的仿真性能当这种电路彼此紧密耦合时的矩阵。

28. 发明授权

US06758315B2 Hydraulic clutch with a turbine torsional vibration damper 失效
标题翻译：带涡轮扭转振动阻尼器的液压离合器
公开(公告)号：US06758315B2
公开(公告)日：2004-07-06
申请号：US10270983
申请日：2002-10-15
申请人： Thomas Bauer , Peter Frey , Ralf Ronnebeck
发明人： Thomas Bauer , Peter Frey , Ralf Ronnebeck
IPC分类号： F16H4502
CPC分类号： F16H45/02 , F16H2045/0247 , F16H2045/0284
摘要： A hydraulic clutch has an impeller wheel, a turbine wheel with a turbine wheel shell, and a torsional vibration damper. The turbine wheel is drivable by the impeller wheel. The turbine wheel shell is mounted in an axial and radial sliding bearing so as to be rotatable with respect to a turbine wheel hub. The torsional vibration damper is arranged on the turbine wheel hub so as to be fixed with respect to rotation relative to it. The turbine wheel hub is drivable by the turbine wheel via the turbine wheel shell and the torsional vibration damper. The turbine wheel shell acts on the torsional vibration damper via a connection element. The axial sliding bearing is spatially offset with respect to the radial sliding bearing.
摘要翻译：液压离合器具有叶轮，具有涡轮机轮壳的涡轮机叶轮和扭转振动阻尼器。涡轮机叶轮可通过叶轮驱动。涡轮机叶轮壳体安装在轴向和径向滑动轴承中，以便相对于涡轮机轮毂可旋转。扭转振动阻尼器布置在涡轮机轮毂上，以相对于其相对于旋转而被固定。涡轮机轮毂可以通过涡轮机叶轮和扭转振动阻尼器由涡轮机叶轮驱动。涡轮机叶轮壳通过连接元件作用在扭转振动阻尼器上。轴向滑动轴承相对于径向滑动轴承空间偏移。

29. 发明授权

US06435998B1 Drive train with rigidity dependent on rotational speed 失效
标题翻译：传动系，刚度依赖于转速
公开(公告)号：US06435998B1
公开(公告)日：2002-08-20
申请号：US09592234
申请日：2000-06-12
申请人： Jörg Sudau , Erwin Wack , Peter Frey
发明人： Jörg Sudau , Erwin Wack , Peter Frey
IPC分类号： F16D314
CPC分类号： F16F15/13157 , F16F15/1478 , F16H45/02 , F16H2045/0268 , F16H2045/0294
摘要： A drive train of a motor vehicle includes a gear arrangement with at least two gear elements moveable relative to one another acts in a torque transmission path between an internal combustion engine and a transmission. The gear arrangement being connected between a drive-side flywheel mass and a gear-side flywheel mass. The gear arrangement includes at least one additional mass having a center of gravity (Sp) which is displaceable radially in relation to an axis of rotation (D) of the torque transmission path as a function of a relative position of the at least two gear elements. In the event of a change in the relative rotary angle between the flywheel masses, a moment of inertia of the torque transmission path also changes, so that there is no definite resonant point and the torque transmission path takes effect as a self-steadying system. Furthermore, the additional mass may be arranged to generate a centrifugally dependent return force directed toward a specific relative rotary angle position. The force acts between two rotary parts rotatable at least to a restricted extent relative to one another and located in the torque transmission path. The specific relative rotary angle position lies between two relative rotary angle boundary positions delimiting a relative rotary angle range of the rotary parts. The gear arrangement may be arranged in a two-mass flywheel or a hydrodynamic clutch device in the motor vehicle drive train.
摘要翻译：机动车辆的传动系包括齿轮装置，其具有可相对于彼此移动的至少两个齿轮元件作用在内燃机和变速器之间的扭矩传递路径中。齿轮装置连接在驱动侧飞轮体和齿轮侧飞轮体之间。齿轮装置包括至少一个附加质量块，其具有重心（Sp），该重心可相对于转矩传递路径的旋转轴线（D）径向移动，作为至少两个齿轮元件的相对位置的函数。在飞轮质量之间的相对旋转角度发生变化的情况下，转矩传递路径的转动惯量也发生变化，因此没有确定的共振点，转矩传递路径作为自稳定系统而起作用。此外，附加质量可以被布置成产生指向特定相对旋转角位置的离心机相关的返回力。所述力作用在两个旋转部件之间，所述两个旋转部件至少相对于彼此可旋转至少限定，并位于转矩传递路径中。特定的相对旋转角位置位于限定旋转部件的相对旋转角度范围的两个相对旋转角度边界位置之间。齿轮装置可以布置在机动车辆传动系中的两质量飞轮或液力离合器装置中。

30. 发明授权

US06361240B1 Connection arrangement for a hydrodynamic torque converter 失效
标题翻译：液力变矩器的连接装置
公开(公告)号：US06361240B1
公开(公告)日：2002-03-26
申请号：US09494703
申请日：2000-01-31
申请人： Karel Kriz , Wolfgang Gude , Friedrich Schramm , Werner Spohn , Peter Frey
发明人： Karel Kriz , Wolfgang Gude , Friedrich Schramm , Werner Spohn , Peter Frey
IPC分类号： F16D3300
CPC分类号： F16H41/24 , Y10T403/4318 , Y10T403/51
摘要： A connection arrangement for producing a rotational connection of a hydrodynamic torque converter with a rotating shaft includes at least one connection element arrangable at a housing of the torque converter and having a first connection area connectable to the housing and a second connection area connectable to the rotating shaft, wherein the first connection area has a limited circumferential extension with respect to the rotational axis (A) of the converter. The first connection area may be arranged at the housing via a riveting.
摘要翻译：用于产生流体动力学变矩器与旋转轴的旋转连接的连接装置包括至少一个连接元件，其可布置在变矩器的外壳处，并且具有可连接到壳体的第一连接区域和可连接到旋转的第二连接区域轴，其中所述第一连接区域相对于所述转换器的旋转轴线（A）具有有限的圆周延伸。第一连接区域可以经由铆接被布置在壳体处。

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