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21. 发明授权

US08263591B2 Bicyclic amides for enhancing glutamatergic synaptic responses 有权
标题翻译：用于增强谷氨酸能突触反应的双环酰胺
公开(公告)号：US08263591B2
公开(公告)日：2012-09-11
申请号：US12733073
申请日：2008-08-08
申请人： Rudolf Mueller , Leslie Street
发明人： Rudolf Mueller , Leslie Street
IPC分类号： A61K31/535 , C07D498/02 , C07D265/00
CPC分类号： A61K31/46 , A61K31/4245 , A61K31/439 , A61K31/519 , A61K31/53 , A61K45/06 , C07D209/52 , C07D451/02 , C07D451/04 , C07D451/06 , C07D453/06 , C07D471/08 , C07D487/08 , C07D491/08
摘要： This invention relates to compounds, pharmaceutical compositions and methods for use in the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for basic and higher order behaviors. These brain networks, which are involved in regulation of breathing, and cognitive abilities related to memory impairment, such as is observed in a variety of dementias, in imbalances in neuronal activity between different brain regions, as is suggested in disorders such as Parkinson's disease, schizophrenia, respiratory depression, sleep apneas, attention deficit hyperactivity disorder and affective or mood disorders, and in disorders wherein a deficiency in neurotrophic factors is implicated, as well as in disorders of respiration such as overdose of an alcohol, an opiate, an opioid, a barbiturate, an anesthetic, or a nerve toxin, or where the respiratory depression results form a medical condition such as central sleep apnea, stroke-induced central sleep apnea, obstructive sleep apnea, congenital hypoventilation syndrome, obesity hypoventilation syndrome, sudden infant death syndrome, Rett syndrome, spinal cord injury, traumatic brain injury, Cheney-Stokes respiration, Ondines curse, Prader-Willi's syndrome and drowning, hi a particular aspect, the invention relates to bicyclic amide compounds useful for treatment of such conditions, and methods of using these compounds for such treatment.
摘要翻译：本发明涉及用于预防和治疗脑功能不全的化合物，药物组合物和方法，包括在负责基本和高级行为的脑网络中的突触中增强受体功能。涉及呼吸调节的这些脑网络，以及与记忆障碍有关的认知能力，例如在各种痴呆中观察到的，在不同脑区域之间的神经元活动不平衡中，如在帕金森病，精神分裂症，呼吸抑制，睡眠呼吸暂停，注意缺陷多动障碍和情感或情绪障碍，以及涉及神经营养因子缺乏的疾病，以及呼吸障碍，例如过量的酒精，阿片剂，阿片样物质，巴比妥酸盐，麻醉剂或神经毒素，或呼吸抑制结果形成中枢性睡眠呼吸暂停，中风引起的中枢性睡眠呼吸暂停，阻塞性睡眠呼吸暂停，先天性通气不足综合征，肥胖低通气综合征，婴儿猝死综合征，Rett综合征，脊髓损伤，创伤性脑损伤，Cheney-Stokes呼吸，Ondines诅咒，Prader-Willi综合征和溺水。在一个特定方面，本发明涉及可用于治疗这些病症的双环酰胺化合物，以及使用这些化合物进行这种治疗的方法。

22. 发明申请

US20120035173A1 DI-SUBSTITUTED AMIDES FOR ENHANCING GLUTAMATERGIC SYNAPTIC RESPONSES 有权
标题翻译：用于增强GLUTAMATERGIC SYNAPTIC RESPONS的DI替代剂
公开(公告)号：US20120035173A1
公开(公告)日：2012-02-09
申请号：US13226146
申请日：2011-09-06
申请人： Leslie Street , Rudolf Mueller , Steven Lee
发明人： Leslie Street , Rudolf Mueller , Steven Lee
IPC分类号： A61K31/4245 , C07D413/12 , A61K31/4439 , A61K31/454 , A61K31/433 , A61P11/00 , A61K31/498 , A61K31/5377 , A61P25/28 , A61P25/16 , A61P25/00 , C07D271/12 , C07D405/12
CPC分类号： A61K31/4245 , A61K45/06 , C07D271/12 , C07D285/14 , C07D405/12 , C07D413/12 , C07D417/12
摘要： This invention relates to compounds, pharmaceutical compositions and methods for use in the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for basic and higher order behaviors. These brain networks, which are involved in regulation of breathing, and cognitive abilities related to memory impairment, such as is observed in a variety of dementias, in imbalances in neuronal activity between different brain regions, as is suggested in disorders such as Parkinson's disease, schizophrenia, respiratory depression, sleep apneas, attention deficit hyperactivity disorder and affective or mood disorders, among numerous others. In a particular aspect, the invention relates to compounds useful for treatment of such conditions, and methods of using these compounds for such treatment.
摘要翻译：本发明涉及用于预防和治疗脑功能不全的化合物，药物组合物和方法，包括在负责基本和高级行为的脑网络中的突触中增强受体功能。涉及呼吸调节的这些脑网络，以及与记忆障碍有关的认知能力，例如在各种痴呆中观察到的，在不同脑区域之间的神经元活动不平衡中，如在帕金森病，精神分裂症，呼吸抑制，睡眠呼吸暂停，注意缺陷多动障碍和情感或情绪障碍等。在一个特定方面，本发明涉及可用于治疗这些病症的化合物，以及使用这些化合物进行这种治疗的方法。

23. 发明申请

US20100173903A1 Bicyclic amide derivatives for the treatmet of respiratory disorders 有权
标题翻译：双环酰胺衍生物用于治疗呼吸系统疾病
公开(公告)号：US20100173903A1
公开(公告)日：2010-07-08
申请号：US12657924
申请日：2010-01-29
申请人： Rudolf Mueller , Leslie J. Street
发明人： Rudolf Mueller , Leslie J. Street
IPC分类号： A61K31/5386 , A61P11/16
CPC分类号： C07D498/08 , A61K31/5375 , A61K45/06 , A61K2300/00
摘要： This invention relates to compounds, pharmaceutical compositions and methods for use in the prevention and treatment of disorders of respiration such as overdose of an alcohol, an opiate, an opioid, a barbiturate, an anesthetic, or a nerve toxin. In a particular aspect, the invention relates to bicyclic amide compounds useful for treatment of such conditions, and methods of using these compounds for such treatment.
摘要翻译：本发明涉及用于预防和治疗呼吸障碍的化合物，药物组合物和方法，例如过量的酒精，阿片剂，阿片样物质，巴比妥酸盐，麻醉剂或神经毒素。在一个特定方面，本发明涉及可用于治疗这些病症的双环酰胺化合物，以及使用这些化合物进行这种治疗的方法。

24. 发明授权

US4944080A Method and apparatus for the longitudinal deburring of sections 失效
标题翻译：截面纵向去毛刺的方法和装置
公开(公告)号：US4944080A
公开(公告)日：1990-07-31
申请号：US175752
申请日：1988-03-31
申请人： Gotz-Peter Blumbach , Willi Brueckner , Rudolf Mueller
发明人： Gotz-Peter Blumbach , Willi Brueckner , Rudolf Mueller
IPC分类号： B23C3/12
CPC分类号： B23C3/12 , Y10T29/5182 , Y10T409/304256 , Y10T409/50164
摘要： Apparatus for the deburring of longitudinal sections by operating a milling head in response to the sensed position of a burr on the section.
摘要翻译：用于响应于所述部分上的毛刺的感测位置操作铣头而对纵向部分去毛刺的装置。

25. 发明授权

US4799703A Wheel suspension for rear wheels of motor vehicles equipped with front wheel steering, especially passenger motor vehicles 失效
标题翻译：配备前轮转向，特别是客车的机动车后轮的车轮悬架
公开(公告)号：US4799703A
公开(公告)日：1989-01-24
申请号：US151660
申请日：1988-02-03
申请人： Rudolf Mueller , Ludwig Strasser
发明人： Rudolf Mueller , Ludwig Strasser
IPC分类号： B60G3/20 , B60G3/22 , B60G7/00 , B60G17/015 , B62D7/14 , B60G3/18 , B60G11/14
CPC分类号： B60G3/202 , B60G3/22 , B60G7/006 , B62D7/146 , B60G2200/182 , B60G2200/46 , B60G2200/462 , B60G2202/12 , B60G2202/24 , B60G2204/14
摘要： In a wheel suspension for steerable rear wheels of motor vehicles, especially passenger motor vehicles, which include in a customary manner a front wheel steering and additionally a rear wheel steering (four wheel steering), each rear wheel-wheel carrier is connected with the vehicle body or the like exclusively by way of guide members of which one cross guide member is displaceable in the vehicle transverse direction for steering purposes by an adjusting motor and serves as support on the side of the wheel of a support spring supporting the main part of the vehicle.
摘要翻译：在用于机动车辆的可转向后轮的车轮悬架中，特别是乘客机动车辆，其包括以前轮转向和另外的后轮转向（四轮转向），每个后轮轮架与车辆连接主体等通过引导构件，其中一个横向导向构件可以在车辆横向方向上移动以便通过调节电机转向，并用作支撑弹簧支撑弹簧的主要部分的支撑侧的支撑件车辆。

26. 发明授权

US4040606A Liquid reaction vessel with means for removing deposits on its inner walls 失效
标题翻译：具有去除其内壁上的沉积物的装置的液体反应容器
公开(公告)号：US4040606A
公开(公告)日：1977-08-09
申请号：US481240
申请日：1974-06-20
申请人： Rudolf Mueller
发明人： Rudolf Mueller
IPC分类号： B01J19/00 , B08B9/08 , B08B9/087 , B01F7/16 , B08B3/00 , B08B9/00
CPC分类号： B08B9/08
摘要： Means for removing deposits formed due to foaming, etc., on the inner walls of a liquid reaction vessel which contains agitating means. Dispersing means are provided attached by arm means to the shaft of the agitator, which are adapted to engage the surface of the reaction mixture, and on increased rotation of said agitator shaft will spray or fling liquid reaction mixture onto said inner walls. The dispersing means can be curved tubular members, channel members, angled plates, paddles, etc. In one embodiment, the dispersing member is spring-biased, normally not engaging said liquid surface, and which will engage said liquid surface upon increased rotational speed.
摘要翻译：用于在包含搅拌装置的液体反应容器的内壁上除去由于起泡等而形成的沉积物的装置。分散装置通过臂装置连接到搅拌器的轴上，搅拌器的轴适于接合反应混合物的表面，并且在所述搅拌器轴的增加的旋转将喷射或将液体反应混合物排放到所述内壁上。分散装置可以是弯曲的管状构件，通道构件，倾斜板，桨等。在一个实施例中，分散构件被弹簧偏置，通常不接合所述液体表面，并且在增加的旋转速度时将与所述液体表面接合。

27. 发明授权

US08168632B2 Bicyclic amide derivatives for the treatment of respiratory disorders 有权
标题翻译：双环酰胺衍生物用于治疗呼吸系统疾病
公开(公告)号：US08168632B2
公开(公告)日：2012-05-01
申请号：US12657924
申请日：2010-01-29
申请人： Rudolf Mueller , Leslie J. Street
发明人： Rudolf Mueller , Leslie J. Street
IPC分类号： A61K31/538
CPC分类号： C07D498/08 , A61K31/5375 , A61K45/06 , A61K2300/00
摘要： This invention relates to compounds, pharmaceutical compositions and methods for use in the prevention and treatment of disorders of respiration such as overdose of an alcohol, an opiate, an opioid, a barbiturate, an anesthetic, or a nerve toxin. In a particular aspect, the invention relates to bicyclic amide compounds useful for treatment of such conditions, and methods of using these compounds for such treatment.
摘要翻译：本发明涉及用于预防和治疗呼吸障碍的化合物，药物组合物和方法，例如过量的酒精，阿片剂，阿片样物质，巴比妥酸盐，麻醉剂或神经毒素。在一个特定方面，本发明涉及可用于治疗这些病症的双环酰胺化合物，以及使用这些化合物进行这种治疗的方法。

28. 发明申请

US20110003835A1 Methods for the treatment of respiratory depression 有权
标题翻译：呼吸抑制治疗方法
公开(公告)号：US20110003835A1
公开(公告)日：2011-01-06
申请号：US12807379
申请日：2010-09-03
申请人： Rudolf Mueller , Leslie Street
发明人： Rudolf Mueller , Leslie Street
IPC分类号： A61K31/46 , A61K31/4748 , A61K31/515 , A61P11/00
CPC分类号： A61K31/46 , A61K31/4245 , A61K31/439 , A61K31/519 , A61K31/53 , A61K45/06 , C07D209/52 , C07D451/02 , C07D451/04 , C07D451/06 , C07D453/06 , C07D471/08 , C07D487/08 , C07D491/08
摘要： This invention relates to compounds, pharmaceutical compositions and methods for use in the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for basic and higher order behaviors. These brain networks, which are involved in regulation of breathing, and cognitive abilities related to memory impairment, such as is observed in a variety of dementias, in imbalances in neuronal activity between different brain regions, as is suggested in disorders such as Parkinson's disease, schizophrenia, respiratory depression, sleep apneas, attention deficit hyperactivity disorder and affective or mood disorders, and in disorders wherein a deficiency in neurotrophic factors is implicated, as well as in disorders of respiration such as overdose of an alcohol, an opiate, an opioid, a barbiturate, an anesthetic, or a nerve toxin, or where the respiratory depression results form a medical condition such as central sleep apnea, stoke-induced central sleep apnea, obstructive sleep apnea, congenital hypoventilation syndrome, obesity hypoventilation syndrome, sudden infant death syndrome, Rett syndrome, spinal cord injury, traumatic brain injury, Cheney-Stokes respiration, Ondines curse, Prader-Willi's syndrome and drowning, hi a particular aspect, the invention relates to bicyclic amide compounds useful for treatment of such conditions, and methods of using these compounds for such treatment.
摘要翻译：本发明涉及用于预防和治疗脑功能不全的化合物，药物组合物和方法，包括在负责基本和高级行为的脑网络中的突触中增强受体功能。涉及呼吸调节的这些脑网络，以及与记忆障碍有关的认知能力，例如在各种痴呆中观察到的，在不同脑区域之间的神经元活动不平衡中，如在帕金森病，精神分裂症，呼吸抑制，睡眠呼吸暂停，注意缺陷多动障碍和情感或情绪障碍，以及涉及神经营养因子缺乏的疾病，以及呼吸障碍，例如过量的酒精，阿片剂，阿片样物质，巴比妥酸盐，麻醉剂或神经毒素，或呼吸抑制结果形成中枢性睡眠呼吸暂停，咳嗽引起的中枢性睡眠呼吸暂停，阻塞性睡眠呼吸暂停，先天性通气不足综合征，肥胖低通气综合征，婴儿猝死综合征，Rett综合征，脊髓损伤，创伤性脑损伤，Cheney-Stokes呼吸，Ondine诅咒， Prader-Willi综合征和溺水在一个特定方面，本发明涉及可用于治疗这些病症的双环酰胺化合物，以及使用这些化合物进行这种治疗的方法。

29. 发明申请

US20100267728A1 3-SUBSTITUTED-1,2,3-TRIAZIN-4-ONE'S AND 3 SUBSTITUTED 1,3-PYRIMIDINONE'S FOR ENHANCING GLUTAMATERGIC SYNAPTIC RESPONSES 审中-公开
标题翻译： 3-取代-1,2,3-三嗪-4-酮和3替代的1,3-吡啶酮用于增强谷氨酸反应性
公开(公告)号：US20100267728A1
公开(公告)日：2010-10-21
申请号：US12733822
申请日：2008-09-19
申请人： Rudolf Mueller , Leslie J. Street , Stanislaw Rachwal , Kashinatham Alisala
发明人： Rudolf Mueller , Leslie J. Street , Stanislaw Rachwal , Kashinatham Alisala
IPC分类号： A61K31/53 , C07D487/14 , C07D239/90 , A61K31/517 , A61P25/16 , A61P25/24 , A61P25/28 , A61P25/20 , A61P25/18 , A61P11/00 , A61P25/00 , A61P25/04
CPC分类号： C07D487/04
摘要： This invention relates to compounds, pharmaceutical compositions and methods for use in the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for basic and higher order behaviors. These brain networks, which are involved in regulation of breathing, and cognitive abilities related to memory impairment, such as is observed in a variety of dementias, in imbalances in neuronal activity between different brain regions, as is suggested in disorders such as Parkinson's disease, schizophrenia, respiratory depression, sleep apneas, attention deficit hyperactivity disorder and affective or mood disorders, and in disorders wherein a deficiency in neurotrophic factors is implicated, as well as in disorders of respiration such as overdose of an alcohol, an opiate, an opioid, a barbiturate, an anesthetic, or a nerve toxin, or where the respiratory depression results form a medical condition such as central sleep apnea, stroke-induced central sleep apnea, obstructive sleep apnea, congenital hypoventilation syndrome, obesity hypoventilation syndrome, sudden infant death syndrome, Rett syndrome, spinal cord injury, traumatic brain injury, Cheney-Stokes respiration, Ondines curse, Prader-Willi's syndrome and drowning. In a particular aspect, the invention relates to compounds useful for treatment of such conditions, and methods of using these compounds for such treatment.
摘要翻译：本发明涉及用于预防和治疗脑功能不全的化合物，药物组合物和方法，包括在负责基本和高级行为的脑网络中的突触中增强受体功能。涉及呼吸调节的这些脑网络，以及与记忆障碍有关的认知能力，例如在各种痴呆中观察到的，在不同脑区域之间的神经元活动不平衡中，如在帕金森病，精神分裂症，呼吸抑制，睡眠呼吸暂停，注意缺陷多动障碍和情感或情绪障碍，以及涉及神经营养因子缺乏的疾病，以及呼吸障碍，例如过量的酒精，阿片剂，阿片样物质，巴比妥酸盐，麻醉剂或神经毒素，或呼吸抑制结果形成中枢性睡眠呼吸暂停，中风引起的中枢性睡眠呼吸暂停，阻塞性睡眠呼吸暂停，先天性通气不足综合征，肥胖低通气综合征，婴儿猝死综合征，Rett综合征，脊髓损伤，创伤性脑损伤，Cheney-Stokes呼吸，Ondines诅咒，Prader-Willi综合征和溺水。在一个特定方面，本发明涉及可用于治疗这些病症的化合物，以及使用这些化合物进行这种治疗的方法。

30. 发明申请

US20100173902A1 Bicyclic amide derivatives for enhancing glutamatergic synaptic responses 有权
标题翻译：用于增强谷氨酸能突触反应的双环酰胺衍生物
公开(公告)号：US20100173902A1
公开(公告)日：2010-07-08
申请号：US12657908
申请日：2010-01-29
申请人： Rudolf Mueller , Leslie J. Street
发明人： Rudolf Mueller , Leslie J. Street
IPC分类号： A61K31/5375 , C07D498/08 , A61P25/00 , A61P25/24 , A61P25/28 , A61P11/00 , A61P25/18
CPC分类号： C07D498/08 , A61K31/5375 , A61K45/06 , A61K2300/00
摘要： This invention relates to compounds, pharmaceutical compositions and methods for use in the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for basic and higher order behaviors. These brain networks, which are involved in cognitive abilities related to memory impairment, such as is observed in a variety of dementias, in imbalances in neuronal activity between different brain regions, as is suggested in disorders such as Parkinson's disease, schizophrenia, sleep apneas, attention deficit hyperactivity disorder and affective or mood disorders, and in disorders wherein a deficiency in neurotrophic factors is implicated, as well as conditions such as stroke-induced central sleep apnea, obstructive sleep apnea, congenital hypoventilation syndrome, obesity hypoventilation syndrome, sudden infant death syndrome, Rett syndrome, spinal cord injury, traumatic brain injury, Cheney-Stokes respiration, Ondines curse, Prader-Willi's syndrome and drowning. In a particular aspect, the invention relates to bicyclic amide compounds useful for treatment of such conditions, and methods of using these compounds for such treatment.
摘要翻译：本发明涉及用于预防和治疗脑功能不全的化合物，药物组合物和方法，包括在负责基本和高级行为的脑网络中的突触中增强受体功能。参与如记忆障碍相关的认知能力的这些脑网络，例如在各种痴呆症中观察到的，在不同脑区域之间的神经元活动不平衡中，正如帕金森病，精神分裂症，睡眠呼吸暂停症，注意缺陷多动障碍和情感或情绪障碍，以及涉及神经营养因子缺乏的疾病，以及诸如卒中诱导的中枢性睡眠呼吸暂停，阻塞性睡眠呼吸暂停，先天性低通气综合征，肥胖低通气综合征，婴儿猝死综合征综合征，Rett综合征，脊髓损伤，创伤性脑损伤，Cheney-Stokes呼吸，Ondine诅咒，Prader-Willi综合征和溺水。在一个特定方面，本发明涉及可用于治疗这些病症的双环酰胺化合物，以及使用这些化合物进行这种治疗的方法。

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