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21. 发明授权

US6055325A Color display of chromosomes or portions of chromosomes 失效
标题翻译：染色体或染色体部分的彩色显示
公开(公告)号：US6055325A
公开(公告)日：2000-04-25
申请号：US942327
申请日：1997-10-01
申请人： Yuval Garini , Dario Cabib , Robert A. Buckwald , Dirk G. Soenksen , Nir Katzir , David Wine , Moshe Lavi
发明人： Yuval Garini , Dario Cabib , Robert A. Buckwald , Dirk G. Soenksen , Nir Katzir , David Wine , Moshe Lavi
IPC分类号： G01B9/02 , A61B3/12 , A61B5/00 , C12Q1/68 , G01B11/06 , G01J3/02 , G01J3/12 , G01J3/26 , G01J3/28 , G01J3/44 , G01J3/453 , G01N21/27 , G01N21/64 , G01N33/48 , G01N33/50 , G01N33/569 , G01N33/58 , G06K9/00 , G06K9/76
CPC分类号： G01N21/6458 , A61B3/12 , C12Q1/6816 , C12Q1/6841 , C12Q1/6883 , G01B11/0675 , G01J3/12 , G01J3/1256 , G01J3/26 , G01J3/2823 , G01J3/4406 , G01J3/453 , G01J3/4535 , G01N21/6428 , G01N33/5005 , G01N33/56966 , G01N33/582 , G06K9/00127 , G06K9/76 , A61B3/1241 , C12Q2600/156 , G01J2003/2866 , G01J3/02 , G01N2021/6417 , G01N2021/6441
摘要： A color display comprising an image of all chromosomes or portions of chromosomes of a cell, each of the chromosomes or portions of chromosomes being painted with a different fluorophore or a combination of fluorophores, the image presenting the chromosomes or portions of chromosomes in different distinctive colors, wherein each of the chromosomes or portions of chromosomes is associated with one of the different distinctive colors.
摘要翻译：一种彩色显示器，其包括所有染色体或细胞染色体部分的图像，每个染色体或染色体部分用不同的荧光团或荧光团的组合进行染色，所述染色体或染色体的部分以不同的特征呈现其中每个染色体或染色体的部分与不同的独特颜色之一相关联。

22. 发明申请

US20110037847A1 Fully Automatic Rapid Microscope Slide Scanner 有权
标题翻译：全自动快速显微镜幻灯片
公开(公告)号：US20110037847A1
公开(公告)日：2011-02-17
申请号：US12910696
申请日：2010-10-22
申请人： Dirk G. Soenksen
发明人： Dirk G. Soenksen
IPC分类号： H04N7/18
CPC分类号： G02B21/367 , G02B21/002 , G02B21/0036 , G02B21/008 , G02B21/14 , G02B21/245 , G02B21/26 , G02B21/32 , G02B21/34 , G02B21/365 , G06F19/00 , H04N1/053 , H04N1/1903 , H04N1/193 , H04N1/19573 , H04N5/2256 , H04N5/23206 , H04N7/18 , H04N7/183 , H04N2201/04727 , H04N2201/04755
摘要： Apparatus for and method of fully automatic rapid scanning and digitizing of an entire microscope sample, or a substantially large portion of a microscope sample, using a linear array detector synchronized with a positioning stage that is part of a computer controlled microscope slide scanner. The invention provides a method for composing the image strips obtained from successive scans of the sample into a single contiguous digital image. The invention also provides a method for statically displaying sub-regions of this large digital image at different magnifications, together with a reduced magnification macro-image of the entire sample. The invention further provides a method for dynamically displaying, with or without operator interaction, portions of the contiguous digital image. In one preferred embodiment of the invention, all elements of the scanner are part of a single-enclosure that has a primary connection to the Internet or to a local intranet. In this embodiment, the preferred sample type is a microscope slide and the illumination and imaging optics are consistent with transmission mode optics optimized for diffraction-limited digital imaging.
摘要翻译：使用与作为计算机控制的显微镜幻灯片扫描器的一部分的定位台同步的线性阵列检测器，全自动快速扫描和数字化整个显微镜样品或显微镜样本的大部分的装置和方法。本发明提供了一种用于组合从样本的连续扫描获得的图像条带到单个邻接数字图像中的方法。本发明还提供了一种用于以不同放大率静态显示该大数字图像的子区域的方法，以及整个样本的缩小的放大宏图像。本发明还提供了一种用于在或不与操作者交互的情况下动态显示邻接数字图像的部分的方法。在本发明的一个优选实施例中，扫描器的所有元件都是具有到互联网或本地内部网的主要连接的单个外壳的一部分。在该实施例中，优选的样品类型是显微镜载玻片，并且照明和成像光学元件与针对衍射极限数字成像优化的透射模式光学元件一致。

23. 发明授权

US06917696B2 Fully automatic rapid microscope slide scanner 有权
标题翻译：全自动快速显微镜幻灯片扫描仪
公开(公告)号：US06917696B2
公开(公告)日：2005-07-12
申请号：US10798457
申请日：2004-03-11
申请人： Dirk G. Soenksen
发明人： Dirk G. Soenksen
IPC分类号： G01N21/17 , G02B21/00 , G02B21/26 , G02B21/32 , G02B21/36 , G06T1/00 , G21K7/00 , H04N1/04 , G06K9/00
CPC分类号： G02B21/367 , G02B21/002 , G02B21/0036 , G02B21/008 , G02B21/14 , G02B21/245 , G02B21/26 , G02B21/32 , G02B21/34 , G02B21/365 , G06F19/00 , H04N1/053 , H04N1/1903 , H04N1/193 , H04N1/19573 , H04N5/2256 , H04N5/23206 , H04N7/18 , H04N7/183 , H04N2201/04727 , H04N2201/04755
摘要： Apparatus for and method of fully automatic rapid scanning and digitizing of an entire microscope sample, or a substantially large portion of a microscope sample, using a linear array detector synchronized with a positioning stage that is part of a computer controlled microscope slide scanner. The invention provides a method for composing the image strips obtained from successive scans of the sample into a single contiguous digital image. The invention also provides a method for statically displaying sub-regions of this large digital image at different magnifications, together with a reduced magnification macro-image of the entire sample. The invention further provides a method for dynamically displaying, with or without operator interaction, portions of the contiguous digital image. In one preferred embodiment of the invention, all elements of the scanner are part of a single-enclosure that has a primary connection to the Internet or to a local intranet. In this embodiment, the preferred sample type is a microscope slide and the illumination and imaging optics are consistent with transmission mode optics optimized for diffraction-limited digital imaging.
摘要翻译：使用与作为计算机控制的显微镜幻灯片扫描器的一部分的定位台同步的线性阵列检测器，全自动快速扫描和数字化整个显微镜样品或显微镜样本的大部分的装置和方法。本发明提供了一种用于组合从样本的连续扫描获得的图像条带到单个邻接数字图像中的方法。本发明还提供了一种用于以不同放大率静态显示该大数字图像的子区域的方法，以及整个样本的缩小的放大宏图像。本发明还提供了一种用于在或不与操作者交互的情况下动态显示邻接数字图像的部分的方法。在本发明的一个优选实施例中，扫描器的所有元件都是具有到互联网或本地内部网的主要连接的单个外壳的一部分。在该实施例中，优选的样品类型是显微镜载玻片，并且照明和成像光学元件与针对衍射极限数字成像优化的透射模式光学元件一致。

24. 发明授权

US6066459A Method for simultaneous detection of multiple fluorophores for in situ hybridization and multicolor chromosome painting and banding 失效
标题翻译：同时检测原位杂交和多色染色体绘制和条带的多种荧光团的方法
公开(公告)号：US6066459A
公开(公告)日：2000-05-23
申请号：US100104
申请日：1998-06-19
申请人： Yuval Garini , Dario Cabib , Robert A. Buckwald , Thomas Ried , Dirk G. Soenksen
发明人： Yuval Garini , Dario Cabib , Robert A. Buckwald , Thomas Ried , Dirk G. Soenksen
IPC分类号： C12N15/09 , C12Q1/68 , G01J3/02 , G01J3/12 , G01J3/26 , G01J3/28 , G01J3/44 , G01J3/453 , G01N21/64 , G01N33/50 , G01N33/569 , G01N33/58 , G02B21/16 , G06K9/00 , G06K9/76 , C07H21/04
CPC分类号： G01N21/6452 , C12Q1/6841 , C12Q1/6883 , G01J3/12 , G01J3/1256 , G01J3/26 , G01J3/2823 , G01J3/4406 , G01J3/453 , G01N21/6428 , G01N21/6458 , G01N33/5005 , G01N33/56966 , G01N33/582 , G06K9/00127 , G06K9/76 , C12Q2600/156 , G01J2003/2866 , G01J3/02 , G01N2021/6417 , G01N2021/6441
摘要： A spectral imaging method for simultaneous detection of multiple fluorophores aimed at detecting and analyzing fluorescent in situ hybridizations employing numerous chromosome paints and/or loci specific probes each labeled with a different fluorophore or a combination of fluorophores for color karyotyping, and at multicolor chromosome banding, wherein each chromosome acquires a specifying banding pattern, which pattern is established using groups of chromosome fragments labeled with various fluorophore or combinations of fluorophores.
摘要翻译：用于同时检测多个荧光团的光谱成像方法，其目的是检测和分析使用多种染色体涂料和/或基因座特异性探针的荧光原位杂交，每个染色体涂料和/或基因座特异性探针用不同的荧光团或用于颜色核型分析的荧光团的组合以及多色染色体条带标记，其中每个染色体获得指定的条带图案，使用由各种荧光团标记的染色体片段或荧光团的组合来建立该图案。

25. 发明授权

US08805050B2 Optimizing virtual slide image quality 有权
标题翻译：优化虚拟幻灯片图像质量
公开(公告)号：US08805050B2
公开(公告)日：2014-08-12
申请号：US13355245
申请日：2012-01-20
申请人： Allen Olson , Dirk G. Soenksen , Kiran Saligrama
发明人： Allen Olson , Dirk G. Soenksen , Kiran Saligrama
IPC分类号： G06K9/00 , G06K9/40
CPC分类号： G02B21/245 , G02B21/002 , G02B21/244 , G02B21/365 , G02B21/367 , G06K9/40 , H04N5/23212
摘要： Systems and methods for assessing and optimizing virtual microscope slide image quality are provided. In order to determine whether any of multiple virtual slide images has an out of focus area and is therefore a candidate for manual inspection or rescanning, various focus points used to scan each virtual slide image are used to calculate a best fit surface for each virtual slide image. The best fit surface is then used to determine whether any of the various focus points are outliers. If it is determined that a virtual slide image is associated with outlying focus points, it is identified as a candidate for manual inspection or rescanning.
摘要翻译：提供了评估和优化虚拟显微镜载玻片图像质量的系统和方法。为了确定多个虚拟幻灯片图像中的任何一个是否具有失焦区域，因此是用于手动检查或重新扫描的候选者，用于扫描每个虚拟幻灯片图像的各种对焦点用于为每个虚拟幻灯片计算最佳拟合曲面图片。然后使用最佳拟合曲面来确定各个焦点中是否有异常值。如果确定虚拟幻灯片图像与外围焦点相关联，则将其识别为手动检查或重新扫描的候选者。

26. 发明授权

US08571286B2 System and method for quality assurance in pathology 有权
标题翻译：病理学质量保证体系和方法
公开(公告)号：US08571286B2
公开(公告)日：2013-10-29
申请号：US13453767
申请日：2012-04-23
申请人： Dirk G. Soenksen , Kathy Zirker-Smith
发明人： Dirk G. Soenksen , Kathy Zirker-Smith
IPC分类号： G06K9/00
CPC分类号： G06K9/00127 , G02B21/365 , G06F19/00 , G06F19/30 , G06K9/00134 , G06K9/03 , G06K9/033 , G06Q50/22 , G06T5/001 , G06T7/0002 , G06T7/0012 , G06T2207/10024 , G06T2207/10056 , G06T2207/30024
摘要： Systems and methods for improving quality assurance in pathology using automated quality assessment and digital image enhancements on digital slides prior to analysis by the pathologist are provided. A digital pathology system (slide scanning instrument and software) creates, assesses and improves the quality of a digital slide. The improved digital slide image has a higher image quality that results in increased efficiency and accuracy in the analysis and diagnosis of such digital slides when they are reviewed on a monitor by a pathologist. These improved digital slides yield a more objective diagnosis than reading the corresponding glass slide under a microscope.
摘要翻译：提供了在病理学家分析之前，通过使用自动化质量评估和数字图像增强技术，改善病理学质量保证的系统和方法。数字病理系统（幻灯片扫描仪器和软件）创建，评估和提高数字幻灯片的质量。改进的数字幻灯片图像具有更高的图像质量，当病理学家在监视器上进行审查时，可以提高这种数字幻灯片的分析和诊断的效率和准确性。这些改进的数字幻灯片比在显微镜下阅读相应的载玻片更容易得到客观的诊断。

27. 发明申请

US20120075457A1 Fully Automatic Rapid Microscope Slide Scanner 有权
标题翻译：全自动快速显微镜幻灯片
公开(公告)号：US20120075457A1
公开(公告)日：2012-03-29
申请号：US13291971
申请日：2011-11-08
申请人： Dirk G. Soenksen
发明人： Dirk G. Soenksen
IPC分类号： H04N7/18
CPC分类号： G02B21/367 , G02B21/002 , G02B21/0036 , G02B21/008 , G02B21/14 , G02B21/245 , G02B21/26 , G02B21/32 , G02B21/34 , G02B21/365 , G06F19/00 , H04N1/053 , H04N1/1903 , H04N1/193 , H04N1/19573 , H04N5/2256 , H04N5/23206 , H04N7/18 , H04N7/183 , H04N2201/04727 , H04N2201/04755
摘要： Apparatus for and method of fully automatic rapid scanning and digitizing of an entire microscope sample, or a substantially large portion of a microscope sample, using a linear array detector synchronized with a positioning stage that is part of a computer controlled microscope slide scanner. The invention provides a method for composing the image strips obtained from successive scans of the sample into a single contiguous digital image.
摘要翻译：使用与作为计算机控制的显微镜幻灯片扫描器的一部分的定位台同步的线性阵列检测器，全自动快速扫描和数字化整个显微镜样品或显微镜样本的大部分的装置和方法。本发明提供了一种用于组合从样本的连续扫描获得的图像条带到单个邻接数字图像中的方法。

28. 发明授权

US08103082B2 Optimizing virtual slide image quality 有权
标题翻译：优化虚拟幻灯片图像质量
公开(公告)号：US08103082B2
公开(公告)日：2012-01-24
申请号：US12711157
申请日：2010-02-23
申请人： Allen Olson , Dirk G. Soenksen , Kiran Saligrama
发明人： Allen Olson , Dirk G. Soenksen , Kiran Saligrama
IPC分类号： G06K9/00 , G06K9/40
CPC分类号： G02B21/245 , G02B21/002 , G02B21/244 , G02B21/365 , G02B21/367 , G06K9/40 , H04N5/23212
摘要： Systems and methods for assessing and optimizing virtual microscope slide image quality are provided. In order to determine whether a virtual slide image has any out of focus areas and is therefore a candidate for manual inspection, the various focus points used to scan the virtual slide image are used to calculate a best fit surface for the virtual slide image. The distance of each focus point from the best fit surface is then calculated and the largest distance is compared to a predetermined value. If the largest distance from a focus point to the best fit surface is larger than the predetermined value, then the virtual slide image is designated as needing a manual inspection and possible re-scan.
摘要翻译：提供了评估和优化虚拟显微镜载玻片图像质量的系统和方法。为了确定虚拟幻灯片图像是否具有任何偏离焦点区域，因此是用于手动检查的候选者，用于扫描虚拟幻灯片图像的各种对焦点用于计算虚拟幻灯片图像的最佳拟合曲面。然后计算每个对焦点与最佳拟合表面的距离，并将最大距离与预定值进行比较。如果从焦点到最佳配合曲面的最大距离大于预定值，则虚拟幻灯片图像被指定为需要手动检查和可能的重新扫描。

29. 发明授权

US08023714B2 System and method for assessing image interpretability in anatomic pathology 有权
标题翻译：用于评估解剖病理学图像解释度的系统和方法
公开(公告)号：US08023714B2
公开(公告)日：2011-09-20
申请号：US11772748
申请日：2007-07-02
申请人： Dirk G. Soenksen
发明人： Dirk G. Soenksen
IPC分类号： G06K9/00
CPC分类号： G06T7/0012 , G06F19/00 , G06F19/321 , G06K9/00127 , G06K9/036
摘要： A portion of imagery data is obtained from a digital slide and a protocol of image analysis/diagnostic tasks is performed on the portion of imagery data by a pathologist or an image analysis module. The result of each task (e.g., success or no success) is recorded and a score is determined for the portion of the imagery data. Multiple portions of imagery data from the digital slide are analyzed and scored and the various scores from the multiple portions of imagery data are calculated to determine an overall score for the digital slide. Regions of the digital slide can be scored separately. Multiple rounds of scoring (by different pathologists and/or different image analysis algorithms) may be employed to increase the accuracy of the score for a digital slide or region thereof.
摘要翻译：从数字幻灯片获得一部分图像数据，并且通过病理学家或图像分析模块对图像数据的一部分执行图像分析/诊断任务的协议。记录每个任务的结果（例如成功或不成功），并且确定图像数据的一部分的得分。对来自数字幻灯片的图像数据的多个部分进行分析和评分，并计算来自图像数据的多个部分的各种分数，以确定数字幻灯片的总分。数字幻灯片的区域可以分开划分。可以采用多轮评分（由不同的病理学家和/或不同的图像分析算法）来增加数字幻灯片或其区域的分数的准确性。

30. 发明申请

US20110141263A1 Achieving Focus in a Digital Pathology System 有权
标题翻译：实现数字病理系统的重点
公开(公告)号：US20110141263A1
公开(公告)日：2011-06-16
申请号：US13031994
申请日：2011-02-22
申请人： Allen Olson , Greg Crandall , Dirk G. Soenksen
发明人： Allen Olson , Greg Crandall , Dirk G. Soenksen
IPC分类号： H04N7/18
CPC分类号： G02B21/365 , G02B21/002 , G02B21/244
摘要： Methods and apparatus are provided for computing focus information prior to scanning digital microscope slide data with a line scan camera. The methods include a point-focus procedure that works by moving the slide to the desired measurement location, moving the objective lens through a predefined set of height values, acquiring imagery data at each height, and determining the height of maximum contrast. The methods also include a ribbon-focus procedure whereby imagery data are acquired continuously, while the slide and objective lens are in motion. Both methods may be applied with either a static or a dynamic implementation.
摘要翻译：提供了使用线扫描相机扫描数字显微镜幻灯片数据之前计算焦点信息的方法和装置。这些方法包括通过将滑块移动到期望的测量位置，通过预定义的一组高度值移动物镜，获取每个高度处的图像数据以及确定最大对比度的高度而起作用的点对焦过程。所述方法还包括色带聚焦程序，其中在幻灯片和物镜运动时连续获取图像数据。两种方法都可以应用于静态或动态实现。

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