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21. 发明申请

US20070077563A1 Method of searching for functional nucleotide molecule 审中-公开
标题翻译：搜索功能核苷酸分子的方法
公开(公告)号：US20070077563A1
公开(公告)日：2007-04-05
申请号：US10569814
申请日：2004-08-25
申请人： Takashi Ueno , Masashige Tanabe , Risa Sumioka , Eiji Kobayashi , Nobuto Koyama , Hiroaki Sagawa , Junichi Mineno , Ikunoshin Kato
发明人： Takashi Ueno , Masashige Tanabe , Risa Sumioka , Eiji Kobayashi , Nobuto Koyama , Hiroaki Sagawa , Junichi Mineno , Ikunoshin Kato
IPC分类号： C12Q1/68 , C07H21/02
CPC分类号： C12N15/63
摘要： A universal method of searching for a nucleic acid capable of effectively inhibiting gene expression; a nucleic acid construct to be used in this method; a vector; and a kit for the above method. This method is characterized in that a nucleic acid construct, which is a nucleic acid construct having a promoter sequence, at least two gene sequences and a poly A signal sequence and in which the above-described at least two gene sequences are transcribed as a single molecule RNA and at least one gene sequence is in the translatable state while at least one gene sequence is encoded in the substantially untranslatable state, is constructed.
摘要翻译：搜索能够有效抑制基因表达的核酸的通用方法; 在该方法中使用的核酸构建体; 一个矢量和上述方法的试剂盒。该方法的特征在于，具有启动子序列，至少两个基因序列和多聚A信号序列的核酸构建体的核酸构建体，其中上述至少两个基因序列被转录为单个分子RNA和至少一个基因序列处于可翻译状态，而至少一个基因序列被编码为基本上不可翻译的状态。

22. 发明授权

US07678368B2 Fucoidan-containing cosmetics 失效
标题翻译：含岩藻依聚糖的化妆品
公开(公告)号：US07678368B2
公开(公告)日：2010-03-16
申请号：US11311341
申请日：2005-12-20
申请人： Shigetoshi Mizutani , Suzu Deguchi , Eiji Kobayashi , Eiji Nishiyama , Hiroaki Sagawa , Ikunoshin Kato
发明人： Shigetoshi Mizutani , Suzu Deguchi , Eiji Kobayashi , Eiji Nishiyama , Hiroaki Sagawa , Ikunoshin Kato
IPC分类号： A61K8/73 , A61P17/14
CPC分类号： A61Q19/10 , A61K8/60 , A61K8/73 , A61K8/9706 , A61K31/04 , A61K31/08 , A61K31/13 , A61K31/70 , A61K33/20 , A61Q5/00 , A61Q5/02 , A61Q7/00 , A61Q19/00 , A61Q19/005 , A61Q19/007 , A61Q19/08 , Y10S514/88
摘要： To find a substance which has a skin cosmeticizing effect such as prevention of skin aging, amelioriation of sensitive skin, or antipruritic action, and can serve as an effective ingredient for a hair-care product, thereby providing cosmetics comprising the effective ingredient. Concretely, there are provided cosmetics characterized in that the cosmetics comprise as an effective ingredient a compound selected from a fucoidan, a degradation product thereof, a sulfated monosaccharide or a salt thereof.
摘要翻译：为了找到具有防止皮肤老化，敏感性皮肤的改善或止痒作用的皮肤美容效果的物质，可以作为护发品的有效成分，从而提供含有效成分的化妆品。具体地，提供了化妆品，其特征在于，所述化妆品包含选自岩藻依聚糖，其降解产物，硫酸化单糖或其盐的化合物作为有效成分。

23. 发明授权

US07268160B2 Remedies 失效
标题翻译：补救措施
公开(公告)号：US07268160B2
公开(公告)日：2007-09-11
申请号：US10182193
申请日：2001-01-26
申请人： Hiromu Ohnogi , Masahiro Shiraga , Eiji Kobayashi , Tuo-Ping Li , Suzu Deguchi , Eiji Nishiyama , Hiroaki Sagawa , Ikunoshin Kato
发明人： Hiromu Ohnogi , Masahiro Shiraga , Eiji Kobayashi , Tuo-Ping Li , Suzu Deguchi , Eiji Nishiyama , Hiroaki Sagawa , Ikunoshin Kato
IPC分类号： A61K31/35 , A61K31/22 , C07D307/02 , C07C67/02
CPC分类号： A61K31/7004 , A23L33/10 , A61K31/12 , A61K31/216 , A61K31/222 , A61K31/352
摘要： The present invention provides a therapeutic agent or prophylactic agent for a disease that requires enhancement of nerve growth factor production, an enhancer for nerve growth factor production, or a food, beverage or feed for enhancing nerve growth factor production, each comprising as an effective ingredient a specified compound or a salt thereof having enhancing activity for nerve growth factor production; a method for enhancing nerve growth factor production, comprising administering to a mammal the above-mentioned compound or a salt thereof; and use of the above-mentioned compound or a salt thereof in the preparation of a therapeutic agent or prophylactic agent for a disease that requires enhancement of nerve growth factor production, an enhancer for nerve growth factor production, or a food, beverage or feed for enhancing nerve growth factor production. In addition, the present invention provides novel compounds having enhancing activity for nerve growth factor production.
摘要翻译：本发明提供了需要增强神经生长因子产生的疾病的治疗剂或预防剂，用于神经生长因子产生的增强剂或用于增强神经生长因子产生的食品，饮料或饲料，其各自包含作为有效成分具有增强神经生长因子生成活性的特定化合物或其盐; 一种用于增强神经生长因子产生的方法，包括向哺乳动物施用上述化合物或其盐; 以及上述化合物或其盐在制备需要增强神经生长因子产生的疾病的治疗剂或预防剂，用于神经生长因子产生的增强剂或食品，饮料或饲料中的用途增强神经生长因子的产生。此外，本发明提供了具有增强神经生长因子产生活性的新型化合物。

24. 发明申请

US20060093566A1 Fucoidan-containing cosmetics 失效
标题翻译：含岩藻依聚糖的化妆品
公开(公告)号：US20060093566A1
公开(公告)日：2006-05-04
申请号：US11311341
申请日：2005-12-20
申请人： Shigetoshi Mizutani , Suzu Deguchi , Eiji Kobayashi , Eiji Nishiyama , Hiroaki Sagawa , Ikunoshin Kato
发明人： Shigetoshi Mizutani , Suzu Deguchi , Eiji Kobayashi , Eiji Nishiyama , Hiroaki Sagawa , Ikunoshin Kato
IPC分类号： A61K8/73
CPC分类号： A61Q19/10 , A61K8/60 , A61K8/73 , A61K8/9706 , A61K31/04 , A61K31/08 , A61K31/13 , A61K31/70 , A61K33/20 , A61Q5/00 , A61Q5/02 , A61Q7/00 , A61Q19/00 , A61Q19/005 , A61Q19/007 , A61Q19/08 , Y10S514/88
摘要： To find a substance which has a skin cosmeticizing effect such as prevention of skin aging, amelioriation of sensitive skin, or antipruritic action, and can serve as an effective ingredient for a hair-care product, thereby providing cosmetics comprising the effective ingredient. Concretely, there are provided cosmetics characterized in that the cosmetics comprise as an effective ingredient a compound selected from a fucoidan, a degradation product thereof, a sulfated monosaccharide or a salt thereof.
摘要翻译：为了找到具有防止皮肤老化，敏感性皮肤的改善或止痒作用的皮肤美容效果的物质，可以作为护发品的有效成分，从而提供含有效成分的化妆品。具体地，提供了化妆品，其特征在于，所述化妆品包含选自岩藻依聚糖，其降解产物，硫酸化单糖或其盐的化合物作为有效成分。

25. 发明授权

US06326405B1 Anticancer agent 失效
标题翻译：抗癌剂
公开(公告)号：US06326405B1
公开(公告)日：2001-12-04
申请号：US09443089
申请日：1999-11-18
申请人： Eiji Kobayashi , Nobuto Koyama , Ikunoshin Kato
发明人： Eiji Kobayashi , Nobuto Koyama , Ikunoshin Kato
IPC分类号： A61K3112
CPC分类号： C07C45/60 , A61K31/12 , A61K31/122 , C07C45/71 , C07C49/707 , C07C49/753
摘要： An anticancer agent in which 4-cyclopentene-1,3-dione represented by the following formula [I] and/or 4-hydroxy-2-cyclopentenone represented by the following formula [II] are/is effective component(s).
摘要翻译：由下式[I]表示的4-环戊烯-1,3-二酮和/或下式[II]表示的4-羟基-2-环戊烯酮的抗癌剂为有效成分。

26. 发明授权

US6111145A Cyclopentenone derivative 失效
标题翻译：环戊烯酮衍生物
公开(公告)号：US6111145A
公开(公告)日：2000-08-29
申请号：US419221
申请日：1999-10-15
申请人： Eiji Kobayashi , Nobuto Koyama , Ikunoshin Kato , Kaoru Inami , Tetsuo Shiba
发明人： Eiji Kobayashi , Nobuto Koyama , Ikunoshin Kato , Kaoru Inami , Tetsuo Shiba
IPC分类号： C07C45/71 , C07C49/753 , C07C49/105 , A61K31/12
CPC分类号： C07C49/753 , C07C45/71
摘要： A cyclopentenone derivative represented by the following formula [I] or an optically active substance or a salt thereof. ##STR1## (In the formula, R.sub.1 and R.sub.2 are same or different and each of them is straight or branched alkyl group, straight or branched alkenyl group, aromatic group, aromatic-aliphatic group or H with a proviso that the case where R.sub.1 =R.sub.2 =H, or R.sub.1 =benzyl group and R.sub.2 =H is excluded.)
摘要翻译：由下式[I]表示的环戊烯酮衍生物或光学活性物质或其盐。（式中，R 1，R 2相同或不同，分别为直链或支链烷基，直链或支链烯基，芳香族基，芳香族 - 脂肪族基或H，条件是R1 = R2 = H ，或R 1 =苄基，并且R 2 = H被排除。

27. 发明授权

US07135291B2 Method of detecting nucleotide polymorphism 失效
标题翻译：检测核苷酸多态性的方法
公开(公告)号：US07135291B2
公开(公告)日：2006-11-14
申请号：US10468128
申请日：2002-02-14
申请人： Hiroaki Sagawa , Eiji Kobayashi , Ikunoshin Kato
发明人： Hiroaki Sagawa , Eiji Kobayashi , Ikunoshin Kato
IPC分类号： C12Q1/68 , C07H21/02 , C07H21/04
CPC分类号： C12Q1/683 , C12Q2521/101
摘要： A Nucleotide useful for detecting a base substitution in a gene, a method for detecting a base substitution in a gene using said Nucleotide, and a kit for the same.
摘要翻译：用于检测基因中碱基取代的核苷酸，使用所述核苷酸检测基因中的碱基取代的方法及其用途。

28. 发明申请

US20060147558A1 Remedies 审中-公开
标题翻译：补救措施
公开(公告)号：US20060147558A1
公开(公告)日：2006-07-06
申请号：US11258163
申请日：2005-10-26
申请人： Hiromu Ohnogi , Masahiro Shiraga , Tuo-Ping Li , Eiji Kobayashi , Kaori Nishimura , Hiroaki Sagawa , Ikunoshin Kato
发明人： Hiromu Ohnogi , Masahiro Shiraga , Tuo-Ping Li , Eiji Kobayashi , Kaori Nishimura , Hiroaki Sagawa , Ikunoshin Kato
IPC分类号： A61K36/899 , A61K36/16 , A61K36/8962 , A61K36/31 , A61K36/906 , A61K36/28 , A61K36/23
CPC分类号： C12G3/06 , A23F3/163 , A23K20/00 , A23K20/10 , A23L2/02 , A23L2/52 , A23L33/105 , A61K31/12 , A61K31/192 , A61K31/216 , A61K31/7048 , A61K36/16 , A61K36/185 , A61K36/23 , A61K36/28 , A61K36/31 , A61K36/48 , A61K36/60 , A61K36/73 , A61K36/896 , A61K36/899 , A61K36/906 , A61K2300/00
摘要： The present invention provides a composition for enhancing growth factor production, comprising a plant-derived enhancer for growth factor production; a therapeutic agent or prophylactic agent for a disease requiring enhancement of growth factor production and a food, beverage or feed for enhancing growth factor production, each comprising the above composition. In addition, the present invention relates to a functional food, beverage or feed excellent in health enhancement.
摘要翻译：本发明提供一种用于增强生长因子生产的组合物，其包含用于生长因子生产的植物来源的增强剂; 用于需要增强生长因子产生的疾病的治疗剂或预防剂和用于增强生长因子产生的食品，饮料或饲料，每种包含上述组合物。此外，本发明涉及健康增强优异的功能性食品，饮料或饲料。

29. 发明授权

US07846703B2 Method for enhancing polymerase activity 有权
标题翻译：增强聚合酶活性的方法
公开(公告)号：US07846703B2
公开(公告)日：2010-12-07
申请号：US11866148
申请日：2007-10-02
申请人： Eiji Kobayashi , Yuki Ueda , Yoshimi Sato , Takashi Uemori , Hiroyuki Mukai , Ikunoshin Kato
发明人： Eiji Kobayashi , Yuki Ueda , Yoshimi Sato , Takashi Uemori , Hiroyuki Mukai , Ikunoshin Kato
IPC分类号： C12N9/10 , C12N9/96 , C07K14/00 , C12Q1/66 , C12P19/34
CPC分类号： C12N9/1241
摘要： A polymerase activity is effectively enhanced by adding an anionic surfactant, in particular an anionic surfactant having a polyethoxyl group, to a reaction mixture containing a polymerase.
摘要翻译：通过向含有聚合酶的反应混合物中加入阴离子表面活性剂，特别是具有聚乙氧基的阴离子表面活性剂，可有效提高聚合酶活性。

30. 发明申请

US20140246414A1 WIRE SOFTENING APPARATUS AND WIRE SOFTENING METHOD 审中-公开
标题翻译：电线设备和电线方法
公开(公告)号：US20140246414A1
公开(公告)日：2014-09-04
申请号：US14351418
申请日：2012-02-29
申请人： Eiji Kobayashi
发明人： Eiji Kobayashi
IPC分类号： C21D9/00 , C21D9/52
CPC分类号： C21D9/0062 , C21D1/32 , C21D1/40 , C21D9/525 , C21D9/573 , C21D9/5732 , C21D9/62 , C22F1/08
摘要： A softening apparatus includes a cooling liquid reservoir for holding a cooling liquid, a first conducting sheave provided outside of the cooling liquid reservoir for applying a voltage to a wire while guiding the wire, and a second conducting sheave provided in the cooling liquid reservoir for letting a current flow through the wire while guiding the wire as the wire is fed via the first conducting sheave. The softening apparatus is also provided with a liquid level detector for detecting a liquid level of the cooling liquid in the cooling liquid reservoir. A heating path length of the wire between the first conducting sheave and the second conducting sheave is controlled based on a result of detection by the liquid level detector.
摘要翻译：软化装置包括：用于保持冷却液的冷却液储存器;设置在冷却液储存器的外侧的第一导流槽，用于在引导导线的同时向线施加电压;以及设置在冷却液储存器中用于放电的第二导流滑轮当导线通过第一导电滑轮进给时，电流通过导线引导导线。软化装置还设置有用于检测冷却液储存器中的冷却液体的液位的液位检测器。基于液面检测器的检测结果，控制第一导电槽轮与第二导电槽轮之间的导线的加热路径长度。

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