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21. 发明申请

US20100061611A1 CO-REGISTRATION OF CORONARY ARTERY COMPUTED TOMOGRAPHY AND FLUOROSCOPIC SEQUENCE 审中-公开
标题翻译：冠状动脉计算机断层扫描和荧光序列的共同注册
公开(公告)号：US20100061611A1
公开(公告)日：2010-03-11
申请号：US12545922
申请日：2009-08-24
申请人： Chenyang Xu , Hari Sundar , Luc Duong , Rui Liao , Andreas Meyer , Ulrich Bill
发明人： Chenyang Xu , Hari Sundar , Luc Duong , Rui Liao , Andreas Meyer , Ulrich Bill
IPC分类号： G06K9/00 , G06T15/00 , G01N23/00
CPC分类号： G06T19/00 , G06T7/136 , G06T7/187 , G06T7/337 , G06T7/38 , G06T2207/20101 , G06T2207/30101
摘要： A method for displaying real-time imagery of coronary arteries including a chronic total occlusion (CTO) includes acquiring three-dimensional image data of coronary arteries using a three-dimensional medical imaging device, wherein the three-dimensional image data includes imagery of the CTO. A radiocontrast agent is administered to a patient. Real-time image data of the coronary arteries are acquired using one or more fluoroscopes. The real-time image data does not include imagery of the CTO and down-stream vessel structure. The three-dimensional image data is co-registered with the real-time image data using an image processing device within a vicinity of the CTO. The co-registered image data are displayed in real-time using a display device to accurately illustrate the location of the CTO within the context of the real-time image data.
摘要翻译：用于显示包括慢性完全闭塞（CTO）在内的冠状动脉的实时图像的方法包括采用三维医学成像装置获取冠状动脉的三维图像数据，其中三维图像数据包括CTO的图像。向患者施用放射性对比剂。使用一个或多个荧光检查器获取冠状动脉的实时图像数据。实时图像数据不包括CTO和下游血管结构的图像。使用CTO附近的图像处理装置将三维图像数据与实时图像数据共同对准。使用显示装置实时显示共同登记的图像数据，以准确地示出CTO在实时图像数据的上下文中的位置。

22. 发明申请

US20090163800A1 TOOLS AND METHODS FOR VISUALIZATION AND MOTION COMPENSATION DURING ELECTROPHYSIOLOGY PROCEDURES 审中-公开
标题翻译：电生理过程中可视化和运动补偿的工具和方法
公开(公告)号：US20090163800A1
公开(公告)日：2009-06-25
申请号：US12335738
申请日：2008-12-16
申请人： Chenyang Xu , Rui Liao , Liron Yatziv , Norbert Strobel
发明人： Chenyang Xu , Rui Liao , Liron Yatziv , Norbert Strobel
IPC分类号： A61B6/00 , A61B5/05
CPC分类号： A61B6/12 , A61B5/0422 , A61B6/466 , A61B6/503 , A61B6/504 , A61B6/5235 , A61B6/541 , A61B6/566 , A61B90/36 , A61B2017/00703 , A61B2090/376
摘要： A method for real-time cardiac visualization includes acquiring fluoroscope imagery from two planes. The location of at least one electrophysiology (EP) device is marked within the fluoroscope imagery from each of the two planes. The location information for the at least one EP device is combined within each of the acquired fluoroscope images from the two planes to determine a 3D location for the at least one EP device. The fluoroscope imagery from at least one of the two planes is displayed with a visual aid superimposed thereon. The visual aid is based on the 3D location of the EP device.
摘要翻译：一种用于实时心脏可视化的方法包括从两个平面获取荧光成像。至少一个电生理学（EP）装置的位置被标记在两个平面中的每一个的荧光图像内。用于至少一个EP设备的位置信息在来自两个平面的所获取的荧光镜图像的每个中组合，以确定用于至少一个EP设备的3D位置。来自两个平面中的至少一个的荧光图像以其上叠加的视觉辅助物显示。视觉辅助是基于EP设备的3D位置。

23. 发明申请

US20090088830A1 SYSTEM AND METHOD FOR INTRAOPERATIVE GUIDANCE OF STENT PLACEMENT DURING ENDOVASCULAR INTERVENTIONS 有权
标题翻译：内镜下静脉置管手术的系统与方法
公开(公告)号：US20090088830A1
公开(公告)日：2009-04-02
申请号：US12031787
申请日：2008-02-15
申请人： Ashraf Mohamed , Chenyang Xu , Frank Sauer , Marcus Pfister , Andrew F. Hall , Klaus Klingenbeck-Regn
发明人： Ashraf Mohamed , Chenyang Xu , Frank Sauer , Marcus Pfister , Andrew F. Hall , Klaus Klingenbeck-Regn
IPC分类号： A61F2/06 , G06K9/00
CPC分类号： G06T19/006 , A61B6/4423 , A61B6/487 , A61B6/504 , A61B34/10 , A61B2034/102 , A61B2034/108 , A61B2090/365 , A61F2/91 , A61F2250/0067 , A61F2310/0097 , G06T7/344 , G06T7/38 , G06T2207/10121 , G06T2207/30101 , G06T2207/30204
摘要： A method for guiding stent deployment during an endovascular procedure includes providing a virtual stent model of a real stent that specifies a length, diameter, shape, and placement of the real stent. The method further includes projecting the virtual stent model onto a 2-dimensional (2D) DSA image of a target lesion, manipulating a stent deployment mechanism to navigate the stent to the target lesion while simultaneously acquiring real-time 2D fluoroscopic images of the stent navigation, and overlaying each fluoroscopic image on the 2D DSA image having the projected virtual stent model image, where the 2D fluoroscopic images are acquired from a C-arm mounted X-ray apparatus, and updating the projection of the virtual stent model onto the fluoroscopic images whenever a new fluoroscopic image is acquired or whenever the C-arm is moved, where the stent is aligned with the virtual stent model by aligning stent end markers with virtual end markers.
摘要翻译：用于在血管内手术期间引导支架展开的方法包括提供实际支架的虚拟支架模型，其指定真实支架的长度，直径，形状和位置。该方法还包括将虚拟支架模型投影到目标损伤的二维（2D）DSA图像上，操纵支架展开机构以将支架导航到目标病变，同时获取支架导航的实时2D透视图像并且将每个透视图像叠加在具有投射的虚拟支架模型图像的2D DSA图像上，其中从C臂安装的X射线装置获取2D透视图像，并且将虚拟支架模型的投影更新到荧光图像上每当获取新的荧光透视图像或每当C形臂移动时，通过将支架终点标记与虚拟末端标记对齐，支架与虚拟支架模型对准。

24. 发明申请

US20080275467A1 Intraoperative guidance for endovascular interventions via three-dimensional path planning, x-ray fluoroscopy, and image overlay 审中-公开
标题翻译：通过三维路径规划，X射线透视和图像叠加进行血管内干预的术中指导
公开(公告)号：US20080275467A1
公开(公告)日：2008-11-06
申请号：US12110415
申请日：2008-04-28
申请人： Rui Liao , Ashraf Mohamed , Yiyong Sun , Chenyang Xu
发明人： Rui Liao , Ashraf Mohamed , Yiyong Sun , Chenyang Xu
IPC分类号： A61B17/00
CPC分类号： A61B6/5235 , A61B5/055 , A61B6/032 , A61B6/12 , A61B6/466 , A61B6/481 , A61B6/504 , A61B17/12022 , A61B34/10 , A61B90/36 , A61B2017/1205 , A61B2090/364 , A61F2/95
摘要： A method for planning a path for an endovascular intervention includes acquiring and displaying 3D angiographic images; selecting a target on the displayed images; extracting a skeleton of a vascular tree from the displayed images; extracting a symbolic vessel path to the target based on the skeleton of the vascular tree; and overlaying and displaying the symbolic vessel path on 2D fluoroscopic images for guiding the endovascular intervention.
摘要翻译：用于规划血管内干预的路径的方法包括获取和显示3D血管造影图像; 在显示的图像上选择目标; 从所显示的图像中提取血管树的骨架; 基于血管树的骨架提取到目标的符号血管路径; 并在2D荧光镜图像上叠加和显示符号血管路径，用于引导血管内介入。

25. 发明申请

US20080095421A1 REGISTERING 2D AND 3D DATA USING 3D ULTRASOUND DATA 有权
标题翻译：使用3D超声数据注册2D和3D数据
公开(公告)号：US20080095421A1
公开(公告)日：2008-04-24
申请号：US11874266
申请日：2007-10-18
申请人： Yiyong Sun , Rui Liao , Chenyang Xu , Frank Sauer
发明人： Yiyong Sun , Rui Liao , Chenyang Xu , Frank Sauer
IPC分类号： A61B5/00
CPC分类号： A61B6/487 , A61B5/06 , A61B5/062 , A61B6/12 , A61B6/481 , A61B6/504 , A61B6/5247 , A61B8/0833 , A61B8/12 , A61B8/4254 , A61B8/4416
摘要： A fluoroscopy image is registered with data representing a volume, identifying a catheter position relative to a volume represented by preoperative volume data. The catheter position relative to a patient volume represented by data acquired without scanning the catheter is displayed. For example, a 2D fluoroscopy image is registered with respect to coordinates of a 3D preoperative CT or MRI volume by registering the fluoroscopy image and the preoperative volume to 3D ultrasound coordinates.
摘要翻译：用表示体积的数据记录荧光透视图像，识别相对于由术前体积数据表示的体积的导管位置。显示相对于由不扫描导管获取的数据表示的患者体积的导管位置。例如，通过将荧光透视图像和术前体积登记到3D超声坐标，相对于3D术前CT或MRI体积的坐标登记2D透视图像。

26. 发明申请

US20070287902A1 Method and Device for Visually Assisting an Electrophysiological Use of a Catheter in the Heart 有权
标题翻译：视力辅助心脏导管电生理使用的方法和装置
公开(公告)号：US20070287902A1
公开(公告)日：2007-12-13
申请号：US10569957
申请日：2004-08-24
申请人： Kristine Fuimaono , Gal Hayam , Yuval Karmi , Reinmar Killmann , Assaf Preiss , Norbert Rahn , Frank Sauer , Chenyang Xu
发明人： Kristine Fuimaono , Gal Hayam , Yuval Karmi , Reinmar Killmann , Assaf Preiss , Norbert Rahn , Frank Sauer , Chenyang Xu
IPC分类号： A61B18/14
CPC分类号： A61B6/032 , A61B5/055 , A61B5/7285 , A61B6/541 , A61B8/14 , A61B8/543 , A61B18/1492 , A61B2018/00375 , A61B2018/00839 , G01R33/5608
摘要： The invention relates to a device and to a method for visual assistance during the electrophysiological use of a catheter in the heart, enabling electroanatomic 3D mapping data relating to an area of the heart to be treated to be visualised during the use of the catheter. Before the catheter is used, 3D image data of a body region containing the area to be treated is detected by means of a method for tomographic 3D imaging. The area to be treated or significant parts thereof are extracted from said 3D image data, in order to obtain selected 3D image data. The electroanatomic 3D mapping data and the selected 3D image data obtained are then classed in terms of position and dimension, and are adjacently visualised, for example, during the catheter ablation. The inventive method and associated device enable the orientation of the operator to be improved during the use of a catheter in the heart.
摘要翻译：本发明涉及一种用于在心脏中电生理使用导管期间的视觉辅助的装置和方法，使得在使用导管期间能够使待处理的心脏区域的电解剖3D图映射数据被可视化。在使用导管之前，通过用于断层3D成像的方法来检测包含待处理区域的身体区域的3D图像数据。从所述3D图像数据中提取要处理的区域或其重要部分，以便获得所选择的3D图像数据。然后根据位置和尺寸对所获得的电解剖3D图像数据和所选择的3D图像数据进行分类，并且例如在导管消融期间相邻地可视化。本发明的方法和相关装置使得在使用心脏中的导管时能够改善操作者的取向。

27. 发明申请

US20070247476A1 Fast smooth up-sampling of binary volumes derived from medical imaging 审中-公开
标题翻译：从医学成像衍生的二进制体积的快速平滑上采样
公开(公告)号：US20070247476A1
公开(公告)日：2007-10-25
申请号：US11699188
申请日：2007-01-29
申请人： Liron Yatziv , Yiyong Sun , Chenyang Xu
发明人： Liron Yatziv , Yiyong Sun , Chenyang Xu
IPC分类号： G09G5/00
CPC分类号： G06T3/4023
摘要： This invention describes a computer method of up-sampling (enlarging) a binary volume where the shapes and regions in the final up-sampled volume have smooth shapes and regions without the jagged edges exhibited in the up-sampled volumes processed by conventional methods. This up-sampling method is suitable for any multi-dimensional binary volumes including 3 dimensional medical imaging data.
摘要翻译：本发明描述了一种二进制体积的上采样（放大）的计算机方法，其中最终上采样体积中的形状和区域具有平滑形状和区域，而在通过常规方法处理的上采样体积中没有锯齿状边缘。该采样方法适用于包括三维医学成像数据的任何多维二进制体积。

28. 发明申请

US20060159342A1 Multilevel image segmentation 有权
标题翻译：多级图像分割
公开(公告)号：US20060159342A1
公开(公告)日：2006-07-20
申请号：US11313102
申请日：2005-12-20
申请人： Yiyong Sun , Herve Lombaert , Leo Grady , Chenyang Xu
发明人： Yiyong Sun , Herve Lombaert , Leo Grady , Chenyang Xu
IPC分类号： G06K9/34
CPC分类号： G06T7/0081 , G06K9/342 , G06T7/11 , G06T7/162 , G06T7/174 , G06T2207/20016 , G06T2207/20036 , G06T2207/20101 , G06T2207/30048
摘要： A multilevel image segmentation technique using graph cuts is disclosed. A reduced resolution image is generated from a full resolution image which is to be segmented. The reduced resolution image is then segmented in order to identify a boundary between an object and a background within the image. The identified boundary then identifies a portion of an increased resolution image which is segmented in order to refine the earlier identified boundary. The steps may be iterated for successively increasing image resolutions in order to refine the boundary as required by a particular application. An initial identification of object and background portions of the image may be provided as input by a user. Alternatively, a user may identify only the object portion, and the background portion may be automatically determined.
摘要翻译：公开了使用图形切割的多级图像分割技术。从要分割的全分辨率图像生成缩小分辨率图像。然后将分辨率降低的图像分割以识别图像内的对象和背景之间的边界。所识别的边界然后识别分段的增加的分辨率图像的一部分，以便改进先前识别的边界。可以迭代步骤以连续增加图像分辨率，以便根据特定应用的要求来细化边界。图像的对象和背景部分的初始识别可以被提供为用户的输入。或者，用户可以仅标识对象部分，并且背景部分可以被自动确定。

29. 发明申请

US20060159323A1 System and method for automatically registering three dimensional cardiac images with electro-anatomical cardiac mapping data 有权
标题翻译：用于自动记录三维心脏图像与电解剖心脏图像数据的系统和方法
公开(公告)号：US20060159323A1
公开(公告)日：2006-07-20
申请号：US11330633
申请日：2006-01-12
申请人： Yiyong Sun , Fred Azar , Chenyang Xu , Frank Sauer , Norbert Rahn
发明人： Yiyong Sun , Fred Azar , Chenyang Xu , Frank Sauer , Norbert Rahn
IPC分类号： G06K9/00 , G06K9/32
CPC分类号： A61B5/0035 , A61B5/042 , A61B5/055 , A61B6/03 , G06T7/33 , G06T2207/30048
摘要： A system and method for automatically registering a three dimensional (3D) pre-operative image of an anatomical structure with intra-operative electrophysiological (EP) points of a 3D electro-anatomical (EA) image map of the anatomical structure is disclosed. The pre-operative image is displayed in a first supporting view. The intra-operative EA image map is displayed in a second supporting view. An alignment of the pre-operative image with the intra-operative map is performed by identifying at least one corresponding point on each image. The view of the pre-operative image is integrated with the EA map based on the alignment.
摘要翻译：公开了一种用于自动登记解剖结构的三维（3D）术前图像的解剖结构的3D电解剖（EA）图像的手术电生理（EP）点的系统和方法。术前图像显示在第一支持视图中。术中EA图像映射显示在第二支持视图中。通过识别每个图像上的至少一个对应点来执行术前图像与手术前图像的对准。基于对齐，将术前图像的视图与EA图集成。

30. 发明申请

US20050249434A1 Fast parametric non-rigid image registration based on feature correspondences 失效
标题翻译：基于特征对应的快速参数非刚性图像配准
公开(公告)号：US20050249434A1
公开(公告)日：2005-11-10
申请号：US11099143
申请日：2005-04-05
申请人： Chenyang Xu , Xiaolei Huang , Yiyong Sun
发明人： Chenyang Xu , Xiaolei Huang , Yiyong Sun
IPC分类号： G06K9/00 , G06K9/32 , G06K9/64
CPC分类号： G06K9/6211
摘要： A method and system for non-rigidly registering a fixed to a moving image utilizing a B-Spline based free form deformation (FFD) model is disclosed. The methodology utilizes sparse feature correspondences to estimate an elastic deformation field in a closed form. In a multi-resolution manner, the method is able to recover small to large non-rigid deformations. The resulting deformation field is globally smooth and guarantees one-to-one mapping between the images being registered. The method generally comprises the steps of: detecting feature points on the fixed image and feature points on the moving image; assigning a feature vector to each feature point; calculating the dissimilarity of each pair of feature vectors for feature pairs on the fixed image and the moving image; calculating the correspondence between feature pairs based on the dissimilarity measure; solving for a dense deformation field P using a closed form FFD model; and transforming the moving image and the feature points on the moving image using a current FFD deformation field estimate.
摘要翻译：公开了一种使用B-Spline的自由形状变形（FFD）模型非固定地将固定到运动图像上的方法和系统。该方法利用稀疏特征对应来估计封闭形式的弹性变形场。以多分辨率方式，该方法能够恢复小到大的非刚性变形。所产生的变形场全局平滑，并保证要注册的图像之间的一对一映射。该方法通常包括以下步骤：检测固定图像上的特征点和运动图像上的特征点; 向每个特征点分配特征向量; 计算固定图像和运动图像上特征对的每对特征向量的不相似性; 基于不相似度计算特征对之间的对应关系; 使用封闭形式的FFD模型求解致密变形场P; 以及使用当前FFD变形场估计来变换运动图像上的运动图像和特征点。

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