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21. 发明申请

US20110136225A1 BIOREACTOR, DEVICES, SYSTEMS AND METHODS 有权
标题翻译：生物反应器，设备，系统和方法
公开(公告)号：US20110136225A1
公开(公告)日：2011-06-09
申请号：US12961309
申请日：2010-12-06
申请人： Gordana Vunjak-Novakovic , Warren Grayson , Qun Wan , Donald Freytes , Amandine Godier-Furnémont , Nina Tandon , Keith Yeager , George Eng , Sarindr Bhumiratana , Robert Maidhof
发明人： Gordana Vunjak-Novakovic , Warren Grayson , Qun Wan , Donald Freytes , Amandine Godier-Furnémont , Nina Tandon , Keith Yeager , George Eng , Sarindr Bhumiratana , Robert Maidhof
IPC分类号： C12N5/071 , C12M3/00 , C12M1/34
CPC分类号： C12M23/44 , C12M21/08 , C12M23/42 , C12M23/46 , C12M23/58 , C12M25/14 , C12M29/10 , C12M29/20 , C12M35/02 , C12M41/46 , C12M41/48
摘要： Disclosed are bioreactor devices, systems and methods. A bioreactor system can include one or more bioreactor modules that can be individually controllable and identifiable. A bioreactor module can be connected to one or more functional modules such as a pump module, a stimulation signal generation module, a motor module, a mechanical transmission module, a gas exchange module, a temperature module, a humidity module and/or a CO2 module, among others. The bioreactor and functional modules can include standard or universal connectors to facilitate connection and movement of modules. The bioreactor system can be controlled and/or monitored by a controller that can individually identify and control each connected module and that can be adapted to collect signal data from sensors embedded in any of the modules.
摘要翻译：公开了生物反应器装置，系统和方法。生物反应器系统可以包括可以单独控制和可识别的一个或多个生物反应器模块。生物反应器模块可以连接到一个或多个功能模块，例如泵模块，刺激信号发生模块，马达模块，机械传动模块，气体交换模块，温度模块，湿度模块和/或二氧化碳模块等。生物反应器和功能模块可以包括标准或通用连接器，以便于模块的连接和移动。生物反应器系统可以被控制器控制和/或监控，所述控制器可以单独地识别和控制每个连接的模块，并且可以适于从嵌入在任何模块中的传感器收集信号数据。

22. 发明授权

US07252982B2 Tissue engineering enhanced by the transfer of a growth factor gene 失效
标题翻译：通过转移生长因子基因增强组织工程
公开(公告)号：US07252982B2
公开(公告)日：2007-08-07
申请号：US09809456
申请日：2001-03-15
申请人： Henning Madry , Gordana Vunjak-Novakovic , Stephen B. Trippel , Lisa E. Freed , Robert Langer
发明人： Henning Madry , Gordana Vunjak-Novakovic , Stephen B. Trippel , Lisa E. Freed , Robert Langer
IPC分类号： C12N11/08 , C12N5/06 , C12N5/00 , C12N5/02 , C12M1/00
CPC分类号： C12N5/0655 , A61K35/12 , C12N5/0068 , C12N2501/105 , C12N2510/00 , C12N2533/40
摘要： Tissue engineered constructs including a matrix and cells transfected with a gene for a growth factor. The constructs may be implanted into a tissue site, where the growth factor gene enhances a metabolic function furthering integration of the construct in the tissue site. If the matrix is biodegradable, the metabolic result may include resorption of the matrix and replacement with tissue synthesized at least in part by the transfected cells.
摘要翻译：包括基质和用生长因子的基因转染的细胞的组织工程构建体。构建体可以植入组织部位，其中生长因子基因增强代谢功能，进一步促进构建体在组织部位的整合。如果基质是可生物降解的，代谢结果可能包括基质的吸收和至少部分由转染的细胞合成的组织置换。

23. 发明授权

US09687348B2 Method of making a personalized bone graft 有权
公开(公告)号：US09687348B2
公开(公告)日：2017-06-27
申请号：US13148735
申请日：2010-03-03
申请人： Gordana Vunjak-Novakovic , Warren L. Grayson , Keith Yeager
发明人： Gordana Vunjak-Novakovic , Warren L. Grayson , Keith Yeager
IPC分类号： C12M3/00 , A61F2/30 , A61F2/28 , C12M1/12 , C12M1/00
CPC分类号： A61F2/28 , A61F2/30942 , A61F2/3099 , A61F2002/30957 , C12M21/08 , C12M25/14 , C12M29/10
摘要： An anatomically-shaped, human bone graft may be cultivated ex vivo using a bioreactor capable of perfusing large complex porous scaffolds. Scaffolds derived from image-based modeling of a target are seeded with human mesenchymal stem cells and cultivated. A bioreactor configured to house complex three-dimensional scaffold geometries provides controlled flow for perfusion of the cells. Dense uniform cellular growth can be attained throughout the entire scaffold as a result of the medium perfusion. In an embodiment, the bioreactor has a mold into which perfusion medium is pumped under pressure and multiple ports through which the medium exits the mold.

24. 发明申请

US20050222687A1 Cartilage implant assembly and method for implantation 审中-公开
标题翻译：软骨植入物组装及植入方法
公开(公告)号：US20050222687A1
公开(公告)日：2005-10-06
申请号：US10815778
申请日：2004-04-02
申请人： Gordana Vunjak-Novakovic , Katherine Truncale , Moon Hae Sunwoo , Arthur Gertzman , William Tomford
发明人： Gordana Vunjak-Novakovic , Katherine Truncale , Moon Hae Sunwoo , Arthur Gertzman , William Tomford
IPC分类号： A61F2/00 , A61F2/28 , A61F2/30 , A61L27/36 , A61L27/48
CPC分类号： A61F2/28 , A61B17/00491 , A61F2/30756 , A61F2/3094 , A61F2/3859 , A61F2/4644 , A61F2002/2817 , A61F2002/2839 , A61F2002/2867 , A61F2002/30004 , A61F2002/30062 , A61F2002/30112 , A61F2002/30113 , A61F2002/30121 , A61F2002/30125 , A61F2002/30136 , A61F2002/30153 , A61F2002/30179 , A61F2002/30224 , A61F2002/30225 , A61F2002/30228 , A61F2002/3028 , A61F2002/30759 , A61F2002/30764 , A61F2002/4635 , A61F2210/0004 , A61F2230/0004 , A61F2230/0006 , A61F2230/0008 , A61F2230/0019 , A61F2230/0058 , A61F2230/0063 , A61F2230/0069 , A61F2250/0014 , A61F2310/00365 , A61F2310/00383 , A61L27/3608 , A61L27/3612 , A61L27/3654 , A61L27/3683 , A61L27/48 , A61L27/52 , A61L2430/06
摘要： The invention is directed toward a cartilage repair assembly comprising a shaped structure of subchondral bone with an integral overlying cartilage cap which is treated to remove cellular debris and proteoglycans and milled cartilage in a bioabsorbable carrier. The shaped structure is dimensioned to fit in a drilled bore in a cartilage defect area so that said shaped bone and cartilage cap when centered in the bore does not engage the side wall of the bore in an interference fit and is surrounded by milled cartilage and carrier. A method for inserting the assembly into a cartilage defect area is disclosed.
摘要翻译：本发明涉及一种软骨修复组件，其包括具有整体上覆软骨帽的软骨下骨的成形结构，其被处理以除去生物可吸收载体中的细胞碎片和蛋白聚糖和研磨的软骨。成形结构的尺寸适于装配在软骨缺损区域中的钻孔中，使得当在孔中心定位时所述成形的骨和软骨帽不会以过盈配合接合孔的侧壁并被碾磨的软骨和载体包围。公开了一种将组件插入软骨缺损区域的方法。

25. 发明申请

US20050112759A1 Application of electrical stimulation for functional tissue engineering in vitro and in vivo 有权
标题翻译：电刺激在体外和体内功能组织工程中的应用
公开(公告)号：US20050112759A1
公开(公告)日：2005-05-26
申请号：US10872577
申请日：2004-06-21
申请人： Milica Radisic , Hyoungshin Park , Robert Langer , Lisa Freed , Gordana Vunjak-Novakovic
发明人： Milica Radisic , Hyoungshin Park , Robert Langer , Lisa Freed , Gordana Vunjak-Novakovic
IPC分类号： A61F2/00 , A61N20060101 , C12N5/00 , C12N5/077 , C12N5/08
CPC分类号： C12N5/0658 , C12N2502/02 , C12N2502/1358 , C12N2529/00
摘要： The present invention provides new methods for the in vitro preparation of bioartificial tissue equivalents and their enhanced integration after implantation in vivo. These methods include submitting a tissue construct to a biomimetic electrical stimulation during cultivation in vitro to improve its structural and functional properties, and/or in vivo, after implantation of the construct, to enhance its integration with host tissue and increase cell survival and functionality. The inventive methods are particularly useful for the production of bioartificial equivalents and/or the repair and replacement of native tissues that contain electrically excitable cells and are subject to electrical stimulation in vivo, such as, for example, cardiac muscle tissue, striated skeletal muscle tissue, smooth muscle tissue, bone, vasculature, and nerve tissue.
摘要翻译：本发明提供了体外制备生物人造组织当量的新方法及其在体内植入后的增强整合。这些方法包括在体外培养过程中将组织构建物递送至仿生电刺激，以改善其结构和功能性质，和/或在植入该构建体后体内，以增强其与宿主组织的整合并增加细胞存活和功能。本发明的方法特别可用于生产生物人造等同物和/或修复和替换含有电可兴奋细胞的天然组织，并且在体内受到电刺激，例如心肌组织，条纹骨骼肌组织，平滑肌肉组织，骨骼，脉管系统和神经组织。

26. 发明申请

US20050064042A1 Cartilage implant plug with fibrin glue and method for implantation 审中-公开
标题翻译：具有纤维蛋白胶的软骨植入物塞和植入方法
公开(公告)号：US20050064042A1
公开(公告)日：2005-03-24
申请号：US10960960
申请日：2004-10-12
申请人： Gordana Vunjak-Novakovic , Katherine Ann Truncale , Moon Sunwoo , Arthur Gertzman
发明人： Gordana Vunjak-Novakovic , Katherine Ann Truncale , Moon Sunwoo , Arthur Gertzman
IPC分类号： A61B17/00 , A61F2/00 , A61F2/02 , A61F2/28 , A61F2/30 , A61F2/38 , A61K35/32 , A61L27/36 , A61L27/38 , A61L27/48 , A61L27/54 , A61L27/56
CPC分类号： A61K35/32 , A61B17/00491 , A61F2/30744 , A61F2/30756 , A61F2/3859 , A61F2002/2817 , A61F2002/2839 , A61F2002/2867 , A61F2002/30062 , A61F2002/30224 , A61F2002/30225 , A61F2002/30759 , A61F2210/0004 , A61F2230/0069 , A61F2310/00365 , A61F2310/00383 , A61K38/00 , A61K38/363 , A61K38/4833 , A61L24/0005 , A61L24/0015 , A61L27/3608 , A61L27/3612 , A61L27/3654 , A61L27/3687 , A61L27/38 , A61L27/48 , A61L27/54 , A61L27/56 , A61L2300/414 , A61L2300/43 , A61L2300/64 , A61L2430/06 , A61K2300/00
摘要： The invention is directed toward a cartilage repair assembly comprising a shaped structure of subchondral bone with an integral overlying cartilage cap which is treated to remove cellular debris and proteoglycans and milled cartilage in a bioabsorbable carrier. The shaped structure is dimensioned to fit in a drilled bore in a cartilage defect area so that said shaped bone and cartilage cap when centered in the bore does not engage the side wall of the bore and is positioned from the side wall of the bone a distance ranging from 10 microns to 1000 microns and is surrounded by milled cartilage and a fibrin thrombin glue. A method for inserting the assembly into a cartilage defect area is disclosed.
摘要翻译：本发明涉及一种软骨修复组件，其包括具有整体上覆软骨帽的软骨下骨的成形结构，其被处理以除去生物可吸收载体中的细胞碎片和蛋白聚糖和研磨的软骨。该成形结构的尺寸适于装配在软骨缺损区域中的钻孔中，使得当在孔中心定位时所述成形的骨和软骨帽不接合孔的侧壁并且从骨的侧壁定位一定距离范围从10微米到1000微米，被碾磨的软骨和纤维蛋白凝血酶胶包围。公开了一种将组件插入软骨缺损区域的方法。

27. 发明申请

US20050037952A1 Effect of bone morphogenetic proteins on engineered cartilage 审中-公开
标题翻译：骨形态发生蛋白对工程软骨的影响
公开(公告)号：US20050037952A1
公开(公告)日：2005-02-17
申请号：US10457248
申请日：2003-06-09
申请人： Lisa Freed , Keith Gooch , Donald Courter , Torsten Blunk , Alisha Sieminski , Gordana Vunjak-Novakovic
发明人： Lisa Freed , Keith Gooch , Donald Courter , Torsten Blunk , Alisha Sieminski , Gordana Vunjak-Novakovic
IPC分类号： A61L27/18 , A61L27/22 , A61L27/38 , A61L27/54 , A61K38/18
CPC分类号： A61L27/3817 , A61L27/18 , A61L27/227 , A61L27/3654 , A61L27/3852 , A61L27/54 , A61L2300/414 , A61L2430/06 , C08L67/04
摘要： Compositions and methods comprising at least one active agent chosen from TGF-P superfamily proteins, including BMPs, and GDFs for increasing the growth rate or modulating the development of engineered cartilage are disclosed. The compositions are useful in the treatment of osteoarthritis, cartilage defects, and in related tissue repair.
摘要翻译：公开了包含至少一种选自TGF-β超家族蛋白（包括BMP）的活性剂和用于增加生长速率或调节工程化软骨发育的GDF的组合物和方法。该组合物可用于治疗骨关节炎，软骨缺损和相关组织修复。

28. 发明授权

US06287340B1 Bioengineered anterior cruciate ligament 有权
公开(公告)号：US06287340B1
公开(公告)日：2001-09-11
申请号：US09312203
申请日：1999-05-14
申请人： Gregory Altman , David Kaplan , Gordana Vunjak-Novakovic , Ivan Martin
发明人： Gregory Altman , David Kaplan , Gordana Vunjak-Novakovic , Ivan Martin
IPC分类号： A61F208
CPC分类号： C12M35/04 , A61F2/08 , A61L27/3604 , A61L27/3691 , A61L27/38 , A61L2430/10 , C12M21/08 , C12M25/14 , Y10S623/901
摘要： The present invention provides a method for producing an anterior cruciate ligament ex vivo. The method comprises seeding pluripotent stem cells in a three dimensional matrix, anchoring the seeded matrix by attachment to two anchors, and culturing the cells within the matrix under conditions appropriate for cell growth and regeneration, while subjecting the matrix to one or more mechanical forces via movement of one or both of the attached anchors. Bone marrow stromal cells are preferably used as the pluripotent cells in the method. Suitable matrix materials are materials to which cells can adhere, such as a gel made from collagen type I. Suitable anchor materials are materials to which the matrix can attach, such as Goinopra coral and also demineralized bone. Optimally, the mechanical forces to which the matrix is subjected mimic mechanical stimuli experienced by an anterior cruciate ligament in vivo. This is accomplished by delivering the appropriate combination of tension, compression, torsion, and shear, to the matrix. The bioengineered ligament which is produced by this method is characterized by a cellular orientation and/or matrix crimp pattern in the direction of the applied mechanical forces, and also by the production of collagen type I, collagen type III, and fibronectin proteins along the axis of mechanical load produced by the mechanical forces. Optimally, the ligament produced has fiber bundles which are arranged into a helical organization. The method for producing an anterior cruciate ligament can be adapted to produce a wide range of tissue types ex vivo by adapting the anchor size and attachment sites to reflect the size of the specific type of tissue to be produced, and also adapting the specific combination of forces applied, to mimic the mechanical stimuli experienced in vivo by the specific type of tissue to be produced. The methods of the present invention can be further modified to incorporate other stimuli experienced in vivo by the particular developing tissue, some examples of the stimuli being chemical stimuli, and electro-magnetic stimuli. Some examples of tissue which can be produced include other ligaments in the body (hand, wrist, elbow, knee), tendon, cartilage, bone, muscle, and blood vessels.

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