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21. 发明授权

US06945951B1 Thrombectomy catheter and system 失效
标题翻译：血栓切除导管及系统
公开(公告)号：US06945951B1
公开(公告)日：2005-09-20
申请号：US09930796
申请日：2001-08-16
申请人： Michael J. Bonnette , John Edward Morris , Steven E. Wiesel , John B. Bridgeman , Debra M. Kozak , Rosemary C. Beaupre , Mark L. Jenson , Cindy M. Setum , Robert C. Dutcher
发明人： Michael J. Bonnette , John Edward Morris , Steven E. Wiesel , John B. Bridgeman , Debra M. Kozak , Rosemary C. Beaupre , Mark L. Jenson , Cindy M. Setum , Robert C. Dutcher
IPC分类号： A61B17/22 , A61B17/32 , A61M1/00 , A61B17/20
CPC分类号： A61B17/32037 , A61B17/3203 , A61M1/0084
摘要： Cross stream thrombectomy catheter and system for fragmentation and removal of thrombus or other material from blood vessels or other body cavities. High velocity saline jets emitted from a toroidal loop jet emanator or other jet emanator in a catheter distal end entrain fluid through inflow orifices, and with flow resistances create a back-pressure which drives cross stream streams through outflow orifices in a radial direction and thence radially and circumferentially to apply normal and drag forces on thrombotic deposits or lesions in the blood vessel or other body cavity, thereby breaking apart and transporting thrombus particles to be entrained through the inflow orifices, whereupon the high velocity jets macerate the thrombus particles which then transit an exhaust lumen or recirculate again via the outflow orifices.
摘要翻译：交叉流血栓切除术导管和用于从血管或其他体腔破裂和去除血栓或其他材料的系统。从导管远端的环形环喷射发生器或其他喷射发射器发射的高速盐水喷射器通过流入孔夹带流体，并且流动阻力产生背压，该背压驱动跨径流通过径向流出孔，并周向地将正常和牵引力施加在血管或其它体腔中的血栓形成沉积物或病变上，从而分离和输送通过流入孔夹带的血栓颗粒，于是高速喷射器将血栓颗粒浸入，排气腔或再次通过外流孔再循环。

22. 发明授权

US06805684B2 Thrombectomy catheter and system 失效
公开(公告)号：US06805684B2
公开(公告)日：2004-10-19
申请号：US09930795
申请日：2001-08-16
申请人： Michael J. Bonnette , John Edward Morris , Steven E. Wiesel , John B. Bridgeman , Debra M. Kozak , Rosemary C. Beaupre , Mark L. Jenson , Cindy M. Setum , Robert C. Dutcher
发明人： Michael J. Bonnette , John Edward Morris , Steven E. Wiesel , John B. Bridgeman , Debra M. Kozak , Rosemary C. Beaupre , Mark L. Jenson , Cindy M. Setum , Robert C. Dutcher
IPC分类号： A61B1720
CPC分类号： A61B17/32037 , A61B17/3203 , A61M1/0084
摘要： Cross stream thrombectomy catheter and system for fragmentation and removal of thrombus or other material from blood vessels or other body cavities. High velocity saline jets emitted from a toroidal loop jet emanator or other jet emanator in a catheter distal end entrain fluid through inflow orifices, and with flow resistances create a back-pressure which drives cross stream streams through outflow orifices in a radial direction and thence radially and circumferentially to apply normal and drag forces on thrombotic deposits or lesions in the blood vessel or other body cavity, thereby breaking apart and transporting thrombus particles to be entrained through the inflow orifices, whereupon the high velocity jets macerate the thrombus particles which then transit an exhaust lumen or recirculate again via the outflow orifices.

23. 发明授权

US06676627B1 Crossflow thrombectomy catheter and system 失效
标题翻译：血栓切除导管及系统
公开(公告)号：US06676627B1
公开(公告)日：2004-01-13
申请号：US09417395
申请日：1999-10-13
申请人： Michael J. Bonnette , John Edward Morris , Steven E. Wiesel , John B. Bridgeman , Debra M. Kozak , Rosemary C. Beaupre , Mark L. Jenson , Cindy M. Setum , Robert C. Dutcher
发明人： Michael J. Bonnette , John Edward Morris , Steven E. Wiesel , John B. Bridgeman , Debra M. Kozak , Rosemary C. Beaupre , Mark L. Jenson , Cindy M. Setum , Robert C. Dutcher
IPC分类号： A61B1720
CPC分类号： A61B17/32037 , A61B17/3203 , A61M1/0084
摘要： Cross stream thrombectomy catheter and system for fragmentation and removal of thrombus or other material from blood vessels or other body cavities. High velocity saline jets emitted from a toroidal loop jet emanator or other jet emanator in a catheter distal end entrain fluid through inflow orifices, and with flow resistances create a back-pressure which drives cross stream streams through outflow orifices in a radial direction and thence radially and circumferentially to apply normal and drag forces on thrombotic deposits or lesions in the blood vessel or other body cavity, thereby breaking apart and transporting thrombus particles to be entrained through the inflow orifices, whereupon the high velocity jets macerate the thrombus particles which then transit an exhaust lumen or recirculate again via the outflow orifices.
摘要翻译：交叉流血栓切除术导管和用于从血管或其他体腔破裂和去除血栓或其他材料的系统。从导管远端的环形环喷射发生器或其他喷射发射器发射的高速盐水喷射器通过流入孔夹带流体，并且流动阻力产生背压，该背压驱动跨径流通过径向流出孔，并周向地将正常和牵引力施加在血管或其它体腔中的血栓形成沉积物或病变上，从而分离和输送通过流入孔夹带的血栓颗粒，于是高速喷射器将血栓颗粒浸入，排气腔或再次通过外流孔再循环。

24. 发明授权

US07572244B2 Miniature cross stream thrombectomy catheter 有权
标题翻译：微型交叉血栓切除术导管
公开(公告)号：US07572244B2
公开(公告)日：2009-08-11
申请号：US10910108
申请日：2004-08-02
申请人： Stephen E. Weisel , Michael J. Bonnette , Hieu V. Le , Debra M. Kozak
发明人： Stephen E. Weisel , Michael J. Bonnette , Hieu V. Le , Debra M. Kozak
IPC分类号： A61M1/00
CPC分类号： A61B17/32037 , A61B17/22 , A61B2017/22084 , Y10T29/49826
摘要： A miniature cross stream thrombectomy catheter useful in small blood vessel thrombectomy procedures. An annulus near the distal end of the miniature cross stream thrombectomy catheter is formed between a hypo-tube and a proximally directed bore of a concentrically aligned flow director whereby jet orifices in the hypo-tube communicate with the annulus to direct jet flows of saline or other fluid around and about the annulus and to be directed proximally from the annulus to pass through one or more outflow orifices and thence to pass through one or more inflow orifices thereby creating an ablation flow therebetween which loosens and carries away thrombotic materials from the walls of a blood vessel.
摘要翻译：一种用于小血管血栓切除手术的小型交叉血栓血栓切除术导管。在微型交叉流血栓切除术导管的远端附近的环形成在同心对准的导流管的下管和近端定向的孔之间，其中下管中的喷射孔与环连通以引导盐水的流动围绕和围绕环的其它流体并且从环形物向近侧引导以通过一个或多个流出孔，并且从而穿过一个或多个流入孔，从而在其间产生消融流，从而从其壁的壁上松开并携带血栓形成材料血管

25. 发明授权

US06719718B2 Thrombectomy catheter and system 失效
公开(公告)号：US06719718B2
公开(公告)日：2004-04-13
申请号：US09930794
申请日：2001-08-16
申请人： Michael J. Bonnette , John Edward Morris , Steven E. Wiesel , John B. Bridgeman , Debra M. Kozak , Rosemary C. Beaupre , Mark L. Jenson , Cindy M. Setum , Robert C. Dutcher
发明人： Michael J. Bonnette , John Edward Morris , Steven E. Wiesel , John B. Bridgeman , Debra M. Kozak , Rosemary C. Beaupre , Mark L. Jenson , Cindy M. Setum , Robert C. Dutcher
IPC分类号： A61B1720
CPC分类号： A61B17/32037 , A61B17/3203 , A61M1/0084
摘要： Cross stream thrombectomy catheter and system for fragmentation and removal of thrombus or other material from blood vessels or other body cavities. High velocity saline jets emitted from a toroidal loop jet emanator or other jet emanator in a catheter distal end entrain fluid through inflow orifices, and with flow resistances create a back-pressure which drives cross stream streams through outflow orifices in a radial direction and thence radially and circumferentially to apply normal and drag forces on thrombotic deposits or lesions in the blood vessel or other body cavity, thereby breaking apart and transporting thrombus particles to be entrained through the inflow orifices, whereupon the high velocity jets macerate the thrombus particles which then transit an exhaust lumen or recirculate again via the outflow orifices.

26. 发明授权

US06764483B1 Thrombectomy catheter and system 失效
公开(公告)号：US06764483B1
公开(公告)日：2004-07-20
申请号：US09915875
申请日：2001-07-26
申请人： Michael J. Bonnette , John Edward Morris , Steven E. Wiesel , John B. Bridgeman , Debra M. Kozak , Rosemary C. Beaupre , Mark L. Jenson , Cindy M. Setum , Robert C. Dutcher
发明人： Michael J. Bonnette , John Edward Morris , Steven E. Wiesel , John B. Bridgeman , Debra M. Kozak , Rosemary C. Beaupre , Mark L. Jenson , Cindy M. Setum , Robert C. Dutcher
IPC分类号： A61M5178
CPC分类号： A61B17/32037 , A61B17/3203 , A61M1/0084
摘要： Cross stream thrombectomy catheter and system for fragmentation and removal of thrombus or other material from blood vessels or other body cavities. High velocity saline jets emitted from a toroidal loop jet emanator or other jet emanator in a catheter distal end entrain fluid through inflow orifices, and with flow resistances create a back-pressure which drives cross stream streams through outflow orifices in a radial direction and thence radially and circumferentially to apply normal and drag forces on thrombotic deposits or lesions in the blood vessel or other body cavity, thereby breaking apart and transporting thrombus particles to be entrained through the inflow orifices, whereupon the high velocity jets macerate the thrombus particles which then transit an exhaust lumen or recirculate again via the outflow orifices.

27. 发明授权

US06676637B1 Single operator exchange fluid jet thrombectomy method 有权
标题翻译：单操作者交换流体喷射血栓切除术
公开(公告)号：US06676637B1
公开(公告)日：2004-01-13
申请号：US09888454
申请日：2001-06-25
申请人： Michael J. Bonnette , Hieu V. Le , John Edward Morris , Stephen E. Weisel , Debra M. Kozak , Robert G. Dutcher
发明人： Michael J. Bonnette , Hieu V. Le , John Edward Morris , Stephen E. Weisel , Debra M. Kozak , Robert G. Dutcher
IPC分类号： A61M5178
CPC分类号： A61B17/32037 , A61B2090/034 , Y10T83/0443 , Y10T83/0453
摘要： A single operator exchange fluid jet thrombectomy method employing a single operator exchange fluid jet thrombectomy device having an outer catheter assembly and separable and exchangeable components in the form of an inner catheter assembly allowing functioning as a rheolytic thrombectomy catheter or as a crossflow thrombectomy catheter. The outer catheter assembly is common to any mode of usage and includes a guide catheter having a lumen through which a guidewire and the greater portion of a hypo-tube carrying a jet emanator and a flow director are passed and advanced. In the method, thrombus is dislodged, entrained, and broken into pieces by fluid jets and evacuated through the lumen of the guide catheter.
摘要翻译：单个操作者交换流体喷射血栓切除术方法，其使用具有外部导管组件的单个操作者交换流体喷射血栓切除装置，以及允许作为溶血性血栓切除术导管或横流血栓切除术导管起作用的内部导管组件形式的可分离和可更换部件。外导管组件对于任何使用模式都是共同的，并且包括具有内腔的引导导管，通过该导管将导丝和携带喷射发生器和导流器的下管的较大部分通过并前进。在该方法中，通过流体射流将血栓移出，夹带并分裂成碎片，并通过引导导管的内腔排出。

28. 发明授权

US06224570B1 Rheolytic thrombectomy catheter and method of using same 有权
标题翻译：溶血性血栓切除术导管及其使用方法
公开(公告)号：US06224570B1
公开(公告)日：2001-05-01
申请号：US09188633
申请日：1998-11-09
申请人： Hieu V. Le , Michael J. Bonnette , John Edward Morris , Steven E. Wiesel , Debra M. Kozak , Cindy M. Setum , Robert G. Dutcher
发明人： Hieu V. Le , Michael J. Bonnette , John Edward Morris , Steven E. Wiesel , Debra M. Kozak , Cindy M. Setum , Robert G. Dutcher
IPC分类号： A61M5178
CPC分类号： A61B17/32037 , A61B2090/034
摘要： A rheolytic thrombectomy catheter and method of using same to remove thrombus from a body vessel or other body cavity. Several embodiments are disclosed. All embodiments include an outer catheter having a lumen and an inner high pressure tube of a size to enable it to be passed through the lumen of the catheter. The distal end of the inner high pressure tube extends beyond the distal end of the catheter and carries a jet cap for directing one or more jets of saline proximally toward the distal end of the catheter. In some embodiments, the catheter has a distally located inwardly directed stationary stop and the inner high pressure tube includes a distally located outwardly directed transitional stop for engaging the inwardly directed stationary stop to thereby position the jet cap at a defined distance from the distal end of the catheter. In other embodiments, a stationary stop is located at the proximal end of the catheter and a transitional stop is carried on the proximal end of the inner high pressure tube. In the embodiments having the stationary and transitional stops located proximally, the inner high pressure tube includes a flow director at its distal end. In use, thrombus is dislodged, entrained, and broken into pieces by the saline jets and evacuated proximally through the lumen of the catheter.
摘要翻译：一种溶解性血栓切除术导管及其使用方法，从身体血管或其他体腔去除血栓。公开了几个实施例。所有实施例包括具有内腔和内部高压管的外导管，其尺寸使其能够穿过导管的内腔。内部高压管的远端延伸超过导管的远端，并且携带用于将一个或多个盐水向近端引导到导管的远端的喷射帽。在一些实施例中，导管具有远侧定位的向内指向的固定止动件，并且内部高压管包括远侧定位的向外指向的过渡止动件，用于接合向内指向的固定止动件，从而将喷射盖定位在距离导管。在其他实施例中，静止止动件位于导管的近端处，并且过渡停止件承载在内部高压管的近端上。在具有位于近侧的静止和过渡止动件的实施例中，内部高压管在其远端包括导流器。在使用中，血栓被移出，夹带并通过盐水喷射器破碎成碎片，并通过导管的内腔向近端排出。

29. 发明授权

US06755803B1 Single operator exchange fluid jet thrombectomy device 有权
标题翻译：单一操作者交换流体喷射血栓切除装置
公开(公告)号：US06755803B1
公开(公告)日：2004-06-29
申请号：US09888455
申请日：2001-06-25
申请人： Hieu V. Le , Michael J. Bonnette , John Edward Morris , Stephen E. Weisel , Debra M. Kozak , Robert G. Dutcher
发明人： Hieu V. Le , Michael J. Bonnette , John Edward Morris , Stephen E. Weisel , Debra M. Kozak , Robert G. Dutcher
IPC分类号： A61B1720
CPC分类号： A61B17/32037 , A61B2090/034 , Y10T83/0443 , Y10T83/0453
摘要： A single operator exchange fluid jet thrombectomy device having an outer catheter assembly and separable and exchangeable components in the form of an inner catheter assembly allowing functioning as a rheolytic thrombectomy catheter or as a crossflow thrombectomy catheter. Embodiments include an outer catheter assembly common to any mode of usage having a guide catheter having a lumen through which a guidewire and the greater portion of a hypo-tube carrying a flow director are passed and advanced. For use as a rheolytic thrombectomy catheter, thrombus is dislodged, entrained, and broken into pieces by jets and evacuated through the lumen of the guide catheter. For use as a crossflow thrombectomy catheter, a flow director having outflow and inflow orifices is provided.
摘要翻译：单个操作者交换流体喷射血栓切除装置，其具有外导管组件和内导管组件形式的可分离和可更换组件，其允许作为溶血性血栓切除术导管或横流血栓切除术导管。实施例包括与任何使用模式共同的外导管组件，其具有具有内腔的引导导管，引导线和携带导流器的下管的较大部分通过该内腔通过并前进。为了用作溶解性血栓切除术导管，血栓被移出，夹带并通过射流破碎成碎片，并通过导管的内腔排出。为了用作横流血栓切除术导管，提供了具有流出和流入孔的导流器。

30. 发明授权

US08475487B2 Cross stream thrombectomy catheter with flexible and expandable cage 有权
标题翻译：交叉流血栓切除导管具有弹性和可扩展的笼
公开(公告)号：US08475487B2
公开(公告)日：2013-07-02
申请号：US11101224
申请日：2005-04-07
申请人： Michael J. Bonnette , Eric J. Thor , Daniel T. Janse
发明人： Michael J. Bonnette , Eric J. Thor , Daniel T. Janse
IPC分类号： A61M29/00 , A61B17/22
CPC分类号： A61B17/320758 , A61B17/00234 , A61B17/320725 , A61B2017/22079 , A61B2017/22082 , A61B2017/320004 , A61B2217/005 , A61B2217/007
摘要： A cross stream thrombectomy catheter with a flexible and expandable cage preferably formed of nitinol for removal of hardened and aged thrombotic material stubbornly attached to the interior of a blood vessel. The cage, which can be mesh or of straight or spiral filament design, is located close to inflow and outflow orifices at the distal portion of a catheter tube and is deployed and extended at a thrombus site for intimate contact therewith and for action of a positionable assembly and subsequent rotation and lineal actuation to abrade, grate, scrape, or otherwise loosen and dislodge difficult to remove thrombus which can interact with cross stream flows to exhaust free and loosened thrombotic particulate through the catheter tube. An alternative embodiment discloses a mechanism involving a threaded tube in rotatable engagement with an internally threaded sleeve to incrementally control the deployment and expansion of the flexible and expandable cages.
摘要翻译：一种交叉流血栓切除术导管，其具有优选由镍钛诺形成的柔性和可膨胀的保持架，用于去除顽固地附着在血管内部的硬化和老化的血栓形成材料。可以是网状或直线或螺旋丝设计的笼子位于靠近导管管的远端部分处的流入和流出孔口，并且在血栓位置部署和延伸以与其紧密接触并且用于可定位的动作组装和随后的旋转和线性致动以磨擦，磨碎，刮擦或以其它方式松动和移除难以去除血栓，其可以与交叉流相互作用以通过导管管排出无松动和松动的血栓形成颗粒。替代实施例公开了一种机构，其涉及可旋转地与内螺纹套筒接合的螺纹管，以递增地控制柔性和可扩展笼的展开和膨胀。

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