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21. 发明申请

US20120193298A1 PLATFORM TECHNOLOGY FOR INDUSTRIAL SEPARATIONS 审中-公开
标题翻译：工业分离平台技术
公开(公告)号：US20120193298A1
公开(公告)日：2012-08-02
申请号：US13443282
申请日：2012-04-10
申请人： Meng H. Lean , Norine E. Chang , Ashutosh Kole , Jeonggi Seo
发明人： Meng H. Lean , Norine E. Chang , Ashutosh Kole , Jeonggi Seo
IPC分类号： B01D21/28 , B01D21/01 , C02F1/52
CPC分类号： B01D61/04 , B01D21/01 , B01D21/26 , B01D21/265 , B01D61/025 , B01D2311/04 , B01F5/0647 , B01F13/0059 , C02F1/001 , C02F1/52 , C02F9/00 , C02F2001/007 , C02F2301/026 , B01D2311/2676 , B01D2311/12
摘要： A method and system for treating a fluid stream includes inputting a fluid stream to an input section of the fluid treatment system and receiving the fluid stream via spiral mixer-conditioner. The spiral mixer-conditioner mixes and conditions the input stream. Thereafter the mixed and conditioned fluid stream is input to a spiral separator where the mixed and conditioned fluid stream is separated into at least two fluid streams, a first fluid stream having particulates in the input stream removed, and the second fluid stream having the particulates in the input fluid stream concentrated.
摘要翻译：用于处理流体流的方法和系统包括将流体流输入到流体处理系统的输入部分并经由螺旋混合器调节器接收流体流。螺旋混合器 - 调节器混合并调节输入流。此后，将混合和调节的流体流输入到螺旋分离器，其中混合和调节的流体流被分离成至少两个流体流，在输入流中除去具有微粒的第一流体流，并且具有颗粒的第二流体流输入流体流集中。

22. 发明申请

US20100314325A1 SPIRAL MIXER FOR FLOC CONDITIONING 审中-公开
标题翻译：螺旋搅拌机
公开(公告)号：US20100314325A1
公开(公告)日：2010-12-16
申请号：US12484005
申请日：2009-06-12
申请人： Meng H. Lean , Armin R. Volkel , Ashutosh Kole , Jeonggi Seo , Nitin S. Parekh
发明人： Meng H. Lean , Armin R. Volkel , Ashutosh Kole , Jeonggi Seo , Nitin S. Parekh
IPC分类号： C02F1/52 , C02F1/66
CPC分类号： C02F1/5281 , C02F1/38 , C02F1/52 , C02F1/66 , C02F9/00 , C02F2209/44
摘要： A system and method for treatment of water. An inlet is operative to receive source water having particles therein. A spiral mixer has a defined spiral channel operative to mix the source water with a coagulant material and an alkalinity material. The spiral mixer is formed to perform in-line coagulation and flocculation processes within the defined spiral channel to form aggregated floc particles. A buffer tank is operative to receive the aggregated floc particles from the spiral mixer. Spiral separator segregates contents of the buffer tank into affluent and waste water that has the aggregated floc particles therein. An outlet is operative to provide a first path for the affluent, and a second path for the waste water having the aggregated floc particles.
摘要翻译：一种处理水的系统和方法。入口可操作以接收其中具有颗粒的源水。螺旋混合器具有限定的螺旋通道，其操作以将源水与凝结剂材料和碱性物质混合。形成螺旋混合器以在限定的螺旋通道内进行在线凝结和絮凝过程以形成聚集的絮状颗粒。缓冲罐用于从螺旋混合器接收聚集的絮凝物颗粒。螺旋分离器将缓冲罐的内容物分离成富集和在其中具有聚集的絮凝物颗粒的废水。出口可操作以为富人提供第一路径，以及用于具有聚集的絮凝物颗粒的废水的第二路径。

23. 发明申请

US20100072142A1 METHOD AND SYSTEM FOR SEEDING WITH MATURE FLOC TO ACCELERATE AGGREGATION IN A WATER TREATMENT PROCESS 审中-公开
标题翻译：用于在水处理过程中加速成熟的方法和系统
公开(公告)号：US20100072142A1
公开(公告)日：2010-03-25
申请号：US12234373
申请日：2008-09-19
申请人： Meng H. Lean , Armin R. Volkel , Ashutosh Kole , Jeonggi Seo
发明人： Meng H. Lean , Armin R. Volkel , Ashutosh Kole , Jeonggi Seo
IPC分类号： C02F1/52 , B01D35/30
CPC分类号： C02F9/00 , B01D21/265 , C02F1/001 , C02F1/38 , C02F1/5236 , C02F1/56 , C02F1/66 , C02F2209/44
摘要： A system and method that uses mature floc as seed particles to promote aggregation in a water treatment process is provided. The seed particles do not need to be recovered as they separate out with the waste steam after a spiral separation. One implementation is to prepare the mature floc off-line and inject periodically into the buffer tank, as needed. Another implementation is to tap into the more mature floc downstream and feedback, as needed, to the buffer tank.
摘要翻译：提供了一种使用成熟絮体作为种子颗粒促进水处理过程中的聚集的系统和方法。种子颗粒在螺旋分离后与废蒸汽分离时不需要回收。一个实现是根据需要将成熟的絮凝物离线制备并定期注入缓冲罐。另一个实施方式是利用更成熟的絮凝物下游，并根据需要反馈给缓冲罐。

24. 发明申请

US20090114607A1 Fluidic Device and Method for Separation of Neutrally Buoyant Particles 审中-公开
标题翻译：用于分离中性浮力颗粒的流体装置和方法
公开(公告)号：US20090114607A1
公开(公告)日：2009-05-07
申请号：US11936729
申请日：2007-11-07
申请人： Meng H. Lean , Jeonggi Seo
发明人： Meng H. Lean , Jeonggi Seo
IPC分类号： B01D21/26 , B04C1/00
CPC分类号： B01D21/265 , B01D2221/10 , B03B5/626
摘要： A technique using a curved channel of a spiral device to introduce a centrifugal force upon neutrally buoyant particles flowing in a fluid, e.g. water, to facilitate improved separation of such particles from the fluid is provided. As these neutrally buoyant particles flow through the channel, a tubular pinch effect causes the particles to flow in a tubular band. The introduced centrifugal force perturbs the tubular band (e.g. forces the tubular band to flow in a manner offset from a center of the channel), resulting in an asymmetric inertial migration of the band toward the inner wall of the channel. This allows for focusing and compaction of suspended particulates into a narrow band for extraction. The separation principle contemplated herein implements a balance of the centrifugal and fluidic forces to achieve asymmetric inertial equilibrium near the inner sidewall.
摘要翻译：使用螺旋装置的弯曲通道的技术将离心力引导到在流体中流动的中性浮力颗粒，例如，水，以便于改善这种颗粒与流体的分离。当这些中性浮力的颗粒流过通道时，管状夹紧效应使颗粒在管状带中流动。引入的离心力扰乱管状带（例如迫使管状带以偏离通道中心的方式流动），导致带朝向通道内壁的不对称惯性迁移。这允许将悬浮颗粒聚焦并压实成窄带以进行萃取。本文考虑的分离原理实现离心和流体力的平衡，以在内侧壁附近实现不对称的惯性平衡。

25. 发明申请

US20090050538A1 Serpentine structures for continuous flow particle separations 有权
标题翻译：用于连续流动颗粒分离的蛇形结构
公开(公告)号：US20090050538A1
公开(公告)日：2009-02-26
申请号：US11606458
申请日：2006-11-30
申请人： Meng H. Lean , Ashutosh Kole , Jeonggi Seo
发明人： Meng H. Lean , Ashutosh Kole , Jeonggi Seo
IPC分类号： B03B5/00
CPC分类号： B01D21/265 , B01D21/0087 , B01D2221/10 , B01L3/502761
摘要： An improved technique for particle separation is provided. A serpentine structure is utilized in a continuous fluid flow environment to allow for suitable separation of particles to occur in a manner that does not require external application of forces to initiate the separation. The geometry of the serpentine structure and associated forces generated in connection with fluid flow therein suffice.
摘要翻译：提供了一种改进的颗粒分离技术。在连续流体流动环境中使用蛇形结构以允许以不需要外部施加力来开始分离的方式适当地分离颗粒。蛇形结构的几何形状和与流体流相关联的相关力足够。

26. 发明申请

US20080230458A1 Vortex structure for high throughput continuous flow separation 有权
标题翻译：用于高通量连续流分离的涡旋结构
公开(公告)号：US20080230458A1
公开(公告)日：2008-09-25
申请号：US11725358
申请日：2007-03-19
申请人： Meng H. Lean , Jeonggi Seo
发明人： Meng H. Lean , Jeonggi Seo
IPC分类号： B01D36/00 , B04C3/00
CPC分类号： B01D45/12 , B01D21/265 , B01D2221/10 , B03B5/32 , B04C1/00 , B04C5/26
摘要： A system to facilitate separation and concentration of particles based on centrifugal force on suspended particles, including biological matter, which are made to flow in a vortex structure is provided. The centrifugal force urges larger particles to collect along outer portions of the vortex flow. Conversely, within a vortex structure, a radial hydrodynamic pressure drop is also amplified to urge smaller particles toward inner portions of the vortex flow. This force created by the pressure can reach magnitudes that encourage a sharp cut-off and improved resolution discrimination between particle sizes. Thus, separated streams of particles can be collected with both increased concentration and purification.
摘要翻译：提供了一种用于基于离心力分离和浓缩颗粒的系统，所述悬浮颗粒（包括生物物质）被制成在涡流结构中流动。离心力促使较大的颗粒沿涡流的外部部分收集。相反，在涡流结构内，径向流体动压压降也被放大，以将较小的颗粒推向涡流的内部。由压力产生的这种力可以达到鼓励锐利截止和提高颗粒尺寸分辨率的大小。因此，分离的颗粒物流可以以增加的浓度和纯化收集。

27. 发明申请

US20080128332A1 Trapping structures for a particle separation cell 有权
标题翻译：用于颗粒分离池的捕获结构
公开(公告)号：US20080128332A1
公开(公告)日：2008-06-05
申请号：US11606457
申请日：2006-11-30
申请人： Meng H. Lean , Jeonggi Seo
发明人： Meng H. Lean , Jeonggi Seo
IPC分类号： B03B5/62 , B03B5/32
CPC分类号： B01D21/0042 , B01D21/006 , B01D21/2488 , B01L3/502761 , B01L2200/0668 , B01L2400/0424 , B01L2400/0496 , B03B5/00 , B03C5/005 , B03C5/028
摘要： Trapping structures are provided for particle separation devices that make use of traveling wave fluid flow. These trapping structures are operative to capture and collect separated particles and present them for extraction. The extraction can be accomplished in conventional manners, such as through the use of suitable sized pipettes.
摘要翻译：提供捕获结构用于利用行波流体流动的颗粒分离装置。这些捕获结构可操作以捕获和收集分离的颗粒并将其提供用于萃取。提取可以以常规方式实现，例如通过使用合适尺寸的移液管。

28. 发明申请

US20120135887A1 CELL HANDLING, ELECTROPORATION AND ELECTROFUSION IN MICROFLUIDIC SYSTEMS 审中-公开
标题翻译：微流体系统中的细胞处理，电化和电解
公开(公告)号：US20120135887A1
公开(公告)日：2012-05-31
申请号：US13291018
申请日：2011-11-07
申请人： Luke P. Lee , Jeonggi Seo , Cristian Ionescu-Zanetti , Michelle Khine , Adrian Lau
发明人： Luke P. Lee , Jeonggi Seo , Cristian Ionescu-Zanetti , Michelle Khine , Adrian Lau
IPC分类号： C40B30/06 , B29C33/38 , C40B60/14
CPC分类号： G01N33/48728 , B01L3/502707 , B01L3/502761 , B01L2200/0668 , B01L2400/0487 , C12M23/16 , C12M35/02 , C12N15/87
摘要： Method and systems provide improved cell handling in microfluidic systems and devices using lateral cell trapping and methods of fabrication of the same that allow for selective low voltage electroporation and electrofusion.
摘要翻译：方法和系统在使用横向细胞捕获的微流体系统和装置中提供改进的细胞处理以及允许选择性低电压电穿孔和电融合的制造方法。

29. 发明申请

US20110045582A1 METHODS AND APPARATUS FOR INTEGRATED CELL HANDLING AND MEASUREMENTS 审中-公开
标题翻译：用于整合细胞处理和测量的方法和装置
公开(公告)号：US20110045582A1
公开(公告)日：2011-02-24
申请号：US10598830
申请日：2005-03-14
申请人： Luke P. Lee , Jeonggi Seo , Cristian Ionescu-Zanetti , Michelle Khine , Poorya Sabounchi , Robin Shaw
发明人： Luke P. Lee , Jeonggi Seo , Cristian Ionescu-Zanetti , Michelle Khine , Poorya Sabounchi , Robin Shaw
IPC分类号： C12M1/42 , G01R19/00 , C23F1/00
CPC分类号： G01N33/48728 , B01L3/502707 , B01L3/502761 , B01L2200/0668 , B01L2200/12 , B01L2200/16 , B01L2300/0645 , B01L2300/0816 , B01L2300/0861 , B01L2300/0867 , B01L2400/049 , B01L2400/0655 , B29C33/3842 , B29C45/372
摘要： Method and systems that provide improved cell handling and assays in microfluidic systems and devices particularly using lateral cell trapping and methods of fabrication of the same.
摘要翻译：在微流体系统和装置中提供改进的细胞处理和测定的方法和系统，特别是使用横向细胞捕获及其制备方法。

30. 发明申请

US20070155016A1 METHOD AND APPARATUS FOR INTEGRATED CELL HANDLING AND MEASUREMENTS 有权
标题翻译：用于整合细胞处理和测量的方法和装置
公开(公告)号：US20070155016A1
公开(公告)日：2007-07-05
申请号：US11466104
申请日：2006-08-21
申请人： Luke Lee , Jeonggi Seo , Cristian Ionescu-Zanetti , Michelle Khine , Adrian Lau
发明人： Luke Lee , Jeonggi Seo , Cristian Ionescu-Zanetti , Michelle Khine , Adrian Lau
IPC分类号： C12N15/74 , C12M1/42 , C12N15/87
CPC分类号： G01N33/48728 , B01L3/502707 , B01L3/502761 , B01L2200/0668 , B01L2400/0487 , C12M23/16 , C12M35/02 , C12N15/87
摘要： Method and systems provide improved cell handling in microfluidic systems and devices using lateral cell trapping and methods of fabrication of the same that allow for selective low voltage electroporation and electrofusion.
摘要翻译：方法和系统在使用横向细胞捕获的微流体系统和装置中提供改进的细胞处理以及允许选择性低电压电穿孔和电融合的制造方法。

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