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21. 发明授权

US5823942A Endoscope with surface and deep portion imaging systems 失效
公开(公告)号：US5823942A
公开(公告)日：1998-10-20
申请号：US898011
申请日：1997-07-25
申请人： Masahiro Toida
发明人： Masahiro Toida
IPC分类号： A61B1/04 , A61B5/00 , G01B9/02 , G01B9/04
CPC分类号： G01B9/02004 , A61B1/063 , A61B1/07 , A61B5/0084 , A61B5/1459 , G01B9/02003 , G01B9/02007 , G01B9/02028 , G01B9/0205 , G01B9/04 , A61B1/00172 , A61B1/0638 , A61B5/0073 , G01B2290/70
摘要： A deep portion visualizing endoscope comprises a flexible fiber bundle, into which a laser beam produced by a frequency-sweep single frequency laser beam source is entered. The laser beam is irradiated from a radiating end of the fiber bundle to the region inside of a sample to be viewed, and is reflected from reflection planes of the sample. The reflected laser beam interferes with a laser beam, which has been split from the laser beam before being reflected from the reflection planes and which has traveled by a predetermined optical path length, and an image signal is thereby obtained. The image signal is composed of a plurality of difference-frequency beat signals such that the frequencies, at which the signal intensities repeatedly become high and low, may vary in accordance with the difference between depths of the reflection planes from the inner surface of the sample. A beat signal, the intensity of which repeatedly becomes high and low at a predetermined frequency, is then discriminated from the image signal. An image of a reflection plane at a specific depth is reproduced from the discriminated beat signal.

22. 发明授权

US5526118A Apparatus for obtaining refractive index distribution information of light scattering media 失效
$Apparatus for obtaining refractive index distribution information of light scattering media$
标题翻译：用于获得光散射介质的折射率分布信息的装置
公开(公告)号：US5526118A
公开(公告)日：1996-06-11
申请号：US350471
申请日：1994-12-07
申请人： Ichirou Miyagawa , Masahiro Toida
发明人： Ichirou Miyagawa , Masahiro Toida
IPC分类号： G01N21/17 , G01N21/41 , G01N21/45 , G01B9/02
CPC分类号： G01N21/41
摘要： A superheterodyne split-beam system is used to measure the refractive index distribution associated with a light scattering medium. Initially, a coherent light beam is split into a first reference light beam and a second light beam. The second light beam is passed through a light scattering medium. Scattered and unscattered portions of the second light beam are separated using the characteristic that the scattered light travels by a longer optical path length than the unscattered light. The first light beam is recombined with the unscattered light beam, and the associated optical path difference is measured. Using the difference between the calculated path difference and a predetermined reference path difference, as well as the thickness of the scattering medium, refractive indices are measured. The use of a photodetector array allows for determining a distribution of the refractive indexes of the inclusions at various portions of the medium.
摘要翻译：超外差分束系统用于测量与光散射介质相关的折射率分布。最初，相干光束被分成第一参考光束和第二光束。第二光束通过光散射介质。使用散射光行进的特性比不散射光更长的光程长度分离第二光束的散射和未散射部分。第一光束与未散射光束重新组合，并且测量相关联的光程差。使用计算的路径差和预定参考路径差之间的差以及散射介质的厚度来测量折射率。使用光电检测器阵列允许确定介质的各个部分处的夹杂物的折射率分布。

23. 发明授权

US07450242B2 Optical tomography apparatus 有权
标题翻译：光学断层摄影装置
公开(公告)号：US07450242B2
公开(公告)日：2008-11-11
申请号：US11535361
申请日：2006-09-26
申请人： Masahiro Toida , Yoshikatsu Morishima , Kazuhiro Tsujita , Hiroshi Fujita
发明人： Masahiro Toida , Yoshikatsu Morishima , Kazuhiro Tsujita , Hiroshi Fujita
IPC分类号： G01B9/02
CPC分类号： G01B9/02004 , A61B5/0066 , A61B5/0071 , A61B5/0073 , A61B5/0084 , A61B5/0086 , G01B9/02003 , G01B9/02014 , G01B9/02044 , G01B9/02091 , G01J3/10 , G01N21/4795
摘要： Low coherence light having a central wavelength λc of 1.1 μm and a full width at half maximum spectrum Δλ of 90 nm is emitted. The low coherence light has wavelength properties suited for the light absorbing properties, the diffusion properties, and the dispersion properties of living tissue. A light dividing means divides the low coherence light into a measuring light beam, which is irradiated onto a measurement target via an optical probe, and a reference light beam that propagates toward an optical path length adjusting means. A multiplexing means multiplexes a reflected light beam, which is the measuring light beam reflected at a predetermined depth of the measurement target, and the reference light beam, to form coherent light. A coherent light detecting means detects the optical intensity of the multiplexed coherent light. An image obtaining means performs image processes, and displays an optical tomographic image on a display apparatus.
摘要翻译：发射具有1.1μm的中心波长lambdac和半峰全宽度的低相干光，发射90nm的Deltalambda。低相干光具有适合于吸光性能，扩散性能和生物体组织的分散性能的波长特性。光分割装置将低相干光分成通过光学探针照射到测量对象上的测量光束和朝向光程长度调节装置传播的参考光束。多路复用装置将作为在测量对象的预定深度处反射的测量光束的反射光和参考光束进行多路复用，以形成相干光。相干光检测装置检测多路复用相干光的光强度。图像获取装置执行图像处理，并在显示装置上显示光学断层图像。

24. 发明申请

US20070159637A1 Optical tomography system 审中-公开
标题翻译：光学断层扫描系统
公开(公告)号：US20070159637A1
公开(公告)日：2007-07-12
申请号：US11540653
申请日：2006-10-02
申请人： Masahiro Toida
发明人： Masahiro Toida
IPC分类号： G01B9/02 , G01J3/45
CPC分类号： G01B9/02044 , A61B5/0066 , A61B5/6852 , G01B9/02003 , G01B9/02048 , G01B9/02091 , G01B2290/45 , G01N21/4795
摘要： In an optical tomography system, interference light is detected and a controller switches between a measurement initiating position adjusting mode and a tomographic image obtaining mode. The interference light is detected by an interference light detecting system including a spectral system which spectrally divides the interference light, a first optical system formed of a plurality of photo-sensors which detects the interference light by the wavelength band and a second optical system detecting a part interference light at a wavelength band which is a part of the whole wavelength band of the spectrally divided interference light in the measurement initiating position adjusting mode. The controller controls the interference light detecting system to detect the interference light with the first optical system in the image obtaining mode and with the second optical system in the measurement initiating position adjusting mode.
摘要翻译：在光学断层摄影系统中，检测到干涉光，并且控制器在测量起始位置调整模式和断层图像获取模式之间切换。干涉光由包括光谱分割干涉光的光谱系统的干涉光检测系统检测出，由多个光传感器形成的第一光学系统，该光传感器通过波长带检测干涉光，第二光学系统检测出在测量起始位置调整模式下，作为光谱分割干涉光的整个波长带的一部分的波长带的部分干涉光。控制器控制干涉光检测系统，以在图像获得模式中检测与第一光学系统的干涉光，并在第二光学系统中测量起始位置调整模式。

25. 发明申请

US20070076221A1 Optical tomography system 审中-公开
标题翻译：光学断层扫描系统
公开(公告)号：US20070076221A1
公开(公告)日：2007-04-05
申请号：US11529523
申请日：2006-09-29
申请人： Masahiro Toida
发明人： Masahiro Toida
IPC分类号： G01B9/02 , G01B11/02
CPC分类号： G01B9/02004 , A61B5/0066 , A61B5/0073 , A61B5/0084 , A61B5/0086 , A61B2562/0242 , G01B9/02003 , G01B9/02048 , G01B9/02091 , G01N21/39 , G01N21/4795 , G01N2021/1787
摘要： In an optical coherence tomography measurement, interference light of the reflected light of the measuring light from the object and the reference light obtained by dividing light emitted from a light source unit is detected. A controller switches between a measurement initiating position adjusting mode in which the position in the direction of depth of the object in which tomographic image signal is to be obtained is adjusted and a tomographic image obtaining mode in which a tomographic image of the object is to be obtained. The controller controls the tomographic image to be obtained from the interference light generated by the laser light in the image obtaining mode and controls the tomographic image to be obtained from the interference light generated by the low coherence light in the measurement initiating position adjusting mode.
摘要翻译：在光学相干断层摄影测量中，检测来自物体的测量光的反射光的干涉光和通过分割从光源单元发射的光获得的参考光。控制器在测量开始位置调整模式之间切换，其中调整要获取断层图像信号的对象的深度方向上的位置，以及其中该对象的断层图像将成为的断层图像获取模式获得。控制器根据图像获取模式中由激光产生的干涉光控制断层图像，并且在测量起始位置调整模式中控制从由低相干光产生的干涉光获得的断层图像。

26. 发明申请

US20070076219A1 Optical tomography system 审中-公开
标题翻译：光学断层扫描系统
公开(公告)号：US20070076219A1
公开(公告)日：2007-04-05
申请号：US11529234
申请日：2006-09-29
申请人： Masahiro Toida
发明人： Masahiro Toida
IPC分类号： G01B9/02 , G01B11/02
CPC分类号： G01B9/02009 , A61B5/0066 , A61B5/0073 , A61B5/6852 , G01B9/02003 , G01B9/02044 , G01B9/02048 , G01B9/02068 , G01B9/02091
摘要： In an optical coherence tomography measurement, a controller switches between a measurement initiating position adjusting mode in which the position in the direction of depth of the object in which a tomographic image signal is to be obtained is adjusted and a tomographic image obtaining mode in which a tomographic image of the object is to be obtained. In the image obtaining mode, the tomographic image is obtained from the interference light by the first low coherence light and in the measurement initiating position adjusting mode, the tomographic image is obtained from the interference light by the second low coherence light.
摘要翻译：在光学相干断层摄影测量中，控制器在测量起始位置调整模式之间切换，其中调整要获得断层图像信号的物体的深度方向上的位置，以及断层图像获取模式，其中要获得对象的断层图像。在图像获取模式中，通过第一低相干光从干涉光获得断层图像，并且在测量起始位置调整模式中，通过第二低相干光从干涉光获得断层图像。

27. 发明申请

US20070076215A1 Optical tomography system 审中-公开
标题翻译：光学断层扫描系统
公开(公告)号：US20070076215A1
公开(公告)日：2007-04-05
申请号：US11529424
申请日：2006-09-29
申请人： Masahiro Toida
发明人： Masahiro Toida
IPC分类号： G01B11/02 , G01B9/02
CPC分类号： A61B5/0073 , A61B5/0066 , G01B9/02003 , G01B9/02004 , G01B9/02048 , G01B9/02068 , G01B9/02091 , G01N21/4795
摘要： In an optical coherence tomography measurement, interference light of the reflected light of the measuring light from the object and the reference light is detected. A controller switches between a measurement initiating position adjusting mode and a tomographic image obtaining mode. A light source which emits light having a predetermined wavelength band is provided and the wavelength emitted from the light source is selected. The controller controls so that a laser beam is emitted while the wavelength is swept at a predetermined period and the tomographic image signal is obtained on the basis of the interference light by the laser beam in the image obtaining mode, while controls so that light of a predetermined wavelength is emitted and the tomographic image signal is obtained on the basis of the interference light by the light of a predetermined wavelength in the measurement initiating position adjusting mode.
摘要翻译：在光学相干断层摄影测量中，检测来自物体的测量光的反射光和参考光的干涉光。控制器在测量起始位置调整模式和断层图像获取模式之间切换。提供发射具有预定波长带的光的光源，并且从光源发射的波长被选择。控制器控制使得在波长以预定周期扫描的同时发射激光束，并且基于图像获得模式中的激光束的干涉光获得断层图像信号，同时控制使得在测量起始位置调整模式中，基于预定波长的光的干涉光，发射预定波长并且获得断层图像信号。

28. 发明授权

US06999608B2 Imaging apparatus 失效
公开(公告)号：US06999608B2
公开(公告)日：2006-02-14
申请号：US09984854
申请日：2001-10-31
申请人： Masahiro Toida
发明人： Masahiro Toida
IPC分类号： G06K9/00
CPC分类号： A61B5/0066 , A61B5/0084
摘要： An compact imaging apparatus having an OCT function is provided. An image formed of the illuminating-light reflected from a examination area is displayed on a monitor. A signal-light for obtaining an optical tomographic image is guided in a fiber through an insertion portion and projected onto a living tissue measurement area by an illuminating lens. The measurement area is scanned with the signal-light by a Piezo actuator moving the output face of the fiber. An OCT obtaining-portion obtains and displays on a monitor an optical tomographic image by using the interference caused by the signal-light reflected from the measurement area and a reference-light. By performing the scanning with the signal-light using an image-obtaining lens, the need to insert a probe for obtaining an optical tomographic image through a forceps port is eliminated. Therefore, the number of required forceps ports is reduced, and the insertion portion can be made thin.

29. 发明授权

US06636755B2 Method and apparatus for obtaining an optical tomographic image of a sentinel lymph node 失效
公开(公告)号：US06636755B2
公开(公告)日：2003-10-21
申请号：US09962195
申请日：2001-09-26
申请人： Masahiro Toida
发明人： Masahiro Toida
IPC分类号： A61B505
CPC分类号： A61K49/0034 , A61B5/0066 , A61B5/0071 , A61B5/418 , G01B9/02003 , G01B9/0203 , G01B9/02031 , G01B9/02091
摘要： An apparatus for obtaining a cellular image to be used in performing a test for pathology of the sentinel lymph node, which is the first lymph node a cancer metastasizes to. The gamma radiation emitted from a near-infrared fluorescent colorant injected in advance into the vicinity of a tumor is detected by use of a gamma-probe. A fiber coupler separates the low-coherence light emitted from the light source of an OCT portion (Optical Coherence Tomography) into a signal-light to be projected onto the sentinel lymph node and a reference-light whose wavelength is slightly shifted. The signal-light is projected onto the sentinel lymph node, and interference is caused between the signal-light reflected from a predetermined depth within the sentinel lymph node and the reference-light. A balance differential detector measures the intensity of the interference-light, and a cellular level ultra high-resolution optical tomographic image of the sentinel lymph node is obtained.

30. 发明授权

US5969815A Glucose concentration measuring method and apparatus with a coherent source and heterodyne interferometer 有权
标题翻译：葡萄糖浓度测量方法和装置，具有相干源和外差干涉仪
公开(公告)号：US5969815A
公开(公告)日：1999-10-19
申请号：US138563
申请日：1998-08-24
申请人： Masahiro Toida , Ichirou Miyagawa
发明人： Masahiro Toida , Ichirou Miyagawa
IPC分类号： A61B3/10 , A61B5/00 , A61B5/145 , A61B10/00 , G01B9/02
CPC分类号： A61B5/1455 , A61B5/14532 , G01B9/02003 , G01B9/02004 , G01B9/02007 , G01B9/02014 , G01B9/02057 , G01B9/0209
摘要： A low coherence light beam is irradiated to the eyeball. A backward scattered light beam, which is reflected from each depth position in the eyeball, and a reference light beam, which is reflected from a mirror capable of moving, are caused to interfere with each other. A first backward scattered light beam, which comes from the interface between the cornea and the anterior aqueous chamber, and a second backward scattered light beam, which comes from the interface between the anterior aqueous chamber and the crystalline lens, are thus separated accurately from each other. An optical absorbance of the anterior aqueous chamber (the aqueous humor) is calculated from the intensities of the two backward scattered light beams. Each of a plurality of low coherence light beams having different wavelengths is irradiated to the eyeball, and the aforesaid operation is repeated. The concentration of glucose in the aqueous humor is measured by utilizing near-infrared spectroscopy. The measurement is thus achieved non-invasively and accurately.
摘要翻译：低相干光束照射到眼球。从眼球中的每个深度位置反射的反向散射光束和从能够移动的反射镜反射的参考光束彼此干涉。因此，从前水溶液室和晶状体之间的界面出来的来自角膜和前水性室之间的界面的第一反向散射光束和第二后向散射光束被精确地分离其他。根据两个后向散射光束的强度计算前部水分室（房水）的光吸收率。将具有不同波长的多个低相干光束中的每一个照射到眼球，并且重复上述操作。通过利用近红外光谱测量房水中的葡萄糖浓度。因此，非侵入性和准确地实现了测量。

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