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21. 发明申请

US20110118311A1 AZOLE COMPOUND 有权
标题翻译： AZOLE化合物
公开(公告)号：US20110118311A1
公开(公告)日：2011-05-19
申请号：US13054057
申请日：2009-07-13
申请人： Satoshi Aoki , Ryosuke Munakata , Noriyuki Kawano , Kiyohiro Samizu , Hiromasa Oka , Takahiro Ishii , Takashi Sugane
发明人： Satoshi Aoki , Ryosuke Munakata , Noriyuki Kawano , Kiyohiro Samizu , Hiromasa Oka , Takahiro Ishii , Takashi Sugane
IPC分类号： A61K31/4545 , C07D417/14 , C07D401/14 , C07D413/14 , A61P29/00
CPC分类号： C07D401/14 , C07D413/14 , C07D417/14
摘要： A compound which is useful as an active ingredient of a pharmaceutical composition for treating neuropathic pain is provided. The present inventors have made extensive studies on compounds having an FAAH inhibitory activity, and as a result, have found that an azole compound substituted with an N-(pyridine-3-yl)oxycarbonyl-piperidin-4-yl group and a phenyl group or a pharmaceutically acceptable salt thereof has an excellent FAAH inhibitory activity, thereby completing the present invention. The compound of the present invention is confirmed to have an excellent FAAH inhibitory activity and an antiallodynic effect in rat models with neuropathic pain, and thus is useful as an agent for preventing and/or an agent for treating neuropathic pain.
摘要翻译：提供了可用作治疗神经性疼痛的药物组合物的活性成分的化合物。本发明人对具有FAAH抑制活性的化合物进行了广泛的研究，结果发现被N-（吡啶-3-基）氧基羰基 - 哌啶-4-基和苯基取代的唑化合物或其药学上可接受的盐具有优异的FAAH抑制活性，从而完成了本发明。确认本发明的化合物在具有神经性疼痛的大鼠模型中具有优异的FAAH抑制活性和抗异常性疼痛作用，因此可用作预防剂和/或治疗神经性疼痛的药剂。

22. 发明申请

US20100085847A1 Optical head device and reading system for multi-layered optical recording medium 有权
标题翻译：用于多层光记录介质的光头设备和读取系统
公开(公告)号：US20100085847A1
公开(公告)日：2010-04-08
申请号：US12585395
申请日：2009-09-14
申请人： Noriyuki Kawano , Jiro Yoshinari , Motohiro Inoue , Atsuko Kosuda , Naoki Hayashida
发明人： Noriyuki Kawano , Jiro Yoshinari , Motohiro Inoue , Atsuko Kosuda , Naoki Hayashida
IPC分类号： G11B7/00
CPC分类号： G11B7/08511 , G11B7/1374 , G11B7/1378 , G11B7/139 , G11B2007/0013
摘要： A recording and reading system for a multi-layered optical recording medium includes: a multi-layered optical recording medium including a plurality of recording layers and a single servo layer; and an optical head. The optical head includes a recording and reading objective lens of a signal recording and reading optical system and a servo objective lens of a servo signal detection optical system that are disposed on a common actuator. The recording and reading objective lens is mounted on the common actuator through a minute-drive apparatus so as to be minutely driven in a focusing direction relative to the servo objective lens. When the servo objective lens is focused on the servo layer, a reading light beam is quickly focused on a target one of the plurality of recording layers.
摘要翻译：一种用于多层光学记录介质的记录和读取系统包括：包括多个记录层和单个伺服层的多层光学记录介质; 和光学头。光头包括信号记录和读取光学系统的记录和读取物镜以及设置在公共致动器上的伺服信号检测光学系统的伺服物镜。记录和读取物镜通过分钟驱动装置安装在公共致动器上，以便相对于伺服物镜在聚焦方向上被微小地驱动。当伺服物镜聚焦在伺服层上时，读取光束被快速聚焦在多个记录层中的目标一个上。

23. 发明授权

US06340678B1 4,4-difluoro-2,3,4,5-tetrahydro-1H-1-benzoazepine derivatives and drug compositions containing them 失效
标题翻译： 4,4-二氟-2,3,4,5-四氢-1H-1-苯并吖庚因衍生物和含有它们的药物组合物
公开(公告)号：US06340678B1
公开(公告)日：2002-01-22
申请号：US09380683
申请日：1999-09-02
申请人： Akira Matsuhisa , Takeshi Murakami , Shuichi Sakuda , Noriyuki Kawano , Kumiko Shibasaki , Akihiro Tanaka
发明人： Akira Matsuhisa , Takeshi Murakami , Shuichi Sakuda , Noriyuki Kawano , Kumiko Shibasaki , Akihiro Tanaka
IPC分类号： A61K3155
CPC分类号： C07D401/14 , C07D403/06 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/06 , C07D417/14 , C07D471/04
摘要： 4,4-difluoro-2,3,4,5-tetrahydro-1H-1-benzoazepine compounds or salts thereof and pharmaceutical compositions containing 4,4-difluoro-2,3,4,5-tetrahydro-1H-1-benzoazepine compounds, or salts thereof, and a pharmaceutically acceptable carrier. The chemical structure of these compounds is characterized by a difluoro group on a ring carbon atom adjacent to an azepine ring carbon atom substituted with a methylidene group. Pharmaceutical compositions containing these compounds are particularly useful as oxytocin antagonists and are effective in inhibiting threatened premature birth or abortion and precesarean birth, and are effective as a remedy for dysmenorrhea and other such conditions.
摘要翻译： 4,4-二氟-2,3,4,5-四氢-1H-1-苯并吖庚因化合物或其盐和含有4,4-二氟-2,3,4,5-四氢-1H-1-苯并吖庚因化合物或其盐和药学上可接受的载体。这些化合物的化学结构的特征在于与亚甲基取代的氮杂环碳原子相邻的环碳原子上的二氟基团。含有这些化合物的药物组合物特别可用作催产素拮抗剂，并且有效地抑制威胁早产或流产和分娩前分娩，并且作为痛经和其它此类病症的补救方法是有效的。

24. 发明授权

US6163416A Objective lens driving device and manufacturing method thereof 失效
标题翻译：物镜驱动装置及其制造方法
公开(公告)号：US6163416A
公开(公告)日：2000-12-19
申请号：US296655
申请日：1999-04-23
申请人： Nobuo Uekusa , Yasuhiro Terasaki , Noriyuki Kawano
发明人： Nobuo Uekusa , Yasuhiro Terasaki , Noriyuki Kawano
IPC分类号： G11B7/09 , G11B7/22 , G02B7/02
CPC分类号： G11B7/22 , G11B7/093 , G11B7/0932 , G11B7/0933 , G11B7/0935
摘要： An objective lens driver in which a movable portion 1 with an objective lens 11 is supported on a fixed portion by two groups of elastic supporting members each being horizontally bent which are disposed on both sides of the objective lens 11 such that each group of elastic supporting members are vertically arranged on each side of the objective lens, and the upper elastic supporting members of the groups of elastic supporting members are spaced from each other horizontally, is improved such that each group of elastic supporting members vertically arranged on each side of the objective lens are not parallel to each other. Further, damping material are fixedly disposed between both ends of the elastic supporting members and stuck onto the elastic supporting members, and the amount of the damping material on one side of the objective lens is different from that of the damping material on the other side of the objective lens, and a method of manufacturing the objective lens driver.
摘要翻译：一种物镜驱动器，其中具有物镜11的可移动部分1由两组弹性支撑构件支撑在固定部分上，每组弹性支撑构件均设置在物镜11的两侧，使得每组弹性支撑构件垂直地布置在物镜的每一侧上，并且弹性支撑构件组的上弹性支撑构件在水平方向上彼此间隔地改善，使得每组垂直布置在物镜的每一侧上的弹性支撑构件镜头不平行。此外，阻尼材料固定地设置在弹性支撑构件的两端之间并且粘附到弹性支撑构件上，并且物镜的一侧上的阻尼材料的量与另一侧的阻尼材料的量不同物镜，以及物镜驱动器的制造方法。

25. 发明授权

US08207199B2 Azole compound 有权
标题翻译：唑类化合物
公开(公告)号：US08207199B2
公开(公告)日：2012-06-26
申请号：US13054057
申请日：2009-07-13
申请人： Satoshi Aoki , Ryosuke Munakata , Noriyuki Kawano , Kiyohiro Samizu , Hiromasa Oka , Takahiro Ishii , Takashi Sugane
发明人： Satoshi Aoki , Ryosuke Munakata , Noriyuki Kawano , Kiyohiro Samizu , Hiromasa Oka , Takahiro Ishii , Takashi Sugane
IPC分类号： A61K31/4545 , C07D417/14 , C07D401/14 , C07D413/14
CPC分类号： C07D401/14 , C07D413/14 , C07D417/14
摘要： A compound which is useful as an active ingredient of a pharmaceutical composition for treating neuropathic pain is provided. The present inventors have made extensive studies on compounds having an FAAH inhibitory activity, and as a result, have found that an azole compound substituted with an N-(pyridine-3-yl)oxycarbonyl-piperidin-4-yl group and a phenyl group or a pharmaceutically acceptable salt thereof has an excellent FAAH inhibitory activity, thereby completing the present invention. The compound of the present invention is confirmed to have an excellent FAAH inhibitory activity and an antiallodynic effect in rat models with neuropathic pain, and thus is useful as an agent for preventing and/or an agent for treating neuropathic pain.
摘要翻译：提供了可用作治疗神经性疼痛的药物组合物的活性成分的化合物。本发明人对具有FAAH抑制活性的化合物进行了广泛的研究，结果发现被N-（吡啶-3-基）氧基羰基 - 哌啶-4-基和苯基取代的唑化合物或其药学上可接受的盐具有优异的FAAH抑制活性，从而完成了本发明。确认本发明的化合物在具有神经性疼痛的大鼠模型中具有优异的FAAH抑制活性和抗异常性疼痛作用，因此可用作预防剂和/或治疗神经性疼痛的药剂。

26. 发明申请

US20110105460A1 TRIAZOLE DERIVATIVE OR SALT THEREOF 有权
标题翻译：三唑衍生物或其盐
公开(公告)号：US20110105460A1
公开(公告)日：2011-05-05
申请号：US13002373
申请日：2009-07-02
申请人： Seiji Yoshimura , Noriyuki Kawano , Tomoaki Kawano , Daisuke Sasuga , Takanori Koike , Hideyuki Watanabe , Hiroki Fukudome , Nobuyuki Shiraishi , Ryosuke Munakata , Hiroaki Hoshii , Kayoko Mihara
发明人： Seiji Yoshimura , Noriyuki Kawano , Tomoaki Kawano , Daisuke Sasuga , Takanori Koike , Hideyuki Watanabe , Hiroki Fukudome , Nobuyuki Shiraishi , Ryosuke Munakata , Hiroaki Hoshii , Kayoko Mihara
IPC分类号： A61K31/4196 , C07D401/12 , A61K31/4439 , C07D249/08 , C07D403/12 , A61K31/506 , C07D413/12 , A61K31/422 , A61K31/4245 , A61K31/5377 , C07D417/12 , A61K31/541 , C07D405/12 , A61K31/427 , C07D413/14 , C07D409/04 , C07D403/10 , C07D471/04 , A61K31/437 , A61P3/10 , A61P25/24 , A61P25/18 , A61P25/28
CPC分类号： C07D249/08 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/10 , C07D417/12
摘要： [Problem] A compound, which can be used for preventing or treating diseases, in which 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) is concerned, in particular, diabetes, insulin resistance, dementia, schizophrenia and depression, is provided.[Means for Solution] It was found that a triazole derivative, in which one of the 3- and 5-positions of the triazole ring has (di)alkylmethyl or cycloalkyl, each of which is substituted with —O— (aryl or a heterocyclic group, each of which may be substituted, or lower alkylene-cycloalkyl), and the other thereof has aryl, a heterocyclic group or cycloalkyl, each of which may be substituted, or a pharmaceutically acceptable salt thereof exhibits potent 11β-HSD1 inhibitory action. From the above, the triazole derivative of the present invention can be used for preventing or treating diabetes, insulin resistance, dementia, schizophrenia and depression.
摘要翻译： [问题]提供了一种可用于预防或治疗疾病的化合物，其中涉及11种β-羟基类固醇脱氢酶（11＆bgr-HSD1），特别是糖尿病，胰岛素抵抗，痴呆，精神分裂症和抑郁症。 [解决方案]发现三唑环的3-和5-位之一具有（二）烷基甲基或环烷基的三唑衍生物，其各自被-O-（芳基或杂环）基团，其各自可以被取代，或低级亚烷基 - 环烷基），另一个具有可以被取代的芳基，杂环基或环烷基，或其药学上可接受的盐显示出有效的11β-HSD1抑制作用。由上可知，本发明的三唑衍生物可用于预防或治疗糖尿病，胰岛素抵抗，痴呆，精神分裂症和抑郁症。

27. 发明申请

US20100103799A1 Optical head device and optical recording and reading system 有权
标题翻译：光头设备和光记录读取系统
公开(公告)号：US20100103799A1
公开(公告)日：2010-04-29
申请号：US12585378
申请日：2009-09-14
申请人： Noriyuki Kawano , Tetsuya Nishiyama , Yoshinori Sato , Koji Mishima , Hajime Utsunomiya
发明人： Noriyuki Kawano , Tetsuya Nishiyama , Yoshinori Sato , Koji Mishima , Hajime Utsunomiya
IPC分类号： G11B7/135
CPC分类号： G11B7/1381 , G11B7/0909 , G11B7/131 , G11B7/1374 , G11B7/1378 , G11B2007/0013
摘要： An optical head device (optical head) for a multi-layered optical recording medium has a focus control mechanism that makes use of astigmatism. The focus control mechanism has a sensor lens that includes a cylindrical lens. The focus control mechanism causes a light beam having passed through the sensor lens to have astigmatism, thereby being focused linearly in the Y direction on a front focal line located closer to the sensor lens and focused linearly in the X direction at a rear focal line located farther therefrom. The optical head also includes a photodetector which is disposed between the front focal line and the rear focal line to detect a focal position from the shape of a light beam. At the position of the front focal line, a shield plate with a window portion is disposed. The window portion has a size so as to allow the focal line to pass therethrough and shield stray light reflected from an unfocused recording layer.
摘要翻译：用于多层光学记录介质的光学头装置（光学头）具有利用散光的聚焦控制机构。聚焦控制机构具有包括柱面透镜的传感器透镜。聚焦控制机构使已经通过传感器透镜的光束具有散光，从而在位于更靠近传感器透镜的前焦点上沿Y方向线性聚焦，并且在位于距离更远光头还包括一个光电检测器，它设置在前焦线和后焦线之间，以从光束的形状检测焦点位置。在前焦线的位置设置有具有窗口部分的屏蔽板。窗口部分具有允许焦线穿过其中并且屏蔽从未聚焦的记录层反射的杂散光的尺寸。

28. 再颁专利

USRE40928E1 Optical pickup 有权
公开(公告)号：USRE40928E1
公开(公告)日：2009-10-06
申请号：US11645328
申请日：2006-12-26
申请人： Noriyuki Kawano , Kouichi Ogura , Yoshio Saito , Mitsuru Kinouchi
发明人： Noriyuki Kawano , Kouichi Ogura , Yoshio Saito , Mitsuru Kinouchi
IPC分类号： G11B7/00
CPC分类号： G11B7/0932 , G11B7/093 , G11B7/0933 , G11B7/0935 , G11B7/0956 , G11B7/22
摘要： An optical pickup comprises an objective-lens driving device including a movable section provided with an objective lens, a focusing coil, and tracking coils, and a fixed section provided with a single magnetic circuit having a magnetic gap, the focusing coil and the tracking coils being disposed in the magnetic gap. The point of application of a tracking-driving force, the point of application of a result force of focusing-driving forces occurring in and outside the magnetic gap, and the position of the center of gravity of the movable section are made to substantially coincide with each other. In addition, the objective lens and the magnetic circuit are disposed within an area of a window in a lower shell of a optical disk. Further, a through hole for accommodating a lower portion of a yoke of the magnetic circuit is provided in a mounting base on which the objective-lens driving device is mounted. An inclining fulcrum and a height adjusting means for inclining the objective-lens driving device about the inclining fulcrum are provided in the vicinities of the through hole.

29. 发明申请

US20090131666A1 ACYLAMINOPIPERIDINE COMPOUND 失效
标题翻译： ACYLAMINOPIPERIDINE化合物
公开(公告)号：US20090131666A1
公开(公告)日：2009-05-21
申请号：US12294145
申请日：2007-03-23
申请人： Toru Kontani , Noriyuki Kawano , Naoyuki Masuda , Koji Kato , Hiroshi Nagata , Hiroshi Inami , Tadashi Terasaka , Kazuhiro Yokoyama , Takahiro Miyazaki
发明人： Toru Kontani , Noriyuki Kawano , Naoyuki Masuda , Koji Kato , Hiroshi Nagata , Hiroshi Inami , Tadashi Terasaka , Kazuhiro Yokoyama , Takahiro Miyazaki
IPC分类号： C07D401/04
CPC分类号： C07D401/04 , C07D401/14 , C07D487/04
摘要： [Problem] To provide a compound which has an excellent activity to modulate the functions of CCR4 or TARC and/or MDC and can be used for the prevention and/or treatment of various inflammatory diseases, allergic diseases, autoimmune diseases and the like. [Means for Resolution] An acylaminopiperidine compound represented by the formula (I) or a pharmaceutically acceptable salt thereof. [Symbols in the formula represent the following meanings; A: a single bond or C1-C6 alkylene, R1: phenyl which may be substituted, etc., R2: —H or C1-C6 alkyl, R3: —H, C1-C6 alkyl or C3-C8 cycloalkyl, R4: pyrrolidin-2-yl which may be substituted, etc., and D: benzene ring or pyrazole ring].
摘要翻译： [问题]提供具有优异活性以调节CCR4或TARC和/或MDC功能的化合物，并可用于预防和/或治疗各种炎性疾病，过敏性疾病，自身免疫性疾病等。 [解决方法]由式（I）表示的酰氨基哌啶化合物或其药学上可接受的盐。 [式中的符号表示以下含义： A：单键或C1-C6亚烷基，R1：可被取代的苯基等，R2：-H或C1-C6烷基，R3：-H，C1-C6烷基或C3-C8环烷基，R4：吡咯烷 -2-基，其可以被取代等，D：苯环或吡唑环]。

30. 发明授权

US07203951B2 Optical head device for an optical disk apparatus reading and writing information on an optical disk 失效
标题翻译：用于光盘装置的光头装置在光盘上读取和写入信息
公开(公告)号：US07203951B2
公开(公告)日：2007-04-10
申请号：US10448358
申请日：2003-05-30
申请人： Noriyuki Kawano , Nobuo Uekusa
发明人： Noriyuki Kawano , Nobuo Uekusa
IPC分类号： G11B7/08
CPC分类号： G11B7/0935 , G11B7/0933 , G11B7/0956
摘要： An optical head device for an optical disk apparatus for optically reading and writing information by irradiating a light spot onto an information recording surface of an optical recording medium, which is capable of moving an objective lens to a predetermined position even when part of the drive coil is included in an neutral area n in the vicinity of the magnetic boundary. There are provided two driving force generating units, including two magnets 50a and 50b disposed in the tangential direction of an optical disk separately on the opposite sides of an objective lens 10, and coil units 60a and 60b for generating the driving force directed against the magnets 50a and 50b disposed on a lens holder 20, and the magnets 50a and 50b and the coil units 60a and 60b are arranged in such a manner that the driving force other than the driving force generated for tracking movement and the moment act against each other at the two driving force generating units.
摘要翻译：一种用于光盘装置的光学头装置，用于通过将光点照射到光学记录介质的信息记录表面上来光学地读取和写入信息，即使当驱动线圈的一部分也能将物镜移动到预定位置时被包含在磁边界附近的中性区域n中。设置有两个驱动力产生单元，包括分别位于物镜10的相对侧的光盘的切线方向上设置的两个磁体50a和50b，以及用于产生驱动力的线圈单元60a和60b 针对设置在透镜保持器20上的磁体50a和50b，并且磁体50a和50b以及线圈单元60a和60b以这样的方式被布置，使得除了为在两个驱动力发生单元处，跟踪运动和力矩相互作用。

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