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21. 发明申请

US20100172993A1 PARTICLES FOR DELIVERY OF ACTIVE INGREDIENTS, PROCESS OF MAKING AND COMPOSITIONS THEREOF 审中-公开
标题翻译：用于输送活性成分的颗粒，其制备方法及其组合物
公开(公告)号：US20100172993A1
公开(公告)日：2010-07-08
申请号：US12377185
申请日：2007-08-10
申请人： Amarjit Singh , Sarabjit Singh , Paramjit Singh , Rajesh Jain
发明人： Amarjit Singh , Sarabjit Singh , Paramjit Singh , Rajesh Jain
IPC分类号： A61K9/14 , A61K31/568 , A61K31/565 , A61K38/02 , A61K39/00 , A61K39/395 , A61K8/23 , A61K8/19 , A61K31/715 , A61K8/60 , A61K8/73 , A61K8/64 , A61K8/66 , A61K8/98 , A61K8/97 , A61K31/137 , A61K31/522 , A01N37/18 , C07C211/30 , C07H15/16 , A61K31/7056 , A61K38/22 , C07D473/18 , C07C233/65 , C07K14/575 , A61K31/52 , A61K38/12 , A61K33/18 , A61K31/635 , A61K36/61 , A61K36/53 , A61K36/534 , A61K36/54 , A61P31/10 , A61P31/12 , A61P33/10 , A61P17/06 , A61P17/10 , A61P11/06 , A61P19/02 , A61P25/24 , A61P3/10 , A61Q5/12 , A61Q5/10 , A61Q5/08 , A61Q17/04 , A61Q15/00 , A61Q13/00
CPC分类号： A61K9/19 , A61K9/5115 , A61K9/5161 , A61K9/5192 , B82Y5/00
摘要： The present invention discloses compositions having particles comprising, inorganic element; one or more active ingredient and optionally a release rate modulating agent, suitable for the delivery of active ingredients to human and animal tissues. The particles are nanoparticles or microparticles or mixtures thereof, made preferably by sol-gel method. The compositions are useful for application to the topical or mucosal surfaces preferably in the form of creams, gels, lotions, dry powders, spray, foam and other suitable forms.
摘要翻译：本发明公开了具有包含无机元素的颗粒的组合物; 一种或多种活性成分和任选的释放速率调节剂，适于向人和动物组织递送活性成分。颗粒是优选通过溶胶 - 凝胶法制备的纳米颗粒或微粒或其混合物。组合物可用于局部或粘膜表面，优选以乳膏，凝胶，洗剂，干粉，喷雾，泡沫和其它合适形式的形式。

22. 发明申请

US20100086592A1 MODIFIED DOSAGE FORMS OF TACROLIMUS 审中-公开
标题翻译：改良剂量剂型
公开(公告)号：US20100086592A1
公开(公告)日：2010-04-08
申请号：US12530011
申请日：2008-03-25
申请人： Amarjit Singh , Sarabjit Singh , Shivanand Puthli , Rajesh Jain
发明人： Amarjit Singh , Sarabjit Singh , Shivanand Puthli , Rajesh Jain
IPC分类号： A61K9/24 , A61K31/436 , A61K9/16
CPC分类号： A61K9/146 , A61K9/1676 , A61K9/5078 , A61K9/5084 , A61K31/436
摘要： The present invention provides a modified release dosage form of tacrolimus that releases two or more amount of tacrolimus upon oral administration, the first amount of tacrolimus releases from the immediate release dosage unit substantially immediately within 0-2 hours followed by a time interval ranging from about 1-10 hours during which substantially no amount of tacrolimus is released from the dosage form, after which a second amount of tacrolimus is released wherein said second amount is released from the delayed release dosage unit either immediately e.g. within 0-2 hours or over a period of time ranging from about 2-12 hours from its initial release from the delayed release dosage unit. The dosage form may further comprise additional amount of tacrolimus to provide additional pulse of tacrolimus. The dosage forms of tacrolimus exhibit improved bioavailability and reduced flux or fluctuation over existing composition of tacrolimus. A method of preparing the dosage forms is also described.
摘要翻译：本发明提供了他克莫司的释放剂量形式，其口服给药释放两种或更多量的他克莫司，第一批量的他克莫司基本上立即在0-2小时内立即从即时释放剂量单位释放，之后是从约 1-10小时，其中基本上没有量的他克莫司从剂型中释放出来，之后第二量的他克莫司被释放，其中所述第二量从延迟释放剂量单位释放，在0-2小时内或超过延迟释放剂量单位从其初始释放约2-12小时的时间段内。剂型还可包含额外量的他克莫司以提供他克莫司的额外脉冲。他克莫司的剂型表现出改善的生物利用度和减少通量或波动超过现有组合的他克莫司。还描述了制备剂型的方法。

23. 发明申请

US20100056493A1 MODIFIED RELEASE PHARMACEUTICAL COMPOSITION AND A PROCESS OF MAKING THE SAME 审中-公开
标题翻译：改性释放药物组合物及其制备方法
公开(公告)号：US20100056493A1
公开(公告)日：2010-03-04
申请号：US12522185
申请日：2008-01-24
申请人： Rajesh Jain , Kour Chand Jindal , Sanjay Boldhane
发明人： Rajesh Jain , Kour Chand Jindal , Sanjay Boldhane
IPC分类号： A61K31/554 , A61K31/5377
CPC分类号： A61K9/2077
摘要： The present invention refers to a modified release pharmaceutical composition comprising an in-situ gelling agent (=0.5 % w/w) and a gellation facilitating agent (e.g. calcium sulfate) in an amount of 2-17.5 % w/w. Additionally, the composition contains a release rate controlling polymer such as an acrylate and optionally a pH independent rate controlling polymer such as HPMC. A preferred active agent is mycophenolate mofetil. A process of making the above described composition is also disclosed.
摘要翻译：本发明涉及包含2-17.5％w / w的量的原位胶凝剂（= 0.5％w / w）和凝胶促进剂（例如硫酸钙）的改性释放药物组合物。此外，组合物含有释放速率控制聚合物如丙烯酸酯和任选的pH独立的速率控制聚合物如HPMC。优选的活性剂是霉酚酸酯。还公开了制备上述组合物的方法。

24. 发明申请

US20090258896A1 COMPOSITION COMPRISING AT LEAST ONE HIGHER ALIPHATIC ALCOHOL AND AN EXTRACT OF GRIFFONIA SIMPLICIFOLIA 失效
标题翻译：至少包含一种较高的脂肪醇和甘草的提取物的组合物
公开(公告)号：US20090258896A1
公开(公告)日：2009-10-15
申请号：US12299317
申请日：2007-05-09
申请人： Rajesh Jain , Kour Chand Jindal
发明人： Rajesh Jain , Kour Chand Jindal
IPC分类号： A61K31/437 , A61K31/405 , A61P3/10
CPC分类号： A61K36/48 , A61K31/045 , A61K36/82 , A61K2300/00
摘要： Novel compositions comprising a combination of at least one higher primary aliphatic alcohol preferably selected from those having 18 to 40 carbon atoms or mixtures thereof, at least one source of 5-hydroxytryptophan (5-HTP) optionally additionally comprising a source of caffeine and/or catechin-polyphenol and/or epigallocatechin gallate as active agents, either alone or in combination with other active agent(s), optionally with one or more excipient(s) are provided. Particularly, the invention relates to compositions and process for preparation of such compositions and method of use thereof for the management of obesity and associated disorders.
摘要翻译：包含至少一种优选选自具有18-40个碳原子的高级伯脂肪醇或其混合物的至少一种5-羟基色氨酸（5-HTP）的组合的新型组合物任选地另外包含咖啡因和/或儿茶素多酚和/或表没食子儿茶素没食子酸酯作为活性剂，单独或与其它活性剂，任选地与一种或多种赋形剂组合使用。特别地，本发明涉及用于制备这种组合物的组合物和方法及其用于治疗肥胖症和相关疾病的方法。

25. 发明申请

US20080247962A1 Pharmaceutical Compositions Comprising Higher Primary Aliphatic Alcohols and Hmg Coa Reductase Inhibitor and Process of Preparation Thereof 审中-公开
标题翻译：包含高级初级脂肪醇和Hmg Coa还原酶抑制剂的药物组合物及其制备方法
公开(公告)号：US20080247962A1
公开(公告)日：2008-10-09
申请号：US10586545
申请日：2005-01-19
申请人： Rajesh Jain , Kour Chand Jindal , Sukhjeet Singh
发明人： Rajesh Jain , Kour Chand Jindal , Sukhjeet Singh
IPC分类号： A61K9/12 , A61K31/045 , A61K31/40 , A61P3/00 , A61K31/351
CPC分类号： A61K31/366 , A61K31/045 , A61K31/40 , A61K45/06 , A61K2300/00
摘要： A novel pharmaceutical composition comprising a mixture of higher primary aliphatic alcohols from (24) to (39) carbon atoms; at least one another component selected from resins and pigments, hydrocarbons, esters, ketones and aldehydes, and phenolic compounds, and HMG CoA reductase inhibitor, its salts, analogs or derivatives thereof, preferably statins, optionally with pharmaceutically acceptable excipients, and process of preparation of such composition is provided. Also provided are method of treatment and use of such composition for reducing abnormal lipid parameters associated with hyperlipidemia.
摘要翻译：一种新型药物组合物，其包含来自（24）至（39）个碳原子的较高级脂族醇的混合物; 选自树脂和颜料，烃，酯，酮和醛中的至少一种组分和酚类化合物，和HMG CoA还原酶抑制剂，其盐，类似物或衍生物，优选他汀类，任选地具有药学上可接受的赋形剂，以及制备方法提供了这种组合物。还提供了治疗和使用这种组合物以减少与高脂血症相关的异常脂质参数的方法。

26. 发明申请

US20080160082A1 Controlled release compositions comprising Nimesulide 审中-公开
标题翻译：包含尼美舒利的控制释放组合物
公开(公告)号：US20080160082A1
公开(公告)日：2008-07-03
申请号：US11978162
申请日：2007-10-26
申请人： Amarjit Singh , Rajesh Jain
发明人： Amarjit Singh , Rajesh Jain
IPC分类号： A61K9/22 , A61K31/18
CPC分类号： A61K9/4891 , A61K9/0004 , A61K9/2054 , A61K9/209 , A61K9/2853 , A61K9/2866 , A61K9/5078 , A61K9/5084 , A61K31/18
摘要： A controlled release pharmaceutical composition for peroral administration including a single unit fast release fraction and a single unit extended release fraction which includes nimesulide as an active drug upto 99% w/w of the composition, one or more release controlling materials from 0.1% to 99% w/w of the composition and pharmaceutical excipients from 0% to 90% w/w of the composition. The nimesulide is present in the fast release fraction and in the extended release fraction.
摘要翻译：用于口服给药的控释药物组合物，包括单一单位快速释放级分和单一单位延长释放级分，其包含尼泊洛尔作为组合物高达99％w / w的活性药物，一种或多种释放控制材料为0.1％至99 ％w / w的组合物和药物赋形剂的组合物的0％至90％w / w。尼美舒利存在于快速释放部分和延长释放部分中。

27. 发明申请

US20070219175A1 Controlled Release Pharmaceutical Composition Comprising An Acid-Insoluble And A Bioadhesive Polymer 审中-公开
标题翻译：包含酸不溶性和生物粘合聚合物的控制释放药物组合物
公开(公告)号：US20070219175A1
公开(公告)日：2007-09-20
申请号：US10551058
申请日：2005-01-05
申请人： Rajesh Jain , Kour Jindal , Sukhjeet Singh
发明人： Rajesh Jain , Kour Jindal , Sukhjeet Singh
IPC分类号： A61K31/43
CPC分类号： A61K9/2095 , A61K9/1635 , A61K9/2081 , A61K9/5026 , A61K9/5036 , A61K9/5042 , A61K31/43 , A61K45/06 , A61K2300/00
摘要： Rapidly disintegrating oral controlled release pharmaceutical compositions and process for preparation of such compositions are provided. The compositions preferably comprise antibiotic(s) as active ingredient, more preferably amoxicillin either alone or in combination with other antibiotic(s). The controlled release compositions comprise at least one active ingredient, and a polymer system comprising of at least two polymers which retard the release of the active ingredient in the stomach while providing rapid release of the said active ingredient in the alkaline contents of small intestine, optionally with other pharmaceutically acceptable excipients. The compositions provide therapeutically effective levels of the active ingredient for extended periods of time, and possess bioadhesive properties.
摘要翻译：提供快速崩解的口服释药药物组合物和制备这些组合物的方法。组合物优选包含抗生素作为活性成分，更优选单独或与其它抗生素组合使用阿莫西林。控释组合物包含至少一种活性成分和包含至少两种聚合物的聚合物体系，所述聚合物延缓了胃中活性成分的释放，同时提供所述活性成分在小肠的碱性成分中的快速释放，任选地与其它药学上可接受的赋形剂。该组合物延长时间段提供治疗有效水平的活性成分，并且具有生物粘合性质。

28. 发明申请

US20070160664A1 Pharmaceutical compositions comprising of proton pump inhibitor and prokinetic agent 审中-公开
标题翻译：包含质子泵抑制剂和促动力剂的药物组合物
公开(公告)号：US20070160664A1
公开(公告)日：2007-07-12
申请号：US11482186
申请日：2006-07-06
申请人： Rajesh Jain , Kour Jindal , Sukhjeet Singh
发明人： Rajesh Jain , Kour Jindal , Sukhjeet Singh
IPC分类号： A61K31/4439 , A61K9/64 , A61K9/24
CPC分类号： A61K31/4439 , A61K9/2081 , A61K9/209 , A61K9/4808 , A61K9/5078 , A61K31/136 , A61K31/138
摘要： Oral pharmaceutical compositions and process for preparation thereof are provided comprising at least one gastric acid suppressing agent, preferably a proton pump inhibitor or its pharmaceutically acceptable salts, esters, hydrates, derivatives or prodrugs, and one or more prokinetic agent or its pharmaceutically acceptable salts, esters, hydrates, derivatives or prodrugs, optionally with other pharmaceutically acceptable excipients, characterized in that the gastric acid suppressing agent is present in a delayed release form and the prokinetic agent is present in a bimodal release form such as an immediate release form to provide an initial loading dose, and a delayed release form to provide a dose with a lag time; with the proviso that the prokinetic agent is not formulated using a hydrophilic rate controlling polymer and is not present in a sustained release form. Method of treatment of gastro esophageal reflux disease, reflux esophagitis, peptic ulcer, gastric ulcer, and other gastric acid related disorders by administering to a patient such a pharmaceutical composition in need thereof is also provided.
摘要翻译：提供了口服药物组合物及其制备方法，其包含至少一种胃酸抑制剂，优选质子泵抑制剂或其药学上可接受的盐，酯，水合物，衍生物或前药，以及一种或多种促动力剂或其药学上可接受的盐，酯，水合物，衍生物或前药，任选地与其它药学上可接受的赋形剂，其特征在于所述胃酸抑制剂以延迟释放形式存在，并且促动力剂以双峰释放形式存在，例如立即释放形式，以提供初始加载剂量和延迟释放形式以提供具有滞后时间的剂量; 条件是促动剂不是使用亲水性速率控制聚合物配制的，并且不以缓释形式存在。还提供了通过向患者施用这种有此需要的药物组合物来治疗胃食管反流病，反流性食管炎，消化性溃疡，胃溃疡和其它胃酸相关疾病的方法。

29. 发明授权

US6008191A Pharmaceutical compositions containing cyclosporin 失效
标题翻译：含有环孢菌素的药物组合物
公开(公告)号：US6008191A
公开(公告)日：1999-12-28
申请号：US136663
申请日：1998-08-19
申请人： Amarjit Singh , Rajesh Jain
发明人： Amarjit Singh , Rajesh Jain
IPC分类号： A61K9/48 , A61K47/00 , A61K47/10 , A61K47/14 , A61K47/44 , A61K38/00 , A61K38/12 , C07K5/00 , C07K7/00
CPC分类号： A61K9/4858 , A61K47/10 , A61K47/14 , A61K47/44
摘要： A novel homogenous alcohol free, free flowing, clear and transparent pharmaceutical composition containing Cyclosporin is disclosed. The amount of Cyclosporin is easily measurable at a wide range of temperature of 15.degree. to 45.degree. C. The composition comprises a Cyclosporin in a hydrophillic carrier medium comprising propylene glycol, a transesterification product of a natural vegetable oil triglyceride and a polyalkylene polyol--such as Apricot Kernel Oil Polyethylene glycol 6 esters--such as Labrafil M1944 and polyethylene hydrogenated castor oils--such as Cremophor RH 40 and Glycerol Triacetate or Triacetin.
摘要翻译：公开了一种新颖的均匀无醇，自由流动，透明和透明的含有环孢菌素的药物组合物。环孢菌素的量可以在15°至45℃的宽温度范围内容易地测量。该组合物包含在亲水载体介质中的环孢菌素，其包含丙二醇，天然植物油甘油三酯的转酯化产物和聚亚烷基多元醇作为杏仁油聚乙二醇6酯，例如Labrafil M1944和聚乙烯氢化蓖麻油，例如Cremophor RH 40和甘油三乙酸酯或三醋精。

30. 发明授权

US5688829A Therapeutic injectable analgesic composition containing nimesulide and a process for the manufacture thereof 失效
标题翻译：含有尼美舒利的治疗性可注射镇痛组合物及其制造方法
公开(公告)号：US5688829A
公开(公告)日：1997-11-18
申请号：US662704
申请日：1996-06-13
申请人： Rajesh Jain , Amarjit Singh
发明人： Rajesh Jain , Amarjit Singh
IPC分类号： A61K9/08 , A61K31/18 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/16 , A61K47/18 , A61P25/04
CPC分类号： A61K31/18 , A61K47/14 , A61K47/18 , A61K9/0019
摘要： Therapeutic injectable analgesic pharmaceutical compositions for intramuscular administration containing nimesulide. The pharmaceutical compositions comprise nimesulide, dimethylacetamide, benzyl benzoate and ethyl oleate.
摘要翻译：含有尼美舒利的肌内注射用治疗性可注射镇痛药物组合物。药物组合物包含尼美舒利，二甲基乙酰胺，苯甲酸苄酯和油酸乙酯。

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