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21. 发明授权

US5656032A Fluid delivery apparatus and method of making same 失效
标题翻译：流体输送装置及其制造方法
公开(公告)号：US5656032A
公开(公告)日：1997-08-12
申请号：US451520
申请日：1995-05-26
申请人： Marshall S. Kriesel , Farhad Kazemzadeh , Matthew Kriesel , William Feng , Steve C. Barber , William J. Kluck
发明人： Marshall S. Kriesel , Farhad Kazemzadeh , Matthew Kriesel , William Feng , Steve C. Barber , William J. Kluck
IPC分类号： A61M5/14 , A61M5/142 , A61M5/152 , A61M5/158 , A61M37/00
CPC分类号： A61M5/1409 , A61M5/1413 , A61M5/14248 , A61M5/152 , A61M2005/1581 , A61M2205/197 , A61M5/1407 , Y10S128/12
摘要： An apparatus for accurately infusing fluids into a patient at specific rates over an extended period of time and the method for making same. The apparatus includes one or more dispensers, of a low profile, laminate or layered construction each having a stored energy source in the form of a distendable membrane or an elastomeric cellular mass, which in cooperation with the base, defined a fluid chamber having a fluid inlet and a fluid outlet. The apparatus further includes, in lieu of a rigid ullage, a high novel, conformable ullage made of yieldable materials. The conformable ullage uniquely conforms to the shape of elastomeric membrane as the membrane returns to its less distended configuration. This arrangement will satisfy even the most stringent delivery tolerance requirements and will elegantly overcome the limitations of materials selection encountered in devices embodying the rigid ullage construction. Additionally, with the novel ullage construction, the ullage can be located either between the base and the fluid to be delivered, or alternatively, can be located between the elastomeric membrane and the fluid to be delivered. Further, a plurality of subreservoirs can be associated with a single ullage thereby making it possible to incorporate a wide variety of delivery profiles within a single device.
摘要翻译：一种用于在更长时间内以特定速率准确地将流体注入患者体内的装置及其制造方法。该设备包括一个或多个分散器，其具有低轮廓，层压或分层结构，每个分配器具有可膨胀膜或弹性体泡沫体形式的储存能量源，其与基底配合，限定了具有流体的流体室入口和流体出口。该装置还包括代替刚性缺损的由可屈服材料制成的高度新颖的，适合的缺口。随着膜返回到较少膨胀的构型，适形的填充与弹性膜的形状完全一致。这种布置将满足最严格的交货公差要求，并且将优雅地克服在体现刚性空间结构的装置中遇到的材料选择的限制。另外，随着新颖的空白结构，空白可以位于基底和要输送的流体之间，或者可以位于弹性膜和要输送的流体之间。此外，多个子储存器可以与单个空白相关联，从而使得可以在单个装置内并入多种递送曲线。

22. 发明授权

US06176845B1 Fluid delivery apparatus with flow indicator and vial fill 失效
公开(公告)号：US06176845B1
公开(公告)日：2001-01-23
申请号：US09165706
申请日：1998-10-02
申请人： Marshall S. Kriesel , Steven M. Arnold , James Garrison , Farhad Kazemzadeh , William F. Kuester, III , Rolf Hogan
发明人： Marshall S. Kriesel , Steven M. Arnold , James Garrison , Farhad Kazemzadeh , William F. Kuester, III , Rolf Hogan
IPC分类号： A61M3700
CPC分类号： A61M5/152 , A61M5/141 , A61M5/16877 , A61M2205/583 , A61M2205/585
摘要： An apparatus for accurately infusing medicinal agents into an ambulatory patient at specific rates over extended periods of time. The apparatus is of a compact, low profile, laminate construction and includes an elastic distendable membrane, chamber having a fluid outlet. Disposed within the fluid chamber is a thin fluid permeable member which precisely controls the rate of fluid flow through the fluid outlet. The apparatus also includes a highly novel fluid flow indicator that provides a readily discernible visible indication of fluid flow through the apparatus. Additionally, the apparatus includes a fill assembly comprising a prefilled vial that can be used to fill the fluid reservoir of the device with a selected medicinal fluid.

23. 发明授权

US5962794A Fluid delivery apparatus with reservior fill assembly 失效
标题翻译：流体输送装置具有储存器填充装置
公开(公告)号：US5962794A
公开(公告)日：1999-10-05
申请号：US017047
申请日：1998-02-02
申请人： Marshall S. Kriesel , Steven M. Arnold , James M. Garrison , Farhad Kazemzadeh
发明人： Marshall S. Kriesel , Steven M. Arnold , James M. Garrison , Farhad Kazemzadeh
IPC分类号： A61M5/152 , A61M5/168 , A61M37/00 , B01L3/00 , G01F1/38 , G01L7/00 , G01L7/02 , G01P13/00
CPC分类号： A61M5/16854 , A61M5/152 , A61M5/16886 , G01P13/0026 , G01P13/0066 , A61M2205/583 , A61M2209/045
摘要： An apparatus for delivering fluids at a precisely controlled rate which comprises a fluid dispensing component having a fluid reservoir for containing the fluids to be delivered and a reservoir fill component which can be removably interconnected with the fluid dispensing component. The dispensing component can be used for the precise infusion of pharmaceutical fluids to an ambulatory patient at controlled rates. The reservoir fill assembly is uniquely designed to accept a vial component of conventional construction which is partially received within a novel adapter subassembly that can readily be removably interconnected with the fluid dispensing component.
摘要翻译：一种用于以精确控制的速率输送流体的装置，其包括具有用于容纳待输送流体的流体储存器的流体分配部件和可与流体分配部件可拆卸地互连的储存器填充部件。分配组件可用于以受控的速率精确地将药液输注到流动患者。储存器填充组件被独特地设计成接受常规结构的小瓶组件，其部分地容纳在新颖的适配器子组件内，其可以容易地与流体分配组件可拆卸地互连。

24. 发明授权

US06645175B2 Variable rate infusion apparatus with indicator and adjustable rate control 失效
公开(公告)号：US06645175B2
公开(公告)日：2003-11-11
申请号：US09858131
申请日：2001-05-14
申请人： Marshall S. Kriesel , Steven M. Arnold , James Garrison , Farhad Kazemzadeh
发明人： Marshall S. Kriesel , Steven M. Arnold , James Garrison , Farhad Kazemzadeh
IPC分类号： A61M3700
CPC分类号： A61M5/152 , A61M5/141 , A61M5/16877
摘要： An apparatus for accurately infusing medicinal agents into an ambulatory patient at specific rates over extended periods of time. The apparatus is of a compact, low profile, laminate construction and includes an elastic distendable membrane, chamber having a fluid outlet. The apparatus also includes a highly novel fluid flow indicator that provides a readily discernible visible indication of fluid flow through the apparatus. Additionally, the apparatus includes a novel adjustable flow rate control means for precisely adjustably controlling the rate of fluid flow from the reservoir of the device.

25. 发明授权

US6159180A Fluid delivery apparatus with flow indicator and vial fill 失效
公开(公告)号：US6159180A
公开(公告)日：2000-12-12
申请号：US139605
申请日：1998-08-24
申请人： Marshall S. Kriesel , Steven M. Arnold , James Garrison , Farhad Kazemzadeh
发明人： Marshall S. Kriesel , Steven M. Arnold , James Garrison , Farhad Kazemzadeh
IPC分类号： A61M5/14 , A61M5/152 , A61M5/168 , A61M37/00
CPC分类号： A61M5/141 , A61M5/152 , A61M2205/583 , A61M2205/585 , A61M5/16877 , Y10S128/12
摘要： An apparatus for accurately infusing medicinal agents into an ambulatory patient at specific rates over extended periods of time. The apparatus is of a compact, low profile, laminate construction and includes an elastic distendable membrane, chamber having a fluid outlet. Disposed within the fluid chamber is a thin fluid permeable member which precisely controls the rate of fluid flow through the fluid outlet. The apparatus also includes a highly novel fluid flow indicator that provides a readily discernible visible indication of fluid flow through the apparatus. Additionally, the apparatus includes a fill assembly comprising a prefilled vial that can be used to fill the fluid reservoir of the device with a selected medicinal fluid.

26. 发明授权

US6105442A Fluid delivery apparatus with reservoir fill assembly 失效
标题翻译：流体输送装置，具有储液器填充组件
公开(公告)号：US6105442A
公开(公告)日：2000-08-22
申请号：US363288
申请日：1999-07-28
申请人： Marshall S. Kriesel , Steven M. Arnold , James Garrison , Farhad Kazemzadeh
发明人： Marshall S. Kriesel , Steven M. Arnold , James Garrison , Farhad Kazemzadeh
IPC分类号： A61M5/152 , A61M5/168 , A61M37/00 , B01L3/00 , G01F1/38 , G01L7/00 , G01L7/02 , G01P13/00
CPC分类号： A61M5/16854 , A61M5/152 , A61M5/16886 , G01P13/0026 , G01P13/0066 , A61M2205/583 , A61M2209/045
摘要： An apparatus for delivering fluids at a precisely controlled rate which comprises a fluid dispensing component having a fluid reservoir for containing the fluids to be delivered and a reservoir fill component which can be removably interconnected with the fluid dispensing component. The dispensing component can be used for the precise infusion of pharmaceutical fluids to an ambulatory patient at controlled rates. The reservoir fill assembly is uniquely designed to accept a vial component of conventional construction which is partially received within a novel adapter subassembly that can readily be removably interconnected with the fluid dispensing component.
摘要翻译：一种用于以精确控制的速率输送流体的装置，其包括具有用于容纳待输送流体的流体储存器的流体分配部件和可与流体分配部件可拆卸地互连的储存器填充部件。分配组件可用于以受控的速率精确地将药液输注到流动患者。储存器填充组件被独特地设计成接受常规结构的小瓶组件，其部分地容纳在新颖的适配器子组件内，其可以容易地与流体分配组件可拆卸地互连。

27. 发明授权

US06086561A Fluid delivery apparatus with reservoir fill assembly 失效
标题翻译：流体输送装置，具有储液器填充组件
公开(公告)号：US06086561A
公开(公告)日：2000-07-11
申请号：US250036
申请日：1999-02-12
申请人： Marshall S. Kriesel , Jmaes M. Garrison , Steven Arnold , Farhad Kazemzadeh
发明人： Marshall S. Kriesel , Jmaes M. Garrison , Steven Arnold , Farhad Kazemzadeh
IPC分类号： A61M5/152 , A61M5/168 , A61M37/00 , B01L3/00 , G01F1/38 , G01L7/00 , G01L7/02 , G01P13/00
CPC分类号： A61M5/16854 , A61M5/152 , A61M5/16886 , G01P1/07 , G01P13/0026 , G01P13/0066 , A61M2205/583 , A61M2205/585 , A61M2209/045
摘要： An apparatus for delivering fluids at a precisely controlled rate which includes a fluid dispensing component having a fluid reservoir for containing the fluids to be delivered and a reservoir fill component which can be removably interconnected with the fluid dispensing component. The reservoir fill assembly is uniquely designed to accept a vial component of conventional construction which is factory filled with the medicinal fluid to be delivered to the patient. The dispenser component embodies a highly novel fluid flow indicator that provides a readily discernible visual indication of fluid flow status through the device.
摘要翻译：一种用于以精确控制的速率输送流体的装置，其包括具有用于容纳待输送流体的流体储存器的流体分配部件和可与流体分配部件可拆卸地互连的储存器填充部件。储存器填充组件被独特地设计成接受常规结构的小瓶部件，该小瓶部件在工厂中填充有要输送给患者的药液。分配器部件体现了高度新颖的流体流量指示器，其提供通过装置的流体流动状态的容易辨别的视觉指示。

28. 发明授权

US5840071A Fluid delivery apparatus with flow indicator and vial fill 失效
公开(公告)号：US5840071A
公开(公告)日：1998-11-24
申请号：US768663
申请日：1996-12-18
申请人： Marshall S. Kriesel , Steven M. Arnold , James Garrison , Farhad Kazemzadeh
发明人： Marshall S. Kriesel , Steven M. Arnold , James Garrison , Farhad Kazemzadeh
IPC分类号： A61M5/14 , A61M5/152 , A61M5/168 , A61M37/00
CPC分类号： A61M5/141 , A61M5/152 , A61M2205/583 , A61M2205/585 , A61M5/16877 , Y10S128/12
摘要： An apparatus for accurately infusing medicinal agents into an ambulatory patient at specific rates over extended periods of time. The apparatus is of a compact, low profile, laminate construction and includes an elastic distendable membrane, chamber having a fluid outlet. Disposed within the fluid chamber is a thin fluid permeable member which precisely controls the rate of fluid flow through the fluid outlet. The apparatus also includes a highly novel fluid flow indicator that provides a readily discernible visible indication of fluid flow through the apparatus. Additionally, the apparatus includes a fill assembly comprising a prefilled vial that can be used to fill the fluid reservoir of the device with a selected medicinal fluid.

29. 发明授权

US5649910A Fluid delivery apparatus and method of making same 失效
标题翻译：流体输送装置及其制造方法
公开(公告)号：US5649910A
公开(公告)日：1997-07-22
申请号：US473649
申请日：1995-06-06
申请人： Marshall S. Kriesel , Steven M. Arnold , James M. Garrison , Farhad Kazemzadeh , William J. Kluck , Steven C. Barber
发明人： Marshall S. Kriesel , Steven M. Arnold , James M. Garrison , Farhad Kazemzadeh , William J. Kluck , Steven C. Barber
IPC分类号： A61M5/14 , A61M5/142 , A61M5/152 , A61M5/175 , A61M37/00
CPC分类号： A61M5/152 , A61M2205/197 , A61M5/1407 , A61M5/14248 , Y10S128/12
摘要： An apparatus for accurately infusing medicinal agents into an ambulatory patient at specific rates over extended periods of time. The apparatus is of a compact, low profile, laminate construction and includes an elastic distendable membrane, which, in cooperation with a thin planar base defines a fluid chamber having a fluid outlet. Disposed within the fluid chamber is a thin fluid permeable member which precisely controls the rate of fluid flow through the fluid outlet. The apparatus also includes a highly novel fluid flow indicator that provides a readily discernible visual indication of fluid flow through the apparatus.
摘要翻译：一种用于在长时间内以特定速率准确地将药剂注入流动患者的装置。该装置具有紧凑的薄型层合结构，并且包括弹性膨胀膜，其与薄平面基底协作限定具有流体出口的流体室。设置在流体室内的是一种薄流体可渗透构件，其精确地控制通过流体出口的流体流速。该设备还包括高度新颖的流体流量指示器，其提供通过该设备的流体流动的容易辨别的视觉指示。

30. 发明授权

US08622965B2 Two part fluid dispenser 有权
标题翻译：两部分流体分配器
公开(公告)号：US08622965B2
公开(公告)日：2014-01-07
申请号：US12455645
申请日：2009-06-03
申请人： Marshall S. Kriesel
发明人： Marshall S. Kriesel
IPC分类号： A61M5/20 , A61M5/00 , A61M5/24 , A61M5/28 , F04B43/00
CPC分类号： A61M5/1407 , A61M5/1413 , A61M5/1454 , A61M5/16804 , A61M5/16881 , A61M39/18 , A61M2205/197 , A61M2205/583
摘要： A dispensing device for dispensing first and second medicaments to a patient that is made up of first and second stand-alone, interconnectable assemblies. The first of these assemblies comprises a fluid reservoir assembly that houses a fluid reservoir defining component while the second assembly comprises a fluid delivery and control assembly that includes an adding assembly for controllably dispensing the second medicament to the patient, a novel flow control means that functions to control the flow of medicinal fluid from the fluid reservoir of the first assembly toward the patient via a plurality of fluid flow control passageways. Because the stand-alone fluid delivery and control assembly is initially totally separate from the fluid reservoir assembly of the apparatus, the fluid flow passageways of the fluid delivery and control assembly can be effectively sterilized using conventional gamma ray sterilization techniques without adversely affecting the medicament contained within the fluid reservoir of the apparatus.
摘要翻译：一种用于将第一和第二药物分配给由第一和第二独立的可互连组件构成的患者的分配装置。这些组件中的第一个包括容纳流体储存器限定部件的流体储存器组件，而第二组件包括流体递送和控制组件，流体输送和控制组件包括用于将第二药剂可控地分配给患者的添加组件，以经由多个流体流动控制通道来控制药液从第一组件的流体储存器朝向患者的流动。由于独立的流体输送和控制组件最初与设备的流体储存器组件完全分离，流体输送和控制组件的流体流动通道可以使用常规的γ射线消毒技术被有效地消毒，而不会对包含的药物产生不利影响在设备的流体储存器内。

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