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21. 发明申请

US20060235223A1 Variolin derivatives and their use as antitumor agents 失效
标题翻译：异喹啉衍生物及其作为抗肿瘤剂的用途
公开(公告)号：US20060235223A1
公开(公告)日：2006-10-19
申请号：US10483525
申请日：2002-07-11
申请人： Modesto Remuiñan , Juan Gonzalez , Carlos Pozo , Carmen Cuevas , Simon Munt , Regan Anderson , Andres Francesh , Jonathan Morris , Ignacio Manzanares
发明人： Modesto Remuiñan , Juan Gonzalez , Carlos Pozo , Carmen Cuevas , Simon Munt , Regan Anderson , Andres Francesh , Jonathan Morris , Ignacio Manzanares
IPC分类号： C07D487/14
CPC分类号： C07D213/64 , C07D213/78 , C07D239/38 , C07D401/06 , C07D401/14 , C07D409/14 , C07D471/06 , C07D471/14
摘要： Variolin derivatives of formula (5) are provided, wherein the substituent groups defined by X2, R1, R2, R3, R6, R7 and R12 are each independently selected from the group consisting of H, OH, OR′, SH, SR′, SOR′, SO2R′, NO2, NH2, NHR′, N(R′)2, NHCOR′, NHSO2R′, CN, halogen, ═O, C(═O)H, C(═O)R′, CO2H, CO2R′, carboxyalkyl, C1-C12 alkyl, C2-C12 alkenyl, C2-C12 alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl and substituted or unsubstituted heteroaromatic; wherein each of the R′ groups is independently selected from the group consisting of H, OH, SH, N02, NH2, CN, halogen, ═O, C(═O)H, C(═O)CH3, CO2H, CO2CH3, C1-C12 alkyl, C2-C12 alkenyl, C2-C12alkynyl, aryl, aralkyl and heteroaromatic; wherein the pairs of groups R1 and R2, R2 and R3, R3 and R12, R12 and R6, or R6 and R7 may be joined into a carbocyclic or heterocyclic ring system.
摘要翻译：提供了式（5）的异喹啉衍生物，其中由X 2，R 1，R 2，R 2， R 3，R 6，R 7和R 12各自独立地选自H，OH，OR' ，SH，SR'，SOR'，SO 2 R'，NO 2，NH 2，NHR'，N（R' （O）H，C（-O）R'，CO 2（OR 2）2，NHCOR'，NHSO 2 R'，CN，卤素， H，CO 2 R'，羧基烷基，C 1 -C 12烷基，C 2 -C 12烷基，C 1 -C 12烷基， C 12 - 12链烯基，C 2 -C 12炔基，取代或未取代的芳基，取代或未取代的芳烷基和取代或未取代的杂芳族; 其中每个R'基团独立地选自H，OH，SH，N，O，NH 2，CN，卤素，-O，C （-O）H，C（-O）CH 3，CO 2 H，CO 2，CH 3， C 1 -C 12烷基，C 2 -C 12链烯基，C 2 -C 12烷基，C 1 -C 12烷基，炔基，芳基，芳烷基和杂芳基; 其中基团R 1和R 2，R 2和R 3，R 3， R 12和R 12，R 12和R 6，或R 6和R 12， 7可以连接到碳环或杂环系中。

22. 发明授权

US07348310B2 Synthetic methods for aplidine and new antitumoral derivatives, methods of making and using them 有权
标题翻译：阿普立定和新抗肿瘤衍生物的合成方法，制备和使用它们的方法
公开(公告)号：US07348310B2
公开(公告)日：2008-03-25
申请号：US10312341
申请日：2001-07-02
申请人： Ignacio Rodriguez , Concepción Polanco , Felix Cuevas , Paloma Mendez , Carmen Cuevas , Pilar Gallego , Simon Munt , Ignacio Manzanares
发明人： Ignacio Rodriguez , Concepción Polanco , Felix Cuevas , Paloma Mendez , Carmen Cuevas , Pilar Gallego , Simon Munt , Ignacio Manzanares
IPC分类号： C07K11/00
CPC分类号： C07K5/0808 , A61K38/00 , C07K5/0205 , C07K7/02
摘要： The invention relates to aplidine derivatives of the general formula: which are useful for the treatment of tumors.
摘要翻译：本发明涉及以下通式的氨基衍生物：其可用于治疗肿瘤。

23. 发明授权

US07795260B2 Synthesis of naturally occurring ecteinascidins and related compounds 有权
公开(公告)号：US07795260B2
公开(公告)日：2010-09-14
申请号：US12273919
申请日：2008-11-19
申请人： Valentin Martinez Barrasa , Pilar Gallego , Carmen Cuevas , Simon Munt , Ignacio Manzanares , Roberto Menchaca , Natividad Rodriguez , Alberto Rodriguez
发明人： Valentin Martinez Barrasa , Pilar Gallego , Carmen Cuevas , Simon Munt , Ignacio Manzanares , Roberto Menchaca , Natividad Rodriguez , Alberto Rodriguez
IPC分类号： A01N43/58 , A01N43/30 , A61K31/50 , A61K31/495 , C07D241/36 , C07D271/00 , C07D487/00 , C07D491/00 , C07D495/00 , C07D497/00 , C07D498/00 , C07D513/00
CPC分类号： C07D515/18 , C07D515/22
摘要： Ecteinascidin compounds with a quinone ring for ring E are active as anti-cancer agents. Related processes and compounds are provided.

24. 发明申请

US20100216987A1 SYNTHESIS OF NATURALLY OCCURING ECTEINASCIDINS AND RELATED COMPOUNDS 有权
标题翻译：天然抗氧化剂及相关化合物的合成
公开(公告)号：US20100216987A1
公开(公告)日：2010-08-26
申请号：US12758182
申请日：2010-04-12
申请人： Valentin Martinez Barrasa , Pilar Gallego , Carmen Cuevas , Simon Munt , Ignacio Manzanares , Roberto Menchaca , Natividad Rodriguez , Alberto Rodriguez
发明人： Valentin Martinez Barrasa , Pilar Gallego , Carmen Cuevas , Simon Munt , Ignacio Manzanares , Roberto Menchaca , Natividad Rodriguez , Alberto Rodriguez
IPC分类号： C07D515/22
CPC分类号： C07D515/18 , C07D515/22
摘要： Ecteinascidin compounds with a quinone ring for ring E are active as anti-cancer agents. Related processes and compounds are provided.
摘要翻译：具有环E的醌环的白in素化合物作为抗癌剂是有活性的。提供相关方法和化合物。

25. 发明授权

US07678765B2 Synthetic methods for aplidine and new antitumoral derivatives, methods of making and using them 有权
标题翻译：阿普立定和新抗肿瘤衍生物的合成方法，制备和使用它们的方法
公开(公告)号：US07678765B2
公开(公告)日：2010-03-16
申请号：US11788866
申请日：2007-04-20
申请人： Ignacio Rodriguez , Concepción Polanco , Felix Cuevas , Paloma Mandez , Carmen Cuevas , Pilar Gallego , Simon Munt , Ignacio Manzanares
发明人： Ignacio Rodriguez , Concepción Polanco , Felix Cuevas , Paloma Mandez , Carmen Cuevas , Pilar Gallego , Simon Munt , Ignacio Manzanares
IPC分类号： A61K38/15 , C07K11/00
CPC分类号： C07K5/0808 , A61K38/00 , C07K5/0205 , C07K7/02
摘要： The invention relates to aplidine derivatives of the general formula: which are useful for the treatment of tumors.
摘要翻译：本发明涉及以下通式的氨基衍生物：其可用于治疗肿瘤。

26. 发明申请

US20080009435A1 Synthetic methods for aplidine and new antitumoral derivatives, methods of making and using them 有权
公开(公告)号：US20080009435A1
公开(公告)日：2008-01-10
申请号：US11788866
申请日：2007-04-20
申请人： Ignacio Rodriguez , Concepcion Polanco , Felix Cuevas , Paloma Mendez , Carmen Cuevas , Pilar Gallego , Simon Munt , Ignacio Manzanares
发明人： Ignacio Rodriguez , Concepcion Polanco , Felix Cuevas , Paloma Mendez , Carmen Cuevas , Pilar Gallego , Simon Munt , Ignacio Manzanares
IPC分类号： A61K38/12 , A61K38/00 , A61P35/00 , C07K11/00 , C07K11/02
CPC分类号： C07K5/0808 , A61K38/00 , C07K5/0205 , C07K7/02
摘要： The invention relates to aplidine derivatives of the general formula: which are useful for the treatment of tumors.

27. 发明授权

US07138547B2 Antitumoral compounds 失效
公开(公告)号：US07138547B2
公开(公告)日：2006-11-21
申请号：US10297352
申请日：2001-06-06
申请人： Jose Luis Aceña , Javier Adrio , Carmen Cuevas , Pilar Gallego , Ignacio Manzanares , Simon Munt , Ignacio Rodriguez
发明人： Jose Luis Aceña , Javier Adrio , Carmen Cuevas , Pilar Gallego , Ignacio Manzanares , Simon Munt , Ignacio Rodriguez
IPC分类号： C07C233/00 , C07D493/00 , A61K31/42 , A61K31/35
CPC分类号： C07D263/24 , C07B2200/07 , C07C211/15 , C07C215/08 , C07C215/52 , C07C217/08 , C07C219/06 , C07C225/06 , C07C233/18 , C07C233/22 , C07C237/08 , C07C251/38 , C07C271/16 , C07C271/22 , C07C275/10 , C07C275/28 , C07C311/04 , C07C335/16 , C07D263/22 , C07F9/091
摘要： New spisulosine derivatives of use in treating tumors are of the formula (I) wherein: each X is the same or different, and represents H, OH, OR′, SH, SR′, SOR′, SO2R′, NO2, NH2, NHR′, N(R′)2, CN, halogen, C(═O)H, C(═O)CH3, CO2H, CO2CH3, substituted or unsubstituted C1–C18 alkyl, substituted or unsubstituted C2–C18 alkenyl, substituted or unsubstituted C2–C18 alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaromatic, or two groups X may together form ═O; Y is NR1, OR1, PR1, SR1, or halogen, wherein the number of substituents R1 is selected to suit the valency and each R1 is independently selected of H, OH, C(═O)R′, P(═O)R′R″, substituted or unsubstituted C1–C18 alkyl, substituted or unsubstituted C2–C18 alkenyl, substituted or unsubstituted C2–C18 alkynyl, substituted or unsubstituted aryl, and wherein the dotted line indicates an optional double bond; each Z is the same different, and represents H, OH, OR′, SH, SR′, SOR′, SO2R′, NO2, NH2, NHR′, N(R′)2, NHC(O)R′, CN, halogen, C(═O)H, C(═O)CH3, CO2H, CO2CH3, substituted or unsubstituted C1–C18 alkyl, substituted or unsubstituted C2–C18 alkenyl, substituted or unsubstituted C2–C18 alkenyl, substituted or unsubstituted C2–C18 alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaromatic, or two groups Z may together form ═O; z is 0 to 25; y is to 0 to 20; R2 is H, C(═O)R′, P(═O)R′R″, S(═O)R′R″, S(═O)2R′, substituted or unsubstituted C1–C18 alkyl, substituted or unsubstituted C2–C18 Alkenyl, substituted or unsubstituted C2–C18 alkynyl, substituted or unsubstituted aryl; R3 is H, C(═O)R′, P(═O)R′R″, S(═O)R′R″, S(═O)2R′, substituted or unsubstituted C1–C18 alkyl, substituted or unsubstituted C2–C18 alkenyl, substituted or unsubstituted C2–C18 alkynyl, substituted or unsubstituted aryl; each of the R′, R″ groups is independently selected from the group consisting of H, OH, NO2, NH2, SH, CN, halogen, ═O, C(═O)H, C(═O)CH3, CO2H, CO2CH3, substituted or unsubstituted C1–C18 alkyl, substituted or unsubstituted C1–C18 alkoxy, substituted or unsubstituted C2–C18 alkenyl, substituted or unsubstituted C2–C18 alkynl, substituted or unsubstituted aryl; there may be one or more unsaturations in the hydrocarbon backbone defined by the chain (II) and salts thereof; with the exception of a C16–C24 2-amino-3-hydroxyalkane or a C16–C24 2-amino-3-hydroxyalkene

28. 发明授权

US08012975B2 Antitumoral analogs of ET-743 有权
标题翻译： ET-743的抗肿瘤类似物
公开(公告)号：US08012975B2
公开(公告)日：2011-09-06
申请号：US11645356
申请日：2006-12-22
申请人： Ignacio Manzanares , Carmen Cuevas , Marta Perez , Maria Jesus Martin , Alberto Rodriguez , Simon Munt
发明人： Ignacio Manzanares , Carmen Cuevas , Marta Perez , Maria Jesus Martin , Alberto Rodriguez , Simon Munt
IPC分类号： C07D471/22 , C07D487/22 , A61K31/496 , A61P35/00
CPC分类号： C07D491/18 , C07D471/18 , C07D471/22 , C07D491/22 , C07D497/22
摘要： Antitumor compounds have the five membered fused ring ecteinascidin structure of the formula (XIV). The present compounds lack a 1,4-bridging group as found in the ecteinascidins. They have at the C-1 position a substituent selected from an optionally protected or derivatised aminomethylene group or an optionally protected or derivatised hydroxymethylene group.
摘要翻译：抗肿瘤化合物具有式（XIV）的五元稠环环虫苷结构。本发明化合物缺乏在ecteinascidins中发现的1,4桥连基团。它们在C-1位具有选自任选保护或衍生的氨基亚甲基或任选保护或衍生的羟基亚甲基的取代基。

29. 发明授权

US07482429B2 Kahalalide F and related compounds 有权
标题翻译： Kahalalide F及相关化合物
公开(公告)号：US07482429B2
公开(公告)日：2009-01-27
申请号：US10182881
申请日：2001-02-09
申请人： Fernando Albericio , Ernest Giralt , Jose Carlos Jimenez , Angel Lopez , Ignacio Manzanares , Ignacio Rodrigues , Miriam Royo
发明人： Fernando Albericio , Ernest Giralt , Jose Carlos Jimenez , Angel Lopez , Ignacio Manzanares , Ignacio Rodrigues , Miriam Royo
IPC分类号： A61K38/00 , A61K38/03
CPC分类号： C07K7/06 , A61K38/00 , C07K7/08
摘要： A process is provided for preparing kahalalide F and which leads to other kahalalide mimic compounds having useful biological activity.
摘要翻译：提供了制备辣椒碱F的方法，并且其导致具有有用生物活性的其它卡哈拉宾模拟化合物。

30. 发明申请

US20080318849A1 Kahalalide F and Related Compounds 审中-公开
标题翻译： Kahalalide F及相关化合物
公开(公告)号：US20080318849A1
公开(公告)日：2008-12-25
申请号：US12198013
申请日：2008-08-25
申请人： Fernando Albericio , Ernest Giralt , Jose Carlos Jimenez , Angel Lopez , Ignacio Manzanares , Ignacio Rodrigues , Miriam Royo
发明人： Fernando Albericio , Ernest Giralt , Jose Carlos Jimenez , Angel Lopez , Ignacio Manzanares , Ignacio Rodrigues , Miriam Royo
IPC分类号： A61K38/12 , C07K7/64 , A61P35/04
CPC分类号： C07K7/06 , A61K38/00 , C07K7/08
摘要： A process is provided for preparing kahalalide F and which leads to other kahalalide mimic compounds having useful biological activity.
摘要翻译：提供了制备辣椒碱F的方法，并且其导致具有有用生物活性的其它卡哈拉宾模拟化合物。

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