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21. 发明申请

US20080039633A1 Process for preparing arylamines 审中-公开
标题翻译：制备芳基胺的方法
公开(公告)号：US20080039633A1
公开(公告)日：2008-02-14
申请号：US11836440
申请日：2007-08-09
申请人： Joerg JUNG , Andreas Meudt , Bernd Wilheilm Lehnemann
发明人： Joerg JUNG , Andreas Meudt , Bernd Wilheilm Lehnemann
IPC分类号： C07D211/98 , C07C209/58 , C07C209/72
CPC分类号： C07C209/10 , C07C213/08 , C07D211/14 , C07D213/75 , C07C211/56 , C07C217/92
摘要： The invention relates to a process for preparing arylamines or heteroarylamines or arylamides or heteroarylamides by cross-coupling of primary or secondary amines or amides with substituted aryl or heteroaryl compounds in the presence of a Brønsted base and a catalyst or precatalyst, wherein the catalyst comprises a) a transition metal, a complex, a salt or a compound of this transition metal selected from the group consisting of Ni, Pd and b) at least one ligand selected from the group consisting of bidentate bis(phosphino)alkanediyls having the following formula in a solvent or solvent mixture, where the radicals Ar1-4 are each, independently of one another, an aryl or heteroaryl substituent selected from the group consisting of phenyl, naphthyl, pyridyl and biphenyl or Ar1-4 is hydrogen, C1-, C2-alkyl, straight-chain, branched or cyclic C3-C8-alkyl, and L is an alkanediyl bridge which has from 1 to 20 carbon atoms.
摘要翻译：本发明涉及通过在布朗斯台德碱和催化剂或预催化剂存在下，将伯胺或仲胺与取代的芳基或杂芳基化合物交联偶联来制备芳基胺或杂芳基胺或芳基酰胺或杂芳基酰胺的方法，其中催化剂包括）过渡金属，络合物，盐或该过渡金属的化合物，其选自Ni，Pd和b）至少一种选自下列式中的至少一种配体：具有下式的二齿双（膦基）烷二基其中基团Ar 1〜4彼此独立地为选自苯基，萘基，吡啶基和联苯基的芳基或杂芳基取代基或Ar ^{1-4是氢，C 1〜C 2 - 烷基，直链，支链或环状的C 3 - -C 8 - 烷基，L是具有1至20个碳原子的烷二基桥。}

22. 发明授权

US07262328B1 Method for the production of aldehydes and ketones by oxidizing primary and secondary alcohols with alkylphosphonic acid anhydrides 有权
标题翻译：通过用烷基膦酸酐氧化伯醇和仲醇生产醛和酮的方法
公开(公告)号：US07262328B1
公开(公告)日：2007-08-28
申请号：US10592439
申请日：2005-04-18
申请人： Andreas Meudt , Stefan Scherer , Claudius Boehm
发明人： Andreas Meudt , Stefan Scherer , Claudius Boehm
IPC分类号： C07C45/38 , C07C45/39
CPC分类号： C07C45/29 , C07B41/06 , C07C269/06 , C07C47/21 , C07C47/54 , C07C49/10 , C07C271/22
摘要： The invention relates to a method for the production of a.) aldehydes of formula (II): R1—CHO and b.) aldehydes of formula (III): R1—C(O)—R2 by reacting a.) primary alcohols (R1CH2—OH) or b.) secondary alcohols (R1—CH(OH)—R2) with cyclic phosphonic acid anhydrides in the presence of dialkyl-, diaryl- and/or alkyl-aryl sulphonic oxides at a temperature in the region of between −100 to +120° C., whereby R1 and/or R2 represent H, a substituted linear or branched C1-C12-alkyl radical, a substituted C3-C10 cycloalkyl-, alkenyl-, aryl- or heteroaryl radical. A cyclic phosphonic acid anhydride is used, preferably, as a 2,4,6-substituted 1,3,5,2,4,6-trioxatriphosphinane of formula (I), wherein R′ independently represents allyl, aryl or open-chained or branched C1-C12-alkyl-radicals. Optionally, the reaction can be carried out in the presence of a tertiary amine base NR53
摘要翻译：本发明涉及一种制备式（II）的醛的方法：R 1 -CHO和b）式（III）的醛：R 1〜通过使a。）伯醇（R 1 CH 2 CH 2 -OH）或b。）二级（C 1 -C 4）在二烷基 - ，二芳基 - 和/或烷基 - 芳基磺酸氧化物的存在下，与环状膦酸酐反应，得到醇（R 1 -CH 2（OH）-R 2）在-100至+ 120℃之间的区域中的温度，其中R 1和/或R 2表示H，取代的直链或支链C 1〜取代的C 3 -C 10 - 环烷基 - ，链烯基 - ，芳基 - 或杂芳基（C 1 -C 6）激进。优选使用环状膦酸酐作为式（I）的2,4,6-取代的1,3,5,2,4,6-三氧杂三磷杂环己烷，其中R'独立地表示烯丙基，芳基或开链或支链C 1 -C 12 - 烷基 - 基团。任选地，反应可以在叔胺碱NR 5 SO 3存在下进行，

23. 发明申请

US20050258553A1 Method for the organometallic production of organic intermediate products comprising carbon-heteroatom bonds achieved by the deprotonation of heteroatoms 审中-公开
标题翻译：通过杂原子脱质子实现的包含碳 - 杂原子键的有机中间产物的有机金属生产方法
公开(公告)号：US20050258553A1
公开(公告)日：2005-11-24
申请号：US10526327
申请日：2003-08-21
申请人： Andreas Meudt , Bernd Lehnemann , Michael Erbes , Klaus Forstinger
发明人： Andreas Meudt , Bernd Lehnemann , Michael Erbes , Klaus Forstinger
IPC分类号： C07B41/00 , C07B43/00 , C07B61/00 , C07C249/16 , C07C251/86 , C07C269/04 , C07C271/28 , C07C281/04 , C07C303/40 , C07C311/53 , C07C319/14 , C07C321/14 , C07D307/42 , C07F9/02 , C07F1/02
CPC分类号： C07D307/42 , C07B41/00 , C07B43/00 , C07C249/16 , C07C269/04 , C07C303/40 , C07C319/14 , C07C321/14 , C07C311/53 , C07C271/28 , C07C251/86
摘要： The invention relates to a method for binding heteroatom-carbon bonds. According to said method, a lithium compound (II) is first generated by reacting aliphatic or aromatic halogen compounds (I) with lithium metal, said compound is then used for the deprotonation of the compounds (III) or (V). The lithium salts of formulas (IV) or (VI) obtained by said deprotonation are subsequently reacted with suitable carbon electrophiles (equation I), said process binding the heteroatom-carbon bond and forming the products (VIII) or (VIII), (equation I).
摘要翻译：本发明涉及一种结合杂原子 - 碳键的方法。根据所述方法，首先通过使脂族或芳族卤素化合物（I）与锂金属反应生成锂化合物（II），然后将所述化合物用于化合物（III）或（V）的去质子化。随后通过所述去质子化获得的式（Ⅳ）或（Ⅵ）的锂盐与合适的碳亲电子（式I）反应，所述方法结合杂原子 - 碳键并形成产物（Ⅷ）或（Ⅷ），一世）。

24. 发明申请

US20050001333A1 Method for producing, via organometallic compounds, organic intermediate products 审中-公开
标题翻译：通过有机金属化合物生产有机中间体产品的方法
公开(公告)号：US20050001333A1
公开(公告)日：2005-01-06
申请号：US10491967
申请日：2002-10-02
申请人： Detlef Wehle , Klaus Forstinger , Andreas Meudt
发明人： Detlef Wehle , Klaus Forstinger , Andreas Meudt
IPC分类号： C07B61/00 , C07C45/00 , C07C45/45 , C07C51/15 , C07F1/02
CPC分类号： C07F1/02 , C07C45/00 , C07C45/45 , C07C51/15 , C07C49/80 , C07C63/70 , C07C63/06
摘要： The present invention provides a process for preparing aryllithium compounds by reacting haloaliphatics with lithium metal to form a lithium alkyl and reacting the lithium alkyl with aromatic halogen compounds of formula (III) in a halogen-metal exchange reaction to form the corresponding lithium aromatics of formula (IV).
摘要翻译：本发明提供了一种通过卤代色谱与锂金属反应形成烷基锂并通过卤代 - 金属交换反应将烷基锂与芳族卤化物（III）卤化物反应形成相应的式（四）。

25. 发明授权

US06657093B2 Preparation of substituted aromatic compounds 有权
标题翻译：取代芳族化合物的制备
公开(公告)号：US06657093B2
公开(公告)日：2003-12-02
申请号：US10171444
申请日：2002-06-13
申请人： Andreas Meudt , Michael Erbes , Klaus Forstinger
发明人： Andreas Meudt , Michael Erbes , Klaus Forstinger
IPC分类号： C07B3704
CPC分类号： C07D307/12 , C07B37/04 , C07C1/26 , C07C41/16 , C07C41/26 , C07C41/30 , C07C45/59 , C07C45/68 , C07C319/20 , C07D213/50 , C07C15/44 , C07C323/22 , C07C43/23 , C07C43/205
摘要： A process for preparing compounds of the formula (II), where the substituents R1 to R5 are each independently H, CH3, straight-chain or branched C1-C8-alkyl, CH(OC1-C5-alkyl)2, CH(C1-C5-alkyl)(OC1-C5-alkyl), CH2(OC1-C5-alkyl), CH(CH3)(OC1-C5-alkyl), C1-C8-alkoxy, N(C1-C5-alkyl)2, phenyl, substituted phenyl, aryl, heteroaryl, S(C1-C5-alkyl) or a radical Caryl, alkyl, and the symbols X1 to 5 are each carbon.
摘要翻译：一种制备式（II）化合物的方法，其中取代基R 1至R 5各自独立地为H，CH 3，直链或支链C 1 -C 8 - 烷基，CH（OC 1 -C 5 - 烷基） 2，CH（C1-C5-烷基）（OC1-C5-烷基），CH2（OC1-C5-烷基），CH（CH3）（OC1-C5-烷基），C1-C8-烷氧基，N（C1-C5 - 烷基）2，苯基，取代的苯基，芳基，杂芳基，S（C 1 -C 5 - 烷基）或基团羧基，烷基，符号X 1至5>各自为碳。

26. 发明授权

US08487134B2 Process for the synthesis of amphetamine derivatives 有权
标题翻译：合成苯丙胺衍生物的方法
公开(公告)号：US08487134B2
公开(公告)日：2013-07-16
申请号：US13122893
申请日：2008-10-09
申请人： Andreas Meudt , Richard Wisdom , Jason Helmke , Quofang Qiu , Paul Meek
发明人： Andreas Meudt , Richard Wisdom , Jason Helmke , Quofang Qiu , Paul Meek
IPC分类号： C07C233/05 , C07C231/02
CPC分类号： C07C231/14 , C07C231/02 , C07C231/12 , Y02P20/55 , C07C237/06
摘要： The invention relates to processes for preparing acylated amphetamine, methamphetamine and dexamphetamine derivatives by reacting the parent amine with the to be-coupled acid or a salt of the to-be coupled acid which acid is optionally protected, in the presence of an alkylphosphonic acid anhydride as coupling agent and, if the acid was protected then cleaving the protecting group(s), in a one-pot reaction or in two or more separate steps.
摘要翻译：本发明涉及制备酰化苯丙胺，甲基苯丙胺和右苯丙胺衍生物的方法，该方法是在烷基膦酸酐存在下，通过使母体胺与被偶联的酸或可被任选被保护的酸的被偶联酸的盐反应作为偶联剂，如果酸被保护，然后在一锅反应或两个或多个分开的步骤中切割保护基。

27. 发明申请

US20110196173A1 Process for the Synthesis of Amphetamine Derivatives 有权
标题翻译：苯酚衍生物合成工艺
公开(公告)号：US20110196173A1
公开(公告)日：2011-08-11
申请号：US13122893
申请日：2008-10-09
申请人： Andreas Meudt , Richard Wisdom , Jason Helmke , Quofang Qiu , Paul Meek
发明人： Andreas Meudt , Richard Wisdom , Jason Helmke , Quofang Qiu , Paul Meek
IPC分类号： C07C237/00
CPC分类号： C07C231/14 , C07C231/02 , C07C231/12 , Y02P20/55 , C07C237/06
摘要： The invention relates to processes for preparing acylated amphetamine, methamphetamine and dexamphetamine derivatives by reacting the parent amine with the to be-coupled acid or a salt of the to-be coupled acid which acid is optionally protected, in the presence of an alkylphosphonic acid anhydride as coupling agent and, if the acid was protected then cleaving the protecting group(s), in a one-pot reaction or in two or more separate steps.
摘要翻译：本发明涉及制备酰化苯丙胺，甲基苯丙胺和右苯丙胺衍生物的方法，该方法是在烷基膦酸酐存在下，通过使母体胺与被偶联的酸或可被任选被保护的酸的被偶联酸的盐反应作为偶联剂，如果酸被保护，然后在一锅反应或两个或多个分开的步骤中切割保护基。

28. 发明授权

US07939688B2 Process for preparing nitriles by elimination reactions 有权
标题翻译：通过消除反应制备腈的方法
公开(公告)号：US07939688B2
公开(公告)日：2011-05-10
申请号：US11996105
申请日：2006-07-05
申请人： Andreas Meudt , Sven Nerdinger , Claudius Boehm
发明人： Andreas Meudt , Sven Nerdinger , Claudius Boehm
IPC分类号： C07C253/20
CPC分类号： C07C253/20 , C07C255/50 , C07C255/51 , C07C255/54
摘要： Process for preparing nitriles by reacting N-alkylcarboxamides (RCO—NHR1) or ammonium salts of carboxylic acids (RCOO—NH3R1+) or carboxylic acids in the presence of alkylamines or ammonium salts (RCOOH+NH2R1, RCOOH+NH3R1+), respectively, R being an arbitrarily substituted linear or branched C1-C12-alkyl radical, a C3-C12 cycloalkyl radical or an alkenyl, alkynyl or aryl or heteroaryl radical and R1 being an arbitrary substituted, linear or branched C2-C1 alkyl radical, a C3-C12 cycloalkyl radical or an alkenyl or alkynyl radical, with phosphonic anhydrides in the presence of an optional base in an organic solvent at a temperature in the range from −30 to 180° C. In advantageous embodiments, the phosphonic anhydride is a 2,4,6-substituted 1,3,5,2,4,6-trioxatriphosphinane 2,4,6-trioxide of the formula (I)
摘要翻译：在烷基胺或铵盐（RCOOH + NH 2 R 1，RCOOH + NH 3 R 1 +）存在下，通过N-烷基羧酰胺（RCO-NHR1）或羧酸铵盐（RCOO-NH 3 R 1 +）或羧酸反应来制备腈的方法，R为任意取代的直链或支链C 1 -C 12烷基，C 3 -C 12环烷基或烯基，炔基或芳基或杂芳基，R 1为任意取代的直链或支链C 2 -C 1烷基，C 3 -C 12环烷基基团或烯基或炔基与膦酸酐在有机溶剂中在任选的碱存在下在-30至180℃的温度下反应。在有利的实施方案中，膦酸酐是2,4,6 式（I）的1,3,5,2,4,6-三氧杂三磷杂环己烷2,4,6-三氧化物

29. 发明申请

US20090143586A1 Method for producing alkyl-substituted aromatic and heteroaromatic compounds by cross-coupling alkyl boronic acids with aryl-or heteroaryl-halogenides or sulfonates under Pd catalysis in the presence of a ligand 审中-公开
标题翻译：通过在烷基硼酸与芳基或杂芳基 - 卤化物或磺酸盐在Pd催化下在配体存在下交叉偶联来制备烷基取代的芳族和杂芳族化合物的方法
公开(公告)号：US20090143586A1
公开(公告)日：2009-06-04
申请号：US11817820
申请日：2006-03-07
申请人： Stefan Scherer , Andreas Meudt , Sven Nerdinger , Bernd Wilhelm Lehnemann , Thomas Jagusch , Victor Snieckus
发明人： Stefan Scherer , Andreas Meudt , Sven Nerdinger , Bernd Wilhelm Lehnemann , Thomas Jagusch , Victor Snieckus
IPC分类号： C07F5/02
CPC分类号： C07C1/321 , C07B37/04 , C07C17/263 , C07C67/343 , C07C2531/24 , C07D213/30 , C07C15/02 , C07C22/08 , C07C69/76
摘要： The invention relates to a method for producing alkyl-substituted aromatic and heteroaromatic compounds by cross-coupling alkyl boronic acids with aryl- or heteroaryl-halogenides or with aryl- or heteroaryl-sulfonates in the presence of a catalyst and of a Brönsted base in a solvent or solvent mixture.
摘要翻译：本发明涉及通过在烷基硼酸与芳基 - 或杂芳基 - 卤化物或与芳基 - 或杂芳基 - 磺酸盐在催化剂存在下交联偶联来制备烷基取代的芳族和杂芳族化合物的方法，溶剂或溶剂混合物。

30. 发明申请

US20080221357A1 Method for Producing Amines from Hydroxamic Acids 有权
标题翻译：羟基酸生产胺的方法
公开(公告)号：US20080221357A1
公开(公告)日：2008-09-11
申请号：US11995000
申请日：2006-07-05
申请人： Andreas Meudt , Claudius Boehm
发明人： Andreas Meudt , Claudius Boehm
IPC分类号： C07C209/54
CPC分类号： C07C269/00 , C07C209/56 , C07C271/12 , C07C271/28
摘要： A method for producing unprotected or carbamate-protected amines of formulae (II) and (III) or R1—NH2 (II) or R1—NHCO2R2 (III) by reacting hydroxamic acids of formula (I) (R1CONHOH) with a) alkylphosphonic acid anhydrite's, b) alcohol R2OH and c) optionally with a base, at a temperature ranging from 100 to +120° C., wherein the hydroxamic acid (I) is produced prior to or during reacting (in situ) and R1 is an optionally substituted linear or branched C1-C12 alkyl radical, substituted C3-C10 cycloalkyl, alkenyl, aryl or heteroaryl radical and R2 is an open-chain, cyclic or branched allyl, aryl or C1 to C12-alkyl radicals, or aryloxy, allyloxy or alkoxy radical possibly substituted with open-chain, cyclic or branched C1 to C12-alkyl radicals.
摘要翻译：制备未受保护或氨基甲酸酯保护的式（II）和（III）的胺或R 1 -NH 2（II）或R 1，通过使式（I）的异羟肟酸（R 1 H CONHOH）与a）烷基膦酸反应，从而将（III）（Ⅳ）无水石膏，b）醇R 2 OH和c）任选地与碱反应，在100至+ 120℃的温度范围内，其中异羟肟酸（I）在反应之前或期间产生（原位）和R 1是任选取代的直链或支链C 1 -C 12烷基，取代的C 3 - 环烷基，芳基或杂芳基，R 2是开链的，环状或支链的烯丙基，芳基或C 1〜或可以被开链，环状或支链C 1〜C 12取代的芳氧基，烯丙氧基或烷氧基， /烷基。

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