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21. 发明授权

US11478646B2 Method and apparatus for monitoring a patient 有权
公开(公告)号：US11478646B2
公开(公告)日：2022-10-25
申请号：US16316548
申请日：2017-07-12
申请人： Jonathan W. Valvano , John A. Pearce , Marc D. Feldman , Kaarthik Rajendran , John Porterfield , Anil Kottam , Wes Johnson
发明人： Jonathan W. Valvano , John A. Pearce , Marc D. Feldman , Kaarthik Rajendran , John Porterfield , Anil Kottam , Wes Johnson
IPC分类号： A61N1/36 , A61N1/365 , G16H40/63 , A61B5/0205 , A61B5/0538 , A61B5/00 , A61N1/05 , A61N1/362 , A61B5/029 , A61B5/08
摘要： An apparatus for monitoring a patient post operation having electrically conducting leads which are adapted to extend from inside the patient. The leads having electrodes adapted to communicate with a heart of the patient and apply electrical signals to the heart. The electrodes providing cardiac signals to the computer in response to the electrical signals so the computer can determine in real time at least one of heart volume, end diastolic heart volume, end systolic heart volume, stroke volume, change in heart volume, change in stroke volume, contractility, respiration rate or tidal volume regarding the patient.

22. 发明申请

US20180078169A1 Method and Apparatus for Monitoring an Organ of a Patient 审中-公开
公开(公告)号：US20180078169A1
公开(公告)日：2018-03-22
申请号：US15816067
申请日：2017-11-17
申请人： Marc D. Feldman , John Porterfield , Karthik Raghavan , Jonathan W. Valvano , John A. Pearce
发明人： Marc D. Feldman , John Porterfield , Karthik Raghavan , Jonathan W. Valvano , John A. Pearce
IPC分类号： A61B5/053 , A61B5/00 , A61B5/029 , A61B5/0295 , A61B5/0452 , A61B5/0476 , A61B5/20 , A61B5/107 , A61B5/08 , A61B5/0488 , A61B5/0215 , A61N1/365 , A61N1/39 , A61N1/368
CPC分类号： A61B5/0537 , A61B5/0031 , A61B5/0215 , A61B5/029 , A61B5/0295 , A61B5/0452 , A61B5/0476 , A61B5/0488 , A61B5/0535 , A61B5/0538 , A61B5/0809 , A61B5/1076 , A61B5/204 , A61B5/441 , A61B5/4519 , A61B5/4878 , A61N1/36521 , A61N1/3684 , A61N1/3962
摘要： An apparatus for determining tissue versus fluid components of an organ include a detector that generates a detector signal based on electrical signals derived from tissue and fluid. The apparatus includes a signal processor in communication with the detector which subtracts in real time a tissue component from the detector signal and produces a fluid volume signal. A method for monitoring a patient's fluid volume of a patient's organ. An apparatus for monitoring a patient's organ. A method for monitoring a patient's organ. A method to piggyback an admittance system onto a AICD/Bi-ventricular Pacemaker for a heart of a patient, in particular a weakened heart having features consistent with congestive heart failure. An apparatus for monitoring an organ, such as a heart, lungs, brain, skeletal muscle, and bladder of a patient which includes a detector which detects the admittance of the organ. The apparatus includes a transmitter in communication with the detector which transmits a wireless signal indicative of the admittance of the organ. A method for monitoring an organ of a patient includes the steps of detecting with a detector the admittance of the organ. There is the step of transmitting with a transmitter in communication with the detector a wireless signal indicative of admittance of the organ.

23. 发明申请

US20150119947A1 Method and Apparatus for Determining Cardiac Performance in a Patient 审中-公开
公开(公告)号：US20150119947A1
公开(公告)日：2015-04-30
申请号：US14588683
申请日：2015-01-02
申请人： Marc D. Feldman , Jonathan W. Valvano , John A. Pearce
发明人： Marc D. Feldman , Jonathan W. Valvano , John A. Pearce
IPC分类号： A61N1/365 , A61N1/362 , A61N1/368 , A61N1/39
摘要： An apparatus for determining heart transplant rejection of a heart in a patient includes at least two electrodes adapted to be sewn into the heart that span the left ventricle. The apparatus includes a voltage generator adapted to be inserted in the patient which generates a voltage to the two electrodes and senses the resulting voltage from the two electrodes. A method for determining heart transplant rejection of a heart in a patient. A pacemaker for a patient (including bi-ventricular pacing and AICDs). The pacemaker includes an RV lead having four electrodes adapted to be inserted into the RV apex. The pacemaker includes a voltage generator which generates a voltage signal to the electrodes and senses the instantaneous voltage along the length of the RV and determines the real and imaginary components to remove the myocardial components of the septum and RV free wall to determine absolute RV blood volume. The pacemaker includes a battery connected to the voltage generator. The pacemaker includes a defibrillator connected to the battery. The pacemaker can also be a bi-ventricular pacemaker to restore RV and LV synchrony during contraction. A method for assisting a heart of a patient.

24. 发明授权

US10376177B2 Low power apparatus and method to measure complex electrical admittance or impedance 有权
公开(公告)号：US10376177B2
公开(公告)日：2019-08-13
申请号：US15044842
申请日：2016-02-16
申请人： Jonathan W. Valvano , Marc D. Feldman , John Porterfield , John A. Pearce , Erik Larson , Lev Shuhatovich , Kathryn Loeffler , Raffaele Cetrulo
发明人： Jonathan W. Valvano , Marc D. Feldman , John Porterfield , John A. Pearce , Erik Larson , Lev Shuhatovich , Kathryn Loeffler , Raffaele Cetrulo
IPC分类号： A61N1/36 , A61B5/053 , A61N1/05 , A61N1/365 , A61N1/37 , A61B5/0215 , A61B5/029
摘要： An apparatus for measuring complex electrical admittance and/or complex electrical impedance in animal or human patients includes a first electrode and at least a second electrode which are adapted to be disposed in the patient. The apparatus includes a housing adapted to be disposed in the patient. The housing has disposed in it a stimulator in electrical communication with at least the first electrode to stimulate the first electrode with either current or voltage, a sensor in electrical communication with at least the second electrode to sense a response from the second electrode based on the stimulation of the first electrode, and a signal processor in electrical communication with the sensor to determine the complex electrical admittance or impedance of the patient.

25. 发明申请

US20160262653A1 Low Power Apparatus and Method to Measure Complex Electrical Admittance or Impedance 审中-公开
公开(公告)号：US20160262653A1
公开(公告)日：2016-09-15
申请号：US15044842
申请日：2016-02-16
申请人： Jonathan W. Valvano , Marc D. Feldman , John Porterfield , John A. Pearce , Erik Larson , Lev Shuhatovich , Kathryn Loeffler , Raffaele Cetrulo
发明人： Jonathan W. Valvano , Marc D. Feldman , John Porterfield , John A. Pearce , Erik Larson , Lev Shuhatovich , Kathryn Loeffler , Raffaele Cetrulo
IPC分类号： A61B5/053 , A61N1/37 , A61B5/0215 , A61N1/365 , A61N1/05 , A61B5/029
CPC分类号： A61B5/0538 , A61B5/0215 , A61B5/029 , A61N1/056 , A61N1/36125 , A61N1/36521 , A61N1/3706
摘要： An apparatus for measuring complex electrical admittance and/or complex electrical impedance in animal or human patients includes a first electrode and at least a second electrode which are adapted to be disposed in the patient. The apparatus includes a housing adapted to be disposed in the patient. The housing has disposed in it a stimulator in electrical communication with at least the first electrode to stimulate the first electrode with either current or voltage, a sensor in electrical communication with at least the second electrode to sense a response from the second electrode based on the stimulation of the first electrode, and a signal processor in electrical communication with the sensor to determine the complex electrical admittance or impedance of the patient.

26. 发明授权

US08706219B2 Method and apparatus for monitoring an organ of a patient 有权
标题翻译：用于监测患者器官的方法和装置
公开(公告)号：US08706219B2
公开(公告)日：2014-04-22
申请号：US12657832
申请日：2010-01-28
申请人： Marc D. Feldman , John Porterfield , Karthik Raghavan , Jonathan W. Valvano , John A. Pearce
发明人： Marc D. Feldman , John Porterfield , Karthik Raghavan , Jonathan W. Valvano , John A. Pearce
IPC分类号： A61N1/362
CPC分类号： A61B5/0537 , A61B5/0031 , A61B5/0215 , A61B5/029 , A61B5/0295 , A61B5/0452 , A61B5/0476 , A61B5/0488 , A61B5/0535 , A61B5/0538 , A61B5/0809 , A61B5/1076 , A61B5/204 , A61B5/441 , A61B5/4519 , A61B5/4878 , A61N1/36521 , A61N1/3684 , A61N1/3962
摘要： An apparatus for determining tissue versus fluid components of an organ include a detector that generates a detector signal based on electrical signals derived from tissue and fluid. The apparatus includes a signal processor in communication with the detector which subtracts in real time a tissue component from the detector signal and produces a fluid volume signal. A method for monitoring a patient's fluid volume of a patient's organ. An apparatus for monitoring a patient's organ. A method for monitoring a patient's organ. A method to piggyback an admittance system onto a AICD/Bi-ventricular Pacemaker for a heart of a patient, in particular a weakened heart having features consistent with congestive heart failure. An apparatus for monitoring an organ, such as a heart, lungs, brain, skeletal muscle, and bladder of a patient which includes a detector which detects the admittance of the organ. The apparatus includes a transmitter in communication with the detector which transmits a wireless signal indicative of the admittance of the organ. A method for monitoring an organ of a patient includes the steps of detecting with a detector the admittance of the organ. There is the step of transmitting with a transmitter in communication with the detector a wireless signal indicative of admittance of the organ.
摘要翻译：用于确定器官的组织与流体成分的装置包括基于从组织和流体得到的电信号产生检测器信号的检测器。该装置包括与检测器通信的信号处理器，其实时地从检测器信号中减去组织成分并产生流体体积信号。一种用于监测患者器官的患者体液量的方法。用于监测患者器官的装置。一种监测患者器官的方法。将导纳系统搭载到患者心脏的AICD /双心室起搏器的方法，特别是具有与充血性心力衰竭一致的特征的弱化心脏。一种用于监测患者的器官（例如心脏，肺，脑，骨骼肌和膀胱）的装置，其包括检测器官的入射的检测器。该装置包括与检测器通信的发射器，其发射指示器官的导纳的无线信号。用于监测患者器官的方法包括以下步骤：用检测器检测器官的导纳。存在与发射机通信的步骤，该发射机与检测器通信，指示器官进入的无线信号。

27. 发明申请

US20130023946A1 Low Power Apparatus and Method to Measure Complex Electrical Admittance or Impedance 有权
标题翻译：低功率设备和测量复杂电导率或阻抗的方法
公开(公告)号：US20130023946A1
公开(公告)日：2013-01-24
申请号：US13425119
申请日：2012-03-20
申请人： Jonathan W. Valvano , Marc D. Feldman , John Porterfield , John A. Pearce , Erik Larson , Lev Shuhatovich , Kathryn Loeffler , Raffaele Cetrulo
发明人： Jonathan W. Valvano , Marc D. Feldman , John Porterfield , John A. Pearce , Erik Larson , Lev Shuhatovich , Kathryn Loeffler , Raffaele Cetrulo
IPC分类号： A61N1/365
CPC分类号： A61B5/0538 , A61B5/0215 , A61B5/029 , A61N1/056 , A61N1/36125 , A61N1/36521 , A61N1/3706
摘要： An apparatus for measuring complex electrical admittance and/or complex electrical impedance in animal or human patients includes a first electrode and at least a second electrode which are adapted to be disposed in the patient. The apparatus includes a housing adapted to be disposed in the patient. The housing has disposed in it a stimulator in electrical communication with at least the first electrode to stimulate the first electrode with either current or voltage, a sensor in electrical communication with at least the second electrode to sense a response from the second electrode based on the stimulation of the first electrode, and a signal processor in electrical communication with the sensor to determine the complex electrical admittance or impedance of the patient.
摘要翻译：用于测量动物或人类患者中的复电导纳和/或复电阻抗的装置包括第一电极和适于设置在患者体内的至少第二电极。该装置包括适于设置在患者体内的壳体。壳体设置有与至少第一电极电连通的刺激器，以用电流或电压来刺激第一电极，传感器至少与第二电极电连通，以基于第二电极感测来自第二电极的响应对第一电极的刺激以及与传感器电通信的信号处理器，以确定患者的复杂电导纳或阻抗。

28. 发明申请

US20100280397A1 Method and apparatus for monitoring an organ of a patient 有权
标题翻译：用于监测患者器官的方法和装置
公开(公告)号：US20100280397A1
公开(公告)日：2010-11-04
申请号：US12657832
申请日：2010-01-28
申请人： Marc D. Feldman , John Porterfield , Karthik Raghavan , Jonathan W. Valvano , John A. Pearce
发明人： Marc D. Feldman , John Porterfield , Karthik Raghavan , Jonathan W. Valvano , John A. Pearce
IPC分类号： A61B5/0215 , A61B5/053 , A61B5/02 , A61B5/08 , A61N1/368
CPC分类号： A61B5/0537 , A61B5/0031 , A61B5/0215 , A61B5/029 , A61B5/0295 , A61B5/0452 , A61B5/0476 , A61B5/0488 , A61B5/0535 , A61B5/0538 , A61B5/0809 , A61B5/1076 , A61B5/204 , A61B5/441 , A61B5/4519 , A61B5/4878 , A61N1/36521 , A61N1/3684 , A61N1/3962
摘要： An apparatus for determining tissue versus fluid components of an organ include a detector that generates a detector signal based on electrical signals derived from tissue and fluid. The apparatus includes a signal processor in communication with the detector which subtracts in real time a tissue component from the detector signal and produces a fluid volume signal. A method for monitoring a patient's fluid volume of a patient's organ. An apparatus for monitoring a patient's organ. A method for monitoring a patient's organ. A method to piggyback an admittance system onto a AICD/Bi-ventricular Pacemaker for a heart of a patient, in particular a weakened heart having features consistent with congestive heart failure. An apparatus for monitoring an organ, such as a heart, lungs, brain, skeletal muscle, and bladder of a patient which includes a detector which detects the admittance of the organ. The apparatus includes a transmitter in communication with the detector which transmits a wireless signal indicative of the admittance of the organ. A method for monitoring an organ of a patient includes the steps of detecting with a detector the admittance of the organ. There is the step of transmitting with a transmitter in communication with the detector a wireless signal indicative of admittance of the organ.
摘要翻译：用于确定器官的组织与流体成分的装置包括基于从组织和流体得到的电信号产生检测器信号的检测器。该装置包括与检测器通信的信号处理器，其实时地从检测器信号中减去组织成分并产生流体体积信号。一种用于监测患者器官的患者体液量的方法。用于监测患者器官的装置。一种监测患者器官的方法。将导纳系统搭载到患者心脏的AICD /双心室起搏器的方法，特别是具有与充血性心力衰竭一致的特征的弱化心脏。一种用于监测患者的器官（例如心脏，肺，脑，骨骼肌和膀胱）的装置，其包括检测器官的入射的检测器。该装置包括与检测器通信的发射器，其发射指示器官的导纳的无线信号。用于监测患者器官的方法包括以下步骤：用检测器检测器官的导纳。存在与发射机通信的步骤，该发射机与检测器通信，指示器官进入的无线信号。

29. 发明授权

US06494832B1 Multifrequency conductance catheter-based system and method to determine LV function in a patient 有权
标题翻译：多通道电导导管系统及方法确定患者的LV功能
公开(公告)号：US06494832B1
公开(公告)日：2002-12-17
申请号：US09649727
申请日：2000-08-28
申请人： Marc D. Feldman , Jonathan W. Valvano , John A. Pearce
发明人： Marc D. Feldman , Jonathan W. Valvano , John A. Pearce
IPC分类号： A61B500
CPC分类号： A61B5/0422 , A61B5/0215 , A61B5/0535 , A61B5/0538
摘要： An apparatus and method for determining cardiac performance in a patient. The apparatus includes a multifrequency conductance catheter for measuring instantaneous volume of a heart chamber with multifrequencies. The apparatus includes a mechanism for measuring instantaneous pressure of the heart chamber. The apparatus includes a mechanism for separating the multifrequencies. The apparatus includes a mechanism for signal processing the instantaneous volume and the pressure of the heart chamber to identify mechanical strength of the chamber and for automatically producing a plurality of desired waveforms at desired frequencies for the conductance catheter. The processing mechanism is connected to the pressure measuring mechanism, the separating mechanism and the volume measuring mechanism.
摘要翻译：一种用于确定患者心脏性能的装置和方法。该装置包括用于测量具有多个频率的心室的瞬时体积的多频电导导管。该装置包括用于测量心室的瞬时压力的机构。该装置包括用于分离多个频率的机构。该装置包括用于信号处理心室的瞬时体积和压力的机构，以识别腔室的机械强度，并用于自动产生用于导电导管的期望频率的多个期望波形。处理机构连接到压力测量机构，分离机构和体积测量机构。

30. 发明授权

US07983736B2 Methods and compositions to reduce scattering of light during therapeutic and diagnostic imaging procedures 有权
标题翻译：在治疗和诊断成像过程中减少光散射的方法和组合物
公开(公告)号：US07983736B2
公开(公告)日：2011-07-19
申请号：US12780647
申请日：2010-05-14
申请人： Joseph W. Villard , Thomas E. Milner , Marc D. Feldman , Jeehoon Kim , Gregory L. Freeman
发明人： Joseph W. Villard , Thomas E. Milner , Marc D. Feldman , Jeehoon Kim , Gregory L. Freeman
IPC分类号： A61B6/00 , A61B5/05
CPC分类号： A61B5/14551 , A61B5/0066 , A61B5/0073 , A61B5/14535 , A61B5/14553 , A61B5/416
摘要： Disclosed are improved methods and compositions for use in light-based in vivo imaging and treatment. The techniques described involve the use of low-scattering, oxygen-carrying blood substitutes in imaging and treatment methods, including OCT imaging. The invention has particular advantages in imaging within the cardiovascular system and highly vascularized or oxygen-dependent tissues.
摘要翻译：公开了用于基于光的体内成像和治疗的改进的方法和组合物。所描述的技术涉及在成像和治疗方法中使用低散射，含氧载体的血液代用品，包括OCT成像。本发明在心血管系统和高度血管化或氧依赖性组织中的成像中具有特别的优点。

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