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21. 发明申请

US20060276669A1 Process for preparing sulfonated arylphosphines 审中-公开
标题翻译：制备磺化芳基膦的方法
公开(公告)号：US20060276669A1
公开(公告)日：2006-12-07
申请号：US11480178
申请日：2006-06-30
申请人： Michael Riedel , Ernst Wiebus , Carl Frohning , Wilfried Fenske , Florian Rampf , Jurgen Herwig , Helmut Bahrmann , Klaus Bergrath , Wolfgang Zgorzel-Ski , Robert Eckl , Hans Bohnen , Richard Fischer , Kurt Schalapski , Wolfgang Greb
发明人： Michael Riedel , Ernst Wiebus , Carl Frohning , Wilfried Fenske , Florian Rampf , Jurgen Herwig , Helmut Bahrmann , Klaus Bergrath , Wolfgang Zgorzel-Ski , Robert Eckl , Hans Bohnen , Richard Fischer , Kurt Schalapski , Wolfgang Greb
IPC分类号： C07F9/02 , C07C45/90
CPC分类号： B01J31/2404 , B01J31/2409 , B01J31/28 , B01J2231/321 , B01J2531/822 , B01J2531/96 , C07C45/50 , C07F9/5022 , C07F9/5054 , C07F9/5095 , C07C47/02
摘要： An aqueous catalyst solution comprising rhodium and an aqueous solution comprising sulfonated arylphosphines by reacting arylphosphines with oleum to form a sulfonation mixture, diluting the sulfonation mixture with water, extracting the diluted sulfonation mixture with a solution of a water-insoluble amine in a water-insoluble organic solvent, reacting the resulting water-immiscible organic phase with a solution of an inorganic base in water, adjusting the resulting aqueous solution of sulfonated arylphosphines of pH of up to 3 by addition of an acid, and passing an inert gas stream through the aqueous solution comprising sulfonated arylphosphines until sulfur dioxide is no longer liberated from the aqueous solution of sulfonated arylphosphines.
摘要翻译：包含铑的水溶液和包含磺化芳基膦的水溶液，通过使芳基膦与发烟硫酸反应形成磺化混合物，用水稀释磺化混合物，用水不溶性胺在水不溶性的溶液中萃取稀释的磺化混合物有机溶剂，使得到的与水不混溶的有机相与无机碱在水中的溶液反应，通过加入酸调节得到的pH为3的磺化芳基膦水溶液，并将惰性气流通过水溶液包含磺化芳基膦的溶液，直到二氧化硫不再从磺化芳基膦的水溶液中释放出来。

22. 发明授权

US06482972B1 Isomeric nonanols and decanols, their preparation, phthalic esters obtained therefrom and their use as plasticizers 失效
标题翻译：异壬醇和癸醇，它们的制备，由其获得的邻苯二甲酸酯及其作为增塑剂的用途
公开(公告)号：US06482972B1
公开(公告)日：2002-11-19
申请号：US08437221
申请日：1995-05-08
申请人： Helmut Bahrmann , Wilfried Fenske , Wolfgang Greb , Peter Heymanns , Peter Lappe , Thomas Müller , Jürgen Szameitat , Ernst Wiebus
发明人： Helmut Bahrmann , Wilfried Fenske , Wolfgang Greb , Peter Heymanns , Peter Lappe , Thomas Müller , Jürgen Szameitat , Ernst Wiebus
IPC分类号： C07C6976
CPC分类号： C08K5/12 , C07C29/175 , C07C45/50 , C07C45/74 , C07C69/80 , C12C11/02 , C07C31/125 , C07C47/21 , C07C47/02
摘要： Mixtures of isomeric nonanols and decanols are obtained by joint aldol condensation of n-butanal and pentanals, and up to 1% by weight of 3-methylbutanal, hydrogenation of the aldol condensation product to the corresponding saturated alcohols, and separation from the reaction mixture of the components boiling at temperatures lower than those of the nonanols and decanols. The pentanals are mixtures of 60 to 90% by weight of n-pentanal and 10 to 40% by weight of 2-methylbutanal. The alcohol mixture is especially suitable for preparing ester plasticizers.
摘要翻译：异构壬醇和癸醇的混合物是通过正丁醛和戊醛的联合醛醇缩合得到的，高达1重量％的3-甲基丁醛，醛醇缩合产物氢化成相应的饱和醇，并从组分在低于壬醇和癸醇的温度下沸腾。戊醛是60至90重量％的正戊醛和10至40重量％的2-甲基丁醛的混合物。醇混合物特别适用于制备酯增塑剂。

23. 发明授权

US5583250A Mixtures of isomeric decyl alcohols, phthalates obtainable therefrom, and their use as plasticizers 失效
标题翻译：异构癸醇的混合物，可从其获得的邻苯二甲酸酯及其作为增塑剂的用途
公开(公告)号：US5583250A
公开(公告)日：1996-12-10
申请号：US484588
申请日：1995-06-07
申请人： Helmut Bahrmann , Wolfgang Greb , Peter Heymanns , Peter Lappe , Thomas M uller , J urgen Szameitat , Ernst Wiebus
发明人： Helmut Bahrmann , Wolfgang Greb , Peter Heymanns , Peter Lappe , Thomas M uller , J urgen Szameitat , Ernst Wiebus
IPC分类号： C07C31/125 , C07C29/141 , C07C29/16 , C07C45/50 , C07C67/08 , C07C69/80 , C08F8/00 , C08F10/00 , C08F10/06 , C08K5/12 , C07C69/76
CPC分类号： C08K5/12 , C07C29/16 , C07C45/50 , C07C67/08 , C07C69/80
摘要： Mixtures of isomeric decyl alcohols obtained by oligomerization of propylene in the presence of deactivated zeolites as catalysts, followed by separation of the nine carbon olefins from the oligomer mixture, then hydroformylation of the 9 carbon olefins to 10 carbon aldehydes, and hydrogenation of the aldehydes to the corresponding alcohols. The mixtures, when esterified with phthalic acid, or anhydride, provide a mixture of isomeric di-decyl phthalates that can be used as plasticizers.
摘要翻译：通过在失活的沸石作为催化剂的存在下将丙烯低聚获得的异构癸醇的混合物，然后从低聚物混合物中分离出9种碳烯烃，然后将9种碳烯烃加氢甲酰化成10种碳醛，并将醛氢化成相应的醇类。当用邻苯二甲酸或酸酐酯化时，混合物提供可用作增塑剂的异构二癸基邻苯二甲酸酯的混合物。

24. 发明申请

US20100332029A1 Medicament/Dosimeter Combination Packaging 审中-公开
标题翻译：药物/剂量计组合包装
公开(公告)号：US20100332029A1
公开(公告)日：2010-12-30
申请号：US12830367
申请日：2010-07-05
申请人： Hans Schreier , Wolfgang Greb
发明人： Hans Schreier , Wolfgang Greb
IPC分类号： G06F17/00 , B65D83/00
CPC分类号： A61M15/008 , A61J7/0076 , A61M5/1723 , A61M2209/06 , A61M2230/00 , A61M2230/20
摘要： A system for individual dosing of a medicament, in accordance with the individual pathological properties (“fingerprint”) of a patient—corresponding physiologically or genetically to the disease status is based on two components: the medicament that is to be taken or administered in a variable individual dosage and a miniaturized indicator system that obtains information from blood, saliva or other bodily fluids and tissues of the patient and displays the information in a readable form so that the patient or the treating physician can immediately read the optimal active substance to be taken or dosage to be administered.
摘要翻译：根据患者的生理或遗传上与疾病状态相对应的患者的个体病理特性（“指纹”），单独给药药物的系统基于两个组成部分：待采取或以可变个体剂量和小型化指示器系统，其从血液，唾液或患者的其他体液和组织获得信息，并以可读形式显示信息，使得患者或治疗医师可立即读取待采取的最佳活性物质或剂量。

25. 发明授权

US07455856B2 Lipid-derivatized bisphosphonic acid 有权
标题翻译：脂质衍生的双膦酸
公开(公告)号：US07455856B2
公开(公告)日：2008-11-25
申请号：US10597059
申请日：2005-01-24
申请人： Wolfgang Greb , Oleg Shyhskov , Gerd-Volker Röschenthaler , Verena Hengst
发明人： Wolfgang Greb , Oleg Shyhskov , Gerd-Volker Röschenthaler , Verena Hengst
IPC分类号： A61K9/127
CPC分类号： C07J51/00 , A61K9/127 , A61K31/66 , C07F9/386 , C23F11/1676
摘要： A bisphosphonic acid of the general formula (I) wherein R1 is H, OH, C1-C6 alkyl C1-C6 alkoxy, C1-C6 hydroxyalkyl, C1-C6 aminoalkyl, C1-C6 halogen alkyl X is a direct bond, alkylen group with 1 to 20 carbon atoms, (CH3)m—(OCR3HCH2)n—(O)o—, wherein R3 is H or CH3 and m is 0 or a number from 1 to 6, n is a number from 1 to 10, preferably 1 to 6, and o is 0 or 1, —(CR4HCH2O)p—, wherein R4 is H or CH3, p is a number from 1 to 10, preferably 1 to 6, (CH3)q—(OCR5HCH2)r—(O)s—(CH3)t—, wherein R5 is H or CH3 and q is 0 or a number from 1 to 6, r is a number from 1 to 10, preferably 1 to 6, and s is 0 or 1, and t is a number from 1 to 6, R2 is a group of the formula (II) as well as their physiologically compatible derivatives in particular salts and trimethyl silyl derivatives.
摘要翻译：通式（I）的二膦酸，其中R 1是H，OH，C 1 -C 6烷基C 1 C 6 -C 6烷氧基，C 1 -C 6羟烷基，C 1 -C 3 > 6个氨基烷基，C 1 -C 6卤代烷基X是直接键，具有1至20个碳原子的亚烷基（CH 3）（OCR 3）HCH 2 O 2 - （O）O 其中R 3为H或CH 3，m为0或1至6的数，n为1至10的数，优选为 1至6，且o为0或1， - （CR 4 HCH 2 O）p - ，其中R 4， / CH 2是H或CH 3，p是1至10，优选1至6的数，（CH 3 3）q - （OCR 5 HCH 2） - （O）S - （CH 3）3 其中R 5为H或CH 3，q为0或数1至6，r为数 1〜10，优选1〜6，s为0或1，t为数 m 1至6，R 2是式（II）的基团以及它们的生理上相容的衍生物，特别是盐和三甲基甲硅烷基衍生物。

26. 发明申请

US20070154537A1 Lipid-derivatized bisphosphonic acid 有权
标题翻译：脂质衍生的双膦酸
公开(公告)号：US20070154537A1
公开(公告)日：2007-07-05
申请号：US10597059
申请日：2005-01-24
申请人： Wolfgang Greb , Oleg Shyhskov , Gerd-Volker Roschenthaler , Verena Hengst
发明人： Wolfgang Greb , Oleg Shyhskov , Gerd-Volker Roschenthaler , Verena Hengst
IPC分类号： A61K9/127 , C07F5/06 , C12N15/88 , C07J51/00
CPC分类号： C07J51/00 , A61K9/127 , A61K31/66 , C07F9/386 , C23F11/1676
摘要： A bisphosphonic acid of the general formula (I) wherein R1 is H, OH, C1-C6 alkyl C1-C6 alkoxy, C1-C6 hydroxyalkyl, C1-C6 aminoalkyl, C1-C6 halogen alkyl X is a direct bond, alkylen group with 1 to 20 carbon atoms, (CH3)m—(OCR3HCH2)n—(O)o— wherein R3 is H or CH3 and m is 0 or a number from 1 to 6, n is a number from 1 to 10, preferably 1 to 6, and o is 0 or 1, —(CR4HCH2O)p— wherein R4 is H or CH3, p is a number from 1 to 10, preferably 1 to 6, (CH3)q—(OCR5HCH2)r—(O)s—(CH3)t—, wherein R5 is H or CH3 and q is 0 or a number from 1 to 6, r is a number from 1 to 10, preferably 1 to 6, and s is 0 or 1, and t is a number from 1 to 6, R2 is a group of the formula (II) as well as their physiologically compatible derivatives, in particular salts and trimethyl silyl derivatives.
摘要翻译：通式（I）的二膦酸，其中R 1是H，OH，C 1 -C 6烷基C 1 C 6 -C 6烷氧基，C 1 -C 6羟烷基，C 1 -C 3 > 6个氨基烷基，C 1 -C 6卤代烷基X是直接键，具有1至20个碳原子的亚烷基（CH 3）（OCR 3）HCH 2 O 2 - （O）O 其中R 3为H或CH 3，m为0或1至6的数，n为1至10的数，优选1 至6，o为0或1， - （CR 4 HCH 2 O）p - 其中R 4 = >是H或CH 3，p是1至10的数，优选1至6，（CH 3 3）q - （OCR （O 3） - （CH 3）3 - （O） - （CH 3）其中R 5是H或CH 3，q是0或1-6的数，r是1的数至10，优选1至6，s为0或1，t为数 1至6，R 2是式（II）的基团以及它们的生理上相容的衍生物，特别是盐和三甲基甲硅烷基衍生物。

27. 发明申请

US20060182809A1 System for transporting active substances in a biological system 审中-公开
标题翻译：在生物系统中运输活性物质的系统
公开(公告)号：US20060182809A1
公开(公告)日：2006-08-17
申请号：US11308484
申请日：2006-03-29
申请人： Helmut Blum , Marcel Roth , Wolfgang Greb
发明人： Helmut Blum , Marcel Roth , Wolfgang Greb
IPC分类号： A61K9/14 , A61K38/00 , A61K38/43 , A61K39/395
CPC分类号： A61K9/5094
摘要： A stabilizer-free system for transporting active substances in a biological system of one or more active substances and magnetic particles is characterized in that the particles are provided with active substance(s) on at least part of their surface. Modification of the magnetic particles is not absolutely required in this system. It can be incorporated both into aqueous and oily suspensions and into microemulsions, oil-in-water emulsions, water-in-oil emulsions and also water-in-oil-in-water emulsions.
摘要翻译：用于在一种或多种活性物质和磁性颗粒的生物体系中输送活性物质的无稳定剂体系的特征在于，颗粒在其表面的至少一部分上具有活性物质。在该系统中，磁性颗粒的改性并不是绝对必需的。它可以并入水性和油性悬浮液中并进入微乳液，水包油乳剂，油包水乳液以及水包油包水乳剂。

28. 发明授权

US06864387B2 Process for preparing sulfonated arylphosphines 有权
标题翻译：制备磺化芳基膦的方法
公开(公告)号：US06864387B2
公开(公告)日：2005-03-08
申请号：US10413014
申请日：2003-04-14
申请人： Michael Riedel , Ernst Wiebus , Carl D Frohning , Wilfried Fenske , Florian Rampf , Jurgen Herwig , Helmut Bahrmann , Klaus Bergrath , Wolfgang Zgorzel-Ski , Robert Eckl , Hans Bohnen , Richard Fischer , Kurt Schalapski , Wolfgang Greb
发明人： Michael Riedel , Ernst Wiebus , Carl D Frohning , Wilfried Fenske , Florian Rampf , Jurgen Herwig , Helmut Bahrmann , Klaus Bergrath , Wolfgang Zgorzel-Ski , Robert Eckl , Hans Bohnen , Richard Fischer , Kurt Schalapski , Wolfgang Greb
IPC分类号： B01J31/24 , B01J31/28 , C07C45/50 , C07F9/50 , C07C304/00
CPC分类号： B01J31/2404 , B01J31/2409 , B01J31/28 , B01J2231/321 , B01J2531/822 , B01J2531/96 , C07C45/50 , C07F9/5022 , C07F9/5054 , C07F9/5095 , C07C47/02
摘要： A process for preparing solutions of sulfonated arylphosphines comprising reacting arylphosphines with oleum, diluting the sulfonation mixture with water, extracting the diluted sulfonation mixture with a solution of a water-insoluble organic solvent, reacting the organic phase with a solution of an inorganic base in water, adjusting the resulting aqueous solutin of sulfonated arylphosphines to a pH of up to 3 by addition of an acid, and passing an inert gas stream through the aqueous solution comprising sulfonated arylphosphines until sulfur is no longer liberated from the aqueous solution of sulfonated arylphosphines.
摘要翻译：一种制备磺化芳基膦溶液的方法，包括使芳基膦与发烟硫酸反应，用水稀释磺化混合物，用水不溶性有机溶剂的溶液萃取稀释的磺化混合物，将有机相与无机碱溶于水通过加入酸将所得的磺化芳基膦的水溶液调节至最高达3的pH，并使惰性气体流通过包含磺化芳基膦的水溶液，直到硫从磺化芳基膦的水溶液中不再释放出来。

29. 发明授权

US06358419B1 Process for the purification of wastewater from the aldolization reaction 失效
标题翻译：从醛醛化反应中净化废水的工艺
公开(公告)号：US06358419B1
公开(公告)日：2002-03-19
申请号：US08641514
申请日：1996-05-01
申请人： Mariola Rötzheim , Wolfgang Greb , Wolfgang Zgorzelski , Carl Dieter Frohning , Klaus Denkmann , Heinz Kalbfell
发明人： Mariola Rötzheim , Wolfgang Greb , Wolfgang Zgorzelski , Carl Dieter Frohning , Klaus Denkmann , Heinz Kalbfell
IPC分类号： C02F144
CPC分类号： C02F1/26 , C02F2101/34 , C02F2103/36 , C02F2209/06 , Y10S210/05 , Y10S210/908 , Y10S210/909
摘要： Wastewater from the aldolization reaction is purified by adjusting its pH to 0 to 6, followed by extraction with monohydric alcohols having at least 8 carbon atoms, hydrocarbons having at least 6 carbon atoms, and mixtures thereof. In some cases, adjustment of the pH causes the formation of an organic phase, which is separated from the remaining wastewater before extraction.
摘要翻译：通过将其pH调节至0至6，然后用具有至少8个碳原子的一元醇，具有至少6个碳原子的烃及其混合物进行萃取来纯化来自醛糖醛酸化反应的废水。在某些情况下，pH的调节会导致有机相的形成，其在萃取之前与剩余废水分离。

30. 发明授权

US6051743A Process for the preparation of predominantly unbranched higher primary alcohols 失效
标题翻译：主要制备无支链高级伯醇的方法
公开(公告)号：US6051743A
公开(公告)日：2000-04-18
申请号：US163086
申请日：1993-12-07
申请人： Helmut Bahrmann , Gregor Deckers , Wolfgang Greb , Peter Heymanns , Peter Lappe , Thomas Muller , Jurgen Szameitat , Ernst Wiebus
发明人： Helmut Bahrmann , Gregor Deckers , Wolfgang Greb , Peter Heymanns , Peter Lappe , Thomas Muller , Jurgen Szameitat , Ernst Wiebus
IPC分类号： B01J31/24 , C07B61/00 , C07C29/141 , C07C29/158 , C07C29/16 , C07C31/125 , C07C45/50 , C23C14/16 , C07C29/14 , C07C29/143 , C07C45/00
CPC分类号： C07C29/16 , C07C29/141 , C07C45/50
摘要： For the preparation of predominantly unbranched higher primary alcohols, olefins from the Fischer-Tropsch synthesis are reacted with hydrogen and carbon monoxide in the presence of water and a catalyst which is rhodium, in metallic form or as a compound, and a water-soluble phosphine. The reaction product obtained is hydrogenated. The water-soluble phosphines employed are compounds whose anion is a phosphine containing at least one sulfonated or carboxylated aromatic radical and whose cation is a quaternary ammonium or phosphonium ion.
摘要翻译：为了制备主要是非支化的高级伯醇，来自费 - 托合成的烯烃在水和催化剂的存在下与氢和一氧化碳反应，该催化剂是金属形式的铑或作为化合物的催化剂，以及水溶性膦。将所得反应产物氢化。使用的水溶性膦是其阴离子是含有至少一个磺化或羧化芳族基团并且其阳离子是季铵或鏻离子的膦的化合物。

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