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21. 发明授权

US07335467B2 Breast cancer antigens 有权
标题翻译：乳腺癌抗原
公开(公告)号：US07335467B2
公开(公告)日：2008-02-26
申请号：US10146473
申请日：2002-05-15
申请人： Matthew J. Scanlan , Ivan Gout , Elisabeth Stockert , Lloyd J. Old , Ali Gure , Yao-Tseng Chen
发明人： Matthew J. Scanlan , Ivan Gout , Elisabeth Stockert , Lloyd J. Old , Ali Gure , Yao-Tseng Chen
IPC分类号： C12Q1/00 , C12Q1/68 , G01N33/567 , G01N33/574 , G01N1/00 , G01N33/48 , C12P19/34
CPC分类号： G01N33/57415 , C12Q1/6886 , C12Q2600/158 , Y10T436/25
摘要： The invention provides methods for diagnosing cancer including breast cancer, based on the identification of certain breast cancer-associated polypeptides as antigens that elicit immune responses in breast cancer. The identified antigens can be utilized as markers for diagnosing breast cancer, and for following the course of treatment of breast cancer.
摘要翻译：本发明提供了鉴定某些乳腺癌相关多肽作为在乳腺癌中引起免疫反应的抗原来诊断包括乳腺癌在内的癌症的方法。鉴定的抗原可用作诊断乳腺癌的标志物，并用于跟踪乳腺癌的治疗过程。

22. 发明授权

US06830924B1 Isolated nucleic acid molecule encoding cancer associated antigens, the antigens per se, and uses thereof 失效
标题翻译：编码癌相关抗原的分离的核酸分子，抗原本身及其用途
公开(公告)号：US06830924B1
公开(公告)日：2004-12-14
申请号：US09270437
申请日：1999-03-16
申请人： Yao-Tseng Chen , Ali Gure , Solam Tsang , Elisabeth Stockert , Elke Jager , Alexander Knuth , Lloyd J. Old
发明人： Yao-Tseng Chen , Ali Gure , Solam Tsang , Elisabeth Stockert , Elke Jager , Alexander Knuth , Lloyd J. Old
IPC分类号： C12N1563
CPC分类号： C07K14/4748 , A61K2039/505
摘要： The invention relates to newly identified cancer associated antigens, referred to as CT7, KOC-2 and KOC-3. The invention also relates to observations regarding known molecule KOC-1. It has been discovered that each of these molecules provokes antibodies when expressed by a subject. The ramifications of this observation are also a part of this invention.
摘要翻译：本发明涉及新鉴定的癌相关抗原，称为CT7，KOC-2和KOC-3。本发明还涉及关于已知分子KOC-1的观察。已经发现，当由受试者表达时，这些分子中的每一个都会引发抗体。该观察结果也是本发明的一部分。

23. 发明授权

US06576756B2 Isolated nucleic acid molecule encoding cancer associated antigen, the antigen itself, and uses thereof 有权
公开(公告)号：US06576756B2
公开(公告)日：2003-06-10
申请号：US09899651
申请日：2001-07-06
申请人： Yao-Tseng Chen , Ali Gure , Solam Tsang , Elisabeth Stockert , Elke Jäger , Knuth Alexander , Lloyd J. Old
发明人： Yao-Tseng Chen , Ali Gure , Solam Tsang , Elisabeth Stockert , Elke Jäger , Knuth Alexander , Lloyd J. Old
IPC分类号： C07H2104
CPC分类号： C07K14/4748 , A61K2039/505
摘要： The invention relates to the isolation of a nucleic acid molecule which encodes a cancer associated antigen. Also a part of the invention is the antigen itself, and the uses of the nucleic acid molecule and the antigen, and peptides derived from it.

24. 发明授权

US06518415B1 Recombinant human anti-Lewis Y antibodies 失效
标题翻译：重组人抗Lewis Y抗体
公开(公告)号：US06518415B1
公开(公告)日：2003-02-11
申请号：US08859648
申请日：1997-05-20
申请人： Kathryn Lesley Armour , Francis Joseph Carr , Lloyd J. Old , Elisabeth Stockert , Sydney Welt , Kunio Kitamura , Pilar Garin-Chesa
发明人： Kathryn Lesley Armour , Francis Joseph Carr , Lloyd J. Old , Elisabeth Stockert , Sydney Welt , Kunio Kitamura , Pilar Garin-Chesa
IPC分类号： C07H2104
CPC分类号： C07K16/34 , C07K16/30 , C07K2317/24 , C07K2319/00
摘要： The invention provides for the production of several humanized murine antibodies specific for the antigen Lewis Y, which is recognized by the murine antibody Lewis Y. The Lewis Y antigen is expressed in normal tissues but the level of expression is higher in certain tumor types so that the antigen can be used as a marker for cells of some breast, colon, gastric, esophageal, pancreatic, duodenal, lung, bladder and renal carcinomas and gastric and islet cell neuroendocrine tumors. The invention also provides for numerous polynucleotide encoding humanized Lewis Y specific antibodies, expression vectors for producing humanized Lewis Y specific antibodies, and host cells for the recombinant production of the humanized antibodies. The invention also provides methods for detecting cancerous cells (in vitro and in vivo) using humanized Lewis Y specific antibodies. Additionally, the invention provides methods of treating cancer using humanized Lewis Y specific antibodies.
摘要翻译：本发明提供对抗原Lewis Y特异性的几种人源化鼠抗体的产生，其被鼠抗体Lewis Y识别。Lewis Y抗原在正常组织中表达，但在某些肿瘤类型中表达水平较高，因此抗原可用作乳腺癌，结肠癌，胃癌，食管癌，胰腺癌，十二指肠癌，肺癌，膀胱癌和肾癌和胃和胰岛细胞神经内分泌肿瘤的细胞标志物。本发明还提供编码人源化Lewis Y特异性抗体的许多多核苷酸，用于产生人源化Lewis Y特异性抗体的表达载体和用于重组产生人源化抗体的宿主细胞。本发明还提供使用人源化Lewis Y特异性抗体检测癌细胞（体外和体内）的方法。另外，本发明提供使用人源化Lewis Y特异性抗体治疗癌症的方法。

25. 发明授权

US6043084A Isolated nucleic acid molecules associated with colon cancer and methods for diagnosing and treating colon cancer 失效
标题翻译：与结肠癌相关的分离的核酸分子以及诊断和治疗结肠癌的方法
公开(公告)号：US6043084A
公开(公告)日：2000-03-28
申请号：US948705
申请日：1997-10-10
申请人： Matthew J. Scanlan , Yao-Tseng Chen , Elisabeth Stockert , Lloyd J. Old
发明人： Matthew J. Scanlan , Yao-Tseng Chen , Elisabeth Stockert , Lloyd J. Old
IPC分类号： A61K38/00 , C07K14/47 , C12N15/12 , C12Q1/68 , G01N33/569 , G01N33/574 , C12N5/10 , C12N15/63
CPC分类号： C07K14/4748 , C12Q1/6886 , G01N33/56977 , G01N33/5748 , A61K38/00
摘要： Various molecules associated with disorders such as colon cancer are disclosed. The invention also discloses diagnostic and therapeutic methods based upon these molecules.
摘要翻译：公开了与诸如结肠癌的疾病相关的各种分子。本发明还公开了基于这些分子的诊断和治疗方法。

26. 发明授权

US5874060A Recombinant human anti-Lewis Y antibodies 失效
公开(公告)号：US5874060A
公开(公告)日：1999-02-23
申请号：US859649
申请日：1997-05-20
申请人： Kathryn Lesley Armour , Francis Joseph Carr , Lloyd J. Old , Elisabeth Stockert , Sydney Welt , Kunio Kitamura , Pilar Garin-Chesa
发明人： Kathryn Lesley Armour , Francis Joseph Carr , Lloyd J. Old , Elisabeth Stockert , Sydney Welt , Kunio Kitamura , Pilar Garin-Chesa
IPC分类号： C07K16/30 , C07K16/34 , A61K51/00 , A61K39/395
CPC分类号： C07K16/34 , C07K16/30 , C07K2317/24 , C07K2319/00
摘要： The invention provides for the production of several humanized murine antibodies specific for the antigen Lewis Y, which is recognized by the murine antibody Lewis Y. The Lewis Y antigen is expressed in normal tissues but the level of expression is higher in certain tumor types so that the antigen can be used as a marker for cells of some breast, colon, gastric, esophageal, pancreatic, duodenal, lung, bladder and renal carcinomas and gastric and islet cell neuroendocrine tumors. The invention also provides for numerous polynucleotide encoding humanized Lewis Y specific antibodies, expression vectors for producing humanized Lewis Y specific antibodies, and host cells for the recombinant production of the humanized antibodies. The invention also provides methods for detecting cancerous cells (in vitro and in vivo) using humanized Lewis Y specific antibodies. Additionally, the invention provides methods of treating cancer using humanized Lewis Y specific antibodies.

27. 发明授权

US5618534A Isolated antigen endo glyx-1 失效
标题翻译：分离的抗原endo glyx-1
公开(公告)号：US5618534A
公开(公告)日：1997-04-08
申请号：US535491
申请日：1995-09-28
申请人： Maria P. Sanz-Moncasi , Pilar Garin-Chesa , Elisabeth Stockert , Lloyd J. Old , Wolfgang J. Rettig
发明人： Maria P. Sanz-Moncasi , Pilar Garin-Chesa , Elisabeth Stockert , Lloyd J. Old , Wolfgang J. Rettig
IPC分类号： G01N33/577 , A61K38/00 , A61K39/395 , A61K47/48 , A61P7/00 , A61P7/02 , A61P29/00 , A61P35/00 , A61P43/00 , C07K14/705 , C07K16/28 , C07K16/46 , C12N5/10 , C12N15/02 , C12P21/08 , A61K39/00
CPC分类号： C07K16/28 , A61K47/48561 , A61K47/48669 , C07K14/705 , A61K38/00
摘要： An antigen which is specific to vascular endothelium is described. Described is a cell surface antigen which consists of four subunits; of 190, 145, 125 and 110 kd as determined by SDS-PAGE under reducing conditions as is a monoclonal antibody specific to this antigen. Uses, both diagnostic and therapeutic, are also described.
摘要翻译：描述了对血管内皮特异的抗原。描述了由四个亚基组成的细胞表面抗原; 在还原条件下通过SDS-PAGE测定的190,145,125和110kd，如对该抗原特异性的单克隆抗体。也描述了诊断和治疗的用途。

28. 发明授权

US07622568B2 Isolated nucleic acid molecules encoding cancer associated antigens, the antigens per se, and uses thereof 有权
标题翻译：编码癌相关抗原的分离的核酸分子，抗原本身及其用途
公开(公告)号：US07622568B2
公开(公告)日：2009-11-24
申请号：US11985028
申请日：2007-11-12
申请人： Dirk Jager , Elisabeth Stockert , Matthew Scanlan , Alexander Knuth , Lloyd Old , Ali Gure , Yao-Tseng Chen , Elke Jager
发明人： Dirk Jager , Elisabeth Stockert , Matthew Scanlan , Alexander Knuth , Lloyd Old , Ali Gure , Yao-Tseng Chen , Elke Jager
IPC分类号： C07H21/02
CPC分类号： C07K14/47
摘要： The invention relates to newly identified cancer associated antigens. It has been discovered that each of these molecules provokes antibodies when expressed by a subject. The ramifications of this observation are also a part of this invention.
摘要翻译：本发明涉及新鉴定的癌症相关抗原。已经发现，当由受试者表达时，这些分子中的每一个都会引发抗体。该观察结果也是本发明的一部分。

29. 发明申请

US20090203123A1 Isolated nucleic acid molecules encoding cancer associated antigens, the antigens per SE, and uses thereof 有权
标题翻译：编码癌症相关抗原的分离的核酸分子，每个SE的抗原及其用途
公开(公告)号：US20090203123A1
公开(公告)日：2009-08-13
申请号：US12011953
申请日：2008-01-30
申请人： Dirk Jager , Elisabeth Stockert , Matthew Scanlan , Ali Gure , Elke Jager , Alexander Knuth , Lloyd Old , Yao-Tseng Chen , Barry C. Picker , Cynthia H. Scanlan
发明人： Dirk Jager , Elisabeth Stockert , Matthew Scanlan , Ali Gure , Elke Jager , Alexander Knuth , Lloyd Old , Yao-Tseng Chen , Barry C. Picker , Cynthia H. Scanlan
IPC分类号： C12N5/10 , C12N15/12 , C12N15/85 , C12N15/82 , C12N1/21 , C12N15/74
CPC分类号： C07K14/47 , C07K14/4748
摘要： The invention relates to newly identified cancer associated antigens. It has been discovered that each of these molecules provokes antibodies when expressed by a subject. The ramifications of this observation are also a part of this invention.
摘要翻译：本发明涉及新鉴定的癌症相关抗原。已经发现，当由受试者表达时，这些分子中的每一个都会引发抗体。该观察结果也是本发明的一部分。

30. 发明授权

US08071717B2 Isolated nucleic acid molecules encoding cancer associated antigens, the antigens per se, and uses thereof 失效
标题翻译：编码癌相关抗原的分离的核酸分子，抗原本身及其用途
公开(公告)号：US08071717B2
公开(公告)日：2011-12-06
申请号：US12589647
申请日：2009-10-27
申请人： Dirk Jager , Elisabeth Stockert , Matthew Scanlan , Alexander Knuth , Lloyd Old , Ali Gure , Yao-Tseng Chen , Elke Jager
发明人： Dirk Jager , Elisabeth Stockert , Matthew Scanlan , Alexander Knuth , Lloyd Old , Ali Gure , Yao-Tseng Chen , Elke Jager
IPC分类号： C07K5/10
CPC分类号： C07K14/47
摘要： The invention relates to newly identified cancer associated antigens. It has been discovered that each of these molecules provokes antibodies when expressed by a subject. The ramifications of this observation are also a part of this invention.
摘要翻译：本发明涉及新鉴定的癌症相关抗原。已经发现，当由受试者表达时，这些分子中的每一个都会引发抗体。该观察结果也是本发明的一部分。

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