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21. 发明申请

US20080027864A1 METHOD AND SYSTEM FOR PREVENTING SKIPPING PLAYBACK OF A SPECIAL CONTENT SECTION OF A DIGITAL MEDIA STREAM 失效
标题翻译：用于防止数字媒体流的特殊内容部分跳出播放的方法和系统
公开(公告)号：US20080027864A1
公开(公告)日：2008-01-31
申请号：US11752358
申请日：2007-05-23
申请人： Yong Hua Lin , Guo Hui Lin , Yu Dong Yang , Yu Yuan
发明人： Yong Hua Lin , Guo Hui Lin , Yu Dong Yang , Yu Yuan
IPC分类号： G06Q99/00 , G06F17/10 , H04L9/00
CPC分类号： G06Q30/02 , G11B20/00086 , G11B20/0021 , G11B20/00282 , G11B20/10 , G11B2020/10537 , H04L9/0861 , H04L2209/60 , H04N5/76 , H04N5/913 , H04N2005/91364
摘要： A method and system for preventing skipping the playback of a special content section of a digital media stream is provided. The method comprises a method for providing a digital media stream on the providing side, and a method for playing back a digital media stream as provided by the above providing method on the playing back side. The providing method comprises: decoding an encoded special content section of a digital media stream; generating an encryption key based on the decoded data of the special content section; encrypting a normal content section of the digital media stream using the encryption key; and providing the digital media stream comprising the encoded special content section and the encrypted normal content section. The playback method comprises: receiving the digital media stream; decoding the special content section of the digital media stream; generating an encryption key based on the decoded data of the special content section by using the same method for generating the encryption key in providing the digital media; decrypting the normal content section of the digital media stream using the encryption key; and playing back the special content section and normal content section of the digital media stream.
摘要翻译：提供了一种用于防止跳过数字媒体流的特殊内容部分的重放的方法和系统。该方法包括在提供方提供数字媒体流的方法，以及用于通过上述回放方面提供的方式来播放数字媒体流的方法。提供方法包括：解码数字媒体流的经编码的特殊内容部分; 基于特殊内容部分的解码数据生成加密密钥; 使用所述加密密钥加密所述数字媒体流的正常内容部分; 以及提供包括编码的特殊内容部分和加密的正常内容部分的数字媒体流。播放方法包括：接收数字媒体流; 解码数字媒体流的特殊内容部分; 通过使用用于在提供数字媒体中生成加密密钥的相同方法，基于特殊内容部分的解码数据生成加密密钥; 使用所述加密密钥解密所述数字媒体流的正常内容部分; 并播放数字媒体流的特殊内容部分和正常内容部分。

22. 发明授权

US08691580B2 Single chemical entities and methods for delivery of oligonucleotides 有权
标题翻译：单一化学实体和递送寡核苷酸的方法
公开(公告)号：US08691580B2
公开(公告)日：2014-04-08
申请号：US13639952
申请日：2011-04-04
申请人： Jeffrey G. Aaronson , Stanley F. Barnett , René Bartz , Steven L. Colletti , Vasant R. Jadhav , Aaron A. Momose , Anthony W. Shaw , David M. Tellers , Thomas J. Tucker , Weimin Wang , Yu Yuan
发明人： Jeffrey G. Aaronson , Stanley F. Barnett , René Bartz , Steven L. Colletti , Vasant R. Jadhav , Aaron A. Momose , Anthony W. Shaw , David M. Tellers , Thomas J. Tucker , Weimin Wang , Yu Yuan
IPC分类号： C07H21/02
CPC分类号： A61K31/713 , A61K47/554 , A61K47/60 , A61K47/64 , A61K47/645 , C07K19/00
摘要： In an embodiment the instant invention discloses a modular composition comprising 1) an oligonucleotide; 2) one or more linkers, which may be the same or different, selected from Table 1, wherein the linkers are attached to the oligonucleotide at any 3′ and/or 5′ end; 3) one or more peptides, which may be the same or different, selected from SEQ ID NOs: 1-59, wherein the peptides are attached to the linkers; and optionally one or more lipids, solubilizing groups and/or targeting ligands attached to the oligonucleotide.
摘要翻译：在一个实施方案中，本发明公开了一种模块化组合物，其包含：1）寡核苷酸; 2）一个或多个可以相同或不同的接头，其选自表1，其中所述接头在任何3'和/或5'末端连接到寡核苷酸; 3）一种或多种可以相同或不同的选自SEQ ID NO：1-59的肽，其中肽连接于接头; 和任选的一种或多种脂质，增溶基团和/或靶向与寡核苷酸连接的配体。

23. 发明授权

US08639697B2 Computer system performance analysis 失效
标题翻译：计算机系统性能分析
公开(公告)号：US08639697B2
公开(公告)日：2014-01-28
申请号：US13459559
申请日：2012-04-30
申请人： Stephen John Heisig , Yan Qi Wang , Jing Xiao , Yu Yuan , Jia Zou
发明人： Stephen John Heisig , Yan Qi Wang , Jing Xiao , Yu Yuan , Jia Zou
IPC分类号： G06F7/00 , G06F17/30
CPC分类号： G06F11/3409 , G06F11/3452 , G06F2201/865 , G06F2201/88
摘要： This invention relates to a method and device for computer system performance analysis. All instructions are split into clusters based on significant offset gaps in top-down processing steps. Comments on instruction clusters can be generated automatically or can be edited manually. The comments can be shared among users for the achievement of portability. Significant clusters can be recognized as hotspots based on predetermined metrics.
摘要翻译：本发明涉及一种用于计算机系统性能分析的方法和装置。基于自上而下的处理步骤中的显着的偏移间隔，所有指令都被分为簇。指令集群的注释可以自动生成，也可以手动编辑。评论可以在用户之间共享，以实现可移植性。可以基于预定的度量将重要的群集识别为热点。

24. 发明申请

US20130253168A1 NOVEL SINGLE CHEMICAL ENTITIES AND METHODS FOR DELIVERY OF OLIGONUCLEOTIDES 审中-公开
标题翻译：新型单一化学实验和交付寡糖的方法
公开(公告)号：US20130253168A1
公开(公告)日：2013-09-26
申请号：US13819578
申请日：2011-08-29
申请人： Steven L. Colletti , Francis Gosselin , Vasant R. Jadhav , Anthony W. Shaw , David M. Tellers , Thomas J. Tucker , Yu Yuan , Daniel Zewge
发明人： Steven L. Colletti , Francis Gosselin , Vasant R. Jadhav , Anthony W. Shaw , David M. Tellers , Thomas J. Tucker , Yu Yuan , Daniel Zewge
IPC分类号： A61K47/48
CPC分类号： C12N15/113 , A61K47/64 , C12N15/111 , C12N15/87 , C12N2310/14 , C12N2310/3513 , C12N2310/3515 , C12N2320/32
摘要： In an embodiment the instant invention discloses a modular composition comprising 1) an oligonueleotide; 2) one or more linkers, which may be the same or different, selected from Table 1, wherein the linkers are attached to the oligonucleotide at the 2′-position of the ribose rings and/or the terminal 3′- and/or 5′-positions of the oligonucleotide; 3) optionally, one or more peptides, which may be the same or different, selected from SEQ ID NOs: 1-59, wherein the peptides are attached to the linkers; and optionally one or more lipids, solubilizing groups and/or targeting ligands attached to the oligonucleotide.
摘要翻译：在一个实施方案中，本发明公开了一种模块化组合物，其包含：1）寡核苷酸; 2）一个或多个可以相同或不同的接头，其选自表1，其中连接体在核糖环和/或末端3'-和/或5的2'-位上连接于寡核苷酸寡核苷酸的位置; 3）任选的一个或多个可以相同或不同的选自SEQ ID NO：1-59的肽，其中肽连接到接头上; 和任选的一种或多种脂质，增溶基团和/或靶向与寡核苷酸连接的配体。

25. 发明授权

US08321834B2 Framework for automatically merging customizations to structured code that has been refactored 失效
标题翻译：自动将自定义结合到已重构的结构化代码的框架
公开(公告)号：US08321834B2
公开(公告)日：2012-11-27
申请号：US12238135
申请日：2008-09-25
申请人： Bruce R Baker , Walfrey Ng , Chenfei Song , Yu Yuan
发明人： Bruce R Baker , Walfrey Ng , Chenfei Song , Yu Yuan
IPC分类号： G06F9/44
CPC分类号： G06F8/71 , G06F8/72
摘要： A method of generating a tool for merging customizations made to a first version of a software artifact when migrating to a second version includes instantiating a mapping element for each top-level element in a first code set that does not have a complementary element in a second code set; requesting and receiving merge instructions for each top-level element for which merge instructions are not provided in the corresponding mapping element; determining whether the merge instructions for each top-level element for which merge instructions are provided require that customizations be merged into the second code set; determining whether the merge instructions for each top-level element set that requires customizations to be merged are valid; requesting and receiving merge instructions for each top-level element for which the merge instructions are not valid; and storing the merge instructions received for each top-level element in the corresponding mapping element.
摘要翻译：当迁移到第二版本时，生成用于合并对软件工件的第一版本进行的定制的工具的方法包括为第二代码集中的第一代码集中的每个顶级元素实例化映射元素，所述第一代码集中的第二代码集合中没有互补元素代码集请求和接收对应映射元素中未提供合并指令的每个顶级元素的合并指令; 确定是否为其提供合并指令的每个顶级元素的合并指令要求定制被合并到第二代码集中; 确定需要自定义合并的每个顶级元素集合的合并指令是否有效; 请求和接收合并指令无效的每个顶级元素的合并指令; 以及将针对每个顶级元素接收的合并指令存储在相应的映射元素中。

26. 发明授权

US08983533B2 Multimode communication terminal and multimode communication implementation 有权
标题翻译：多模通信终端和多模通信实现
公开(公告)号：US08983533B2
公开(公告)日：2015-03-17
申请号：US13462313
申请日：2012-05-02
申请人： Yong Hua Lin , Hong Hua Song , Yu Dong Yang , Yu Yuan , You Zhou
发明人： Yong Hua Lin , Hong Hua Song , Yu Dong Yang , Yu Yuan , You Zhou
IPC分类号： H04M1/00 , G01N3/24 , G01N19/04
CPC分类号： G01N3/24 , G01N19/04 , G01N2203/0025 , G01N2203/021 , G01N2203/0623
摘要： A method for enabling a MIMO operation mode in a multimode communication terminal includes switching a first channel module to have parameter characteristics consistent with those of a second channel module, so that the multimode communication terminal enables the MIMO operation mode by using the first channel module and the second channel module at the same time. The method also includes extracting corresponding parameters from the second channel module and configuring the first channel module to be switched with the extracted parameters, such that the first channel module and second channel module enable the multimode communication terminal to perform MIMO communication. The method further includes issuing, upon determination of a switch, notification instructions to means in channel switch layer means and changing a data channel associated with the first channel module, such that the first channel module and second channel module can be adapted to the MIMO operation mode.
摘要翻译：一种在多模通信终端中实现MIMO操作模式的方法，包括切换第一信道模块以使参数特性与第二信道模块的参数特性一致，使得多模通信终端通过使用第一信道模块来启用MIMO操作模式，第二通道模块同时进行。该方法还包括从第二信道模块中提取相应的参数，并且利用提取的参数来配置要切换的第一信道模块，使得第一信道模块和第二信道模块使多模通信终端能够执行MIMO通信。该方法还包括在确定切换时发出通知指令以在信道切换层装置中进行装置，并改变与第一信道模块相关联的数据信道，使得第一信道模块和第二信道模块可适用于MIMO操作模式。

27. 发明授权

US08930899B2 Artifact divider for large scale application builds 有权
标题翻译：用于大规模应用构建的人工分隔器
公开(公告)号：US08930899B2
公开(公告)日：2015-01-06
申请号：US13589129
申请日：2012-08-18
申请人： Keith Chi-Hang Chan , Yu Yuan
发明人： Keith Chi-Hang Chan , Yu Yuan
IPC分类号： G06F9/44 , G06F9/445
CPC分类号： G06F8/41 , G06F8/54 , G06F8/61
摘要： A method for building an application installation repository is disclosed herein. In one embodiment a build directory comprising a plurality of application objects is evaluated. Artifact generation rules may also be evaluated with respect to the application objects and the build directory. Object groupings, each comprising one or more application objects of the plurality of application objects, are defined according to the evaluations of the artifact generation rules and the hierarchical directory structure and artifacts are generated according to the object groupings. An installable application is generated that includes the generated artifacts. Artifacts may be further grouped into sharable units and assemblies according to rules and organization of application objects in the build directory. A delta build including only artifacts corresponding to modified files and correspondingly modified metadata may also be generated according to methods disclosed herein. A corresponding computer program product is also disclosed.
摘要翻译：本文公开了一种用于构建应用程序安装存储库的方法。在一个实施例中，评估包括多个应用对象的构建目录。还可以针对应用对象和构建目录来评估人工制作规则。每个包含多个应用对象中的一个或多个应用对象的对象分组根据对象生成规则的评估被定义，并且根据对象分组生成分层目录结构和伪像。生成包含生成的工件的可安装应用程序。工件可以根据构建目录中的应用程序对象的规则和组织进一步分组为可共享的单元和组件。也可以根据本文公开的方法来生成仅包括对应于经修改的文件的工件和对应修改的元数据的增量版本。还公开了相应的计算机程序产品。

28. 发明申请

US20130041133A1 NOVEL SINGLE CHEMICAL ENTITIES AND METHODS FOR DELIVERY OF OLIGONUCLEOTIDES 有权
标题翻译：新型单一化学实验和交付寡糖的方法
公开(公告)号：US20130041133A1
公开(公告)日：2013-02-14
申请号：US13639952
申请日：2011-04-04
申请人： Jeffrey G. Aaronson , Stanley F. Barnett , René Bartz , Steven L. Colletti , Vasant R. Jadhav , Aaron A. Momose , Anthony W. Shaw , David M. Tellers , Thomas J. Tucker , Weimin Wang , Yu Yuan
发明人： Jeffrey G. Aaronson , Stanley F. Barnett , René Bartz , Steven L. Colletti , Vasant R. Jadhav , Aaron A. Momose , Anthony W. Shaw , David M. Tellers , Thomas J. Tucker , Weimin Wang , Yu Yuan
IPC分类号： C07K17/00
CPC分类号： A61K31/713 , A61K47/554 , A61K47/60 , A61K47/64 , A61K47/645 , C07K19/00
摘要： In an embodiment the instant invention discloses a modular composition comprising 1) an oligonucleotide; 2) one or more linkers, which may be the same or different, selected from Table 1, wherein the linkers are attached to the oligonucleotide at any 3′ and/or 5′ end; 3) one or more peptides, which may be the same or different, selected from SEQ ID NOs: 1-59, wherein the peptides are attached to the linkers; and optionally one or more lipids, solubilizing groups and/or targeting ligands attached to the oligonucleotide.
摘要翻译：在一个实施方案中，本发明公开了一种模块化组合物，其包含：1）寡核苷酸; 2）一个或多个可以相同或不同的接头，其选自表1，其中所述接头在任何3'和/或5'末端连接到寡核苷酸; 3）一种或多种可以相同或不同的选自SEQ ID NO：1-59的肽，其中肽连接于接头; 和任选的一种或多种脂质，增溶基团和/或靶向与寡核苷酸连接的配体。

29. 发明授权

US08286132B2 Comparing and merging structured documents syntactically and semantically 失效
标题翻译：在语法和语义上比较和合并结构化文档
公开(公告)号：US08286132B2
公开(公告)日：2012-10-09
申请号：US12238080
申请日：2008-09-25
申请人： Yu Yuan , Scott M Guminy
发明人： Yu Yuan , Scott M Guminy
IPC分类号： G06F9/44
CPC分类号： G06F17/30908 , G06F17/2288
摘要： A method of performing a three-way merge includes receiving first, second, and third versions of a structured document containing first, second, and third pluralities of elements respectively; deserializing the first, second, and third versions to generate first, second, and third tree-structured data models respectively representing the first, second, and third versions; generating an identifier for each node of each data model that is unique within the data model by applying identifier determination rules to a context describing the element corresponding to the node; comparing each identifier in the first data model with each identifier in the second data model to identify each node in the first data model not having matching identifiers with any node in the second data model and to link each pair of nodes having matching identifiers; and applying comparison rules to the contexts of each linked pair of nodes to identify differences therebetween.
摘要翻译：执行三向合并的方法包括分别接收包含第一，第二和第三多个元素的结构化文档的第一，第二和第三版本; 反序列化第一，第二和第三版本以生成分别表示第一，第二和第三版本的第一，第二和第三树结构化数据模型; 通过将标识符确定规则应用于描述对应于该节点的元素的上下文来生成数据模型中唯一的每个数据模型的每个节点的标识符; 将第一数据模型中的每个标识符与第二数据模型中的每个标识符进行比较，以识别第一数据模型中没有与第二数据模型中的任何节点具有匹配标识符的每个节点并链接具有匹配标识符的每对节点; 以及将比较规则应用于每个链接的节点对的上下文以识别它们之间的差异。

30. 发明申请

US20100081786A1 Homogeneous Erythropoietin and Other Peptides and Proteins, Methods and Intermediates for Their Preparation 有权
标题翻译：均匀促红细胞生成素和其他肽和蛋白质，其制备方法和中间体
公开(公告)号：US20100081786A1
公开(公告)日：2010-04-01
申请号：US12296608
申请日：2007-04-11
申请人： Samuel J. Danishefsky , J. David Warren , Jiehao Chen , Bin Wu , Gong Chen , Qian Wan , Zhongping Tan , Cindy Kan , Yu Yuan , Zihao Hua , Krishnakumar Ranganathan , John D. Trzupek
发明人： Samuel J. Danishefsky , J. David Warren , Jiehao Chen , Bin Wu , Gong Chen , Qian Wan , Zhongping Tan , Cindy Kan , Yu Yuan , Zihao Hua , Krishnakumar Ranganathan , John D. Trzupek
IPC分类号： C07K14/505 , C07K1/00
CPC分类号： C07K14/505 , C07K9/00 , C12P21/005
摘要： The present invention provides isolated homogeneous polyfunctionalized proteins (e.g., erythropoietin), isolated glycopeptides, and a method for preparing polyfunctionalized peptides and/or proteins via cysteine-free native chemical ligation. In certain embodiments, the invention provides an isolated homogeneous polyfunctionalized protein having the structure (I). In certain other embodiments, the invention provides an isolated glycopeptide having Formula (II). In certain other embodiments, the inventive method is a method for preparing a polyfunctionalized peptide comprising a peptidic backbone made up of four or more amino acids, wherein two or more non-adjacent amino acids are independently substituted with a moiety having the structure (III)-LH. wherein A and L1 are as defined herein.
摘要翻译：本发明提供了分离的均相多官能化蛋白质（例如红细胞生成素），分离的糖肽，以及通过不含半胱氨酸的天然化学连接制备多官能化肽和/或蛋白质的方法。在某些实施方案中，本发明提供具有结构（I）的分离的均相多官能化蛋白质。在某些其它实施方案中，本发明提供了具有式（II）的分离的糖肽。在某些其他实施方案中，本发明的方法是制备多功能化肽的方法，其包含由四个或更多个氨基酸组成的肽主链，其中两个或多个不相邻氨基酸独立地被具有结构（III）的部分取代， -LH。其中A和L1如本文所定义。

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