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21. 发明授权

US08830821B2 Method for supporting MPLS transport path recovery with multiple protection entities 有权
标题翻译：支持多路保护实体的MPLS传输路径恢复方法
公开(公告)号：US08830821B2
公开(公告)日：2014-09-09
申请号：US13311128
申请日：2011-12-05
申请人： Daniel Cohn , Rafi Ram
发明人： Daniel Cohn , Rafi Ram
IPC分类号： H04J1/16 , H04L12/28
CPC分类号： H04J3/14 , H04L45/12 , H04L45/22 , H04L45/28 , H04L45/50
摘要： A system and method for selecting MPLS network transport entities between a first endpoint and a second endpoint are presented. Working and protection entities are selected from a set of available entities based upon minimizing the probability of simultaneous failure and/or minimizing a cost function base upon one or more metrics.
摘要翻译：提出了一种用于在第一端点和第二端点之间选择MPLS网络传输实体的系统和方法。基于一个或多个度量基于最小化同时故障的概率和/或使成本函数最小化，从一组可用实体中选择工作和保护实体。

22. 发明申请

US20120263453A1 METHOD FOR SUPPORTING SNCP OVER PACKET NETWORK 有权
标题翻译：支持分组网络SNCP的方法
公开(公告)号：US20120263453A1
公开(公告)日：2012-10-18
申请号：US13087438
申请日：2011-04-15
申请人： Daniel Cohn , Rafi Ram
发明人： Daniel Cohn , Rafi Ram
IPC分类号： H04B10/00
CPC分类号： H04B10/032 , H04L45/28 , H04L45/68 , H04L49/557 , H04Q11/0066 , H04Q2011/0081
摘要： A method is presented for supporting SNCP over a packet network connecting to two SDH sub-networks and transporting one or more SDH paths that are SNCP-protected in both SDH sub-networks. The packet network connects to each of two sub-network interconnection points by a working path and a protection path. The packet sub-network may provide the same type of path protection as an SDH sub-network using SNCP, while avoiding bandwidth duplication.
摘要翻译：提出了一种通过连接到两个SDH子网络的分组网络来支持SNCP并传送在两个SDH子网络中被SNCP保护的一个或多个SDH路径的方法。分组网络通过工作路径和保护路径连接到两个子网络互连点中的每一个。分组子网络可以提供与使用SNCP的SDH子网络相同类型的路径保护，同时避免带宽复制。

23. 发明申请

US20090074819A1 POLYMERIC NANO-SHELLS 审中-公开
标题翻译：聚合纳米银
公开(公告)号：US20090074819A1
公开(公告)日：2009-03-19
申请号：US11719247
申请日：2005-11-15
申请人： Daniel Cohn , Gilad Lando
发明人： Daniel Cohn , Gilad Lando
IPC分类号： A61K47/32 , C08J3/05 , C07K1/00 , A61K9/00
CPC分类号： B01J13/14 , B82Y30/00
摘要： The present invention provides a method for manufacturing polymeric nano-structures (nano-shells), wherein the nano-structures are hollow and respond to a temperature change by reversibly changing their volume, and the method comprises the steps of providing a polymer forming supramolecular structures when dispersed in a liquid environment, dispersing the polymer in a liquid environment to form the supramolecular structures and crosslinking the supramolecular structures, where the crosslinking occurs with the structures, whereby the nano-shells are obtained. The nano-structures manufactured according to the present invention are useful in sequestering, transporting, or scavenging hydrophobic or hydrophilic materials.
摘要翻译：本发明提供一种制造聚合物纳米结构（nano-shell）的方法，其中纳米结构是中空的并且通过可逆地改变其体积来应对温度变化，并且该方法包括以下步骤：提供形成超分子结构的聚合物当分散在液体环境中时，将聚合物分散在液体环境中以形成超分子结构并交联超分子结构，其中与结构发生交联，由此获得纳米壳。根据本发明制造的纳米结构可用于螯合，运输或清除疏水或亲水材料。

24. 发明申请

US20080063620A1 Novel reverse thermo-sensitive block copolymers 审中-公开
标题翻译：新型反向热敏嵌段共聚物
公开(公告)号：US20080063620A1
公开(公告)日：2008-03-13
申请号：US11979590
申请日：2007-11-06
申请人： Daniel Cohn , Alejandro Sosnik , Michael Kheyfetz
发明人： Daniel Cohn , Alejandro Sosnik , Michael Kheyfetz
IPC分类号： A61K31/74 , A61F2/00 , A61P43/00 , C08L53/00
CPC分类号： A61K47/34 , A61L27/18 , A61L27/54 , A61L2400/06 , C08G63/66 , C08G63/664 , C08L71/02
摘要： The invention provides a responsive polymeric system, comprising: a polymeric responsive component capable of undergoing a transition that results in a sharp increase in viscosity in response to a change in temperature at a predetermined body site; wherein the polymeric component comprises hydrophilic and hydrophobic segments covalently bound within the polymer component, by at least one chain extender or coupling agent, having at least 2 functional groups; wherein the hydrophilic and hydrophobic segments do not display Reverse Thermal Gelation behavior of their own at clinically relevant temperatures and; wherein the viscosity of the polymeric component increases by at least about 2 times upon exposure to a predetermined trigger.
摘要翻译：本发明提供一种响应性聚合物体系，其包括：能够经历转变的聚合物响应组分，其导致响应于预定体部位处温度变化引起的粘度急剧增加; 其中所述聚合物组分包含通过至少一种具有至少2个官能团的增链剂或偶联剂共价结合在聚合物组分内的亲水和疏水链段; 其中所述亲水和疏水链段在临床相关温度下不显示其本身的反向热凝胶行为; 其中所述聚合物组分的粘度在暴露于预定触发剂时增加至少约2倍。

25. 发明授权

US06870012B2 Chain-extended peo/ppo/peo block copolymer, optionally with polyester blocks, combined with cellular or bioactive material 有权
标题翻译：链延长的peo / ppo / peo嵌段共聚物，任选地具有聚酯嵌段，与细胞或生物活性材料组合
公开(公告)号：US06870012B2
公开(公告)日：2005-03-22
申请号：US10422559
申请日：2003-04-24
申请人： Daniel Cohn , Avraham Levi
发明人： Daniel Cohn , Avraham Levi
IPC分类号： C08G63/664 , C08G65/332 , C08L71/02 , A61K47/34 , C08G65/08
CPC分类号： C08G65/3324 , C08G63/664 , C08L71/02 , C08L2205/05 , C08L2666/18
摘要： A composition exhibiting reverse thermal gellation properties comprises a block polymer having the structure: {[An(BCB)An]}m wherein A is a polyester unit, B is a poly(ethylene oxide) unit, C is a poly(propylene oxide) unit, E is a chain extender unit, n=0-20, and m is greater than 2. The ethylene oxide:propylene oxide ratio ranges from about 0.2:1 to about 40:1. The composition has a final viscosity at a final temperature of more than twice the initial viscosity at an initial temperature wherein the final temperature is at least 10° C. higher than the initial temperature. The composition is combined with either a cellular material for tissue engineering, a cellular material for effecting repair or healing in a patient, or a bioactive agent.
摘要翻译：具有逆热凝胶性的组合物包含具有以下结构的嵌段聚合物：其中A是聚酯单元，B是聚（环氧乙烷）单元，C是聚（环氧丙烷）单元，E是扩链剂单元，n = 0-20，m大于2.环氧乙烷：环氧丙烷的比例为约0.2:1至约40:1。该组合物在最终温度下的初始粘度的最终粘度为初始温度的两倍，其中最终温度比起始温度高至少10℃。组合物与用于组织工程的细胞材料，用于在患者中进行修复或愈合的细胞材料或生物活性剂组合。

26. 发明申请

US20050008609A1 Multi-component reverse thermo-sensitive polymeric systems 审中-公开
标题翻译：多组分反向热敏聚合体系
公开(公告)号：US20050008609A1
公开(公告)日：2005-01-13
申请号：US10789431
申请日：2004-02-27
申请人： Daniel Cohn , Alejandro Sosnik
发明人： Daniel Cohn , Alejandro Sosnik
IPC分类号： A61K9/00 , A61K31/74 , A61K47/34
CPC分类号： A61K9/0024 , A61K47/34
摘要： A multi-component environmentally responsive polymeric system, having at least two environmentally responsive polymeric components capable of undergoing a transition that results in a sharp increase in viscosity in response to a change in temperature at a predetermined body site, wherein the at least two components display different reverse thermal gelation behavior in the human body.
摘要翻译：一种多组分环境响应的聚合物体系，其具有至少两种环境响应性聚合物组分，其能够经历转变，其导致响应于在预定体部位处的温度变化引起的粘度急剧增加，其中所述至少两种组分显示不同的反向热凝胶化行为在人体内。

27. 发明授权

US06579951B1 Chain-extended or crosslinked polyethylene oxide/polypropylene oxide/polyethylene oxide block polymer with optional polyester blocks 有权
标题翻译：链可延长或交联的聚环氧乙烷/聚环氧丙烷/聚环氧乙烷嵌段聚合物与可选的聚酯嵌段
公开(公告)号：US06579951B1
公开(公告)日：2003-06-17
申请号：US09587983
申请日：2000-06-06
申请人： Daniel Cohn , Avraham Levi
发明人： Daniel Cohn , Avraham Levi
IPC分类号： C08G63664
CPC分类号： C08G65/3324 , C08G63/664 , C08L71/02 , C08L2205/05 , C08L2666/18
摘要： A composition exhibiting reverse thermal gellation properties comprises a block polymer having the structure: {[An(BCB)An]}m wherein A is a polyester unit, B is a poly(ethylene oxide) unit, C is a poly(propylene oxide unit, E is a chain extender or crosslinking agent unit, n ranges from 0 to 20, and m is greater than 2, said block polymer possessing an EO (ethylene xide):PO (propylene oxide) ratio ranging from about 0.2:1 to about 40:1, said composition having a final viscosity at a final temperature of more than twice the initial viscosity at an initial temperature, said final temperature being at least 10° C. higher than said initial temperature.
摘要翻译：具有逆热凝胶性的组合物包含具有以下结构的嵌段聚合物：其中A是聚酯单元，B是聚（环氧乙烷）单元，C是聚（环氧丙烷单元，E是增链剂或交联剂单元，n为0至20，m大于2，所述嵌段聚合物具有EO（乙烯基）：PO（环氧丙烷）比为约0.2:1至约40:1，所述组合物具有最终粘度在初始温度下的初始粘度的两倍以上的最终温度下，所述最终温度比所述初始温度高至少10℃。

28. 发明授权

US06211249B1 Polyester polyether block copolymers 失效
标题翻译：聚酯聚醚嵌段共聚物
公开(公告)号：US06211249B1
公开(公告)日：2001-04-03
申请号：US09006664
申请日：1998-01-13
申请人： Daniel Cohn , Theodor Stern , Avraham Levi
发明人： Daniel Cohn , Theodor Stern , Avraham Levi
IPC分类号： A61K4734
CPC分类号： C08G69/44 , A61L31/06 , C08G63/08 , C08G63/664 , C08L67/04 , C08L77/12
摘要： The present invention relates to novel bioabsorbable polymeric compositions based upon AB polyester polyether or related diblocks and triblocks. Compositions according to the present invention may be used in medical applications, for example, for reducing or preventing adhesion formation subsequent to medical procedures such as surgery, for producing surgical articles including stents and grafts, as coatings, sealants, lubricants, as transient barriers in the body, for materials which control the release of bioactive agents in the body, for wound and bum dressings and producing biodegradable articles, among numerous others.
摘要翻译：本发明涉及基于AB聚酯聚醚或相关二嵌段和三嵌段的新型生物可吸收聚合物组合物。根据本发明的组合物可以用于医疗应用中，例如用于减少或防止医疗程序如手术之后的粘附形成，用于生产包括支架和移植物的外科用品，作为涂层，密封剂，润滑剂，作为瞬时屏障身体，用于控制身体中生物活性剂释放的材料，用于伤口和烧伤敷料以及生产可生物降解的制品等等。

29. 发明申请

US20130046534A1 MECHANISM FOR DYNAMIC SIGNALING OF ENCODER CAPABILITIES 有权
标题翻译：编码器功能动态信号的机制
公开(公告)号：US20130046534A1
公开(公告)日：2013-02-21
申请号：US13588445
申请日：2012-08-17
申请人： Rafi Rabipour , Chung-Cheung Chu , Daniel Cohn
发明人： Rafi Rabipour , Chung-Cheung Chu , Daniel Cohn
IPC分类号： G10L19/12
CPC分类号： H04M7/0072 , G10L19/00 , H04L65/1059 , H04L65/608 , H04W28/18 , H04W88/181
摘要： The present disclosure provides systems and methods for dynamically signaling encoder capabilities of vocoders of corresponding communication nodes. In one embodiment, during a call between a first communication node and a second communication node, a control node (e.g., base station controller or mobile switching center) for the first communication node sends capability information for a voice encoder of a vocoder of the first communication node to a control node for the second communication node. As a result, the second communication node is enabled to select and request a preferred encoder mode for the voice encoder of the vocoder of the first communication node based on the capabilities of the voice encoder of the vocoder of the first communication node.
摘要翻译：本公开提供用于动态地信令相应通信节点的声码器的编码器能力的系统和方法。在一个实施例中，在第一通信节点和第二通信节点之间的呼叫期间，用于第一通信节点的控制节点（例如，基站控制器或移动交换中心）发送用于第一通信节点的声码器的语音编码器的能力信息通信节点到第二通信节点的控制节点。结果，第二通信节点能够基于第一通信节点的声码器的语音编码器的能力来选择并请求第一通信节点的声码器的语音编码器的优选编码器模式。

30. 发明申请

US20070116666A1 Methods and compositions for reducing or eliminating post-surgical adhesion formation 审中-公开
公开(公告)号：US20070116666A1
公开(公告)日：2007-05-24
申请号：US11652730
申请日：2007-01-12
申请人： Daniel Cohn , Eli Pines , Anna Hotovely
发明人： Daniel Cohn , Eli Pines , Anna Hotovely
IPC分类号： A61K31/785 , A61K31/765 , C08F20/00
CPC分类号： C08G69/44 , A61K31/765 , A61K31/77 , A61K31/785 , A61L31/06 , C08G63/08 , C08G63/664 , C08L77/12 , C08L67/04 , C08L67/025
摘要： The present invention relates to a method for reducing adhesions associated with post-operative surgery. The present method comprises administering or affixing a polymeric composition preferably comprising chain extended, coupled or crosslinked polyester/poly(oxyalkylene) ABA triblocks or AB diblocks having favorable EO/LA ratios to a site in the body which has been subjected to trauma, e.g. by surgery, excision or inflammatory disease. In the present invention, the polymeric material provides a barrier to prevent or reduce the extent of adhesions forming.

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